Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0358 | 0.6484 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0045 | 0.0504 | 0.1298 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0127 | 0.2062 | 0.7262 |
Trypanosoma brucei | calpain, putative | 0.0131 | 0.2136 | 1 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0131 | 0.2136 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.2064 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.015 | 0.0232 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0127 | 0.2064 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0504 | 0.1298 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0127 | 0.2064 | 0.3184 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0306 | 0.0065 |
Echinococcus multilocularis | geminin | 0.0163 | 0.2764 | 0.9601 |
Loa Loa (eye worm) | acetyltransferase | 0.0169 | 0.2873 | 0.2858 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0164 | 0.2782 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0504 | 0.0359 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0504 | 0.1298 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0169 | 0.2873 | 0.2764 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0306 | 0.0569 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0358 | 0.6484 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.1381 | 0.452 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0091 | 0.1381 | 0.5876 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0131 | 0.2136 | 1 |
Brugia malayi | phosphofructokinase | 0.0127 | 0.2064 | 0.1943 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0091 | 0.1381 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0504 | 0.0359 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0157 | 0.2644 | 0.9474 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.2064 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0091 | 0.1381 | 0.643 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0127 | 0.2064 | 0.7029 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0091 | 0.1381 | 0.125 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.2064 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0127 | 0.2064 | 0.1943 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0294 | 0.0423 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.015 | 0.02 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0131 | 0.2136 | 1 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1381 | 0.6141 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0045 | 0.0504 | 0.1343 |
Trypanosoma brucei | hypothetical protein | 0.0131 | 0.2136 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.0306 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.015 | 0.013 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.015 | 0.02 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.005 | 0.059 | 0.1671 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0294 | 0.0423 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0169 | 0.2873 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.015 | 0.02 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0127 | 0.2064 | 0.7272 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.005 | 0.059 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0045 | 0.0504 | 0.0748 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1381 | 0.6141 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.0501 | 0.117 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0306 | 0.0065 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0157 | 0.2644 | 0.9158 |
Schistosoma mansoni | polycystin 1-related | 0.0045 | 0.0504 | 0.1298 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0358 | 0.6484 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0358 | 0.6484 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0358 | 0.6484 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0358 | 0.6484 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0615 | 0.1706 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.015 | 0.0232 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0151 | 0.013 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0091 | 0.1381 | 0.452 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0.0528 | 0.1972 |
Giardia lamblia | Kinase, PLK | 0.0091 | 0.1381 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0091 | 0.1381 | 0.4675 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0169 | 0.2873 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0127 | 0.2064 | 0.964 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0306 | 0.0811 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0157 | 0.2644 | 0.2629 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0306 | 0.039 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0294 | 0.0423 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0127 | 0.2062 | 0.702 |
Schistosoma mansoni | loxhd1 | 0.0045 | 0.0504 | 0.1298 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0045 | 0.0504 | 0.1298 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0045 | 0.0504 | 0.1298 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0157 | 0.2644 | 0.2532 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.015 | 0.02 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0127 | 0.2064 | 0.7029 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0135 | 0.2225 | 0.7621 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0306 | 0.0811 |
Onchocerca volvulus | 0.0027 | 0.0151 | 0.0003 | |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0091 | 0.1381 | 0.6199 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0045 | 0.0504 | 0.0748 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0294 | 0.0423 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0127 | 0.2064 | 0.2048 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0091 | 0.1381 | 0.5876 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0.0528 | 0.1972 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0151 | 0.013 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.005 | 0.059 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0358 | 0.6484 | 0.5 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0127 | 0.2064 | 0.3162 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0127 | 0.2064 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0046 | 0.0511 | 0.1993 |
Schistosoma mansoni | lipoxygenase | 0.0045 | 0.0504 | 0.1298 |
Trypanosoma brucei | polo-like protein kinase | 0.0091 | 0.1381 | 0.5876 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0151 | 0.013 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0306 | 0.0782 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1381 | 0.6141 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0.0528 | 0.1972 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Schistosoma mansoni | kinase | 0.0046 | 0.0524 | 0.1372 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0127 | 0.2064 | 0.7029 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0127 | 0.2064 | 0.9609 |
Schistosoma mansoni | lipoxygenase | 0.0127 | 0.2062 | 0.702 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0135 | 0.2225 | 0.7621 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0504 | 0.0484 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.005 | 0.059 | 0.088 |
Echinococcus granulosus | geminin | 0.0163 | 0.2764 | 0.9931 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0294 | 0.0423 |
Brugia malayi | Doublecortin family protein | 0.0045 | 0.0504 | 0.0359 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0306 | 0.0158 |
Echinococcus granulosus | RUN | 0.0045 | 0.0504 | 0.1343 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1381 | 0.6141 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0127 | 0.2064 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.0306 | 0.0065 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.015 | 0.02 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0127 | 0.2064 | 0.9609 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0306 | 0.0065 |
Trypanosoma brucei | variant surface glycoprotein (VSG), putative | 0.0131 | 0.2136 | 1 |
Trypanosoma brucei | calpain-like protein, putative | 0.0131 | 0.2136 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0306 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.015 | 0.013 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.0501 | 0.117 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0306 | 0.0065 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0157 | 0.2644 | 0.9158 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0131 | 0.2136 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.015 | 0.02 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0294 | 0.0423 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0045 | 0.0504 | 0.1343 |
Echinococcus multilocularis | RUN | 0.0045 | 0.0504 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.015 | 0.013 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0358 | 0.6484 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.015 | 0.02 |
Brugia malayi | 6-phosphofructokinase | 0.0127 | 0.2064 | 0.1943 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0306 | 0.0065 |
Onchocerca volvulus | 0.0045 | 0.0504 | 0.2875 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.015 | 0.02 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0131 | 0.2136 | 1 |
Onchocerca volvulus | 0.0091 | 0.1377 | 0.9966 | |
Onchocerca volvulus | 0.0045 | 0.0504 | 0.2875 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0306 | 0.0065 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0.0528 | 0.1972 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0091 | 0.1381 | 0.1363 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0127 | 0.2064 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0127 | 0.2064 | 0.2048 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0306 | 0.0065 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0127 | 0.2064 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.2764 | 0.9601 |
Onchocerca volvulus | 0.0027 | 0.0151 | 0.0003 | |
Loa Loa (eye worm) | phosphofructokinase | 0.0127 | 0.2064 | 0.2048 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.2764 | 0.9601 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0021 | 0.0032 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1381 | 0.6141 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1381 | 0.6141 |
Loa Loa (eye worm) | doublecortin family protein | 0.0045 | 0.0504 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.0542 | 1 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0045 | 0.0504 | 0.1343 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0127 | 0.2064 | 1 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0131 | 0.2136 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0306 | 0.0285 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0046 | 0.0511 | 0.0758 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0034 | 0.0294 | 0.0751 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0306 | 0.0569 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0046 | 0.0511 | 0.1883 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0141 | 0.0121 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0.0528 | 0.1972 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0504 | 0.0484 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.005 | 0.059 | 0.1669 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.1381 | 0.6141 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.005 | 0.059 | 0.1671 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0504 | 0.1298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.