TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 587.729 | Formula: C33H37N3O5S
H donors: 1 H acceptors: 4 LogP: 5.04 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H](N1C[C@@H](C)[C@H](CN(Cc2ccc(cc2)Oc2ccccc2)C)Oc2c(S1(=O)=O)ccc(c2)c1ccncc1)C
InChi: 1S/C33H37N3O5S/c1-24-20-36(25(2)23-37)42(38,39)33-14-11-28(27-15-17-34-18-16-27)19-31(33)41-32(24)22-35(3)21-26-9-12-30(13-10-26)40-29-7-5-4-6-8-29/h4-19,24-25,32,37H,20-23H2,1-3H3/t24-,25-,32+/m1/s1
InChiKey: KBDYTXJNXXZTGD-VJQVOXFUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0059	0.0059
Onchocerca volvulus		0.0317	0.3449	0.373
Echinococcus multilocularis	cpg binding protein	0.0034	0.0311	0.0311
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0059	0.0059
Toxoplasma gondii	EGF family domain-containing protein	0.0317	0.3449	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Brugia malayi	Muscle positioning protein 4	0.0317	0.3449	0.3771
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0059	0.0065
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0153	0.1629	0.1781
Echinococcus multilocularis	neurogenic locus protein delta	0.0317	0.3449	0.3449
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0048
Echinococcus multilocularis	Tolloid protein 1	0.083	0.9146	0.9146
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0153	0.1629	0.1781
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.013	0.0142
Echinococcus multilocularis	slit 2 protein	0.0317	0.3449	0.3449
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0059	0.0059
Onchocerca volvulus		0.0317	0.3449	0.373
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0059	0.0059
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1781
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0317	0.3449	0.373
Echinococcus granulosus	laminin	0.083	0.9146	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.013	0.0142
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0059	0.0065
Schistosoma mansoni	notch	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1781
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0059	0.0065
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0553	0.0604
Onchocerca volvulus	Putative cubilin	0.0317	0.3449	0.373
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1781
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0059	0.0065
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.083	0.9146	1
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0022	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0059	0.0065
Brugia malayi	notch-like transmembrane receptor	0.0317	0.3449	0.3771
Onchocerca volvulus		0.0153	0.1629	0.1727
Onchocerca volvulus		0.0153	0.1629	0.1727
Onchocerca volvulus		0.0153	0.1629	0.1727
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0059	0.0065
Schistosoma mansoni	cpg binding protein	0.0032	0.029	0.0317
Loa Loa (eye worm)	hypothetical protein	0.083	0.9146	1
Schistosoma mansoni	hypothetical protein	0.0153	0.1629	0.1781
Echinococcus multilocularis	fibropellin Ia	0.0317	0.3449	0.3449
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	0.3771
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Onchocerca volvulus	Neurogenic locus notch homolog	0.0317	0.3449	0.373
Schistosoma mansoni	egf-like domain protein	0.083	0.9146	1
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	0.3771
Brugia malayi	nuclear hormone receptor	0.0011	0.0059	0.0065
Brugia malayi	EGF-like domain containing protein	0.0317	0.3449	0.3771
Echinococcus granulosus	cpg binding protein	0.0034	0.0311	0.034
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus multilocularis	notch	0.0317	0.3449	0.3449
Echinococcus multilocularis	protein jagged 1	0.0317	0.3449	0.3449
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0317	0.3449	0.3449
Onchocerca volvulus		0.0317	0.3449	0.373
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0014	0.5
Brugia malayi	Fibulin-1 precursor	0.083	0.9146	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0059	0.0065
Brugia malayi	Trypsin-like protease protein 5	0.0153	0.1629	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0059	0.0065
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0317	0.3449	0.3449
Onchocerca volvulus	Arrow homolog	0.083	0.9146	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0059	0.0065
Echinococcus multilocularis	neurogenic locus notch protein	0.0317	0.3449	0.3449
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0059	0.0065
Echinococcus granulosus	neural cadherin	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.083	0.9146	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0357	0.039
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1629	0.1781
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.069	0.0754
Loa Loa (eye worm)	notch protein	0.0317	0.3449	0.3771
Schistosoma mansoni	notch	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1629	0.1781
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0059	0.0065
Onchocerca volvulus		0.0317	0.3449	0.373
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0059	0.0065
Echinococcus granulosus	Mastin	0.0153	0.1629	0.1781
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0059	0.0065
Schistosoma mansoni	laminin gamma-3 chain	0.0317	0.3449	0.3771
