TDR Targets

Basic information

Technical information

TDR Targets ID: 21039
Name: N-(9-benzamido-1,10-phenanthrolin-2-yl)benzam ide
MW: 418.447 | Formula: C26H18N4O2
H donors: 2 H acceptors: 4 LogP: 4.79 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)Nc1ccc2c(n1)c1nc(ccc1cc2)NC(=O)c1ccccc1
InChi: 1S/C26H18N4O2/c31-25(19-7-3-1-4-8-19)29-21-15-13-17-11-12-18-14-16-22(28-24(18)23(17)27-21)30-26(32)20-9-5-2-6-10-20/h1-16H,(H,27,29,31)(H,28,30,32)
InChiKey: SRGPIQNSWGWCDB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[9-(benzoylamino)-1,10-phenanthrolin-2-yl]benzamide
N-[9-[(oxo-phenylmethyl)amino]-1,10-phenanthrolin-2-yl]benzamide
N-[9-(phenylcarbonylamino)-1,10-phenanthrolin-2-yl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	hypothetical protein	0.0088	0.0273	1
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0088	0.0273	1
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0047	0.0151
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0088	0.0273	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0047	0.1662
Trypanosoma cruzi	GUP1, putative	0.0088	0.0273	1
Leishmania major	glycerol uptake protein, putative	0.0088	0.0273	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0047	0.0151
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Brugia malayi	diacylglycerol acyltransferase	0.0088	0.0273	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0002	0.0001
Loa Loa (eye worm)	MBOAT family protein	0.0088	0.0273	0.0906
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0088	0.0273	0.0906
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0128	0.0406	0.135
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0047	0.1662
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0011	0.0029
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0042	0.0135
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0014	0.0042
Schistosoma mansoni	hypothetical protein	0.0128	0.0406	0.135
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0047	0.1662
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0011	0.0325
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0042	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0047	0.0151
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0011	0.0029
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0161	0.5143
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0011	0.0325
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0047	0.0151
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0042	0.0135
Echinococcus granulosus	dnaJ subfamily B	0.0412	0.1351	0.4507
Loa Loa (eye worm)	DR-78	0.001	0.0011	0.0029
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0128	0.0406	0.135
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0047	0.1662
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0047	0.1662
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0047	0.0151
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0088	0.0273	0.0906
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0011	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0047	0.1662
Brugia malayi	nuclear receptor RXR	0.0011	0.0014	0.0468
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0047	0.0151
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0021
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0047	0.1662
Brugia malayi	MBOAT family protein	0.0088	0.0273	1
Schistosoma mansoni	hypothetical protein	0.0412	0.1351	0.4507
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0047	0.0151
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0011	0.0029
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0088	0.0273	0.0906
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0011	0.0029
Onchocerca volvulus		0.0088	0.0273	1
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0088	0.0273	0.0906
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Trypanosoma cruzi	glycerol uptake protein, putative	0.0088	0.0273	1
Loa Loa (eye worm)	hhat protein	0.0088	0.0273	0.0906
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0047	0.0151
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0047	0.0151
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0047	0.1662
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0088	0.0273	0.0906
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0273	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0042	0.0135
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0047	0.0151
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0011	0.0325
Loa Loa (eye worm)	MBOAT family protein	0.0088	0.0273	0.0906
Trypanosoma brucei	glycerol uptake protein, putative	0.0088	0.0273	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0047	0.1662
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0149	0.0474	0.1579
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0047	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Echinococcus multilocularis	microtubule associated protein 2	0.0703	0.2322	0.775
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0088	0.0273	0.0906
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0047	0.1662
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0047	0.0151
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0047	0.1662
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0047	0.0151
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0002	0.0001
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0088	0.0273	0.0906
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0047	0.0151
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0047	0.0151
Brugia malayi	steroid hormone receptor	0.0021	0.0047	0.1662
Brugia malayi	nuclear hormone receptor	0.001	0.0011	0.0325
Echinococcus granulosus	sterol O acyltransferase 1	0.0905	0.2995	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0047	0.1662
Treponema pallidum	alginate O-acetylation protein (algI)	0.0088	0.0273	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0042	0.1486
Onchocerca volvulus		0.001	0.0011	0.0325
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0088	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Leishmania major	glycerol uptake protein, putative	0.0088	0.0273	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0011	0.0325
Brugia malayi	ecdysone receptor	0.001	0.0011	0.0325
Onchocerca volvulus		0.001	0.0011	0.0325
Leishmania major	glycerol uptake protein, putative	0.0088	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0905	0.2995	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0047	0.0151
Leishmania major	glycerol uptake protein, putative	0.0088	0.0273	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0047	0.0151
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0047	0.0151
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0047	0.0151
Brugia malayi	ecdysteroid receptor	0.0021	0.0047	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0042
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0008	0.0021
Echinococcus granulosus	cpg binding protein	0.0031	0.008	0.0262
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0088	0.0273	0.0906
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0014	0.0042
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0047	0.1662
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0088	0.0273	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0011	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0047	0.0151
Entamoeba histolytica	vacuolar protein sorting 26	0.0088	0.0273	1
Brugia malayi	nuclear hormone receptor	0.0021	0.0047	0.1662
Schistosoma mansoni	zinc finger protein	0.0088	0.0273	0.0906
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0011	0.0029
Echinococcus multilocularis	dnaJ subfamily B	0.0412	0.1351	0.4507
Echinococcus multilocularis	cpg binding protein	0.0031	0.008	0.0262
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0014	0.0042
Brugia malayi	tailless protein	0.001	0.0011	0.0325
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0042	0.1541
Brugia malayi	conserved hypotetical protein	0.001	0.0011	0.0325
Schistosoma mansoni	microtubule-associated protein tau	0.0703	0.2322	0.775
