TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 297.43 | Formula: C17H4D14FN3
H donors: 0 H acceptors: 1 LogP: 4.4 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: c1([2H])cc2c(c(c1[2H])[2H])n(c(c2C([2H])([2H])[2H])[2H])N(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])c1ccncc1F
InChi: 1S/C17H18FN3/c1-3-10-20(17-8-9-19-11-15(17)18)21-12-13(2)14-6-4-5-7-16(14)21/h4-9,11-12H,3,10H2,1-2H3/i1D3,2D3,3D2,4D,5D,7D,10D2,12D
InChiKey: BTDHTARYCBHHPJ-VSNDFMTHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1291
Schistosoma mansoni	fusion	0.0078	0.1635	0.3377
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1243
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.3798
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0621	0.3798
Loa Loa (eye worm)	brahma associated protein	0.0219	0.481	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2266	0.4693
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0611	0.1243
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0449	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0006	0.0016	0.0377
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.2266	0.471
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0612	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Echinococcus multilocularis	zinc finger protein Ran binding	0.0078	0.1635	0.3377
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0078	0.1635	1
Onchocerca volvulus		0.0078	0.1635	0.3087
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0597	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1635	0.3377
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0419
Schistosoma mansoni	hypothetical protein	0.0219	0.481	1
Schistosoma mansoni	hypothetical protein	0.0219	0.481	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.1326
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2266	0.4693
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0597	0.1241
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0419
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1212
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Giardia lamblia	Hexose transporter	0.0015	0.0217	0.346
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0612	0.0597
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0715	0.4375
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0175	0.0333
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0219	0.481	0.7269
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0217	0.5239
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0333	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.0219	0.481	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0612	0.0597
Trypanosoma cruzi	WLM domain containing protein, putative	0.0078	0.1635	1
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0611	0.1271
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0414	0.083
Plasmodium falciparum	protein kinase 7	0.0299	0.6617	0.6612
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0078	0.1635	0.3377
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0419
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0134	0.3243
Echinococcus granulosus	ring and YY1 binding protein	0.0078	0.1635	0.3377
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0134	0.0247
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0419
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.1635	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1291
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0006	0.0016	0.0024
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0078	0.1635	0.3377
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.481	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0715	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Onchocerca volvulus		0.0219	0.481	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.1635	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0414	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0715	0.4375
Chlamydia trachomatis	SWIB complex protein	0.0219	0.481	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1635	0.3377
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0078	0.1635	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0621	0.1291
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.045
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1243
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0217	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1635	0.3377
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0217	0.1326
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.045
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0078	0.1635	0.3377
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0715	0.4375
Leishmania major	hypothetical protein, conserved	0.0078	0.1635	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.045
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0414	0.083
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0419
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0078	0.1635	1
Giardia lamblia	Kinase, NEK	0.0006	0.0016	0.0011
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0612	0.0597
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0006	0.0016	0.0377
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0597	0.1212
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0219	0.481	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.3798
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0219	0.481	0.4802
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.3798
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0414	0.083
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0217	0.0419
Schistosoma mansoni	brg-1 associated factor	0.0219	0.481	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0217	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0217	0.0419
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2266	0.4693
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0611	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0414	0.083
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Trypanosoma cruzi	hexose transporter	0.0033	0.0621	0.3798
Leishmania major	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0095
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2266	0.4693
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.086
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0078	0.1635	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0217	0.0419
Toxoplasma gondii	protein kinase, putative	0.0299	0.6617	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0171	0.3734	0.3724
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0419
Echinococcus multilocularis	General substrate transporter	0.0091	0.193	0.3994
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0219	0.481	0.4802
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0611	0.3741
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0217	0.045
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.253
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1635	0.3377
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	0.5587
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0463	0.0932
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0715	0.0701
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0006	0.0016	0.0095
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.3798
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0715	0.4375
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0597	0.1212
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0217	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0219	0.481	1
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0566	0.1149
Trypanosoma cruzi	WLM domain containing protein, putative	0.0078	0.1635	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Loa Loa (eye worm)	sugar transporter	0.0015	0.0217	0.0419
Entamoeba histolytica	protein kinase, putative	0.0032	0.0611	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0419
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0217	0.5239
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1243
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0078	0.1635	0.3377
Plasmodium vivax	sugar transporter, putative	0.0015	0.0217	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0217	0.6499
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0016	0.0001
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.1326
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2266	0.4693
Leishmania major	hypothetical protein, conserved	0.0078	0.1635	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0612	0.0597
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0217	0.0327
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0414	0.6932
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0597	0.1212
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0078	0.1635	1
Brugia malayi	brahma associated protein 60 kDa	0.0219	0.481	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.045
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0032
Schistosoma mansoni	glucose transporter	0.0015	0.0217	0.0419
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0217	0.1326
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1212
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0419
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Brugia malayi	brahma associated protein 60 kDa	0.0219	0.481	1
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0414	0.0625
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0414	0.6849
