Detailed information for compound 210262

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 612.314 | Formula: C23H39Cl6N6-----
  • H donors: 4 H acceptors: 1 LogP: 6.68 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCNCCCCN(CCCN)CCCCNc1ccnc2c1ccc(c2)Cl.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
  • InChi: 1S/C23H39ClN6.5ClH/c24-20-7-8-21-22(9-15-29-23(21)19-20)28-14-2-4-17-30(18-6-11-26)16-3-1-12-27-13-5-10-25;;;;;/h7-9,15,19,27H,1-6,10-14,16-18,25-26H2,(H,28,29);5*1H/p-5
  • InChiKey: MUIWELILGSNQMR-UHFFFAOYSA-I  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.026 0.0413
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.2142 1
Schistosoma mansoni protein kinase 0.0036 0.0358 0.0355
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0112 0.0108
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0364 0.1686
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.026 0.12
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.026 0.6227
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Entamoeba histolytica hypothetical protein 0.0022 0.0183 0.0255
Echinococcus multilocularis tyrosine kinase 0.0009 0.0018 0.0014
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0381 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0183 0.018
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.005 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0364 0.0357
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0234 0.0231
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.026 0.12
Echinococcus granulosus tyrosine kinase 0.0009 0.0018 0.0014
Brugia malayi hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.005 0.0066
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.0185 0.0182
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.026 1
Chlamydia trachomatis glutamine binding protein 0.0038 0.0381 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Plasmodium falciparum thioredoxin reductase 0.0081 0.0934 0.1498
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0185 0.2256 0.4452
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0185 0.0182
Brugia malayi ecdysteroid receptor 0.0012 0.005 0.0066
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0036 0.0358 0.0495
Echinococcus multilocularis receptor type guanylyl cyclase 0.0009 0.0018 0.0014
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0003 0.0000089063
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0349 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.005 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.005 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.005 0.0066
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0234 0.0174
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0086
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0364 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.005 0.0066
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0234 0.0231
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0423 0.0779
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0211 0.0208
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0112 0.0073
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0234 0.0372
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.026 0.0257
Brugia malayi nuclear hormone receptor 0.0012 0.005 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.026 0.12
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0349 0.0346
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.005 0.0066
Giardia lamblia DNA repair protein RAD52 0.0345 0.4297 0.5932
Onchocerca volvulus 0.0016 0.0112 0.0132
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0423 0.0675
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0349 0.0346
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.005 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.005 0.0066
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0112 0.0151
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.033 0.0327
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0165 0.0226
Brugia malayi major facilitator superfamily protein 0.0016 0.0112 0.0151
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0112 0.0151
Onchocerca volvulus 0.0012 0.005 0.0046
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0395 0.4927 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0009 0.0019 0.0016
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0086
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Echinococcus granulosus glutamate receptor 2 0.0022 0.0185 0.0182
Brugia malayi Receptor family ligand binding region containing protein 0.0009 0.0018 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0086
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0234 0.0231
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.0568 0.0565
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0165 0.0226
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0571 0.7167 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0183 0.018
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0349 0.0704
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.139 0.3201
Brugia malayi Sugar transporter family protein 0.0117 0.139 0.1936
Plasmodium falciparum glutathione reductase 0.0028 0.026 0.0413
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0358 0.0617
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0381 0.0559
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0358 0.0355
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.005 0.0066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.005 0.0047
Entamoeba histolytica protein kinase, putative 0.0036 0.0358 0.0499
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Schistosoma mansoni glucose transport protein 0.0117 0.139 0.1387
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0358 0.0571
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0018 0.002
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0086 0.0115
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.0568 0.0565
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0089 0.0086
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0365
Onchocerca volvulus Putative transporter 0.0016 0.0112 0.0132
Brugia malayi hypothetical protein 0.0022 0.0183 0.0251
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0234 0.0245
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0185 0.2256 0.8875
Schistosoma mansoni hypothetical protein 0.0168 0.2044 0.2042
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0185 0.0182
Schistosoma mansoni hypothetical protein 0.0117 0.139 0.1387
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0571 0.7167 1
Plasmodium falciparum thioredoxin reductase 0.0028 0.026 0.0413
Plasmodium falciparum mitogen-activated protein kinase 2 0.0189 0.2306 0.3707
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.005 0.0066
Leishmania major protein kinase, putative 0.0036 0.0358 0.1658
