Detailed information for compound 2070534

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.421 | Formula: C16H20N4O2S
  • H donors: 0 H acceptors: 3 LogP: 1.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccnc(n1)N1CCN(CC1)C(=O)Cc1ccc(s1)C
  • InChi: 1S/C16H20N4O2S/c1-12-3-4-13(23-12)11-15(21)19-7-9-20(10-8-19)16-17-6-5-14(18-16)22-2/h3-6H,7-11H2,1-2H3
  • InChiKey: XSPVVAAFQKUZFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0377 0.1332
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0264 0.0265
Brugia malayi hypothetical protein 0.0035 0.03 0.03
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.2239 0.2246
Loa Loa (eye worm) hypothetical protein 0.0504 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0144 0.094
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0075 0.1118 0.1122
Brugia malayi nuclear hormone receptor 0.0035 0.03 0.03
Schistosoma mansoni thyroid hormone receptor 0.0075 0.1118 0.1592
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0075 0.1118 0.1118
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0426 0.46
Echinococcus multilocularis musashi 0.0026 0.0107 0.0107
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0035 0.03 0.0301
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.169 0.169
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.037 0.0372
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.03 0.0301
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0075 0.1118 0.1592
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0264 1
Brugia malayi nuclear receptor NHR-88 0.0035 0.03 0.03
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0075 0.1118 0.1054
Schistosoma mansoni hypothetical protein 0.036 0.702 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.03 0.023
Trichomonas vaginalis adenylate cyclase, putative 0.0039 0.0377 0.1332
Entamoeba histolytica hypothetical protein 0.0069 0.1004 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.1004 0.1007
Schistosoma mansoni hypothetical protein 0.006 0.0812 0.1156
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0426 0.0357
Echinococcus granulosus FTZ F1 alpha 0.0075 0.1118 0.1122
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0144 0.0643
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0264 0.1178
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0426 0.0357
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.037 0.0372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.03 0.0301
Brugia malayi Importin beta-1 subunit 0.0028 0.0144 0.0144
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0072 0.0452
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.004 0.0387 0.0318
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.2239 0.319
Schistosoma mansoni zinc finger protein 0.0035 0.03 0.0427
Brugia malayi tailless protein 0.0035 0.03 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0075 0.1118 0.1054
Brugia malayi bHLH-PAS transcription factor 0.0111 0.187 0.187
Schistosoma mansoni nuclear hormone receptor 0.0035 0.03 0.0427
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0841 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.004 0.0387 0.0552
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0264 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0264 0.0265
Leishmania major protein kinase, putative 0.0039 0.0377 0.1551
Mycobacterium leprae Possible regulatory protein 0.0039 0.0377 0.145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0387 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0377 0.1332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Onchocerca volvulus 0.0111 0.187 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.2239 0.8609
Onchocerca volvulus 0.0075 0.1118 0.5734
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.037 0.1306
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0075 0.1118 0.1122
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.037 0.1306
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0377 0.1332
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.004 0.0387 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0264 0.0265
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.037 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0075 0.1118 0.1118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Brugia malayi steroid hormone receptor 0.0075 0.1118 0.1118
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.037 0.1306
Echinococcus multilocularis FTZ F1 alpha 0.0075 0.1118 0.1122
Loa Loa (eye worm) hypothetical protein 0.0502 0.9967 0.9967
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0426 0.4844
Echinococcus multilocularis survival motor neuron protein 1 0.0502 0.9967 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.03 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0075 0.1118 0.1054
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0264 0.2834
Schistosoma mansoni hypothetical protein 0.0102 0.169 0.2407
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0035
Brugia malayi ecdysone receptor 0.0035 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Schistosoma mansoni hypothetical protein 0.0069 0.1004 0.143
Brugia malayi intermediate filament protein 0.0026 0.0107 0.0107
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.3181 0.3181
Echinococcus granulosus importin subunit beta 1 0.0028 0.0144 0.0145
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.2239 0.2246
Brugia malayi Nuclear hormone receptor E75 0.0035 0.03 0.03
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.03 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.1118 0.1122
Echinococcus multilocularis transfer RNA-Lys 0.0111 0.187 0.1876
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0039 0.0377 0.0378
Onchocerca volvulus 0.0035 0.03 0.1093
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0377 0.424
Brugia malayi hypothetical protein 0.004 0.0387 0.0387
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0264 0.0193
Schistosoma mansoni coup transcription factor 0.0075 0.1118 0.1592
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0075 0.1118 0.1592
Schistosoma mansoni lamin 0.0026 0.0107 0.0152
Schistosoma mansoni RAR-like nuclear receptor 0.0075 0.1118 0.1592
Entamoeba histolytica hypothetical protein 0.0069 0.1004 1
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0841 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.1118 0.1122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0075 0.1118 0.1122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.03 0.1093
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0264 0.2495
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.03 0.0301
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0264 0.1178
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0075 0.1118 0.1122
