TDR Targets

Basic information

Technical information

TDR Targets ID: 208903
Name: N-benzyl-4-(2-fluorophenyl)-3-methylquinoline -2-carboxamide
MW: 370.419 | Formula: C24H19FN2O
H donors: 1 H acceptors: 2 LogP: 5.39 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1nc2ccccc2c(c1C)c1ccccc1F)NCc1ccccc1
InChi: 1S/C24H19FN2O/c1-16-22(18-11-5-7-13-20(18)25)19-12-6-8-14-21(19)27-23(16)24(28)26-15-17-9-3-2-4-10-17/h2-14H,15H2,1H3,(H,26,28)
InChiKey: ZAQVSWUKWOBQNH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-benzyl-4-(2-fluorophenyl)-3-methyl-quinoline-2-carboxamide
N-benzyl-4-(2-fluorophenyl)-3-methyl-2-quinolinecarboxamide
4-(2-fluorophenyl)-3-methyl-N-(phenylmethyl)quinoline-2-carboxamide
N-benzyl-4-(2-fluorophenyl)-3-methyl-quinaldamide
4-(2-fluorophenyl)-3-methyl-N-(phenylmethyl)-2-quinolinecarboxamide
N-(benzyl)-4-(2-fluorophenyl)-3-methyl-quinaldamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Peripheral-type benzodiazepine receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Mycobacterium ulcerans	tryptophan-rich sensory protein	Get druggable targets OG5_129542	All targets in OG5_129542
Brugia malayi	TspO/MBR family protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Echinococcus granulosus	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Echinococcus multilocularis	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Schistosoma mansoni	peripheral-type benzodiazepine receptor	Get druggable targets OG5_129542	All targets in OG5_129542