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0089 0.0086
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0112 0.0151
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0571 0.7167 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Plasmodium vivax sugar transporter, putative 0.0016 0.0112 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.0089 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.005 0.0066
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0089 0.0086
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0112 0.0073
Brugia malayi hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0358 0.0495
Onchocerca volvulus 0.0571 0.7167 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0183 0.0251
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.026 0.0371
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0018 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.005 0.0066
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.005 0.0047
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0183 0.0251
Leishmania major glucose transporter, lmgt3 0.0036 0.0364 0.1686
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0211 0.0208
Echinococcus granulosus expressed protein 0.0429 0.5364 0.5363
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.026 0.12
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0358 0.0495
Entamoeba histolytica DNA repair protein, putative 0.0008 0.0003 0.0005
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0358 0.0571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Echinococcus granulosus FTZ F1 alpha 0.0012 0.005 0.0047
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0112 0.0108
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0183 0.018
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0349 0.0346
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0364 0.1686
Schistosoma mansoni glucose transporter 0.0016 0.0112 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Mycobacterium tuberculosis Probable dehydrogenase 0.0185 0.2256 0.4452
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0183 0.018
Toxoplasma gondii thioredoxin reductase 0.0081 0.0934 0.2059
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0211 0.0208
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0364 0.1686
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.005 0.0047
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0211 0.0291
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0185 0.0182
Echinococcus multilocularis tyrosine protein kinase shark 0.0237 0.2919 0.2916
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.005 0.0047
Schistosoma mansoni thyroid hormone receptor 0.0012 0.005 0.0047
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2142 0.2877
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.005 0.0047
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0185 0.0182
Schistosoma mansoni glucose transport protein 0.0117 0.139 0.1387
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0183 0.018
Leishmania major glucose transporter, lmgt2 0.0036 0.0364 0.1686
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.005 0.0066
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0185 0.0182
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.026 0.12
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.005 0.0047
Plasmodium vivax glutathione reductase, putative 0.0081 0.0934 0.1498
Trypanosoma brucei glucose transporter 1E 0.0036 0.0364 0.1686
Trypanosoma brucei sugar transporter, putative 0.0016 0.0112 0.0506
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0189 0.2306 0.3707
Plasmodium vivax hexose transporter 0.0117 0.139 0.2232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0358 0.0355
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0234 0.1081
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0381 1
Mycobacterium tuberculosis Probable reductase 0.0185 0.2256 0.4452
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0183 0.018
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0234 0.0323
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0183 0.018
Trypanosoma brucei trypanothione reductase 0.0081 0.0934 0.4353
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.005 0.0066
Brugia malayi PXA domain containing protein 0.0022 0.0183 0.0251
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0211 0.0291
Schistosoma mansoni hypothetical protein 0.0168 0.2044 0.2042
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0183 0.0251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.005 0.0047
Schistosoma mansoni tyrosine kinase 0.0009 0.0018 0.0014
Brugia malayi Sugar transporter family protein 0.0016 0.0112 0.0151
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0183 0.018
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0089 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.005 0.0047
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.026 0.021
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0234 0.0245
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.005 0.0046
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.026 0.12
Trypanosoma cruzi hexose transporter, putative 0.002 0.0155 0.0707
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0358 0.1658
Schistosoma mansoni nuclear hormone receptor 0.0012 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Schistosoma mansoni coup transcription factor 0.0012 0.005 0.0047
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0211 0.0208
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0112 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.005 0.0066
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0089 0.0086
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0205 0.2518 0.4998
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0358 0.0495
Brugia malayi Cam kinase protein 1 0.0036 0.0358 0.0495
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.026 0.0413
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0349 0.0482
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.0089 0.012
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0183 0.018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.026 0.0308
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.0089 0.012
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0234 0.1081
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0183 0.0251
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0112 0.0108
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0183 0.018
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.0089 0.0086
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.026 0.12
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0089 0.0086
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0089 0.012
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0358 0.0617
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0183 0.018
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.005 0.0046
