Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0486 | 0.0475 |
Onchocerca volvulus | 0.0029 | 0.0053 | 0.015 | |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0065 | 0.0549 | 0.1172 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0416 | 0.145 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0065 | 0.0549 | 0.1172 |
Brugia malayi | beta-lactamase family protein | 0.0029 | 0.0053 | 0.0042 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0065 | 0.0549 | 0.1172 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0065 | 0.0549 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0065 | 0.0549 | 0.0539 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0053 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.1626 | 0.5818 |
Echinococcus granulosus | choline O acetyltransferase | 0.0065 | 0.0549 | 0.1193 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0027 | 0.0014 | 0.0719 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0416 | 0.0405 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0029 | 0.0053 | 0.0141 |
Onchocerca volvulus | 0.0065 | 0.0549 | 0.2055 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0065 | 0.0549 | 0.1172 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0416 | 0.0882 |
Brugia malayi | glutaminase DH11.1 | 0.0224 | 0.2786 | 0.2778 |
Echinococcus granulosus | geminin | 0.0141 | 0.1626 | 0.3533 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0065 | 0.0549 | 1 |
Onchocerca volvulus | 0.0212 | 0.2617 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0416 | 0.145 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0486 | 0.0475 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0416 | 0.0903 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0054 | 0.5 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0065 | 0.0549 | 0.1172 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0065 | 0.0549 | 0.1172 |
Brugia malayi | Pre-SET motif family protein | 0.0027 | 0.0014 | 0.0003 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0353 | 0.4603 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0053 | 0.0092 |
Brugia malayi | beta-lactamase family protein | 0.0029 | 0.0053 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0053 | 0.0042 |
Trichomonas vaginalis | glutaminase, putative | 0.0224 | 0.2786 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0054 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0029 | 0.0053 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0486 | 0.0475 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0065 | 0.0549 | 0.1172 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0027 | 0.0014 | 0.0007 |
Schistosoma mansoni | choline o-acyltransferase | 0.0065 | 0.0549 | 0.1931 |
Mycobacterium leprae | Probable lipase LipE | 0.0029 | 0.0053 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0416 | 0.0405 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0065 | 0.0549 | 0.0539 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0054 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0212 | 0.2617 | 0.9384 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0054 | 0.0043 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0065 | 0.0549 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0054 | 0.0143 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0029 | 0.0053 | 0.0115 |
Onchocerca volvulus | 0.0065 | 0.0549 | 0.2055 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0029 | 0.0053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0014 | 0.0003 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0027 | 0.0014 | 0.003 |
Plasmodium vivax | SET domain protein, putative | 0.0027 | 0.0014 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0549 | 0.0539 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0053 | 0.0092 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0486 | 0.0475 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0416 | 0.145 |
Toxoplasma gondii | ABC1 family protein | 0.0029 | 0.0053 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0065 | 0.0549 | 0.0539 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0065 | 0.0549 | 0.1193 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0029 | 0.0054 | 0.0093 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0065 | 0.0549 | 0.1172 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0353 | 0.4603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0053 | 0.0042 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0029 | 0.0053 | 0.0042 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0065 | 0.0549 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0065 | 0.0549 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0353 | 0.4603 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0065 | 0.0549 | 0.0539 |
Onchocerca volvulus | 0.0029 | 0.0053 | 0.015 | |
Brugia malayi | beta-lactamase | 0.0029 | 0.0053 | 0.0042 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0065 | 0.0549 | 0.1172 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0416 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0053 | 0.0042 |
Schistosoma mansoni | glutaminase | 0.0224 | 0.2786 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0188 | 0.2287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0053 | 0.0042 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0065 | 0.0549 | 0.1172 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0027 | 0.0014 | 0.0007 |
Onchocerca volvulus | 0.0029 | 0.0053 | 0.015 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0186 | 0.2256 | 0.2247 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0065 | 0.0549 | 0.0539 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0353 | 0.4603 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0224 | 0.2786 | 0.2778 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0065 | 0.0549 | 0.1172 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0416 | 0.0882 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0353 | 0.4603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0218 | 0.0207 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0026 | 0.0011 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0029 | 0.0053 | 0.0042 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0065 | 0.0549 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0053 | 0.0042 |
Onchocerca volvulus | 0.0065 | 0.0549 | 0.2055 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0065 | 0.0549 | 0.1172 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0026 | 0.0011 | 0.0023 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0218 | 0.0735 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0029 | 0.0054 | 0.0116 |
Brugia malayi | Pre-SET motif family protein | 0.0186 | 0.2256 | 0.2247 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0065 | 0.0549 | 0.1172 |
Mycobacterium ulcerans | glutaminase | 0.0224 | 0.2786 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0065 | 0.0549 | 0.0539 |
Loa Loa (eye worm) | beta-lactamase | 0.0029 | 0.0053 | 0.0042 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0054 | 0.5 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0065 | 0.0549 | 0.1172 |
Loa Loa (eye worm) | glutaminase 2 | 0.0224 | 0.2786 | 0.2778 |
Schistosoma mansoni | choline o-acyltransferase | 0.0065 | 0.0549 | 0.1931 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0053 | 1 |
Echinococcus multilocularis | geminin | 0.0141 | 0.1626 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0053 | 0.0042 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0029 | 0.0054 | 0.0143 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.1626 | 0.5818 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0218 | 0.0207 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0029 | 0.0053 | 0.0141 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0065 | 0.0549 | 0.1172 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.0053 | 0.0783 |
Onchocerca volvulus | 0.0065 | 0.0549 | 0.2055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.