Detailed information for compound 2070135

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.484 | Formula: C19H24N4O2S
  • H donors: 1 H acceptors: 3 LogP: 2.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(C(=O)c1cccs1)C)NCc1cccnc1N1CCCCC1
  • InChi: 1S/C19H24N4O2S/c1-22(19(25)16-8-6-12-26-16)14-17(24)21-13-15-7-5-9-20-18(15)23-10-3-2-4-11-23/h5-9,12H,2-4,10-11,13-14H2,1H3,(H,21,24)
  • InChiKey: HIUFMKVXEQMCKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0219 0.5843
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0104 0.1076 0.1076
Onchocerca volvulus 0.0036 0.0219 0.1233
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2369 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0104 0.1076 0.7218
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.0385 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0104 0.1076 0.1076
Echinococcus multilocularis survival motor neuron protein 1 0.0213 0.2442 0.2442
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.0459 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Schistosoma mansoni thyroid hormone receptor 0.0159 0.1774 0.1774
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.1774 0.1774
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0104 0.1076 0.1076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0104 0.1076 0.1076
Brugia malayi hypothetical protein 0.0048 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0055 0.0459 0.0419
Brugia malayi PAS domain containing protein 0.0021 0.0038 0.0038
Schistosoma mansoni aldehyde dehydrogenase 0.0027 0.0104 0.0104
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0219 1
Plasmodium vivax vivapain-2 0.0036 0.0219 1
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0219 0.0219
Toxoplasma gondii cathepsin CPL 0.0036 0.0219 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0083 0.081 0.0771
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.1076 0.1076
Echinococcus granulosus jun protein 0.0037 0.0233 0.0233
Loa Loa (eye worm) ctsf protein 0.0036 0.0219 0.0177
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0125 0.1337 0.356
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.1076 0.1076
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0385 0.0385
Onchocerca volvulus 0.0036 0.0219 0.1233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0385 0.0385
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0219 0.0582
Trypanosoma cruzi Aph-1 protein, putative 0.0317 0.3755 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0104 0.1076 0.1038
Brugia malayi Cathepsin L-like precursor 0.0036 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0104 0.1076 0.1076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0289 0.3399 0.3371
Brugia malayi ecdysteroid receptor 0.0104 0.1076 0.1076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0027 0.0104 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0104 0.1076 0.1076
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0104 0.1076 0.1076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0104 0.1076 0.1038
Onchocerca volvulus 0.0049 0.0385 0.2393
Loa Loa (eye worm) hypothetical protein 0.0072 0.0673 0.0634
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.1076 0.1076
Loa Loa (eye worm) fibroinase 0.0036 0.0219 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0104 0.1076 0.1076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.1076 0.1076
Echinococcus granulosus cathepsin l1 0.0036 0.0219 0.0219
Echinococcus granulosus nuclear factor of activated T cells 5 0.0032 0.0176 0.0176
Onchocerca volvulus 0.0043 0.0313 0.1893
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0207 0.2369 0.2337
Leishmania major cathepsin L-like protease 0.0036 0.0219 0.0826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Brugia malayi follicle stimulating hormone receptor 0.0289 0.3399 0.3399
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0104 0.1076 0.1076
Onchocerca volvulus 0.0036 0.0219 0.1233
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.1475 0.6224
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0104 0.1076 0.1076
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.1475 0.6224
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0104 0.1076 0.1076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.1076 0.1076
Schistosoma mansoni retinoic acid receptor RXR 0.0272 0.3184 0.3184
Schistosoma mansoni hypothetical protein 0.003 0.0146 0.0146
Schistosoma mansoni jun-related protein 0.003 0.0146 0.0146
Brugia malayi hypothetical protein 0.0213 0.2442 0.2442
Brugia malayi Steroid receptor seven-up type 2 0.0104 0.1076 0.1076
Onchocerca volvulus 0.0029 0.0133 0.0638
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.0385 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.007 0.0294
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.1118 0.2978
Entamoeba histolytica cysteine protease, putative 0.0036 0.0219 0.5843
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0032 0.0176 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0104 0.1076 0.1076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Echinococcus granulosus ecdysone induced protein 78C 0.0104 0.1076 0.1076
Brugia malayi steroid hormone receptor 0.0104 0.1076 0.1076
Schistosoma mansoni nuclear receptor 0.0049 0.0385 0.0385
Leishmania major cathepsin L-like protease 0.0137 0.1486 1
Echinococcus granulosus FTZ F1 alpha 0.0104 0.1076 0.1076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0385 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0104 0.1076 0.1038
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0219 0.0177
Schistosoma mansoni nuclear receptor 0.0049 0.0385 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0219 0.0219
Schistosoma mansoni zinc finger protein 0.0049 0.0385 0.0385
Brugia malayi Cathepsin L-like precursor 0.0036 0.0219 0.0219
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.0385 0.0344
Trypanosoma cruzi Aph-1 protein, putative 0.0317 0.3755 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Loa Loa (eye worm) steroid hormone receptor 0.0104 0.1076 0.1038
Loa Loa (eye worm) hypothetical protein 0.0143 0.1562 0.1526
