Detailed information for compound 2108374

Basic information

Technical information
  • TDR Targets ID: 2108374
  • Name: N-ethyl-4-methylpiperazine-1-carbothioamide
  • MW: 187.306 | Formula: C8H17N3S
  • H donors: 1 H acceptors: 0 LogP: 0.33 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=S)N1CCN(CC1)C
  • InChi: 1S/C8H17N3S/c1-3-9-8(12)11-6-4-10(2)5-7-11/h3-7H2,1-2H3,(H,9,12)
  • InChiKey: IKFGASOKNGAZHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethyl-4-methyl-piperazine-1-carbothioamide
  • N-ethyl-4-methyl-1-piperazinecarbothioamide
  • 4-Methyl-piperazine-1-carbothioic acid ethylamide
  • BAS 04887295

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0086 0.2365 0.2323
Echinococcus multilocularis peregrin 0.0092 0.2547 0.2506
Chlamydia trachomatis SWIB complex protein 0.0337 1 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.1004 0.0954
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Echinococcus multilocularis GPCR, family 2 0.0015 0.0188 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0697 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0434 0.0425
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0425 0.0425
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0196 0.5713 0.5713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0697 0.0688
Giardia lamblia GTOR 0.0042 0.1027 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0433 0.0424
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0188 0.0134
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0425 0.0373
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.001 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0012 0.0108 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0425 0.0373
Loa Loa (eye worm) acetylcholine receptor protein 0.001 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1173 0.1165
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.012 0.3388 0.3388
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0188 0.0134
Loa Loa (eye worm) hypothetical protein 0.012 0.3388 0.3388
Loa Loa (eye worm) TAR-binding protein 0.006 0.1556 0.1556
Onchocerca volvulus Putative nachr subunit 0.0023 0.0425 0.0373
Loa Loa (eye worm) glutaminase 2 0.0256 0.7546 0.7546
Onchocerca volvulus 0.0023 0.0425 0.0373
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.1556 0.1556
Toxoplasma gondii target of rapamycin (TOR), putative 0.0031 0.0697 0.0688
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0042 0.1027 0.0978
Loa Loa (eye worm) hypothetical protein 0.0032 0.071 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0575 0.0566
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 0.0425 0.0425
Onchocerca volvulus 0.0023 0.0425 0.0373
Trypanosoma cruzi WLM domain containing protein, putative 0.012 0.3388 1
Loa Loa (eye worm) hypothetical protein 0.012 0.3388 0.3388
Loa Loa (eye worm) LGC-31 protein 0.0023 0.0425 0.0425
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 0.0425 0.0373
Echinococcus granulosus SWI:SNF matrix associated 0.0337 1 1
Brugia malayi SWIB/MDM2 domain containing protein 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Schistosoma mansoni enhancer of polycomb 0.0014 0.0163 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0434 0.0425
Onchocerca volvulus 0.0023 0.0425 0.0373
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.001 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.3388 1
Schistosoma mansoni nAChR subunit 0.0023 0.0425 0.0373
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.012 0.3388 0.3382
Echinococcus multilocularis enhancer of polycomb 0.0014 0.0163 0.0109
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0425 0.0373
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0425 0.0373
Mycobacterium ulcerans glutaminase 0.0256 0.7546 0.5
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Schistosoma mansoni tar DNA-binding protein 0.006 0.1556 0.151
Onchocerca volvulus 0.012 0.3388 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0763 0.0755
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0425 0.0373
Echinococcus multilocularis nAChR subunit 0.0023 0.0425 0.0373
Onchocerca volvulus 0.012 0.3388 0.3352
Echinococcus granulosus enhancer of polycomb 0.0014 0.0163 0.0109
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0425 0.0373
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0425 0.0373
Trypanosoma brucei hypothetical protein, conserved 0.012 0.3388 1
Leishmania major hypothetical protein, conserved 0.012 0.3388 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.012 0.3388 0.3352
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0337 1 1
Plasmodium vivax hypothetical protein, conserved 0.0337 1 1
Schistosoma mansoni nAChR subunit 0.0023 0.0425 0.0373
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.012 0.3388 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 0.0425 0.0425
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0042 0.1027 0.2665
Schistosoma mansoni glutaminase 0.0256 0.7546 0.7532
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 0.0425 0.0373
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 0.0425 0.0373
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0014 0.017 0.0116
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0015 0.0207 0.0153
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 0.0425 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.1004 0.0954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.017 0.0161
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.1004 0.0954
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0108 0.0054
Echinococcus granulosus nAChR subunit 0.0012 0.0108 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0188 0.0134
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0425 0.0373
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.1027 0.1027
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0337 1 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Echinococcus multilocularis SWI:SNF matrix associated 0.0337 1 1
Echinococcus multilocularis nAChR subunit 0.0012 0.0108 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0433 0.0424
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.012 0.3388 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Schistosoma mansoni tar DNA-binding protein 0.006 0.1556 0.151
Toxoplasma gondii PHD-finger domain-containing protein 0.0023 0.0435 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0603 0.0594
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0042 0.1027 0.2665
Trichomonas vaginalis conserved hypothetical protein 0.0337 1 1
Onchocerca volvulus 0.0012 0.0108 0.0054
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0108 0.0054
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.012 0.3388 1
Echinococcus granulosus peregrin 0.0092 0.2547 0.2506
Leishmania major hypothetical protein, conserved 0.012 0.3388 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.0347 0.0552
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0012 0.0108 0.0054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.017 0.0161
Brugia malayi YY1-associated factor 2 0.012 0.3388 0.3352
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0425 0.0373
Brugia malayi RNA binding protein 0.006 0.1556 0.151
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0763 0.0755
Trypanosoma cruzi WLM domain containing protein, putative 0.012 0.3388 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0425 0.0373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0188 0.0134
