TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.833 | Formula: C19H21ClN2O5
H donors: 3 H acceptors: 5 LogP: 2.51 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)C1=C(C)N(CC)C(=C(C1c1ccccc1Cl)C(=O)O)C(=O)O
InChi: 1S/C19H21ClN2O5/c1-4-21-17(23)13-10(3)22(5-2)16(19(26)27)15(18(24)25)14(13)11-8-6-7-9-12(11)20/h6-9,14H,4-5H2,1-3H3,(H,21,23)(H,24,25)(H,26,27)
InChiKey: LXKAQMWETQWIPQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References
Homo sapiens	phosphorylase, glycogen	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0088	0.2555	0.2266
Leishmania major	pentamidine resistance protein 1	0.0088	0.2555	0.2555
Leishmania major	ABC-thiol transporter	0.0088	0.2555	0.2555
Schistosoma mansoni	multidrug resistance protein	0.0088	0.2555	0.2296
Brugia malayi	hypothetical protein	0.0088	0.2555	0.2555
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0088	0.2555	0.2753
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0275	1	1
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG89	0.0045	0.0821	0.0821
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG96	0.0045	0.0821	0.0821
Trypanosoma brucei	ABC transporter, putative	0.0257	0.9281	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0821	0.0884
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0275	1	1
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.0088	0.2555	0.2555
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0275	1	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0088	0.2555	0.0332
Entamoeba histolytica	P-glycoprotein 6, putative	0.0088	0.2555	0.2093
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0275	1	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.0257	0.9281	0.9159
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0088	0.2555	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0275	1	1
Trypanosoma brucei	ATP-binding cassette protein subfamily G	0.0045	0.0821	0.0884
Brugia malayi	P-glycoprotein-like protein	0.0088	0.2555	0.2555
Echinococcus multilocularis	ATP binding cassette sub family B	0.0088	0.2555	0.13
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0275	1	1
Entamoeba histolytica	P-glycoprotein-2	0.0275	1	1
Echinococcus granulosus	multidrug resistance associated protein 1	0.0088	0.2555	0.13
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0257	0.9281	1
Brugia malayi	ABC transporter family protein	0.0088	0.2555	0.2555
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.0088	0.2555	0.2093
Entamoeba histolytica	ABC transporter, putative	0.0088	0.2555	0.2093
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0088	0.2555	0.2753
Echinococcus granulosus	glycogen phosphorylase	0.0261	0.9437	0.9342
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG107	0.0045	0.0821	0.0821
Leishmania major	p-glycoprotein e	0.0088	0.2555	0.2555
Brugia malayi	RNA recognition motif domain containing protein	0.006	0.1442	0.1442
Trichomonas vaginalis	ABC transporter, putative	0.0275	1	1
Schistosoma mansoni	multidrug resistance protein	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.9764	0.9764
Leishmania major	ATP-binding cassette protein subfamily G, member 1, putative	0.0045	0.0821	0.0821
Brugia malayi	carbohydrate phosphorylase	0.0261	0.9437	0.9437
Trypanosoma brucei	ATP-binding cassette protein, putative	0.0257	0.9281	1
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.0088	0.2555	0.2555
Schistosoma mansoni	tar DNA-binding protein	0.006	0.1442	0.1145
Echinococcus granulosus	multidrug resistance protein 1	0.0275	1	1
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0088	0.2555	0.2555
Schistosoma mansoni	tar DNA-binding protein	0.006	0.1442	0.1145
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0088	0.2555	1
Toxoplasma gondii	ABC transporter family protein	0.0088	0.2555	0.2555
Brugia malayi	ABC transporter	0.0082	0.2318	0.2318
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.0212	0.7507	0.7352
Trichomonas vaginalis	abcb9, putative	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0584	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0584	0.0584
Plasmodium falciparum	ABC transporter B family member 7, putative	0.0088	0.2555	0.2555
Echinococcus multilocularis	ATP binding cassette sub family B	0.0088	0.2555	0.13
Loa Loa (eye worm)	ABC transporter	0.0088	0.2555	0.2555
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0113	0.3539	0.3138
Loa Loa (eye worm)	ABC transporter	0.0088	0.2555	0.2555
Entamoeba histolytica	glycogenphosphorylase, putative	0.0113	0.3539	0.3138
Giardia lamblia	Multidrug resistance-associated protein 1	0.0088	0.2555	0.0332
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0088	0.2555	0.13
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0584	0.063
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0932	0.0932
Plasmodium falciparum	multidrug resistance-associated protein 2	0.0088	0.2555	0.2555
