Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Polycystic kidney disease protein | 0.001 | 0.0082 | 0.0074 |
Loa Loa (eye worm) | doublecortin family protein | 0.001 | 0.0082 | 0.0038 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0074 | 0.1325 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0.019 | 0.0331 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0092 | 0.0058 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0009 | 0.005 | 0.0015 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0107 | 0.0072 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0014 | 0.0165 | 0.0121 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0092 | 0.0058 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0357 | 0.6851 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0156 | 0.2924 | 0.4241 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0007 | 0.0016 | 0.0047 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.003 | 0.0465 | 0.0635 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.003 | 0.0465 | 0.0431 |
Schistosoma mansoni | rab6-interacting | 0.001 | 0.0082 | 0.0074 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.003 | 0.0465 | 0.0431 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0016 | 0.019 | 0.0232 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0151 | 0.2834 | 1 |
Brugia malayi | cation channel family protein | 0.0333 | 0.6383 | 0.6367 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.019 | 0.0156 |
Brugia malayi | Doublecortin family protein | 0.001 | 0.0082 | 0.0038 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0092 | 0.0058 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0009 | 0.0051 | 0.0016 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0014 | 0.0165 | 0.0238 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.003 | 0.0465 | 0.0635 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0059 | 0.1031 | 0.1466 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0107 | 0.0072 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Trichomonas vaginalis | mannosyltransferase 1, putative | 0.0034 | 0.0549 | 0.0516 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.019 | 0.0156 |
Brugia malayi | hypothetical protein | 0.001 | 0.0082 | 0.0038 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0009 | 0.0066 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0337 | 0.0294 |
Brugia malayi | MIR domain containing protein | 0.0034 | 0.0549 | 0.0507 |
Leishmania major | hypothetical protein, conserved | 0.0125 | 0.2321 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0177 | 0.3343 | 0.4855 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0014 | 0.0165 | 0.0193 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0358 | 0.6879 | 0.6868 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0107 | 0.0072 |
Loa Loa (eye worm) | ryanodine receptor | 0.0059 | 0.1031 | 0.0991 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0184 | 0.3469 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.003 | 0.0465 | 0.1334 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0021 | 0.0294 | 0.0251 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.003 | 0.0465 | 0.0422 |
Echinococcus granulosus | stromal cell derived factor 2 | 0.0034 | 0.0549 | 0.0759 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0092 | 0.0058 |
Schistosoma mansoni | alpha-glucosidase | 0.0078 | 0.1399 | 0.2005 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0009 | 0.0051 | 0.0016 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0014 | 0.0165 | 0.013 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0014 | 0.0165 | 0.0293 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.003 | 0.0465 | 0.0431 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0107 | 0.0072 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0011 | 0.0107 | 0.0309 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0011 | 0.01 | 0.0065 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0184 | 0.3469 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0011 | 0.01 | 0.0065 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.019 | 0.0232 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.001 | 0.0082 | 0.0074 |
Echinococcus multilocularis | RUN | 0.001 | 0.0082 | 0.0074 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0011 | 0.01 | 0.0056 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.003 | 0.0465 | 1 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0034 | 0.0549 | 0.0759 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0016 | 0.019 | 0.0147 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0014 | 0.0165 | 0.013 |
Echinococcus granulosus | geminin | 0.0188 | 0.3547 | 0.5155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0009 | 0.005 | 0.0015 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6521 | 0.6509 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.003 | 0.0465 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0082 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0277 | 0.0234 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0016 | 0.019 | 0.0147 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0092 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.01 | 0.0056 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6521 | 0.6509 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6521 | 0.6509 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.002 | 0.0277 | 0.0359 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0028 | 0.0438 | 0.0596 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.003 | 0.0465 | 0.0431 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0029 | 0.0441 | 0.06 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0096 | 0.1764 | 0.254 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0121 | 0.2242 | 0.3242 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0016 | 0.019 | 0.0147 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0011 | 0.01 | 0.0287 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0011 | 0.01 | 0.0065 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.003 | 0.0465 | 0.0431 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0011 | 0.01 | 0.0065 |
Schistosoma mansoni | ryanodine receptor related | 0.0218 | 0.4135 | 0.6017 |
Brugia malayi | hypothetical protein | 0.001 | 0.0082 | 0.0038 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6521 | 0.6509 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0465 | 0.1083 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0357 | 0.6851 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0025 | 0.0377 | 0.0507 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0008 | 0.0044 | 0.0018 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.001 | 0.0082 | 0.0074 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0014 | 0.0165 | 0.013 |