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0104 0.1076 0.1076
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0037 0.0233 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2369 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Schistosoma mansoni cellular tumor antigen P53 0.0022 0.0042 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2369 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0055 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0219 0.0177
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0385 0.0385
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0385 0.0385
Brugia malayi nuclear hormone receptor 0.0049 0.0385 0.0385
Brugia malayi hypoxia-induced factor 1 0.0066 0.0603 0.0603
Brugia malayi nuclear receptor RXR 0.0049 0.0385 0.0385
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0459 0.0459
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0385 0.0385
Loa Loa (eye worm) cysteine protease 0.0036 0.0219 0.0177
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0179
Brugia malayi nuclear receptor NHR-88 0.0104 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0028
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0385 0.0385
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0219 1
Onchocerca volvulus 0.0036 0.0219 0.1233
Schistosoma mansoni aryl hydrocarbon receptor 0.0021 0.0038 0.0038
Brugia malayi Fibroblast growth factor family protein 0.0143 0.1562 0.1562
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0104 0.1076 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Echinococcus granulosus tumor protein p63 0.0149 0.1642 0.1642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0104 0.1076 0.1038
Brugia malayi tailless protein 0.0049 0.0385 0.0385
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.1486 0.3957
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.007 0.1859
Brugia malayi Cathepsin L-like precursor 0.0036 0.0219 0.0219
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.0385 0.0385
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0313 0.0313
Brugia malayi hypothetical protein 0.0049 0.0385 0.0385
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.1475 0.6224
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0219 0.0219
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0037 0.0233 0.0233
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0027 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.007 0.0294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.1076 0.1076
Leishmania major cathepsin L-like protease 0.0137 0.1486 1
Onchocerca volvulus Tyrosine kinase homolog 0.0077 0.0741 0.4879
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.1076 0.1076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0104 0.1076 0.1076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0219 0.0219
Leishmania major cathepsin L-like protease 0.0036 0.0219 0.0826
Brugia malayi hypothetical protein 0.0049 0.0385 0.0385
Schistosoma mansoni survival motor neuron protein 0.0043 0.0313 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.1475 0.6224
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.1475 0.6224
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0219 0.0219
Brugia malayi cathepsin L-like precursor 0.0024 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0104 0.1076 0.1076
Schistosoma mansoni hypothetical protein 0.0043 0.0313 0.0313
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0459 0.0459
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0219 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0104 0.1076 0.1038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Brugia malayi nuclear receptor RXR 0.0055 0.0459 0.0459
Brugia malayi hypothetical protein 0.0072 0.0673 0.0673
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0813 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.1475 0.6224
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0055 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.0385 0.0344
Schistosoma mansoni RAR-like nuclear receptor 0.0104 0.1076 0.1076
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2369 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Entamoeba histolytica hypothetical protein 0.0048 0.0374 1
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.0385 0.0385
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.1486 0.3957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Brugia malayi photoreceptor-specific nuclear receptor 0.0104 0.1076 0.1076
Echinococcus granulosus gamma secretase subunit aph 1 0.0813 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0219 0.0177
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.0385 0.0385
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.1076 0.1076
Onchocerca volvulus 0.0036 0.0219 0.1233
Onchocerca volvulus Bile acid receptor homolog 0.0104 0.1076 0.7218
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0104 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0028
Onchocerca volvulus 0.0036 0.0219 0.1233
Echinococcus multilocularis cysteine protease 0.0036 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.0385 0.0344
Loa Loa (eye worm) DR-78 0.0049 0.0385 0.0344
Brugia malayi Cathepsin L-like precursor 0.0036 0.0219 0.0219
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0219 0.1233
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0385 0.0385
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0207 0.2369 0.2369
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0027 0.0104 0.0104
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.081 0.081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0219 0.0923
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2369 1
Onchocerca volvulus 0.0104 0.1076 0.7218
Echinococcus multilocularis jun protein 0.0037 0.0233 0.0233
Brugia malayi Cathepsin L-like precursor 0.0036 0.0219 0.0219
Brugia malayi nuclear receptor NHR-67 0.0049 0.0385 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.0385 0.0385
Leishmania major cathepsin L-like protease 0.0036 0.0219 0.0826
Trichomonas vaginalis glucosylceramidase, putative 0.0143 0.1567 0.6612
Brugia malayi hypothetical protein 0.0029 0.0133 0.0133
