Detailed information for compound 2069766

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.472 | Formula: C18H31N5O
  • H donors: 1 H acceptors: 2 LogP: 1.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cnn(c1)CCCNC(=O)N1CCCCC(C1)N1CCCC1
  • InChi: 1S/C18H31N5O/c1-16-13-20-23(14-16)12-6-8-19-18(24)22-11-3-2-7-17(15-22)21-9-4-5-10-21/h13-14,17H,2-12,15H2,1H3,(H,19,24)
  • InChiKey: VLMYPNWRHICDEH-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0113 0.3709 0.3709
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0005 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0312 0.6218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus multilocularis ryanodine receptor 44f 0.0065 0.2075 0.2075
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0312 0.0535
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0113 0.3709 0.3709
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0312 0.6218
Onchocerca volvulus Cathepsin L homolog 0.0008 0.0137 0.1174
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.1086 0.1086
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.1086 0.1086
Entamoeba histolytica ABC transporter, putative 0.0006 0.0062 0.01
Leishmania major cathepsin L-like protease 0.0032 0.095 0.2436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) hypothetical protein 0.0006 0.0042 0.0072
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0312 0.6218
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0312 0.6218
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0008 0.0115 0.0115
Onchocerca volvulus 0.0008 0.0137 0.1174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Schistosoma mansoni hypothetical protein 0.0297 1 1
Brugia malayi bHLH-PAS transcription factor 0.0039 0.117 0.1899
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Leishmania major cathepsin L-like protease 0.0032 0.095 0.2436
Echinococcus granulosus serine/threonine protein kinase 0.0006 0.0042 0.0042
Schistosoma mansoni cathepsin F (C01 family) 0.0006 0.0042 0.0042
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0113 0.3709 0.635
Echinococcus granulosus serine:threonine protein kinase N2 0.0008 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0006 0.0042 0.0072
Toxoplasma gondii cathepsin CPL 0.0008 0.0137 0.3386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) fibroinase 0.0008 0.0137 0.0235
Brugia malayi hypoxia-induced factor 1 0.0162 0.5376 0.8978
Echinococcus granulosus stromal cell derived factor 2 0.0018 0.0477 0.0477
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0132 0.2072
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0137 0.0306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Echinococcus granulosus transcription factor Dp 1 0.0065 0.2083 0.2083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2939 0.2939
Schistosoma mansoni ryanodine receptor related 0.0118 0.3862 0.3862
Trichomonas vaginalis mannosyltransferase 1, putative 0.0018 0.0477 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0312 0.0312
Echinococcus multilocularis protein kinase c iota type 0.0011 0.0241 0.0241
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0024 0.0668 0.0668
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0312 0.0688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0008 0.0137 0.0137
Loa Loa (eye worm) MIR domain-containing protein 0.0018 0.0477 0.0817
Echinococcus multilocularis cathepsin L cysteine protease 0.0008 0.0137 0.0137
Echinococcus multilocularis nervana 2 0.0005 0.0019 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Schistosoma mansoni serine/threonine-protein kinase 0.0006 0.0042 0.0042
Brugia malayi Cytochrome P450 family protein 0.0024 0.0679 0.1072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus multilocularis stromal cell derived factor 2 0.0018 0.0477 0.0477
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2939 0.2939
Echinococcus multilocularis geminin 0.0297 1 1
Echinococcus multilocularis cysteine protease 0.0008 0.0137 0.0137
Onchocerca volvulus 0.0006 0.0042 0.0357
Loa Loa (eye worm) hypothetical protein 0.0006 0.0042 0.0072
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Loa Loa (eye worm) ryanodine receptor 0.0032 0.0932 0.1596
Schistosoma mansoni single-minded 0.0052 0.1634 0.1634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2939 0.2939
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Echinococcus multilocularis rac serine:threonine kinase 0.0006 0.0042 0.0042
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0005 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Onchocerca volvulus Cathepsin L homolog 0.0008 0.0137 0.1174
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0312 0.6218
