Detailed information for compound 2088692

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 675.836 | Formula: C40H41N3O5S
  • H donors: 2 H acceptors: 4 LogP: 6.43 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCC[C@H]1N(Cc2c1c(nc(c2)C(=O)NCc1ccc(cc1)Oc1ccccc1)c1cccc(c1)c1cccc(c1)OC)S(=O)C(C)(C)C
  • InChi: 1S/C40H41N3O5S/c1-40(2,3)49(46)43-26-31-24-35(39(45)41-25-27-16-18-33(19-17-27)48-32-13-6-5-7-14-32)42-38(37(31)36(43)20-21-44)30-12-8-10-28(22-30)29-11-9-15-34(23-29)47-4/h5-19,22-24,36,44H,20-21,25-26H2,1-4H3,(H,41,45)/t36-,49?/m1/s1
  • InChiKey: AHRQYPJAGHNBHY-WOZSFPNOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0203 0.5052
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0599 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0163 0.0162
Schistosoma mansoni hypothetical protein 0.0051 0.0434 0.1245
Leishmania major importin beta-1 subunit, putative 0.0025 0.0142 0.2002
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0583 0.2202
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0553 0.1094
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.1974
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Leishmania major protein kinase, putative 0.0066 0.0598 0.8517
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0203 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0608 0.269
Entamoeba histolytica hypothetical protein 0.0048 0.04 0.6679
Leishmania major hypothetical protein, conserved 0.0027 0.0163 0.2308
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0599 0.0597
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0599 0.0597
Loa Loa (eye worm) hypothetical protein 0.0249 0.2644 0.7593
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.032 1
Loa Loa (eye worm) sugar transporter 0.003 0.0203 0.0579
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.04 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.04 0.1149
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0608 0.8651
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0163 0.0162
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1184
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0203 0.6328
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1006 0.3801
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.04 0.0399
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.012 0.2978
Schistosoma mansoni ran 0.0022 0.0116 0.0334
Entamoeba histolytica protein kinase, putative 0.0066 0.0598 1
Toxoplasma gondii sugar transporter ST1 0.003 0.0203 0.0305
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0203 0.5052
Plasmodium falciparum hexose transporter 0.0214 0.2255 0.2253
Echinococcus granulosus importin subunit beta 1 0.003 0.0206 0.0407
Loa Loa (eye worm) hypothetical protein 0.0064 0.0583 0.1672
Brugia malayi Sugar transporter family protein 0.003 0.0203 0.0762
Leishmania major GTP-binding protein, putative 0.0022 0.0116 0.164
Trypanosoma cruzi sugar transporter, putative 0.003 0.0203 0.2874
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0583 0.1676
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0162 0.0321
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1184
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0598 0.8517
Plasmodium falciparum importin beta, putative 0.003 0.0206 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus geminin 0.0179 0.1857 0.3674
Brugia malayi Cam kinase protein 1 0.0066 0.0598 0.2258
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0203 0.0762
Schistosoma mansoni ran 0.0022 0.0116 0.0334
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0702 0.0701
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0598 0.2648
Brugia malayi hypothetical protein 0.0027 0.0163 0.0612
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0702 1
Brugia malayi hypothetical protein 0.003 0.0203 0.0762
Schistosoma mansoni glucose transport protein 0.0214 0.2255 0.6476
Loa Loa (eye worm) hypothetical protein 0.0102 0.1006 0.2886
Trypanosoma cruzi glucose transporter, putative 0.003 0.0203 0.2874
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1184
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.04 0.0603
Loa Loa (eye worm) hypothetical protein 0.0052 0.0449 0.1286
Schistosoma mansoni importin beta-1 0.003 0.0206 0.0591
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0228 0.045
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0228 0.0855
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0203 0.0402
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0402
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0702 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0228 0.045
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0583 0.1155
Brugia malayi hypothetical protein 0.003 0.0203 0.0762
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0402
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0203 0.2874
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0163 0.0162
Trichomonas vaginalis glucose transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) hypothetical protein 0.007 0.0646 0.1851
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1184
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1006 0.3801
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.5054 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Giardia lamblia Hexose transporter 0.003 0.0203 0.346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0228 0.0649
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0203 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0206 0.0204
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0583 0.1676
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0608 0.269
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0608 0.269
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0334 0.1477
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0702 1
Entamoeba histolytica hypothetical protein 0.0025 0.0142 0.235
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4461
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0162 0.0321
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4461
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0116 0.023