Echinococcus granulosus	ATP binding cassette sub family G	0.0257	0.9281	0.9159
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.0088	0.2555	0.2555
Plasmodium vivax	ABC transporter B family member 3, putative	0.0088	0.2555	0.2555
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0261	0.9437	0.9342
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0082	0.2318	0.2052
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0821	0.0884
Plasmodium falciparum	multidrug resistance-associated protein 1	0.0088	0.2555	0.2555
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0275	1	1
Brugia malayi	RE11181p	0.0039	0.0584	0.0584
Brugia malayi	multidrug resistance related protein 1	0.0088	0.2555	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2555	0.2555
Echinococcus multilocularis	ATP binding cassette sub family B	0.0088	0.2555	0.13
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0088	0.2555	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0088	0.2555	0.2266
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0275	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0088	0.2555	0.2093
Schistosoma mansoni	smdr1	0.0088	0.2555	0.2296
Plasmodium falciparum	multidrug resistance protein 1	0.0275	1	1
Plasmodium vivax	multidrug resistance protein 2, putative	0.0088	0.2555	0.2555
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0088	0.2555	0.2266
Schistosoma mansoni	tar DNA-binding protein	0.006	0.1442	0.1145
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0193	0.6728	0.5741
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0275	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0275	1	1
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0088	0.2555	0.2266
Loa Loa (eye worm)	transcription factor SMAD2	0.0113	0.3562	0.3562
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0088	0.2555	0.2753
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0275	1	1
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0088	0.2555	0.2555
Brugia malayi	ABC transporter	0.0088	0.2555	0.2555
Echinococcus granulosus	glycogen phosphorylase	0.0261	0.9437	0.9342
Entamoeba histolytica	ABC transporter, putative	0.0257	0.9281	0.9236
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.0257	0.9281	0.9256
Entamoeba histolytica	glycogen phosphorylase, putative	0.0113	0.3539	0.3138
Loa Loa (eye worm)	ABC transporter	0.0088	0.2555	0.2555
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.0257	0.9281	0.9281
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0275	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0275	1	1
Trypanosoma cruzi	ATP-binding cassette protein subfamily G	0.0045	0.0821	0.0884
Echinococcus multilocularis	ATP binding cassette sub family B	0.0088	0.2555	0.13
Schistosoma mansoni	ABC transporter	0.0039	0.0584	0.0257
Schistosoma mansoni	multidrug resistance protein	0.0275	1	1
Schistosoma mansoni	smdr2	0.0275	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.006	0.1442	0.1442
Trypanosoma brucei	ABC transporter, putative	0.0045	0.0821	0.0884
Trichomonas vaginalis	ABC transporter, putative	0.0275	1	1
Echinococcus multilocularis	glycogen phosphorylase	0.0261	0.9437	0.9342
Plasmodium vivax	ABC transporter B family member 6, putative	0.0088	0.2555	0.2555
Schistosoma mansoni	multidrug resistance protein	0.0082	0.2318	0.2052
Loa Loa (eye worm)	MH2 domain-containing protein	0.0113	0.3562	0.3562
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0275	1	1
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0088	0.2555	0.2555
Plasmodium falciparum	multidrug resistance protein 2	0.0088	0.2555	0.2555
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.0257	0.9281	0.9281
Entamoeba histolytica	hypothetical protein	0.0088	0.2555	0.2093
Echinococcus granulosus	ATP binding cassette sub family B	0.0088	0.2555	0.13
Echinococcus granulosus	multidrug resistance protein 1	0.0275	1	1
Entamoeba histolytica	multidrug resistance protein, putative	0.0088	0.2555	0.2093
Loa Loa (eye worm)	glycogen phosphorylase	0.0261	0.9437	0.9437
Trichomonas vaginalis	abcb9, putative	0.0275	1	1
Giardia lamblia	ABC transporter, putative	0.0088	0.2555	0.0332
Echinococcus multilocularis		0.0088	0.2555	0.13
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.0257	0.9281	0.9281
Schistosoma mansoni	tar DNA-binding protein	0.006	0.1442	0.1145
Brugia malayi	RNA binding protein	0.006	0.1442	0.1442
Trypanosoma cruzi	ABC transporter, putative	0.0039	0.0584	0.063
Loa Loa (eye worm)	TAR-binding protein	0.006	0.1442	0.1442
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0275	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0088	0.2555	0.0308
Schistosoma mansoni	multidrug resistance protein	0.0088	0.2555	0.2296
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Plasmodium vivax	ABC transporter B family member 5, putative	0.0088	0.2555	0.2555
Brugia malayi	TAR-binding protein	0.006	0.1442	0.1442