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0183	0.0604
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0047	0.1662
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0088	0.0273	0.0906
Mycobacterium tuberculosis	Probable histidinol dehydrogenase HisD (HDH)	0.3005	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0088	0.0273	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0011	0.0325
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Trypanosoma cruzi	glycerol uptake protein, putative	0.0088	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0042
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0047	0.0151
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0011	0.0029
Loa Loa (eye worm)	hhat protein	0.0088	0.0273	0.0906
Loa Loa (eye worm)	MBOAT family protein	0.0088	0.0273	0.0906
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0011	0.0029
Schistosoma mansoni	nuclear receptor	0.001	0.0011	0.0029
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0042	0.1541
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Brugia malayi	MBOAT family protein	0.0088	0.0273	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0047	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0273	0.0906
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0014	0.0468
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0047	0.0151
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0088	0.0273	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0047	0.1662
Entamoeba histolytica	hypothetical protein, conserved	0.0088	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0042
Schistosoma mansoni	sterol O-acyltransferase 1	0.0905	0.2995	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.0021
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0011	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0047	0.1662
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0273	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0002	0.0001
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0088	0.0273	0.0906
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.0474	0.1579
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.0474	0.1579
Echinococcus multilocularis	sterol O acyltransferase 1	0.0905	0.2995	1
Brugia malayi	MBOAT family protein	0.0088	0.0273	1
Echinococcus granulosus	microtubule associated protein 2	0.0703	0.2322	0.775
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0047	0.0151
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0014	0.0042
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0088	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0075	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0816	0.2701	0.9016
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0042	0.0135
Schistosoma mansoni	cpg binding protein	0.0029	0.0075	0.0243
Brugia malayi	nuclear receptor NHR-88	0.001	0.0011	0.0325
Brugia malayi	hypothetical protein	0.0011	0.0014	0.0468
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0088	0.0273	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0047	0.0151
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0011	0.0325
Brugia malayi	hypothetical protein	0.0011	0.0014	0.0468
Brugia malayi	nuclear receptor RXR	0.001	0.0011	0.0325
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0088	0.0273	0.0906
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0047	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0273	0.0906
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0088	0.0273	1
Entamoeba histolytica	hypothetical protein	0.0088	0.0273	1
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0011	0.0029
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0088	0.0273	0.0906
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Brugia malayi	nuclear receptor NHR-67	0.001	0.0011	0.0325
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0088	0.0273	0.0906
Trichomonas vaginalis	porcupine, putative	0.0088	0.0273	1
Onchocerca volvulus		0.0029	0.0075	0.2685
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0047	0.0151
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0014	0.0042
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0011	0.0029
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0042	0.5
Mycobacterium ulcerans	histidinol dehydrogenase	0.3005	1	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0008	0.0216
Brugia malayi	Hhat protein	0.0088	0.0273	1
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0088	0.0273	0.0906
Schistosoma mansoni	ap endonuclease	0.0019	0.0042	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0273	0.0906
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0088	0.0273	0.0906
Trypanosoma cruzi	glycerol uptake protein, putative	0.0088	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0042
Brugia malayi	hypothetical protein	0.001	0.0011	0.0325
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0088	0.0273	0.0906
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0047	0.0151
Schistosoma mansoni	zinc finger protein	0.001	0.0011	0.0029
Leishmania major	glycerol uptake protein, putative	0.0088	0.0273	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0088	0.0273	1
Leishmania major	hypothetical protein, conserved	0.0088	0.0273	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0011	0.0029
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0047	0.0151
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0047	0.1662
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0088	0.0273	0.0906
Onchocerca volvulus		0.0021	0.0047	0.1662
Schistosoma mansoni	coup transcription factor	0.0021	0.0047	0.0151
Trypanosoma brucei	glycerol uptake protein, putative	0.0088	0.0273	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0047	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Trypanosoma cruzi	GUP1, putative	0.0088	0.0273	1
Brugia malayi	MBOAT family protein	0.0088	0.0273	1
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0047	0.1662
Brugia malayi	hypothetical protein	0.001	0.0011	0.0325
Schistosoma mansoni	nuclear receptor	0.001	0.0011	0.0029
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0088	0.0273	0.0906
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0088	0.0273	0.0906
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0011	0.0029
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0011	0.0029
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0047	0.0151
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0088	0.0273	0.0906
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0011	0.0325
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0047	0.0151
Brugia malayi	MBOAT family protein	0.0088	0.0273	1
Schistosoma mansoni	hypothetical protein	0.0088	0.0273	0.0906
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0011	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0151
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0088	0.0273	0.0906
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0088	0.0273	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0047	0.1662
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0047	0.0151
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0047	0.0151
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0014	0.0468
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0075	0.2685
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0047	0.0151
Loa Loa (eye worm)	hypothetical protein	0.001	0.0011	0.0029
Schistosoma mansoni	cpg binding protein	0.0031	0.008	0.0262
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0047	0.1662
Schistosoma mansoni	cpg binding protein	0.0031	0.008	0.0262

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.05 uM	Minimum inhibitory concentration measured against M. gallisepticum K514 in the presence of extra copper	ChEMBL.	2002460
MIC (functional)	> 100 uM	Minimum inhibitory concentration measured against M. gallisepticum K514 in the absence of extra copper	ChEMBL.	2002460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL278923
PubChem: 1006362

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 21039