Schistosoma mansoni | rab6-interacting | 0.001 | 0.0082 | 0.0074 |
Brugia malayi | Protein kinase c protein 2 | 0.0024 | 0.0354 | 0.0311 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0092 | 0.0058 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.034 | 0.6521 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0107 | 0.0072 |
Schistosoma mansoni | lipoxygenase | 0.001 | 0.0082 | 0.0074 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0011 | 0.01 | 0.0065 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0096 | 0.1764 | 0.1727 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 1 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0011 | 0.0107 | 0.0023 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0096 | 0.1764 | 0.1727 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6521 | 0.6509 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2924 | 0.2892 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0271 | 0.5172 | 0.7537 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0016 | 0.019 | 0.0232 |
Onchocerca volvulus | 0.0034 | 0.0549 | 0.0725 | |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0014 | 0.0165 | 0.0121 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0465 | 0.1083 |
Schistosoma mansoni | polycystin 1-related | 0.001 | 0.0082 | 0.0074 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.0082 | 0.0074 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6521 | 0.6509 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0028 | 0.0438 | 0.0596 |
Schistosoma mansoni | lipoxygenase | 0.0029 | 0.0441 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3343 | 0.3313 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.001 | 0.0072 | 0.0037 |
Echinococcus granulosus | RUN | 0.001 | 0.0082 | 0.0074 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.003 | 0.0465 | 0.0431 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0008 | 0.0044 | 0.0018 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6521 | 0.6509 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0011 | 0.01 | 0.0065 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0014 | 0.0165 | 0.0293 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0009 | 0.0051 | 0.0016 |
Leishmania major | alpha glucosidase II subunit, putative | 0.003 | 0.0465 | 0.1643 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0096 | 0.1764 | 0.254 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.3547 | 0.5155 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0151 | 0.2834 | 0.5 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0011 | 0.0107 | 0.0034 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.001 | 0.0082 | 0.0074 |
Schistosoma mansoni | alpha glucosidase | 0.003 | 0.0465 | 0.0635 |
Echinococcus multilocularis | stromal cell derived factor 2 | 0.0034 | 0.0549 | 0.0759 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0011 | 0.01 | 0.0027 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0014 | 0.0165 | 0.0195 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.001 | 0.0082 | 0.0074 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0008 | 0.0044 | 0.0018 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.001 | 0.0082 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0156 | 0.2924 | 0.4241 |
Brugia malayi | Protein kinase domain containing protein | 0.0016 | 0.019 | 0.0147 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0034 | 0.0549 | 0.0507 |
Schistosoma mansoni | alpha-glucosidase | 0.0078 | 0.1399 | 0.2005 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0121 | 0.2242 | 0.3242 |
Plasmodium falciparum | LCCL domain-containing protein | 0.001 | 0.0082 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0074 | 0.1325 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0358 | 0.6879 | 0.6868 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.4024 | 0.3997 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0096 | 0.1764 | 0.254 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0074 | 0.1325 | 0.5 |
Onchocerca volvulus | 0.0078 | 0.1399 | 0.2045 | |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.001 | 0.0082 | 0.0074 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0518 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0082 | 0.0038 |
Echinococcus granulosus | protein kinase C gamma type | 0.0025 | 0.0377 | 0.0507 |
Entamoeba histolytica | MIR domain protein | 0.0034 | 0.0549 | 0.1644 |
Echinococcus multilocularis | geminin | 0.0188 | 0.3547 | 0.5155 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3945 | 0.3919 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.3547 | 0.5155 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.003 | 0.0465 | 0.1334 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0014 | 0.0165 | 0.0193 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0028 | 0.0438 | 0.0596 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0011 | 0.01 | 0.0065 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.002 | 0.0277 | 0.0359 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.003 | 0.0465 | 0.0431 |
Trichomonas vaginalis | AGC family protein kinase | 0.0016 | 0.019 | 0.0156 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0011 | 0.01 | 0.0065 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0014 | 0.0165 | 0.0238 |
Schistosoma mansoni | loxhd1 | 0.001 | 0.0082 | 0.0074 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0014 | 0.0165 | 0.0475 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.003 | 0.0465 | 0.0431 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0123 | 0.0089 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0028 | 0.0438 | 0.0596 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.003 | 0.0465 | 0.0422 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0014 | 0.0165 | 0.0475 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0014 | 0.0165 | 0.0195 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0151 | 0.2834 | 0.2809 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0029 | 0.0441 | 0.06 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0014 | 0.0165 | 0.0195 |
Trypanosoma brucei | glucosidase, putative | 0.003 | 0.0465 | 0.1339 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0218 | 0.4135 | 0.4109 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0357 | 0.6851 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.002 | 0.0277 | 0.0359 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0092 | 0.0058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.