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0079 0.1953
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0608 0.8651
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0608 0.8651
Plasmodium vivax hexose transporter 0.0214 0.2255 0.2253
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0116 0.0174
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0599 0.0903
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.04 0.0792
Schistosoma mansoni hypothetical protein 0.0214 0.2255 0.6476
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0079 0.2446
Echinococcus multilocularis importin subunit beta 1 0.003 0.0206 0.0407
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0161 0.0459
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4461
Schistosoma mansoni protein kinase 0.0066 0.0598 0.1718
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0599 0.0597
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0598 0.2258
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0599 0.0597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0608 0.8651
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1006 0.2886
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0702 1
Brugia malayi RNA, U transporter 1 0.0086 0.083 0.3136
Toxoplasma gondii protein kinase, putative 0.0606 0.6612 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0346 0.3725 0.3724
Brugia malayi major facilitator superfamily protein 0.003 0.0203 0.0762
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus General substrate transporter 0.0184 0.1919 0.3797
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Schistosoma mansoni glucose transporter 0.003 0.0203 0.0583
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0162 0.0321
Loa Loa (eye worm) sugar transporter 0.0214 0.2255 0.6474
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0346 0.3725 0.5632
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0163 0.0245
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Schistosoma mansoni hypothetical protein 0.0179 0.1857 0.5333
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0002 0.0003
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0203 0.0583
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0079 0.6559
Brugia malayi hypothetical protein 0.003 0.0203 0.0762
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Toxoplasma gondii facilitative glucose transporter GT1 0.0214 0.2255 0.3408
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0434 0.1635
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0402
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0116 0.023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0598 0.1715
Echinococcus granulosus snurportin 1 0.0325 0.3482 0.6889
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0599 0.0903
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0203 0.0762
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.04 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1184
Entamoeba histolytica protein kinase, putative 0.0066 0.0598 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0583 0.2202
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.04 0.0792
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2644 0.5231
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0608 0.269
Loa Loa (eye worm) hypothetical protein 0.003 0.0206 0.0587
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0203 0.5052
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.04 0.5689
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0203 0.2874
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.04 0.5689
Schistosoma mansoni protein kinase 0.0066 0.0598 0.1718
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0115
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.3482 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0598 0.1184
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Toxoplasma gondii sugar transporter ST2 0.003 0.0203 0.0305
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Trypanosoma brucei glucose transporter 1E 0.0066 0.0608 0.8651
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Leishmania major glucose transporter, lmgt3 0.0066 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4461
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0206 0.2916
Onchocerca volvulus 0.0051 0.0434 1
Brugia malayi Sugar transporter family protein 0.0214 0.2255 0.8527
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0203 0.0402
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0598 0.1715
Leishmania major glucose transporter, lmgt2 0.0066 0.0608 0.8651
Leishmania major glucose transporter, lmgt1 0.0066 0.0608 0.8651
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0608 0.269
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trypanosoma brucei sugar transporter, putative 0.003 0.0203 0.2874
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0608 0.269
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0608 0.8651
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0608 0.8651
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0583 0.2583
Echinococcus multilocularis GPCR, family 2 0.0032 0.0228 0.045
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0203 0.0579
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0702 1
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0203 0.0894
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0702 0.0701
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0228 0.0649
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Loa Loa (eye worm) hypothetical protein 0.0048 0.04 0.1145
Trypanosoma cruzi hexose transporter, putative 0.003 0.0203 0.2874
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0079 0.1953
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0608 0.269
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.012 1
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.04 0.6849
Echinococcus multilocularis snurportin 1 0.0325 0.3482 0.6889
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0002 0.0003
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0206 0.0309
Leishmania major hypothetical protein, conserved 0.003 0.0203 0.2874