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0059	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0153	0.1629	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1629	0.1781
Schistosoma mansoni	hypothetical protein	0.0018	0.013	0.0142
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0059	0.0065
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0059	0.0065
Echinococcus granulosus	delta-like protein 1	0.0317	0.3449	0.3771
Brugia malayi	EGF-like domain containing protein	0.0317	0.3449	0.3771
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0022	0.0024
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0014	0.5
Onchocerca volvulus	Slit protein homolog	0.0317	0.3449	0.373
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.013	0.0142
Schistosoma mansoni	septate junction protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1629	0.1781
Brugia malayi	Trypsin family protein	0.0153	0.1629	0.1781
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0153	0.1629	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0553	0.0604
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1781
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Echinococcus granulosus	protein jagged 2	0.0317	0.3449	0.3771
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0059	0.0065
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0059	0.0065
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0059	0.0065
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	0.3771
Schistosoma mansoni	slit	0.0317	0.3449	0.3771
Brugia malayi	EGF-like domain containing protein	0.0317	0.3449	0.3771
Brugia malayi	Calcium binding EGF domain containing protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.013	0.0142
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0059	0.0065
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0044	0.0048
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0014	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0059	0.0059
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.083	0.9146	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Echinococcus granulosus	neurogenic locus protein delta	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0018	0.013	0.0142
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0043	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1629	0.1781
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0059	0.0065
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.083	0.9146	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0059	0.0065
Brugia malayi	ecdysteroid receptor	0.0011	0.0059	0.0065
Echinococcus multilocularis	protein jagged 1	0.0317	0.3449	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Brugia malayi	EGF-like domain containing protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.083	0.9146	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0014	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0059	0.0065
Echinococcus granulosus	neurogenic locus notch protein	0.0317	0.3449	0.3771
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.013	0.0142
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0059	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0059	0.0065
Schistosoma mansoni	coup transcription factor	0.0011	0.0059	0.0065
Echinococcus multilocularis	GPCR, family 2	0.0018	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0018	0.013	0.0142
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0059	0.0065
Brugia malayi	CXXC zinc finger family protein	0.0032	0.029	0.0317
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0014	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0059	0.0059
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0022	0.0024
Schistosoma mansoni	hypothetical protein	0.0038	0.0357	0.039
Echinococcus granulosus	slit 2 protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus granulosus	glycoprotein Antigen 5	0.0153	0.1629	0.1781
Echinococcus multilocularis	Mastin	0.0153	0.1629	0.1629
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0059	0.0059
Echinococcus multilocularis	transmembrane protease serine 3	0.0153	0.1629	0.1629
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0014	0.5
Onchocerca volvulus		0.0153	0.1629	0.1727
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Brugia malayi	Trypsin family protein	0.0153	0.1629	0.1781
Echinococcus granulosus	neurogenic locus notch protein	0.0317	0.3449	0.3771
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus granulosus	transmembrane protease serine 3	0.0153	0.1629	0.1781
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0059	0.0065
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0153	0.1629	0.1781
Echinococcus multilocularis	enteropeptidase	0.0153	0.1629	0.1629
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0153	0.1629	0.1629
Mycobacterium ulcerans	hypothetical protein	0.0153	0.1629	0.5
Schistosoma mansoni	cpg binding protein	0.0034	0.0311	0.034
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0059	0.0065
Echinococcus multilocularis	fibrillin 1	0.083	0.9146	0.9146
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0553	0.0604
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0059	0.0065
Brugia malayi	Trypsin family protein	0.0153	0.1629	0.1781
Echinococcus multilocularis	laminin	0.083	0.9146	0.9146