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	vacuolar h atpase	Peripheral-type benzodiazepine receptor	169 aa	137 aa	25.5 %
Onchocerca volvulus		Peripheral-type benzodiazepine receptor	169 aa	156 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	hypothetical protein	0.0045	0.077	0.1148
Brugia malayi	Fibulin-1 precursor	0.0275	0.6707	0.6833
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0248	0.0253
Schistosoma mansoni	hypothetical protein	0.0402	1	1
Echinococcus granulosus	neurogenic locus notch protein 4	0.0121	0.273	0.273
Echinococcus granulosus	protein jagged 1	0.0121	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Brugia malayi	Cytochrome P450 family protein	0.0057	0.1081	0.1101
Loa Loa (eye worm)	PAN domain-containing protein	0.0045	0.077	0.0784
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1148	0.1148
Onchocerca volvulus		0.0322	0.7933	0.8015
Schistosoma mansoni	notch	0.0121	0.273	0.273
Schistosoma mansoni	cpg binding protein	0.003	0.0371	0.0371
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Echinococcus multilocularis	enteropeptidase	0.0236	0.5699	0.5699
Loa Loa (eye worm)	hypothetical protein	0.0115	0.2573	0.2622
Onchocerca volvulus		0.0322	0.7933	0.8015
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1319	0.1663
Schistosoma mansoni	cpg binding protein	0.003	0.0371	0.0371
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Brugia malayi	hypothetical protein	0.0115	0.2573	0.2622
Loa Loa (eye worm)	hypothetical protein	0.0115	0.2573	0.2622
Echinococcus granulosus	delta-like protein 1	0.0121	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Echinococcus multilocularis	geminin	0.0166	0.3908	0.3908
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1319	0.1967
Loa Loa (eye worm)	TK/ROR protein kinase	0.0182	0.4307	0.4387
Toxoplasma gondii	PAN domain-containing protein	0.0045	0.077	0.1148
Onchocerca volvulus		0.0045	0.077	0.0464
Echinococcus multilocularis	glycoprotein Antigen 5	0.0236	0.5699	0.5699
Brugia malayi	EGF-like domain containing protein	0.0121	0.273	0.2781
Schistosoma mansoni	hypothetical protein	0.0121	0.273	0.273
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0275	0.6707	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0329	0.0335
Brugia malayi	EGF-like domain containing protein	0.0121	0.273	0.2781
Onchocerca volvulus		0.0115	0.2573	0.2366
Schistosoma mansoni	hypothetical protein	0.0121	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0275	0.6707	0.6833
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Echinococcus multilocularis	transmembrane protease serine 3	0.0115	0.2573	0.2573
Onchocerca volvulus		0.0121	0.273	0.2531
Toxoplasma gondii	PAN domain-containing protein	0.0045	0.077	0.1148
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0182	0.4307	0.5
Echinococcus granulosus	slit 2 protein	0.0121	0.273	0.273
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0329	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0045	0.077	0.1148
Loa Loa (eye worm)	hypothetical protein	0.0275	0.6707	0.6833
Brugia malayi	EGF-like domain containing protein	0.0121	0.273	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.0784
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0115	0.2573	0.2573
Echinococcus multilocularis	neurogenic locus notch protein	0.0121	0.273	0.273
Brugia malayi	EGF-like domain containing protein	0.0121	0.273	0.2781
Echinococcus granulosus	transmembrane protease serine 3	0.0115	0.2573	0.2573
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0248	0.0253
Toxoplasma gondii	PAN domain-containing protein	0.0045	0.077	0.1148
Brugia malayi	Protein kinase domain containing protein	0.0182	0.4307	0.4387
Onchocerca volvulus		0.0045	0.077	0.0464
Brugia malayi	Cadherin domain containing protein	0.0121	0.273	0.2781
Onchocerca volvulus		0.0045	0.077	0.0464
Onchocerca volvulus	Putative cubilin	0.0121	0.273	0.2531
Schistosoma mansoni	notch	0.0121	0.273	0.273
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Brugia malayi	hypothetical protein	0.013	0.2964	0.3019
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0275	0.6707	0.6833
Brugia malayi	Trypsin family protein	0.0115	0.2573	0.2622
Brugia malayi	Calcium binding EGF domain containing protein	0.0275	0.6707	0.6833
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0115	0.2573	0.2573
Loa Loa (eye worm)	PAN domain-containing protein	0.0045	0.077	0.0784
Schistosoma mansoni	cell polarity protein	0.0121	0.273	0.273
Onchocerca volvulus		0.0115	0.2573	0.2366
Loa Loa (eye worm)	hypothetical protein	0.0322	0.7933	0.8082
Toxoplasma gondii	microneme protein MIC17B	0.0045	0.077	0.1148
Onchocerca volvulus		0.0121	0.273	0.2531
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.0784
Onchocerca volvulus		0.0121	0.273	0.2531
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Onchocerca volvulus		0.0322	0.7933	0.8015
Onchocerca volvulus	Slit protein homolog	0.0121	0.273	0.2531
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Echinococcus granulosus	geminin	0.0166	0.3908	0.3908
Schistosoma mansoni	hypothetical protein	0.0121	0.273	0.273
Toxoplasma gondii	subtilisin SUB12	0.0045	0.077	0.1148
Loa Loa (eye worm)	hypothetical protein	0.0322	0.7933	0.8082
Echinococcus multilocularis	slit 2 protein	0.0121	0.273	0.273
Giardia lamblia	High cysteine protein	0.0121	0.273	0.5
Echinococcus multilocularis	neurogenic locus protein delta	0.0121	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Brugia malayi	Kringle domain containing protein	0.0182	0.4307	0.4387
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0248	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0121	0.273	0.273
Brugia malayi	Trypsin family protein	0.0115	0.2573	0.2622
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1319	0.1319