Brugia malayi	hypothetical protein	0.0039	0.0584	0.0584
Entamoeba histolytica	glycogen phosphorylase, putative	0.0261	0.9437	0.9402
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0275	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0275	1	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2318	0.2318
Schistosoma mansoni	glycogen phosphorylase	0.0261	0.9437	0.9418
Brugia malayi	ABC transporter transmembrane region family protein	0.0088	0.2555	0.2555
Brugia malayi	ABC transporter transmembrane region family protein	0.0082	0.2318	0.2318
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0275	1	1
Loa Loa (eye worm)	RNA binding protein	0.006	0.1442	0.1442
Echinococcus granulosus	ATP binding cassette sub family G	0.0257	0.9281	0.9159
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0088	0.2555	0.2753
Schistosoma mansoni	hypothetical protein	0.0212	0.7507	0.742
Loa Loa (eye worm)	hypothetical protein	0.0275	1	1
Plasmodium falciparum	ABC transporter B family member 6, putative	0.0088	0.2555	0.2555
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0088	0.2555	0.2266
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.0257	0.9281	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2555	0.2555
Entamoeba histolytica	P-glycoprotein 5, putative	0.0275	1	1
Brugia malayi	ABC transporter family protein	0.0275	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0047	0.0932	0.0932
Echinococcus granulosus	Glycosyl transferase family 35	0.0261	0.9437	0.9342
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0261	0.9437	0.9267
Entamoeba histolytica	glycogen phosphorylase, putative	0.0261	0.9437	0.9402
Trypanosoma cruzi	ABC transporter, putative	0.0257	0.9281	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0275	1	1
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0088	0.2555	0.2753
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0088	0.2555	0.2753
Brugia malayi	ABC transporter family protein	0.0218	0.7743	0.7743
Trypanosoma cruzi	ABC transporter, putative	0.0045	0.0821	0.0884
Schistosoma mansoni	tar DNA-binding protein	0.006	0.1442	0.1145
Echinococcus multilocularis	glycogen phosphorylase	0.0261	0.9437	0.9342
Trypanosoma brucei	multidrug resistance protein E	0.0088	0.2555	0.2753
Plasmodium vivax	multidrug resistance protein 1, putative	0.0275	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0275	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0193	0.6728	0.6177
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0047	0.0932	0.0932
Trypanosoma cruzi	ATP-binding cassette protein subfamily G	0.0045	0.0821	0.0884
Entamoeba histolytica	P-glycoprotein-2	0.0275	1	1
Entamoeba histolytica	P-glycoprotein 6, putative	0.0088	0.2555	0.2093
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0088	0.2555	0.2555
Trichomonas vaginalis	taga, putative	0.0275	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0269	0.9764	0.9724
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0275	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0193	0.6728	0.6177
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.0088	0.2555	0.2555
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0088	0.2555	0.13
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0088	0.2555	0.2555
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG87	0.0045	0.0821	0.0821
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0088	0.2555	0.2555
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0088	0.2555	0.2753
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0275	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0275	1	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0082	0.2318	0.1842
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0088	0.2555	0.5
Plasmodium falciparum	ABC transporter B family member 3, putative	0.0088	0.2555	0.2555
Echinococcus multilocularis	ATP binding cassette sub family G	0.0257	0.9281	0.9159
Entamoeba histolytica	P-glyco protein 6, putative	0.0275	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0275	1	1
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0275	1	1
Leishmania major	ATP-binding cassette protein subfamily G, member 2, putative	0.0045	0.0821	0.0821
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0257	0.9281	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0275	1	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0088	0.2555	0.2555
Schistosoma mansoni	glycogen phosphorylase	0.0261	0.9437	0.9418
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0088	0.2555	0.2555
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0088	0.2555	0.2555
Entamoeba histolytica	P-glycoprotein-1	0.0275	1	1
Leishmania major	p-glycoprotein	0.0275	1	1
Trypanosoma cruzi	ABC transporter, putative	0.0039	0.0584	0.063
Schistosoma mansoni	multidrug resistance protein	0.0088	0.2555	0.2296
Onchocerca volvulus		0.0275	1	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0082	0.2318	0.1024