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0014	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0059	0.0065
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.083	0.9146	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0059	0.0065
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	0.3771
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0553	0.0604
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus multilocularis	glycoprotein Antigen 5	0.0153	0.1629	0.1629
Echinococcus granulosus	GPCR family 2	0.0018	0.013	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Onchocerca volvulus		0.0153	0.1629	0.1727
Schistosoma mansoni	hypothetical protein	0.0018	0.013	0.0142
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1781
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Brugia malayi	Trypsin family protein	0.0153	0.1629	0.1781
Brugia malayi	EGF-like domain containing protein	0.0317	0.3449	0.3771
Echinococcus granulosus	notch	0.0317	0.3449	0.3771
Brugia malayi	Calcium binding EGF domain containing protein	0.083	0.9146	1
Schistosoma mansoni	notch	0.0317	0.3449	0.3771
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0317	0.3449	0.3771
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.083	0.9146	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Schistosoma mansoni	hypothetical protein	0.0018	0.013	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.083	0.9146	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0317	0.3449	0.3771
Echinococcus granulosus	protein jagged 1	0.0317	0.3449	0.3771
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0044
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.013	0.013
Loa Loa (eye worm)	trypsin family protein	0.0153	0.1629	0.1781
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0059	0.0065
Echinococcus granulosus	protein jagged 2	0.0317	0.3449	0.3771
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0059	0.0065
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0059	0.0065
Brugia malayi	Cadherin domain containing protein	0.0317	0.3449	0.3771
Brugia malayi	EGF-like domain containing protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0065
Echinococcus granulosus	enteropeptidase	0.0153	0.1629	0.1781
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.083	0.9146	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0317	0.3449	0.3771
Brugia malayi	GCC2 and GCC3 family protein	0.0317	0.3449	0.3771
Echinococcus multilocularis	protein jagged 2	0.0317	0.3449	0.3449
Echinococcus granulosus	protein jagged 1	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0014	0.5
Schistosoma mansoni	cpg binding protein	0.0034	0.0311	0.034
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0059	0.0065
Echinococcus granulosus	fibropellin Ia	0.0317	0.3449	0.3771
Schistosoma mansoni	notch	0.0317	0.3449	0.3771
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1629
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.029	0.0317
Brugia malayi	steroid hormone receptor	0.0011	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1629	0.1781
Brugia malayi	hypothetical protein	0.0153	0.1629	0.1781
Echinococcus multilocularis	neurogenic locus protein delta	0.0317	0.3449	0.3449
Echinococcus granulosus	Tolloid protein 1	0.083	0.9146	1
Loa Loa (eye worm)	Notch2	0.0317	0.3449	0.3771
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0059	0.0059
Echinococcus multilocularis	neurogenic locus notch protein	0.0317	0.3449	0.3449
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0059	0.0059
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0059	0.0065
Echinococcus multilocularis	neural cadherin	0.0317	0.3449	0.3449
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Brugia malayi	EGF-like domain containing protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0059	0.0065
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1781
Onchocerca volvulus		0.0153	0.1629	0.1727
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0357	0.039
Onchocerca volvulus		0.0317	0.3449	0.373
Echinococcus granulosus	neurogenic locus notch protein 4	0.0317	0.3449	0.3771
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0059	0.0065
Toxoplasma gondii	calcium binding egf domain-containing protein	0.083	0.9146	1
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0317	0.3449	0.3771
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0059	0.0065
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0014	0.5
Brugia malayi	Delta serrate ligand family protein	0.0317	0.3449	0.3771
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.1629	0.1781
Giardia lamblia	High cysteine protein	0.0317	0.3449	0.5
Schistosoma mansoni	cell polarity protein	0.0317	0.3449	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3449	0.3771
Schistosoma mansoni	notch	0.0317	0.3449	0.3771
Onchocerca volvulus		0.0032	0.029	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1629	0.1781
Brugia malayi	Cadherin domain containing protein	0.0317	0.3449	0.3771
Toxoplasma gondii	calcium binding egf domain-containing protein	0.083	0.9146	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.1629	0.1781
Schistosoma mansoni	notch	0.0317	0.3449	0.3771
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0059	0.0065

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3560655

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2095166