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0322	0.7933	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0236	0.5699	0.5699
Echinococcus granulosus	neurogenic locus notch protein	0.0121	0.273	0.273
Mycobacterium leprae	putative cytochrome p450	0.0015	0	0.5
Toxoplasma gondii	kringle domain-containing protein	0.0182	0.4307	0.6421
Echinococcus multilocularis	neural cadherin	0.0121	0.273	0.273
Schistosoma mansoni	hypothetical protein	0.0121	0.273	0.273
Brugia malayi	Trypsin family protein	0.0395	0.9816	1
Onchocerca volvulus		0.0045	0.077	0.0464
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Brugia malayi	EGF-like domain containing protein	0.0121	0.273	0.2781
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0121	0.273	0.2531
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1319	0.3063
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Trypanosoma brucei	cytochrome P450, putative	0.0025	0.0248	1
Echinococcus granulosus	tissue type plasminogen activator	0.0182	0.4307	0.4307
Onchocerca volvulus		0.0395	0.9816	1
Onchocerca volvulus		0.028	0.6841	0.6865
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1319	0.1319
Toxoplasma gondii	PAN domain-containing protein	0.0045	0.077	0.1148
Echinococcus multilocularis	neurogenic locus protein delta	0.0121	0.273	0.273
Brugia malayi	Calcium binding EGF domain containing protein	0.0121	0.273	0.2781
Loa Loa (eye worm)	PAN domain-containing protein	0.0045	0.077	0.0784
Onchocerca volvulus		0.0115	0.2573	0.2366
Mycobacterium leprae	Conserved hypothetical protein	0.0015	0	0.5
Loa Loa (eye worm)	trypsin family protein	0.0115	0.2573	0.2622
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.0784
Onchocerca volvulus	Arrow homolog	0.0275	0.6707	0.6723
Schistosoma mansoni	hypothetical protein	0.0166	0.3908	0.3908
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.1081	0.1101
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0115	0.2573	0.2573
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0322	0.7933	0.7933
Echinococcus granulosus	protein jagged 2	0.0121	0.273	0.273
Schistosoma mansoni	cpg binding protein	0.0028	0.0329	0.0329
Toxoplasma gondii	PAN domain-containing protein	0.0045	0.077	0.1148
Schistosoma mansoni	notch	0.0121	0.273	0.273
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0115	0.2573	0.2573
Echinococcus multilocularis	fibrillin 1	0.0275	0.6707	0.6707
Echinococcus multilocularis	protein jagged 1	0.0121	0.273	0.273
Onchocerca volvulus		0.0045	0.077	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Brugia malayi	GCC2 and GCC3 family protein	0.0121	0.273	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0395	0.9816	1
Echinococcus granulosus	cpg binding protein	0.003	0.0371	0.0371
Echinococcus granulosus	fibropellin Ia	0.0121	0.273	0.273
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0115	0.2573	0.2622
Onchocerca volvulus		0.0121	0.273	0.2531
Toxoplasma gondii	microneme protein MIC17C	0.0045	0.077	0.1148
Echinococcus granulosus	Mastin	0.0236	0.5699	0.5699
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Echinococcus multilocularis	protein jagged 2	0.0121	0.273	0.273
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1319	1
Echinococcus multilocularis	Tolloid protein 1	0.0275	0.6707	0.6707
Toxoplasma gondii	microneme protein, putative	0.0045	0.077	0.1148
Brugia malayi	Cadherin domain containing protein	0.0121	0.273	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0322	0.7933	0.8082
Schistosoma mansoni	hypothetical protein	0.0121	0.273	0.273
Loa Loa (eye worm)	notch protein	0.0121	0.273	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0115	0.2573	0.2622
Loa Loa (eye worm)	hypothetical protein	0.0275	0.6707	0.6833
Echinococcus granulosus	neurogenic locus protein delta	0.0121	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0275	0.6707	0.6833
Echinococcus multilocularis	tissue type plasminogen activator	0.0182	0.4307	0.4307
Schistosoma mansoni	notch	0.0121	0.273	0.273
Leishmania major	cytochrome p450-like protein	0.0025	0.0248	0.0576
Echinococcus multilocularis	notch	0.0121	0.273	0.273
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1319	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Echinococcus multilocularis	translocator protein	0.0322	0.7933	0.7933
Loa Loa (eye worm)	PAN domain-containing protein	0.0045	0.077	0.0784
Echinococcus multilocularis	protein jagged 1	0.0121	0.273	0.273
Echinococcus granulosus	protein jagged 1	0.0121	0.273	0.273
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0115	0.2573	0.2573
Toxoplasma gondii	EGF family domain-containing protein	0.0121	0.273	0.407
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Toxoplasma gondii	microneme protein MIC17A	0.0045	0.077	0.1148
Echinococcus multilocularis	Mastin	0.0236	0.5699	0.5699
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0275	0.6707	0.6707
Brugia malayi	Calcium binding EGF domain containing protein	0.0121	0.273	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Toxoplasma gondii	hypothetical protein	0.0045	0.077	0.1148
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1319	0.1663
Echinococcus granulosus	protein jagged 2	0.0121	0.273	0.273
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1319	0.1663
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0275	0.6707	1
Echinococcus granulosus	translocator protein	0.0322	0.7933	0.7933
Onchocerca volvulus		0.0121	0.273	0.2531
Schistosoma mansoni	laminin gamma-3 chain	0.0121	0.273	0.273
Schistosoma mansoni	notch	0.0121	0.273	0.273
Toxoplasma gondii	PAN domain-containing protein	0.0045	0.077	0.1148
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0121	0.273	0.2781
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0115	0.2573	0.2573
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Echinococcus granulosus	glycoprotein Antigen 5	0.0236	0.5699	0.5699