Onchocerca volvulus 0.0102 0.169 0.8978
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0377 0.1551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.037 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.1118 0.1118
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0264 0.1014
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0075 0.1118 0.1054
Echinococcus granulosus intermediate filament protein 0.0026 0.0107 0.0107
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0426 0.4844
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.2239 0.8609
Schistosoma mansoni retinoic acid receptor RXR 0.0075 0.1118 0.1592
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.03 0.0301
Brugia malayi nuclear receptor NHR-67 0.0035 0.03 0.03
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.037 0.1306
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.2239 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0387 0.0387
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0569 0.6621
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.0841 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0107 0.0152
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0841 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.03 0.0301
Schistosoma mansoni nuclear receptor 0.0035 0.03 0.0427
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0377 0.1332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.1118 0.1118
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.037 0.1654
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.037 0.1306
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0377 0.424
Onchocerca volvulus Protein ultraspiracle homolog 0.0075 0.1118 0.5734
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0731 0.863
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Brugia malayi ecdysteroid receptor 0.0075 0.1118 0.1118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0075 0.1118 0.1122
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.3181 0.3191
Brugia malayi hypothetical protein 0.0069 0.1004 0.1004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.1118 0.1122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.1118 0.1122
Onchocerca volvulus 0.0039 0.0377 0.1532
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0264 0.2495
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0146 0.2601 1
Entamoeba histolytica hypothetical protein 0.0069 0.1004 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0264 0.0265
Loa Loa (eye worm) hypothetical protein 0.004 0.0387 0.0318
Entamoeba histolytica hypothetical protein 0.0069 0.1004 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0144 0.0073
Mycobacterium ulcerans putative regulatory protein 0.0111 0.187 0.7191
Brugia malayi Cytochrome P450 family protein 0.0041 0.0426 0.0426
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.037 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0075 0.1118 0.1118
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0072 0.2719
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0426 0.1637
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0377 0.424
Schistosoma mansoni survival motor neuron protein 0.0102 0.169 0.2407
Brugia malayi Steroid receptor seven-up type 2 0.0075 0.1118 0.1118
Onchocerca volvulus 0.0101 0.1658 0.8796
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.037 0.1521
Leishmania major cathepsin L-like protease 0.0061 0.0841 0.3657
Leishmania major protein kinase, putative 0.0039 0.0377 0.1551
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.03 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.037 0.4158
Brugia malayi hypoxia-induced factor 1 0.0465 0.9192 0.9192
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0075 0.1118 0.1054
Trypanosoma brucei glucosidase, putative 0.0039 0.037 0.3882
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0264 0.0376
Echinococcus granulosus single minded 2 0.0111 0.187 0.1876
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0146 0.2601 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0072 0.2719
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0146 0.2601 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0072 0.0452
Schistosoma mansoni nuclear receptor 0.0035 0.03 0.0427
Brugia malayi nuclear receptor RXR 0.0035 0.03 0.03
Brugia malayi RNA, U transporter 1 0.0079 0.1204 0.1204
Schistosoma mansoni nuclear hormone receptor 0.0075 0.1118 0.1592
Brugia malayi hypothetical protein 0.0024 0.0072 0.0072
Brugia malayi Nuclear hormone receptor E75 0.0035 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Schistosoma mansoni alpha-glucosidase 0.015 0.2678 0.3815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0075 0.1118 0.1054
Echinococcus multilocularis aryl hydrocarbon receptor 0.0039 0.0377 0.0378
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0377 0.1332
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.03 0.0301
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0426 0.0357
Schistosoma mansoni hypothetical protein 0.036 0.702 1
Mycobacterium tuberculosis Probable aminotransferase 0.0146 0.2601 1
Loa Loa (eye worm) DR-78 0.0035 0.03 0.023
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0144 0.094
Brugia malayi nuclear receptor RXR 0.004 0.0387 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.037 0.4158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.1118 0.1118
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.3181 0.3191
Onchocerca volvulus 0.0035 0.03 0.1093
Echinococcus granulosus lamin dm0 0.0026 0.0107 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0264 0.0265
Brugia malayi isocitrate dehydrogenase 0.0034 0.0264 0.0264
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.2239 0.8609
Leishmania major hypothetical protein, conserved 0.0024 0.0072 0.0165
Echinococcus multilocularis lamin 0.0026 0.0107 0.0107
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.2239 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0377 0.424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Brugia malayi hypothetical protein 0.0502 0.9967 0.9967
Brugia malayi hypothetical protein 0.0035 0.03 0.03
Echinococcus granulosus aryl hydrocarbon receptor 0.0039 0.0377 0.0378
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.03 0.0301
Echinococcus granulosus snurportin 1 0.0297 0.5708 0.5727
Plasmodium falciparum importin beta, putative 0.0028 0.0144 0.5463
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Onchocerca volvulus Bile acid receptor homolog 0.0075 0.1118 0.5734
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0146 0.2601 1
Schistosoma mansoni single-minded 0.015 0.2678 0.3815
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0075 0.1118 0.1122
Brugia malayi Cytochrome P450 family protein 0.0041 0.0426 0.0426
