TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 325.408 | Formula: C18H23N5O
H donors: 1 H acceptors: 2 LogP: 1.71 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1n(C)nc(c1CNCc1cccc(c1)Cn1cccn1)C
InChi: 1S/C18H23N5O/c1-14-17(18(24-3)22(2)21-14)12-19-11-15-6-4-7-16(10-15)13-23-9-5-8-20-23/h4-10,19H,11-13H2,1-3H3
InChiKey: VFPVWBQHGIFBBV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1044	0.1044
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0236	0.7132	0.7132
Onchocerca volvulus		0.0055	0.1044	0.1044
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.009	0.2233	0.2233
Brugia malayi	excitatory GABA receptor EXP-1A	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.009	0.2233	0.2233
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.1044
Onchocerca volvulus		0.0055	0.1044	0.1044
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.009	0.2233	0.2233
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.009	0.2233	0.2233
Toxoplasma gondii	hypothetical protein	0.0055	0.1044	0.5
Plasmodium falciparum	amino acid transporter, putative	0.0055	0.1044	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.004	0.0548	0.0548
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.009	0.2233	0.2233
Brugia malayi	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.009	0.2233	0.2233
Onchocerca volvulus		0.009	0.2233	0.2233
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.009	0.2233	0.2233
Schistosoma mansoni	nAChR subunit	0.009	0.2233	0.2233
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0049	0.084	0.084
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.009	0.2233	0.2233
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0049	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0176	0.5113	0.5113
Brugia malayi	Cation transporter family protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0322	1	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.009	0.2233	0.2233
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0042	0.0606	0.0606
Brugia malayi	hypothetical protein	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Onchocerca volvulus		0.0042	0.0606	0.0606
Echinococcus granulosus	vesicular acetylcholine transporter	0.0176	0.5113	0.5113
Loa Loa (eye worm)	ACC-1 protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.009	0.2233	0.2233
Plasmodium vivax	amine transporter, putative	0.0055	0.1044	0.5
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0055	0.1044	0.1044
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0042	0.0606	0.0606
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.004	0.0548	0.0548
Schistosoma mansoni	nAChR subunit	0.009	0.2233	0.2233
Schistosoma mansoni	nAChR subunit	0.009	0.2233	0.2233
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.004	0.0548	0.0548
Echinococcus multilocularis	nAChR subunit	0.0049	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Onchocerca volvulus		0.009	0.2233	0.2233
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.009	0.2233	0.2233
Onchocerca volvulus		0.009	0.2233	0.2233
Echinococcus multilocularis	geminin	0.0148	0.4156	0.4156
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Schistosoma mansoni	nAChR subunit	0.009	0.2233	0.2233
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0055	0.1044	0.1044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.004	0.0548	0.0548
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.2233	0.2233
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0236	0.7132	0.7132
Brugia malayi	Cation transporter family protein	0.009	0.2233	0.2233
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0055	0.1044	0.5
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.009	0.2233	0.2233
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.004	0.0548	0.0548
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.2233	0.2233
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.004	0.0548	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.1044
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.009	0.2233	0.2233
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.009	0.2233	0.2233
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0176	0.5113	0.5113
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Schistosoma mansoni	nAChR subunit	0.009	0.2233	0.2233
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0293	0.9039	0.9039
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Schistosoma mansoni	nAChR subunit	0.0042	0.0606	0.0606
Brugia malayi	hypothetical protein	0.0042	0.0606	0.0606
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Loa Loa (eye worm)	norepinephrine transporter	0.0322	1	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Schistosoma mansoni	sodium/chloride dependent transporter	0.0055	0.1044	0.1044
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0042	0.0606	0.0606
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0042	0.0606	0.0606
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.004	0.0548	0.0548
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0322	1	1
Schistosoma mansoni	nAChR subunit	0.0042	0.0606	0.0606
Echinococcus multilocularis	glycine receptor subunit beta	0.009	0.2233	0.2233
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0668	0.0668
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0049	0.084	0.084
Onchocerca volvulus		0.0055	0.1044	0.1044
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0322	1	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0055	0.1044	0.1044
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.009	0.2233	0.2233
Echinococcus granulosus	glycine receptor subunit beta	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Echinococcus multilocularis	nAChR subunit	0.009	0.2233	0.2233
Echinococcus granulosus	glycine receptor subunit alpha 1	0.009	0.2233	0.2233
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0322	1	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.0322	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0207
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0236	0.7132	0.7132
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Echinococcus granulosus	nAChR subunit	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1044	0.1044
Schistosoma mansoni	nAChR subunit	0.009	0.2233	0.2233
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.009	0.2233	0.2233
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0236	0.7132	0.7132