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0219	0.481	0.4802
Schistosoma mansoni	glucose transport protein	0.0106	0.2266	0.4693
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1291
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0219	0.481	0.7269
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0078	0.1635	0.3377
Schistosoma mansoni	hypothetical protein	0.0106	0.2266	0.4693
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0419
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0621	0.3798
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0217	0.1326
Loa Loa (eye worm)	sugar transporter	0.0106	0.2266	0.4693
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.2266	0.3424
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0078	0.1635	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0611	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Leishmania major	hypothetical protein, conserved	0.0078	0.1635	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0621	0.1291
Plasmodium vivax	hexose transporter	0.0106	0.2266	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0612	0.0597
Schistosoma mansoni	RNA binding protein	0.0078	0.1635	0.3377
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0611	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1635	0.3377
Schistosoma mansoni	zinc finger protein	0.0078	0.1635	0.3377
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0621	0.1291
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0348	0.0724
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0715	0.4375
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Echinococcus granulosus	SWI:SNF matrix associated	0.0219	0.481	1
Echinococcus granulosus	Zinc finger RanBP2 type	0.0078	0.1635	0.3377
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0078	0.1635	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.1635	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.253
Echinococcus granulosus	General substrate transporter	0.0091	0.193	0.3994
Chlamydia trachomatis	DNA topoisomerase I	0.0219	0.481	1
Onchocerca volvulus		0.0078	0.1635	0.3087
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0414	0.083
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0612	0.0597
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0286	0.1747
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1243
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0095
Mycobacterium ulcerans	sugar transporter	0.0015	0.0217	0.5239
Schistosoma mansoni	hypothetical protein	0.0078	0.1635	0.3377
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0419
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0419
Leishmania major	hypothetical protein, conserved	0.0078	0.1635	1
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0217	0.0327
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0597	0.9752
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0219	0.481	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0621	0.1291
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0217	0.6499
Brugia malayi	Sugar transporter family protein	0.0106	0.2266	0.4693
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0006	0.0016	0.0468
Plasmodium vivax	hypothetical protein, conserved	0.0219	0.481	0.4802
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0612	0.0597
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0217	0.045
Leishmania major	hypothetical protein, conserved	0.0015	0.0217	0.1326
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0078	0.1635	0.3087
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0414	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Echinococcus multilocularis	SWI:SNF matrix associated	0.0219	0.481	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0597	0.1212
Leishmania major	glucose transporter, lmgt1	0.0033	0.0621	0.3798
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1243
Plasmodium falciparum	hexose transporter	0.0106	0.2266	0.2253
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0217	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0078	0.1635	0.247
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0414	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.253
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Giardia lamblia	Sugar-proton symporter	0.0015	0.0217	0.346
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0611	0.1243
Brugia malayi	YY1-associated factor 2	0.0078	0.1635	0.3377
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.045
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0217	0.5239
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0419
Echinococcus multilocularis	SWI:SNF matrix associated	0.0219	0.481	1
Leishmania major	hypothetical protein, conserved	0.0078	0.1635	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0419
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0419
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0078	0.1635	0.3377
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0095
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0419
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0419
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0217	0.045
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0715	0.1081
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0414	0.083
Schistosoma mansoni	glucose transport protein	0.0106	0.2266	0.4693
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0134	1
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.1635	1
Schistosoma mansoni	hypothetical protein	0.0219	0.481	1
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0566	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.3798
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.3798
Entamoeba histolytica	hypothetical protein	0.0024	0.0414	0.6679
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0419
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0612	0.0925
Onchocerca volvulus		0.0078	0.1635	0.3087
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0621	0.3798
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Toxoplasma gondii	glycyl-tRNA synthetase	0.0006	0.0016	0.0024
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0419
Schistosoma mansoni	protein kinase	0.0032	0.0611	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Echinococcus multilocularis	SWI:SNF matrix associated	0.0219	0.481	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Leishmania major	glucose transporter, lmgt2	0.0033	0.0621	0.3798
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0171	0.3734	0.3724
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0414	0.083
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Echinococcus multilocularis	ring and YY1 binding protein	0.0078	0.1635	0.3377
Giardia lamblia	Kinase, NEK	0.0006	0.0016	0.0011
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0612	0.0597
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0171	0.3734	0.5643
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Schistosoma mansoni	TRABID protein (C64 family)	0.0078	0.1635	0.3377
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0414	0.0399
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0419
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0095
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2266	0.4693
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.1635	1
Toxoplasma gondii	ran binding protein	0.0078	0.1635	0.247
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0419
Onchocerca volvulus		0.0078	0.1635	0.3087
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2266	0.4693
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1243
Schistosoma mansoni	glucose transport protein	0.0106	0.2266	0.4693
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0612	0.0925
Brugia malayi	Cam kinase protein 1	0.0032	0.0611	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0597	0.1212
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0611	0.1243
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0078	0.1635	0.3377
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.3798
Giardia lamblia	Kinase	0.0006	0.0016	0.0011
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0006	0.0016	0.0262
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0419
Leishmania major	protein kinase, putative	0.0032	0.0611	0.3741
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.2266	0.4693
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0612	0.0597
Leishmania major	glucose transporter, lmgt3	0.0033	0.0621	0.3798
Entamoeba histolytica	protein kinase, putative	0.0032	0.0611	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0419
Echinococcus granulosus	zinc finger protein Ran binding	0.0078	0.1635	0.3377
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0217	0.0419
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0078	0.1635	0.1622
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0419
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0611	0.1243
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0217	0.0327
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0217	0.1326

Activities

Activity type	Activity value	Assay description	Source	Reference
CLH (ADMET)	= 0.217 nmol/min	Clearance in human liver microsomes assessed as initial mean metabolism rate at 5 uM at protein concentration of 1 mg/ml measured per mg protein up to 30 mins by LC-MS/MS analysis	ChEMBL.	25900628

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3585642

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1936739