Detailed information for compound 2069766

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.472 | Formula: C18H31N5O
  • H donors: 1 H acceptors: 2 LogP: 1.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cnn(c1)CCCNC(=O)N1CCCCC(C1)N1CCCC1
  • InChi: 1S/C18H31N5O/c1-16-13-20-23(14-16)12-6-8-19-18(24)22-11-3-2-7-17(15-22)21-9-4-5-10-21/h13-14,17H,2-12,15H2,1H3,(H,19,24)
  • InChiKey: VLMYPNWRHICDEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine-protein kinase 0.0006 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0029 0.0854 0.2278
Schistosoma mansoni cathepsin F (C01 family) 0.0008 0.0137 0.0137
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0008 0.0115 0.0197
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0714 0.1899
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0113 0.3709 1
Mycobacterium ulcerans epoxide hydrolase EphA 0.0072 0.2311 1
Brugia malayi Protein kinase domain containing protein 0.0008 0.0115 0.0123
Echinococcus granulosus ryanodine receptor 44f 0.0084 0.2718 0.2718
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus granulosus multidrug resistance associated protein 7 0.0006 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Onchocerca volvulus 0.0008 0.0137 0.1174
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0005 0.0019 0.0019
Leishmania major protein kinase, putative 0.0014 0.0318 0.0704
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0115 0.168
Echinococcus multilocularis multidrug resistance associated protein 1 0.0006 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0105
Echinococcus multilocularis serine:threonine protein kinase N2 0.0008 0.0115 0.0115
Entamoeba histolytica protein kinase, putative 0.0013 0.0303 0.0755
Echinococcus multilocularis protein kinase c iota type 0.0011 0.0241 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Loa Loa (eye worm) hypothetical protein 0.0006 0.0042 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2939 0.2939
Echinococcus multilocularis serine:threonine protein kinase 38 0.0008 0.0115 0.0115
Echinococcus granulosus nervana 2 0.0005 0.0019 0.0019
Trichomonas vaginalis mannosyltransferase 1, putative 0.0018 0.0477 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0024 0.0668 0.0668
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0008 0.0115 0.0115
Brugia malayi bHLH-PAS transcription factor 0.0039 0.117 0.1899
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2939 0.2939
Schistosoma mansoni hypothetical protein 0.0297 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0006 0.0062 0.0033
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0008 0.0115 0.0115
Schistosoma mansoni serine/threonine kinase 0.0008 0.0115 0.0115
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0008 0.0137 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0006 0.0042 0.0046
Echinococcus multilocularis Glutaredoxin protein 5 0.0005 0.0019 0.0019
Entamoeba histolytica cysteine protease, putative 0.0008 0.0137 0.0306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) AGC/NDR protein kinase 0.0008 0.0115 0.0197
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.0267 0.0267
Entamoeba histolytica MIR domain protein 0.0018 0.0477 0.1228
Schistosoma mansoni hypothetical protein 0.0297 1 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0312 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2939 0.2939
Leishmania major hypothetical protein, conserved 0.0067 0.2149 0.5724
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0006 0.0062 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Brugia malayi multidrug resistance related protein 1 0.0006 0.0062 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0267 0.0267
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0072 0.2311 0.5
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0008 0.0115 0.0197
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Brugia malayi hypothetical protein 0.0176 0.5841 0.9759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Brugia malayi Protein kinase domain containing protein 0.0008 0.0115 0.0123
Loa Loa (eye worm) hypothetical protein 0.0112 0.3683 0.6306
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0008 0.0137 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0113 0.3709 0.635
Echinococcus multilocularis RNA directed DNA polymerase 0.0024 0.0668 0.0668
Onchocerca volvulus 0.0014 0.0312 0.267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0312 0.0535
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.1086 0.1086
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0008 0.0115 0.0115
Echinococcus granulosus multidrug resistance associated protein 1 0.0006 0.0062 0.0062
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.117 0.117
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0312 0.6218
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0005 0.0025 0.0025
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0312 0.6218
Echinococcus granulosus protein kinase c iota type 0.0011 0.0241 0.0241
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0113 0.3709 1
Toxoplasma gondii AGC kinase 0.0013 0.0285 1
Giardia lamblia MRP-like ABC transporter 0.0006 0.0062 1
Echinococcus granulosus serine/threonine protein kinase 0.0006 0.0042 0.0042
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Onchocerca volvulus 0.0008 0.0137 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0679 0.1162
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0008 0.0115 0.0115
Brugia malayi Protein kinase domain containing protein 0.0013 0.0303 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.1086 0.1086
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0113 0.3709 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus granulosus cathepsin l1 0.0008 0.0137 0.0137
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0036 0.1086 0.1086
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0113 0.3709 0.3709