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0217 0.2493 0.2493
Echinococcus granulosus cathepsin l1 0.0024 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0459 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0219 0.0219
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.0385 0.0385
Onchocerca volvulus 0.0049 0.0385 0.2393
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0027 0.0104 0.5
Brugia malayi hypothetical protein 0.0055 0.0459 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.0385 0.0385
Brugia malayi conserved hypotetical protein 0.0049 0.0385 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0219 0.5843
Schistosoma mansoni transcription factor LCR-F1 0.0048 0.0374 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Plasmodium vivax vivapain-2 0.0036 0.0219 1
Trypanosoma brucei Aph-1 protein, putative 0.0317 0.3755 1
Onchocerca volvulus 0.0024 0.007 0.0192
Schistosoma mansoni nuclear hormone receptor 0.0104 0.1076 0.1076
Schistosoma mansoni hypothetical protein 0.0055 0.0466 0.0466
Schistosoma mansoni hypothetical protein 0.0048 0.0374 0.0374
Onchocerca volvulus Protein ultraspiracle homolog 0.0104 0.1076 0.7218
Brugia malayi Cathepsin L-like precursor 0.0036 0.0219 0.0219
Onchocerca volvulus Glucosylceramidase homolog 0.0136 0.1475 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0104 0.1076 0.1076
Brugia malayi ecdysone receptor 0.0049 0.0385 0.0385
Schistosoma mansoni coup transcription factor 0.0104 0.1076 0.1076
Brugia malayi nuclear hormone receptor 0.0104 0.1076 0.1076
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0219 0.1233
Echinococcus granulosus survival motor neuron protein 1 0.0213 0.2442 0.2442
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.007 0.007
Echinococcus multilocularis cysteine protease 0.0036 0.0219 0.0219
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0048 0.0374 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0219 0.0923
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0104 0.1076 0.1076
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0219 0.0826
Schistosoma mansoni aldehyde dehydrogenase 0.0027 0.0104 0.0104
Echinococcus multilocularis tumor protein p63 0.0149 0.1642 0.1642
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Onchocerca volvulus 0.0036 0.0219 0.1233
Brugia malayi Fibroblast growth factor family protein 0.0143 0.1562 0.1562
Leishmania major cathepsin L-like protease 0.0036 0.0219 0.0826
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Leishmania major cathepsin L-like protease 0.0036 0.0219 0.0826
Brugia malayi bZIP transcription factor family protein 0.0037 0.0233 0.0233
Entamoeba histolytica hypothetical protein 0.0048 0.0374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.1486 0.3957
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0213 0.2442 0.2411
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0104 0.1076 0.1076
Onchocerca volvulus 0.0076 0.0725 0.4764
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0143 0.1562 0.1526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Entamoeba histolytica hypothetical protein 0.0048 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Brugia malayi Cathepsin L-like precursor 0.0024 0.007 0.007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0104 0.1076 0.1076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0027 0.0104 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0219 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.1076 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923
Brugia malayi hypothetical protein 0.0055 0.0459 0.0459
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0385 0.2393
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0272 0.3184 0.3184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1486 0.3957
Loa Loa (eye worm) hypothetical protein 0.0055 0.0459 0.0419
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.0344
Schistosoma mansoni gamma-secretase subunit aph-1 0.0813 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0027 0.0104 0.5
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0219 0.1233
Trypanosoma cruzi cruzipain precursor, putative 0.0137 0.1486 0.3957
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.0385 0.0385
Echinococcus multilocularis FTZ F1 alpha 0.0104 0.1076 0.1076
Schistosoma mansoni single-minded 0.0021 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0104 0.1076 0.1038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0104 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0104 0.1076 0.1038
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.0385 0.0385
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2369 1
Schistosoma mansoni thyroid hormone receptor 0.0159 0.1774 0.1774
Trichomonas vaginalis glucosylceramidase, putative 0.0136 0.1475 0.6224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0104 0.1076 0.1038
Echinococcus multilocularis ecdysone induced protein 78C 0.0104 0.1076 0.1076
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.0459 0.0419
Loa Loa (eye worm) hypothetical protein 0.0055 0.0459 0.0419
Brugia malayi nuclear receptor NHR-88 0.0049 0.0385 0.0385
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0219 1
Giardia lamblia Hypothetical protein 0.0143 0.1562 0.5
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0385 0.0385
Leishmania major cathepsin L-like protease 0.0137 0.1486 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0048 0.0374 0.0374
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.0459 0.0459
Trichomonas vaginalis glucosylceramidase, putative 0.0143 0.1567 0.6612
Loa Loa (eye worm) hypothetical protein 0.0055 0.0459 0.0419
Echinococcus multilocularis gamma secretase subunit aph 1 0.0813 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0385 0.2393
Brugia malayi Cathepsin L-like precursor 0.0024 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0219 0.0923
Entamoeba histolytica hypothetical protein 0.0048 0.0374 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0066 0.0603 0.0563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0219 0.0923

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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