Loa Loa (eye worm)	hypothetical protein	0.015	0.4235	0.4235
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0042	0.0606	0.0606
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.009	0.2233	0.2233
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Echinococcus granulosus	geminin	0.0148	0.4156	0.4156
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0236	0.7132	0.7132
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0055	0.1044	0.1044
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0055	0.1044	0.1044
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	GABA receptor subunit	0.0049	0.084	0.084
Brugia malayi	latrophilin 2 splice variant baaae	0.003	0.0207	0.0207
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Onchocerca volvulus		0.0322	1	1
Leishmania major	C-8 sterol isomerase-like protein	0.0293	0.9039	0.5
Schistosoma mansoni	neurotransmitter gated ion channel	0.0042	0.0606	0.0606
Onchocerca volvulus	Putative nachr subunit	0.0236	0.7132	0.7132
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0236	0.7132	0.7132
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Echinococcus granulosus	sodium and chloride dependent glycine	0.0055	0.1044	0.1044
Onchocerca volvulus		0.009	0.2233	0.2233
Onchocerca volvulus		0.0049	0.084	0.084
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0236	0.7132	0.7132
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0176	0.5113	0.5113
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.009	0.2233	0.2233
Plasmodium vivax	hypothetical protein, conserved	0.0055	0.1044	0.5
Echinococcus granulosus	serotonin transporter	0.0322	1	1
Brugia malayi	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0043	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0322	1	1
Schistosoma mansoni	hypothetical protein	0.0148	0.4156	0.4156
Schistosoma mansoni	nAChR subunit	0.009	0.2233	0.2233
Echinococcus multilocularis	glycine receptor subunit beta	0.009	0.2233	0.2233
Loa Loa (eye worm)	serotonin transporter b	0.0322	1	1
Echinococcus granulosus	glycine receptor subunit beta	0.009	0.2233	0.2233
Schistosoma mansoni	neurotransmitter gated ion channel	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1044	0.1044
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	LGC-31 protein	0.009	0.2233	0.2233
Toxoplasma gondii	hypothetical protein	0.0055	0.1044	0.5
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0043	0.0668	0.0668
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0055	0.1044	0.1044
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0055	0.1044	0.1044
Echinococcus granulosus	glycine receptor subunit alpha 1	0.009	0.2233	0.2233
Entamoeba histolytica	hypothetical protein	0.0049	0.084	0.5
Echinococcus granulosus	sodium and chloride dependent glycine	0.0055	0.1044	0.1044
Echinococcus multilocularis	serotonin transporter	0.0322	1	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0236	0.7132	0.7132
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0049	0.084	0.084
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.009	0.2233	0.2233
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0322	1	1
Brugia malayi	Cation transporter family protein	0.009	0.2233	0.2233
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.004	0.0548	0.0548
Onchocerca volvulus		0.0049	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.009	0.2233	0.2233
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0049	0.084	0.084
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0055	0.1044	0.1044
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0176	0.5113	0.5113
Onchocerca volvulus		0.009	0.2233	0.2233
Schistosoma mansoni	acetylcholine receptor-related	0.0042	0.0606	0.0606
Schistosoma mansoni	hypothetical protein	0.003	0.0207	0.0207
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Loa Loa (eye worm)	ACC-1 protein	0.009	0.2233	0.2233
Schistosoma mansoni	hypothetical protein	0.0148	0.4156	0.4156
Schistosoma mansoni	sodium/chloride dependent transporter	0.0055	0.1044	0.1044
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Schistosoma mansoni	vesicular acetylcholine transporter	0.0176	0.5113	0.5113
Loa Loa (eye worm)	hypothetical protein	0.0049	0.084	0.084
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.009	0.2233	0.2233
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.004	0.0548	0.0548
Brugia malayi	hypothetical protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0042	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0606	0.0606
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.0606	0.0606
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0293	0.9039	0.9039
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0055	0.1044	0.1044
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0042	0.0606	0.0606
Onchocerca volvulus		0.0042	0.0606	0.0606
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0043	0.0668	0.0668
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Loa Loa (eye worm)	acetylcholine receptor protein	0.0042	0.0606	0.0606
Onchocerca volvulus		0.0042	0.0606	0.0606
Echinococcus granulosus	nAChR subunit	0.0049	0.084	0.084
Echinococcus granulosus	glycine receptor subunit alpha 1	0.009	0.2233	0.2233
Schistosoma mansoni	neurotransmitter gated ion channel	0.0049	0.084	0.084
Brugia malayi	hypothetical protein	0.0042	0.0606	0.0606
Onchocerca volvulus		0.009	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.009	0.2233	0.2233
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.2233	0.2233
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0055	0.1044	0.1044
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0055	0.1044	0.1044
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0049	0.084	0.084
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0236	0.7132	0.7132
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0042	0.0606	0.0606
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.2233	0.2233
Plasmodium falciparum	transporter, putative	0.0055	0.1044	0.5
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.009	0.2233	0.2233
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0293	0.9039	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.009	0.2233	0.2233
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0293	0.9039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1044	0.1044

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3489366

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2068842