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0008 0.0115 0.0197
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0008 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0115 0.3757 0.6432
Echinococcus multilocularis geminin 0.0297 1 1
Plasmodium vivax vivapain-2 0.0008 0.0137 1
Entamoeba histolytica protein kinase, putative 0.0008 0.0115 0.0245
Giardia lamblia ABC transporter, putative 0.0006 0.0062 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0115 0.0197
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0312 0.0312
Brugia malayi PAS domain containing protein 0.0052 0.1634 0.268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus granulosus RNA directed DNA polymerase 0.0024 0.0668 0.0668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.095 0.2537
Onchocerca volvulus Cathepsin F homolog 0.0008 0.0137 0.1174
Entamoeba histolytica protein kinase, putative 0.0013 0.0285 0.0708
Loa Loa (eye worm) hypothetical protein 0.0096 0.3114 0.5331
Echinococcus multilocularis cathepsin L cysteine protease 0.0008 0.0137 0.0137
Brugia malayi MIR domain containing protein 0.0018 0.0477 0.0732
Echinococcus multilocularis cysteine protease 0.0008 0.0137 0.0137
Loa Loa (eye worm) multidrug resistance-associated protein 0.0005 0.0014 0.0024
Echinococcus multilocularis stromal cell derived factor 2 0.0018 0.0477 0.0477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0113 0.3709 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0312 0.6218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0312 0.6218
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Giardia lamblia Multidrug resistance-associated protein 1 0.0006 0.0062 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0113 0.3709 0.3709
Onchocerca volvulus 0.0008 0.0137 0.1174
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0008 0.0109 0.1547
Entamoeba histolytica hypothetical protein 0.0006 0.0062 0.01
Echinococcus granulosus single minded 2 0.0039 0.117 0.117
Loa Loa (eye worm) hypothetical protein 0.0006 0.0042 0.0072
Echinococcus multilocularis serine threonine protein kinase 0.0033 0.0961 0.0961
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2939 0.2939
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.5376 0.9205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0099 0.3233 0.8712
Giardia lamblia Multidrug resistance-associated protein 1 0.0006 0.006 0.9533
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Leishmania major cysteine peptidase A (CPA) 0.0008 0.0137 0.0208
Entamoeba histolytica multidrug resistance protein, putative 0.0006 0.0062 0.01
Toxoplasma gondii cathepsin CPL 0.0008 0.0137 0.3386
Schistosoma mansoni serine/threonine-protein kinase 0.0006 0.0042 0.0042
Trypanosoma cruzi Protein kinase B 0.0006 0.0042 0.008
Echinococcus multilocularis nervana 2 0.0005 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0312 0.6218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Entamoeba histolytica cysteine proteinase, putative 0.0006 0.0042 0.0047
Echinococcus multilocularis transcription factor Dp 1 0.0065 0.2083 0.2083
Echinococcus granulosus cathepsin L cysteine proteinase 0.0008 0.0137 0.0137
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0006 0.0062 0.0105
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Loa Loa (eye worm) hypothetical protein 0.0006 0.006 0.0102
Echinococcus granulosus stromal cell derived factor 2 0.0018 0.0477 0.0477
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0018 0.0477 0.0477
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0312 0.6218
Echinococcus granulosus cathepsin l cysteine peptidase 0.0008 0.0137 0.0137
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Schistosoma mansoni ryanodine receptor related 0.0118 0.3862 0.3862
Loa Loa (eye worm) hypothetical protein 0.0084 0.2718 0.4654
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0008 0.0115 0.0115
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Onchocerca volvulus 0.0008 0.0137 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Plasmodium falciparum cysteine proteinase falcipain 3 0.0008 0.0137 1
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0005 0.0025 0.0034
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0146 0.484 0.484
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0008 0.0137 0.0137
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0312 0.6218
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0312 0.0813
Leishmania major cathepsin L-like protease 0.0032 0.095 0.2436
Echinococcus granulosus NDR protein kinase 0.0008 0.0115 0.0115
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0137 0.0339
Echinococcus multilocularis serine:threonine protein kinase N2 0.0008 0.0115 0.0115
Onchocerca volvulus 0.0006 0.0042 0.0357
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0006 0.0042 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Leishmania major protein kinase, putative 0.0014 0.0318 0.0704
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.095 0.2537
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0137 0.0161
Echinococcus granulosus ryanodine receptor 44f 0.0065 0.2075 0.2075
Onchocerca volvulus Cathepsin L homolog 0.0008 0.0137 0.1174
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0312 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0668 0.1144
Loa Loa (eye worm) hypothetical protein 0.0176 0.5841 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Schistosoma mansoni single-minded 0.0052 0.1634 0.1634
Leishmania major cathepsin L-like protease 0.0032 0.095 0.2436
Echinococcus multilocularis rac serine:threonine kinase 0.0006 0.0042 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Echinococcus granulosus Glutaredoxin protein 5 0.0005 0.0019 0.0019
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.0267 0.0267
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.2939 0.4876
Trypanosoma cruzi multidrug resistance protein E, putative 0.0006 0.0062 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Loa Loa (eye worm) ryanodine receptor 0.0032 0.0932 0.1596