Leishmania major glucose transporter, lmgt1 0.0036 0.0364 0.1686
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0205 0.2518 1
Echinococcus multilocularis microtubule associated protein 2 0.0793 1 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0112 0.0108
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0089 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Echinococcus granulosus thioredoxin glutathione reductase 0.0082 0.0948 0.0945
Onchocerca volvulus 0.0016 0.0112 0.0132
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2142 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0211 0.0208
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0183 0.018
Toxoplasma gondii protein kinase, putative 0.033 0.4105 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.005 0.0047
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0234 0.0174
Brugia malayi major facilitator superfamily protein 0.0016 0.0112 0.0151
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0112 0.0506
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0183 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0358 0.0349
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.005 0.0047
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.026 0.0281
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0234 0.0231
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.026 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.005 0.0066
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.026 0.0413
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0571 0.7167 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Schistosoma mansoni tyrosine kinase 0.0232 0.285 0.2847
Echinococcus granulosus receptor type guanylyl cyclase 0.0009 0.0018 0.0014
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0234 0.0372
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0358 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.005 0.0066
Onchocerca volvulus 0.0016 0.0112 0.0132
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0349 0.0487
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0358 0.0617
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0185 0.2256 0.4452
Echinococcus granulosus General substrate transporter 0.01 0.1181 0.1178
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0364 0.1686
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0183 0.018
Giardia lamblia NADH oxidase lateral transfer candidate 0.0028 0.026 0.021
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0211 0.029
Schistosoma mansoni glucose transport protein 0.0117 0.139 0.1387
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.005 0.0047
Plasmodium vivax thioredoxin reductase, putative 0.0081 0.0934 0.1498
Plasmodium vivax CDK-related protein kinase 6, putative 0.0496 0.6216 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0571 0.7167 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Leishmania major trypanothione reductase 0.0081 0.0934 0.4353
Loa Loa (eye worm) hypothetical protein 0.0035 0.0349 0.0482
Trypanosoma brucei glucose transporter 2A 0.0036 0.0364 0.1686
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Brugia malayi steroid hormone receptor 0.0012 0.005 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.026 0.0413
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.026 0.0358
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0185 0.2256 0.4452
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0234 0.0214
Leishmania major hypothetical protein, conserved 0.0016 0.0112 0.0506
Schistosoma mansoni protein kinase 0.0036 0.0358 0.0355
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0185 0.2256 0.4452
Entamoeba histolytica protein kinase, putative 0.0036 0.0358 0.0499
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0112 0.0151
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0184 0.0151
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.0185 0.0182
Schistosoma mansoni microtubule-associated protein tau 0.0793 1 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0112 0.0506
Echinococcus multilocularis geminin 0.0168 0.2044 0.2042
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0089 0.0086
Entamoeba histolytica hypothetical protein 0.0098 0.1153 0.1608
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0089 0.0086
Loa Loa (eye worm) hypothetical protein 0.0026 0.0234 0.0323
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0571 0.7167 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.026 0.0281
Onchocerca volvulus 0.0016 0.0112 0.0132
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0349 0.0336
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0183 0.018
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0086
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.005 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Echinococcus multilocularis expressed protein 0.0429 0.5364 0.5363
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0358 0.0571
Leishmania major hypothetical protein, conserved 0.0176 0.2142 1
Entamoeba histolytica hypothetical protein 0.0022 0.0183 0.0255
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.005 0.0046
Entamoeba histolytica DNA repair protein, putative 0.0008 0.0003 0.0005
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0571 0.7167 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0381 0.0452
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0364 0.0357
Onchocerca volvulus 0.0016 0.0112 0.0132
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0183 0.0251
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0183 0.018
Echinococcus multilocularis 0.0008 0.0003 0.0000089063
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0183 0.018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.026 0.0371
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.026 0.021
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0112 0.0506
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0112 0.0506
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0183 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Loa Loa (eye worm) sugar transporter 0.0016 0.0112 0.0151
Onchocerca volvulus 0.0016 0.0112 0.0132
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0364 0.0357
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.0568 0.0565
Trypanosoma cruzi trypanothione reductase, putative 0.0081 0.0934 0.4353
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.2142 1
Mycobacterium ulcerans sugar transporter 0.0016 0.0112 0.0073
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0089 0.0086
Mycobacterium tuberculosis Probable oxidoreductase 0.0205 0.2518 0.4998
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.005 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.005 0.0066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.026 0.0281
Brugia malayi hypothetical protein 0.0016 0.0112 0.0151
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.139 0.1387
Schistosoma mansoni protein kinase 0.0036 0.0358 0.0355