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Onchocerca volvulus 0.0008 0.0137 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0005 0.0025 0.0025
Echinococcus multilocularis multidrug resistance associated protein 1 0.0006 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Echinococcus multilocularis multidrug resistance associated protein 4 0.0005 0.0012 0.0012
Giardia lamblia ABC transporter, putative 0.0006 0.0062 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0013 0.0285 0.0489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2939 0.2939
Entamoeba histolytica hypothetical protein 0.0006 0.0062 0.01
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0006 0.0042 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0679 0.1162
Leishmania major hypothetical protein, conserved 0.0067 0.2149 0.5724
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.5376 0.9205
Leishmania major cysteine peptidase A (CPA) 0.0008 0.0137 0.0208
Brugia malayi PAS domain containing protein 0.0052 0.1634 0.268
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0008 0.0137 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0312 0.5
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0008 0.0137 1
Entamoeba histolytica protein kinase, putative 0.0013 0.0303 0.0755
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.095 0.2537
Entamoeba histolytica protein kinase, putative 0.0008 0.0115 0.0245
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Schistosoma mansoni hypothetical protein 0.0297 1 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.1634 0.1634
Echinococcus multilocularis serine:threonine protein kinase N2 0.0008 0.0115 0.0115
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0005 0.0025 0.0034
Loa Loa (eye worm) AGC/AKT protein kinase 0.0013 0.0303 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0267 0.0267
Entamoeba histolytica protein kinase, putative 0.0013 0.0285 0.0708
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0099 0.3233 0.8695
Entamoeba histolytica multidrug resistance protein, putative 0.0006 0.0062 0.01
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0312 0.0312
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Loa Loa (eye worm) hypothetical protein 0.0006 0.006 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0146 0.484 0.484
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0113 0.3709 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0024 0.0668 0.0668
Entamoeba histolytica MIR domain protein 0.0018 0.0477 0.1228
Loa Loa (eye worm) ctsf protein 0.0008 0.0137 0.0235
Brugia malayi MIR domain containing protein 0.0018 0.0477 0.0732
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0137 0.0161
Entamoeba histolytica protein kinase, putative 0.0013 0.0303 0.0755
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0113 0.3709 0.3709
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0312 0.0312
Echinococcus granulosus ryanodine receptor 44f 0.0084 0.2718 0.2718
Brugia malayi multidrug resistance related protein 1 0.0006 0.0062 0.0033
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Mycobacterium ulcerans epoxide hydrolase EphA 0.0072 0.2311 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0008 0.0115 0.0115
Onchocerca volvulus 0.0008 0.0137 0.1174
Onchocerca volvulus 0.0008 0.0137 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0312 0.6218
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0008 0.0115 0.0115
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0008 0.0115 0.0197
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0008 0.0137 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Plasmodium falciparum cysteine proteinase falcipain 3 0.0008 0.0137 1
Schistosoma mansoni cathepsin F (C01 family) 0.0008 0.0137 0.0137
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0032 0.0932 0.0932
Plasmodium vivax vivapain-2 0.0008 0.0137 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0113 0.3709 1
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0018 0.0477 0.0477
Loa Loa (eye worm) multidrug resistance-associated protein 0.0005 0.0014 0.0024
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus multilocularis cysteine protease 0.0008 0.0137 0.0137
Echinococcus granulosus cathepsin l cysteine peptidase 0.0008 0.0137 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Brugia malayi p70 ribosomal S6 kinase beta 0.0013 0.0285 0.041
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0072 0.2311 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0006 0.0062 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0008 0.0115 0.0115