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0261	0.9437	0.9267
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0088	0.2555	0.2093
Plasmodium falciparum	ABC transporter G family member 2	0.0257	0.9281	0.9281
Brugia malayi	latrophilin 2 splice variant baaae	0.0032	0.0336	0.0336
Trichomonas vaginalis	ABC transporter, putative	0.0275	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0275	1	1
Trichomonas vaginalis	abcb9, putative	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0584	0.0584
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0275	1	1
Brugia malayi	MH2 domain containing protein	0.0113	0.3562	0.3562
Brugia malayi	ABC transporter family protein	0.0088	0.2555	0.2555
Entamoeba histolytica	glycogen phosphorylase, putative	0.0113	0.3539	0.3138
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0113	0.3539	0.3398
Entamoeba histolytica	P-glycoprotein-2, putative	0.0082	0.2318	0.1842
Echinococcus granulosus	ATP binding cassette sub family B	0.0088	0.2555	0.13
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0088	0.2555	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0336	0.0336
Schistosoma mansoni	multidrug resistance protein	0.0275	1	1
Giardia lamblia	Glycogen phosphorylase	0.0261	0.9437	1
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0088	0.2555	0.2753
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0088	0.2555	0.2753
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.0088	0.2555	0.2555
Brugia malayi	ABC transporter family protein	0.0088	0.2555	0.2555
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0088	0.2555	0.2093
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0275	1	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0088	0.2555	0.2555
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0275	1	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0088	0.2555	0.2555
Echinococcus multilocularis	multidrug resistance protein 1	0.0275	1	1
Plasmodium falciparum	ABC transporter B family member 5, putative	0.0088	0.2555	0.2555
Plasmodium vivax	ABC transporter B family member 7, putative	0.0088	0.2555	0.2555
Schistosoma mansoni	multidrug resistance protein	0.0088	0.2555	0.2296
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0275	1	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0088	0.2555	0.2555
Giardia lamblia	ABC transporter	0.0251	0.9044	0.9448
Plasmodium vivax	ABC transporter G family member 2, putative	0.0257	0.9281	0.9281
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0269	0.9764	0.9724
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0275	1	1
Leishmania major	ATP-binding cassette protein subfamily G, member 5, putative	0.0045	0.0821	0.0821
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0275	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0088	0.2555	0.2093
Loa Loa (eye worm)	hypothetical protein	0.0275	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0047	0.0932	0.0932
Plasmodium vivax	ABC transporter B family member 4, putative	0.0088	0.2555	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2555	0.2555
Echinococcus multilocularis	multidrug resistance protein 1	0.0275	1	1
Schistosoma mansoni	multidrug resistance protein	0.0088	0.2555	0.2296
Schistosoma mansoni	ABC transporter	0.0218	0.7743	0.7665
Echinococcus granulosus	multidrug resistance associated protein 7	0.0088	0.2555	0.13
Echinococcus granulosus	ATP binding cassette sub family G	0.0257	0.9281	0.9159
Toxoplasma gondii	ABC transporter, putative	0.0088	0.2555	0.2555
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.0088	0.2555	0.2093
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0088	0.2555	0.2555
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0088	0.2555	0.2296
Plasmodium falciparum	ABC transporter B family member 4, putative	0.0088	0.2555	0.2555
Echinococcus multilocularis	multidrug resistance protein 1	0.0193	0.6728	0.6177
Entamoeba histolytica	P-glycoprotein-5	0.0275	1	1
Trypanosoma brucei	p-glycoprotein	0.0088	0.2555	0.2753
Schistosoma mansoni	glycogen phosphorylase	0.0113	0.3539	0.3315
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0257	0.9281	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.0257	0.9281	0.9159
Loa Loa (eye worm)	ABC transporter	0.0218	0.7743	0.7743
Giardia lamblia	MRP-like ABC transporter	0.0088	0.2555	0.0332

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12.4 nM	In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)	ChEMBL.	14505637
IC50 (binding)	= 12.4 nM	In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)	ChEMBL.	14505637
IC50 (binding)	= 19.9 nM	In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa)	ChEMBL.	14505637
IC50 (binding)	= 19.9 nM	In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa)	ChEMBL.	14505637

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL114846

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 200811