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0571 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.005 0.0047
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0571 0.7167 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.026 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.005 0.0066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.005 0.0066
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0189 0.2306 0.5495
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0089 0.0086
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0112 0.0174
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0112 0.0108
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0358 0.0571
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Echinococcus multilocularis NMDA receptor 0.0015 0.0089 0.0086
Loa Loa (eye worm) sugar transporter 0.0117 0.139 0.1936
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.005 0.0047
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0112 0.0506
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0423 0.0675
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0183 0.0251
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0345 0.4297 0.5995
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0358 0.0571
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0183 0.018
Plasmodium falciparum hexose transporter 0.0117 0.139 0.2232
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.005 0.0047
Schistosoma mansoni tyrosine kinase 0.0237 0.2919 0.2916
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0349 0.0482
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Brugia malayi PXA domain containing protein 0.0022 0.0183 0.0251
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.005 0.0066
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0018 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.005 0.0047
Plasmodium falciparum protein kinase 6 0.0496 0.6216 1
Echinococcus granulosus tyrosine protein kinase shark 0.0237 0.2919 0.2916
Echinococcus multilocularis General substrate transporter 0.01 0.1181 0.1178
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0183 0.0251
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0184 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Schistosoma mansoni protein kinase 0.0009 0.0018 0.0014
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0364 0.1686
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0205 0.2518 0.4998
Entamoeba histolytica hypothetical protein 0.0022 0.0183 0.0255
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus granulosus geminin 0.0168 0.2044 0.2042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Treponema pallidum NADH oxidase 0.0028 0.026 0.6227
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.005 0.0047
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0364 0.1686
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0234 0.5434
Plasmodium falciparum glutathione reductase 0.0081 0.0934 0.1498
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0089 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.005 0.0066
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.026 0.12
Echinococcus multilocularis thioredoxin glutathione reductase 0.0082 0.0948 0.0945
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0112 0.0151
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0571 0.7167 1
Plasmodium falciparum protein kinase 7 0.033 0.4105 0.6603
Loa Loa (eye worm) thioredoxin reductase 0.0081 0.0934 0.1299
Brugia malayi hypothetical protein 0.0022 0.0183 0.0251
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.1153 0.1608
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0183 0.018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.026 0.12
Onchocerca volvulus 0.0016 0.0112 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0364 0.0357
Loa Loa (eye worm) glutathione reductase 0.0081 0.0934 0.1299
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2142 0.2877
Schistosoma mansoni thyroid hormone receptor 0.0012 0.005 0.0047
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0349 0.0346
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0364 0.1686
Brugia malayi glutathione reductase 0.0081 0.0934 0.1299
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0183 0.018
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0193 0.0116
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0364 0.0357
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.033 0.0327
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0183 0.018
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.026 0.0257
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0234 0.1081
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0234 0.0308
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0185 0.0182
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0183 0.018
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0358 0.0571
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0183 0.018
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0349 0.0482
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0081 0.0934 0.1708
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Brugia malayi Sugar transporter family protein 0.0016 0.0112 0.0151
Entamoeba histolytica hypothetical protein 0.0026 0.0234 0.0327
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0008 0.0003 0.0000089063
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.005 0.0066
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0183 0.0101
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0571 0.7167 1
Brugia malayi Thioredoxin reductase 0.0081 0.0934 0.1299
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.005 0.0047
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0571 0.7167 1
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0364 0.0357
Brugia malayi Guanylyl cyclase protein 23 0.0009 0.0018 0.002
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0358 0.0571
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.005 0.0047
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.139 0.1812
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Schistosoma mansoni tyrosine kinase 0.0009 0.0018 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Trypanosoma cruzi hexose transporter 0.0036 0.0364 0.1686
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0358 0.0571
Echinococcus granulosus dna repair and recombination protein rad54 0.0008 0.0003 0.0000089063
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0089 0.0086
Onchocerca volvulus 0.0016 0.0112 0.0132

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Cytotoxicity against murine leukemia (L1210) cells was determined at 47h ChEMBL. 11606133
IC50 (functional) > 100 uM Cytotoxicity against murine leukemia (L1210) cells was determined at 94h ChEMBL. 11606133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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