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Echinococcus multilocularis serine:threonine protein kinase N2 0.0008 0.0115 0.0115
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Loa Loa (eye worm) AGC/PKN protein kinase 0.0008 0.0115 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0029 0.0854 0.2278
Plasmodium vivax vivapain-2 0.0008 0.0137 1
Onchocerca volvulus 0.0008 0.0137 0.1174
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0312 0.0813
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Echinococcus granulosus cathepsin L cysteine proteinase 0.0008 0.0137 0.0137
Echinococcus granulosus cathepsin l1 0.0006 0.0042 0.0042
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0008 0.0115 0.0115
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0005 0.0019 0.0019
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0312 0.6218
Echinococcus multilocularis multidrug resistance associated protein 7 0.0006 0.0062 0.0062
Trypanosoma cruzi multidrug resistance protein E, putative 0.0006 0.0062 0.0134
Leishmania major protein kinase, putative 0.0014 0.0318 0.0704
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0115 0.168
Loa Loa (eye worm) hypothetical protein 0.0084 0.2718 0.4654
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.095 0.2537
Loa Loa (eye worm) hypothetical protein 0.0014 0.0312 0.0535
Loa Loa (eye worm) hypothetical protein 0.0028 0.0794 0.1359
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0312 0.6218
Loa Loa (eye worm) hypothetical protein 0.0112 0.3683 0.6306
Echinococcus granulosus single minded 2 0.0039 0.117 0.117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2939 0.2939
Loa Loa (eye worm) hypothetical protein 0.0115 0.3757 0.6432
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0312 0.6218
Entamoeba histolytica PH domain containing protein kinase, putative 0.0006 0.0042 0.0046
Echinococcus granulosus multidrug resistance associated protein 7 0.0006 0.0062 0.0062
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.095 0.2537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0006 0.0062 0.0134
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.117 0.117
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0312 0.0312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) AGC/NDR protein kinase 0.0008 0.0115 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.0267 0.0457
Loa Loa (eye worm) hypothetical protein 0.0024 0.0668 0.1144
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0008 0.0109 0.1547
Brugia malayi ABC transporter transmembrane region family protein 0.0006 0.0062 0.0033
Giardia lamblia MRP-like ABC transporter 0.0006 0.0062 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0025 0.07 0.1198
Giardia lamblia Multidrug resistance-associated protein 1 0.0006 0.0062 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0714 0.1899
Echinococcus granulosus ryanodine receptor 44f 0.0065 0.2075 0.2075
Onchocerca volvulus Cathepsin F homolog 0.0008 0.0137 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0312 0.6218
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Echinococcus granulosus Protein kinase C brain isozyme 0.0036 0.1086 0.1086
Brugia malayi protein kinase C II. 0.0012 0.0267 0.0378
Echinococcus multilocularis Glutaredoxin protein 5 0.0005 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2939 0.2939
Brugia malayi Hr1 repeat family protein 0.0008 0.0115 0.0123
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0006 0.0062 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0115 0.168
Schistosoma mansoni serine/threonine kinase 0.0008 0.0115 0.0115
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Mycobacterium leprae Possible regulatory protein 0.0014 0.0312 0.5
Echinococcus granulosus Glutaredoxin protein 5 0.0005 0.0019 0.0019
Onchocerca volvulus 0.0018 0.0477 0.4076
Echinococcus multilocularis cathepsin L cysteine protease 0.0008 0.0137 0.0137
Schistosoma mansoni cathepsin F (C01 family) 0.0008 0.0137 0.0137
Trypanosoma cruzi Protein kinase B 0.0006 0.0042 0.008
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0312 0.6218
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Brugia malayi Protein kinase c protein 2 0.0029 0.0826 0.1319
Brugia malayi hypothetical protein 0.0176 0.5841 0.9759
Onchocerca volvulus 0.0008 0.0137 0.1174
Loa Loa (eye worm) cysteine protease 0.0008 0.0137 0.0235
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0008 0.0137 0.0235
Echinococcus granulosus cathepsin l1 0.0008 0.0137 0.0137
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.2939 0.4876
Echinococcus granulosus nervana 2 0.0005 0.0019 0.0019
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0113 0.3709 1