Echinococcus multilocularis ryanodine receptor 44f 0.0084 0.2718 0.2718
Onchocerca volvulus 0.0008 0.0137 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0312 0.6218
Trypanosoma brucei rac serine-threonine kinase, putative 0.0013 0.0303 0.0661
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0025 0.07 0.1198
Loa Loa (eye worm) cysteine protease 0.0008 0.0137 0.0235
Echinococcus multilocularis nervana 2 0.0005 0.0019 0.0019
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0005 0.0019 0.0019
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.095 0.2537
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Onchocerca volvulus 0.0018 0.0477 0.4076
Loa Loa (eye worm) fibroinase 0.0008 0.0137 0.0235
Echinococcus multilocularis cysteine protease 0.0008 0.0137 0.0137
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0312 0.0535
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0113 0.3709 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0006 0.0062 0.0134
Echinococcus granulosus multidrug resistance associated protein 4 0.0005 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0113 0.3709 0.3709
Entamoeba histolytica PH domain containing protein kinase, putative 0.0006 0.0042 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2939 0.2939
Loa Loa (eye worm) AGC/PKN protein kinase 0.0008 0.0115 0.0197
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0115 0.168
Echinococcus granulosus transcription factor Dp 1 0.0065 0.2083 0.2083
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0008 0.0137 0.0235
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.0267 0.0457
Echinococcus granulosus cathepsin l1 0.0006 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0312 0.6218
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Echinococcus multilocularis cathepsin L cysteine protease 0.0008 0.0137 0.0137
Schistosoma mansoni cathepsin F (C01 family) 0.0008 0.0137 0.0137
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0013 0.0285 0.0489
Brugia malayi p70 ribosomal S6 kinase beta 0.0013 0.0285 0.041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Entamoeba histolytica ABC transporter, putative 0.0006 0.0062 0.01
Echinococcus multilocularis multidrug resistance associated protein 4 0.0005 0.0012 0.0012
Plasmodium vivax vivapain-2 0.0008 0.0137 1
Onchocerca volvulus 0.0008 0.0137 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0115 0.168
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0113 0.3709 0.6171
Loa Loa (eye worm) hypothetical protein 0.0008 0.0137 0.0235
Onchocerca volvulus Cathepsin L homolog 0.0008 0.0137 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Brugia malayi Protein kinase c protein 2 0.0029 0.0826 0.1319
Echinococcus granulosus Protein kinase C brain isozyme 0.0036 0.1086 0.1086
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0137 0.0306
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0137 0.0306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2939 0.2939
Giardia lamblia Multidrug resistance-associated protein 1 0.0006 0.0062 1
Brugia malayi cation channel family protein 0.018 0.5984 1
Schistosoma mansoni cathepsin F (C01 family) 0.0006 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Loa Loa (eye worm) hypothetical protein 0.0028 0.0794 0.1359
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0312 0.6218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus granulosus nervana 2 0.0005 0.0019 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0132 0.2072
Leishmania major cathepsin L-like protease 0.0032 0.095 0.2436
Loa Loa (eye worm) hypothetical protein 0.0006 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Brugia malayi hypoxia-induced factor 1 0.0162 0.5376 0.8978
Echinococcus multilocularis ryanodine receptor 44f 0.0065 0.2075 0.2075
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0312 0.0312
Echinococcus granulosus protein kinase C gamma type 0.0033 0.0961 0.0961
Onchocerca volvulus 0.0039 0.117 1
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0032 0.0932 0.0932
Brugia malayi protein kinase C II. 0.0012 0.0267 0.0378
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0008 0.0137 0.0137
Onchocerca volvulus 0.0008 0.0137 0.1174
Entamoeba histolytica protein kinase, putative 0.0013 0.0303 0.0755
Loa Loa (eye worm) MIR domain-containing protein 0.0018 0.0477 0.0817
Echinococcus granulosus serine threonine protein kinase nrc 0.0005 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.1634 0.1634
Mycobacterium leprae Possible regulatory protein 0.0014 0.0312 0.5
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0099 0.3233 0.8695
Echinococcus granulosus serine:threonine protein kinase N2 0.0008 0.0115 0.0115
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0118 0.3862 0.6429
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0312 0.0813
Schistosoma mansoni atypical protein kinase C 0.0011 0.0241 0.0241
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0312 0.6218
Brugia malayi Cytochrome P450 family protein 0.0024 0.0679 0.1072
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0312 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0008 0.0137 0.0235
Loa Loa (eye worm) ctsf protein 0.0008 0.0137 0.0235
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.095 0.2537
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Brugia malayi Hr1 repeat family protein 0.0008 0.0115 0.0123
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0312 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2939 0.2939
Echinococcus multilocularis multidrug resistance associated protein 7 0.0006 0.0062 0.0062
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0096 0.3114 0.3114
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0005 0.0025 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.2939 0.5032
Loa Loa (eye worm) AGC/AKT protein kinase 0.0013 0.0303 0.0518

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.