Onchocerca volvulus		0.0045	0.077	0.0464
Onchocerca volvulus		0.0115	0.2573	0.2366
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0248	0.0253
Schistosoma mansoni	hypothetical protein	0.0121	0.273	0.273
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0275	0.6707	0.6833
Leishmania major	hypothetical protein, conserved	0.0182	0.4307	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Echinococcus granulosus	neurogenic locus notch protein	0.0121	0.273	0.273
Echinococcus granulosus	notch	0.0121	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0395	0.9816	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0121	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Echinococcus granulosus	neural cadherin	0.0121	0.273	0.273
Toxoplasma gondii	microneme protein MIC4	0.0045	0.077	0.1148
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.0784
Echinococcus granulosus	enteropeptidase	0.0236	0.5699	0.5699
Onchocerca volvulus		0.0045	0.077	0.0464
Echinococcus multilocularis	fibropellin Ia	0.0121	0.273	0.273
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Echinococcus multilocularis	cpg binding protein	0.003	0.0371	0.0371
Schistosoma mansoni	hypothetical protein	0.0166	0.3908	0.3908
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0395	0.9816	0.9816
Echinococcus multilocularis	neurogenic locus notch protein	0.0121	0.273	0.273
Echinococcus multilocularis	laminin	0.0275	0.6707	0.6707
Schistosoma mansoni	hypothetical protein	0.0115	0.2573	0.2573
Brugia malayi	Calcium binding EGF domain containing protein	0.0121	0.273	0.2781
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0395	0.9816	0.9816
Schistosoma mansoni	egf-like domain protein	0.0275	0.6707	0.6707
Loa Loa (eye worm)	Notch2	0.0121	0.273	0.2781
Onchocerca volvulus		0.0322	0.7933	0.8015
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0275	0.6707	0.6833
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Schistosoma mansoni	notch	0.0121	0.273	0.273
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0121	0.273	0.273
Mycobacterium ulcerans	hypothetical protein	0.0115	0.2573	0.3244
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Loa Loa (eye worm)	hypothetical protein	0.0182	0.4307	0.4387
Brugia malayi	notch-like transmembrane receptor	0.0121	0.273	0.2781
Onchocerca volvulus		0.0182	0.4307	0.4193
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1319	0.1319
Brugia malayi	Trypsin family protein	0.0115	0.2573	0.2622
Loa Loa (eye worm)	hypothetical protein	0.0275	0.6707	0.6833
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Onchocerca volvulus		0.0045	0.077	0.0464
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0248	0.0253
Brugia malayi	TspO/MBR family protein	0.0322	0.7933	0.8082
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.0784
Echinococcus granulosus	Tolloid protein 1	0.0275	0.6707	0.6707
Echinococcus multilocularis	dnaJ subfamily B	0.0402	1	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.2573	0.2622
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0025	0.0248	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0322	0.7933	0.8082
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0115	0.2573	0.2573
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Loa Loa (eye worm)	PAN domain-containing protein	0.0045	0.077	0.0784
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Brugia malayi	EGF-like domain containing protein	0.0121	0.273	0.2781
Brugia malayi	Delta serrate ligand family protein	0.0121	0.273	0.2781
Brugia malayi	Muscle positioning protein 4	0.0121	0.273	0.2781
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0983	0.1465
Schistosoma mansoni	slit	0.0121	0.273	0.273
Trypanosoma cruzi	hypothetical protein, conserved	0.0182	0.4307	1
Schistosoma mansoni	septate junction protein	0.0121	0.273	0.273
Echinococcus granulosus	laminin	0.0275	0.6707	0.6707
Onchocerca volvulus		0.0115	0.2573	0.2366
Onchocerca volvulus		0.0045	0.077	0.0464
Onchocerca volvulus	Neurogenic locus notch homolog	0.0121	0.273	0.2531
Schistosoma mansoni	hypothetical protein	0.0121	0.273	0.273
Onchocerca volvulus		0.0045	0.077	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0275	0.6707	0.6833
Loa Loa (eye worm)	hypothetical protein	0.0121	0.273	0.2781
Brugia malayi	EGF-like domain containing protein	0.0121	0.273	0.2781
Schistosoma mansoni	hypothetical protein	0.0182	0.4307	0.4307
Plasmodium falciparum	cysteine repeat modular protein 1	0.0182	0.4307	0.5
Brugia malayi	Trypsin-like protease protein 5	0.0115	0.2573	0.2622
Loa Loa (eye worm)	CYP4Cod1	0.0025	0.0248	0.0253
Onchocerca volvulus		0.0045	0.077	0.0464
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0248	0.0576
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Schistosoma mansoni	cercarial elastase (S01 family)	0.0115	0.2573	0.2573
Loa Loa (eye worm)	hypothetical protein	0.0115	0.2573	0.2622
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0115	0.2573	0.2573
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0115	0.2573	0.2573
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0045	0.077	0.1148
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.0784
Brugia malayi	PAN domain containing protein	0.0045	0.077	0.0784
Schistosoma mansoni	hypothetical protein	0.0115	0.2573	0.2573

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1490 nM	Inhibitory activity against specific binding of [3H]-CB 34 to peripheral benzodiazepine receptor in rat cortical membranes was evaluated	ChEMBL.	12904061
IC50 (binding)	= 1490 nM	Inhibitory activity against specific binding of [3H]-CB 34 to peripheral benzodiazepine receptor in rat cortical membranes was evaluated	ChEMBL.	12904061

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11111446

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 208903