Plasmodium vivax sugar transporter, putative 0.003 0.0203 0.0201
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0203 0.0402
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0203 0.0305
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0583 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1184
Schistosoma mansoni hypothetical protein 0.0325 0.3482 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Plasmodium vivax CDK-related protein kinase 6, putative 0.091 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0203 0.0201
Mycobacterium ulcerans sugar transporter 0.003 0.0203 0.5052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4461
Schistosoma mansoni glucose transport protein 0.0214 0.2255 0.6476
Schistosoma mansoni hypothetical protein 0.007 0.0646 0.1855
Brugia malayi Importin beta-1 subunit 0.003 0.0206 0.0773
Loa Loa (eye worm) hypothetical protein 0.0027 0.0163 0.0465
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0163 0.2308
Trypanosoma brucei glucose transporter 2A 0.0066 0.0608 0.8651
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0228 0.0855
Toxoplasma gondii sugar transporter ST3 0.003 0.0203 0.0305
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0646 0.2438
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0599 0.0597
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0002 0.0004
Trypanosoma cruzi hexose transporter 0.0066 0.0608 0.8651
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0203 0.0762
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0142 0.0622
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2644 0.5231
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0142 0.2002
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0206 0.2916
Entamoeba histolytica Ran family GTPase 0.0022 0.0116 0.1925
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0203 0.6328
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.032 0.5469
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.04 0.1149
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0142 0.0622
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Echinococcus granulosus neuropeptide s receptor 0.0466 0.5054 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.04 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.04 0.6849
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0002 0.0003
Brugia malayi hypothetical protein 0.0249 0.2644 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1184
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0402
Brugia malayi Sugar transporter family protein 0.003 0.0203 0.0762
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0116 0.0115
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0228 0.045
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0599 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Schistosoma mansoni survival motor neuron protein 0.0051 0.0434 0.1245
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0402
Echinococcus multilocularis geminin 0.0179 0.1857 0.3674
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0599 0.0597
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0702 0.106
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.5054 1
Trichomonas vaginalis ran, putative 0.0022 0.0116 0.051
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.032 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0228 0.045
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0402
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4461
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0608 0.8651
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0435
Loa Loa (eye worm) hypothetical protein 0.0064 0.0583 0.1672
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0583 1
Echinococcus multilocularis General substrate transporter 0.0184 0.1919 0.3797
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0553 0.1094
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Schistosoma mansoni protein kinase 0.0066 0.0598 0.1718
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0214 0.2255 0.4461
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0203 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0598 0.1715
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.2255 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.5054 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0599 0.0597
Brugia malayi major facilitator superfamily protein 0.003 0.0203 0.0762
Plasmodium falciparum mitogen-activated protein kinase 2 0.0346 0.3725 0.3724
Schistosoma mansoni glucose transport protein 0.0214 0.2255 0.6476
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0272 0.386
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.012 0.2978
Brugia malayi lysyl-tRNA synthetase 0.0048 0.04 0.1508
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0583 0.1155
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0163 0.2308
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.04 0.5689
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0583 0.9752
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0402
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0163 0.2308
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4461
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.04 0.1769
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0002 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0142 0.0622
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0079 0.6559
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0598 0.1718
Echinococcus granulosus GPCR family 2 0.0032 0.0228 0.045
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0402
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0203 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.04 1
Giardia lamblia Sugar-proton symporter 0.003 0.0203 0.346
Schistosoma mansoni hypothetical protein 0.0179 0.1857 0.5333
Chlamydia trachomatis glutamine binding protein 0.0019 0.0079 0.1953
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0599 0.0903
Plasmodium falciparum protein kinase 7 0.0606 0.6612 0.6612
Brugia malayi hypothetical protein 0.0017 0.0058 0.0215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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