Brugia malayi Protein kinase domain containing protein 0.0013 0.0303 0.0439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0008 0.0115 0.0197
Trypanosoma brucei rac serine-threonine kinase, putative 0.0013 0.0303 0.0661
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0099 0.3233 0.8712
Brugia malayi Cathepsin L-like precursor 0.0008 0.0137 0.0161
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0006 0.0062 0.0105
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0312 0.0813
Onchocerca volvulus 0.0014 0.0312 0.267
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0113 0.3709 1
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0137 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Giardia lamblia Multidrug resistance-associated protein 1 0.0006 0.006 0.9533
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0113 0.3709 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0318 0.0828
Echinococcus multilocularis serine threonine protein kinase 0.0033 0.0961 0.0961
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0008 0.0115 0.0115
Echinococcus granulosus nervana 2 0.0005 0.0019 0.0019
Echinococcus granulosus serine threonine protein kinase nrc 0.0005 0.0025 0.0025
Echinococcus multilocularis ryanodine receptor 44f 0.0084 0.2718 0.2718
Echinococcus granulosus multidrug resistance associated protein 4 0.0005 0.0012 0.0012
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0137 0.0306
Brugia malayi Protein kinase domain containing protein 0.0008 0.0115 0.0123
Loa Loa (eye worm) hypothetical protein 0.0008 0.0115 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0137 0.2196
Brugia malayi cation channel family protein 0.018 0.5984 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.5841 1
Schistosoma mansoni multidrug resistance protein 0.0006 0.0062 0.0062
Entamoeba histolytica cysteine protease, putative 0.0008 0.0137 0.0306
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0118 0.3862 0.6429
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Loa Loa (eye worm) hypothetical protein 0.0008 0.0137 0.0235
Echinococcus granulosus multidrug resistance associated protein 1 0.0006 0.0062 0.0062
Leishmania major protein kinase, putative 0.0014 0.0318 0.0704
Echinococcus granulosus protein kinase C gamma type 0.0033 0.0961 0.0961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2939 0.2939
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0036 0.1086 0.1086
Schistosoma mansoni atypical protein kinase C 0.0011 0.0241 0.0241
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Onchocerca volvulus 0.0039 0.117 1
Toxoplasma gondii AGC kinase 0.0013 0.0285 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.2939 0.5032
Echinococcus granulosus NDR protein kinase 0.0008 0.0115 0.0115
Echinococcus multilocularis nervana 2 0.0005 0.0019 0.0019
Echinococcus multilocularis transcription factor Dp 1 0.0065 0.2083 0.2083
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0008 0.0115 0.0115
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0008 0.0115 0.0197
Echinococcus granulosus RNA directed DNA polymerase 0.0024 0.0668 0.0668
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.0267 0.0267
Entamoeba histolytica ATP-binding cassette protein, putative 0.0006 0.0062 0.01
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.0267 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0137 0.2196
Entamoeba histolytica cysteine proteinase, putative 0.0006 0.0042 0.0047
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0008 0.0137 0.0137
Onchocerca volvulus 0.0008 0.0137 0.1174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0113 0.3709 0.6171
Brugia malayi Protein kinase domain containing protein 0.0008 0.0115 0.0123
Leishmania major cathepsin L-like protease 0.0008 0.0137 0.0208
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0115 0.168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.095 0.2436
Echinococcus granulosus protein kinase c iota type 0.0011 0.0241 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0303 0.5991
Leishmania major cathepsin L-like protease 0.0032 0.095 0.2436
Loa Loa (eye worm) hypothetical protein 0.0006 0.0062 0.0105
Schistosoma mansoni serine/threonine-protein kinase 0.0006 0.0042 0.0042
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0096 0.3114 0.3114
Entamoeba histolytica PH domain containing protein kinase, putative 0.0006 0.0042 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0096 0.3114 0.5331
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.095 0.2537

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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