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0075 0.1118 0.1592
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0075 0.1118 0.1122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0075 0.1118 0.1592
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Echinococcus granulosus survival motor neuron protein 1 0.0502 0.9967 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.03 0.0301
Loa Loa (eye worm) hypothetical protein 0.004 0.0387 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.1118 0.1118
Brugia malayi conserved hypotetical protein 0.0035 0.03 0.03
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0144 0.0145
Schistosoma mansoni nuclear hormone receptor 0.0035 0.03 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0075 0.1118 0.1118
Loa Loa (eye worm) hypothetical protein 0.004 0.0387 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0075 0.1118 0.1118
Echinococcus granulosus lamin 0.0026 0.0107 0.0107
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0377 0.1332
Echinococcus multilocularis snurportin 1 0.0297 0.5708 0.5727
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.1004 0.143
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0075 0.1118 0.1122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.1118 0.1118
Echinococcus multilocularis geminin 0.036 0.702 0.7043
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.03 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Schistosoma mansoni importin beta-1 0.0028 0.0144 0.0205
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.3181 0.3131
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0035 0.03 0.0427
Echinococcus multilocularis lamin dm0 0.0026 0.0107 0.0107
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0039 0.0377 0.0308
Leishmania major cathepsin L-like protease 0.0061 0.0841 0.3657
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0075 0.1118 0.1122
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0377 0.1332
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0072 0.2719
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.3181 0.3191
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0039 0.0377 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0264 0.2834
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0377 0.424
Brugia malayi photoreceptor-specific nuclear receptor 0.0075 0.1118 0.1118
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0075 0.1118 0.1122
Loa Loa (eye worm) steroid hormone receptor 0.0075 0.1118 0.1054
Schistosoma mansoni alpha-glucosidase 0.015 0.2678 0.3815
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.03 0.03
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0107 0.0107
Mycobacterium ulcerans hypothetical protein 0.0146 0.2601 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0264 0.1036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.004 0.0387 0.0389
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0039 0.0377 0.0378
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0039 0.0377 0.1332
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0075 0.1118 0.1122
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.5708 0.5677
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0377 0.424
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0075 0.1118 0.1118
Schistosoma mansoni thyroid hormone receptor 0.0075 0.1118 0.1592
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0264 0.0265
Brugia malayi nuclear hormone receptor 0.0075 0.1118 0.1118
Brugia malayi nuclear receptor NHR-88 0.0075 0.1118 0.1118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0841 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0377 0.0308
Plasmodium vivax importin-beta 2, putative 0.0028 0.0144 0.5463
Echinococcus granulosus ecdysone induced protein 78C 0.0075 0.1118 0.1122
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0039 0.0377 0.1332
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0377 0.1332
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0264 0.0264
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0107 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.1118 0.1118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.2239 0.8609
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Schistosoma mansoni aryl hydrocarbon receptor 0.015 0.2678 0.3815
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0387 0.0387
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.1004 0.1007
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0072 0.032
Loa Loa (eye worm) hypothetical protein 0.0075 0.1118 0.1054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.1118 0.1118
Schistosoma mansoni hypothetical protein 0.0297 0.5708 0.8131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0075 0.1118 0.1054
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.023
Schistosoma mansoni alpha glucosidase 0.0039 0.037 0.0528
Loa Loa (eye worm) hypoxia-induced factor 1 0.0465 0.9192 0.9186
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.03 0.0301
Schistosoma mansoni steroid hormone receptor ad4bp 0.0075 0.1118 0.1592
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.03 0.0301
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0075 0.1118 0.1592
Leishmania major cathepsin L-like protease 0.0061 0.0841 0.3657
Echinococcus granulosus geminin 0.036 0.702 0.7043
Loa Loa (eye worm) hypothetical protein 0.004 0.0387 0.0318
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.037 0.346
Brugia malayi hypothetical protein 0.004 0.0387 0.0387
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.037 0.346
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0075 0.1118 0.1118
Loa Loa (eye worm) hypothetical protein 0.0026 0.0097 0.0025
Schistosoma mansoni lamin 0.0026 0.0107 0.0152
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0035 0.03 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.2239 0.319
Loa Loa (eye worm) hypothetical protein 0.004 0.0387 0.0318
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.037 0.037
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0075 0.1118 0.5734
Leishmania major cytochrome p450-like protein 0.0041 0.0426 0.1772
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.03 0.1093
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0107 0.0035
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.037 0.1306
Loa Loa (eye worm) nuclear hormone receptor 0.0035 0.03 0.023
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.03 0.0301
Brugia malayi PAS domain containing protein 0.015 0.2678 0.2678
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0075 0.1118 0.1592
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.037 0.0301

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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