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0042 0.1027 0.2665
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.012 0.3388 1
Leishmania major hypothetical protein, conserved 0.012 0.3388 1
Echinococcus multilocularis zinc finger protein Ran binding 0.012 0.3388 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.017 0.0161
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.017 0.017
Trichomonas vaginalis set domain proteins, putative 0.0223 0.6539 0.6535
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0034 0.0764 0.1848
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.1004 0.0954
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.1161 0.1113
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0425 0.0373
Schistosoma mansoni tar DNA-binding protein 0.006 0.1556 0.151
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0425 0.0373
Schistosoma mansoni tar DNA-binding protein 0.006 0.1556 0.151
Loa Loa (eye worm) hypothetical protein 0.012 0.3388 0.3388
Onchocerca volvulus 0.0023 0.0425 0.0373
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.012 0.3388 0.3352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.1027 0.0978
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0042 0.1027 0.0978
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0084 0.2297 0.2255
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.3388 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1161 0.1161
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 0.0425 0.0373
Onchocerca volvulus 0.0012 0.0108 0.0054
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0425 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0763 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0433 0.0424
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0042 0.1027 1
Loa Loa (eye worm) glutaminase 0.0256 0.7546 0.7546
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0108 0.0054
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 0.0425 0.0373
Schistosoma mansoni hypothetical protein 0.0015 0.0188 0.0134
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0425 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0763 0.0755
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0425 0.0373
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Plasmodium vivax SET domain protein, putative 0.0028 0.0594 0.0167
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0425 0.0373
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0188 0.0134
Schistosoma mansoni hypothetical protein 0.0015 0.0188 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0697 0.0688
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.017 0.0116
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0425 0.0373
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 0.0425 0.0373
Onchocerca volvulus 0.012 0.3388 0.3352
Brugia malayi brahma associated protein 60 kDa 0.0337 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0594 0.0543
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.012 0.3388 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.012 0.3388 0.3352
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0425 0.0373
Trypanosoma cruzi target of rapamycin kinase 3 0.0034 0.0764 0.1848
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0034 0.0764 0.1848
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0337 1 1
Echinococcus granulosus tar DNA binding protein 0.006 0.1556 0.151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.1004 0.0954
Schistosoma mansoni hypothetical protein 0.0337 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0042 0.1027 0.2665
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.0425 0.0373
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0042 0.1027 0.0978
Schistosoma mansoni nAChR subunit 0.0023 0.0425 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1027 0.1019
Schistosoma mansoni hypothetical protein 0.0032 0.071 0.066
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.071 0.066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0188 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.1004 0.0954
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Echinococcus multilocularis PHD finger protein rhinoceros 0.0023 0.0435 0.0382
Echinococcus granulosus Zinc finger RanBP2 type 0.012 0.3388 0.3352
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 0.0425 0.0373
Brugia malayi RNA recognition motif domain containing protein 0.006 0.1556 0.151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Schistosoma mansoni RNA binding protein 0.012 0.3388 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0508 0.05
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0108 0.0054
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0042 0.1027 0.2665
Chlamydia trachomatis DNA topoisomerase I 0.0337 1 0.5
Brugia malayi excitatory GABA receptor EXP-1A 0.0023 0.0425 0.0373
Brugia malayi Pre-SET motif family protein 0.0196 0.5713 0.569
Echinococcus multilocularis ring and YY1 binding protein 0.012 0.3388 0.3352
Brugia malayi Pre-SET motif family protein 0.0028 0.0594 0.0543
Loa Loa (eye worm) hypothetical protein 0.012 0.3388 0.3388
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Echinococcus granulosus enhancer of polycomb 0.0014 0.0163 0.0109
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Schistosoma mansoni brg-1 associated factor 0.0337 1 1
Schistosoma mansoni nAChR subunit 0.0023 0.0425 0.0373
Onchocerca volvulus 0.012 0.3388 0.3352
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.0028 0.0594 0.0594
Schistosoma mansoni zinc finger protein 0.012 0.3388 0.3352
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0425 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0697 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1027 0.1019
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.3388 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0023 0.0435 0.0382
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.012 0.3388 1
Onchocerca volvulus 0.0023 0.0425 0.0373
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0337 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0015 0.0207 0.0153
Echinococcus multilocularis SWI:SNF matrix associated 0.0337 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.1004 0.0954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.1004 0.0954
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0337 1 1
Brugia malayi Cation transporter family protein 0.0023 0.0425 0.0373
Schistosoma mansoni nAChR subunit 0.0023 0.0425 0.0373
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.012 0.3388 0.3352
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0594 0.0543
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0563 0.0511
Loa Loa (eye worm) RNA binding protein 0.006 0.1556 0.1556
Echinococcus granulosus zinc finger protein Ran binding 0.012 0.3388 0.3352
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Onchocerca volvulus Alhambra homolog 0.0023 0.0435 0.0382
Schistosoma mansoni enhancer of polycomb 0.0014 0.0163 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.012 0.3388 0.3352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0108
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0425 0.0373
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0594 0.0543
Loa Loa (eye worm) GABA receptor subunit 0.0012 0.0108 0.0108
Schistosoma mansoni enhancer of polycomb 0.0014 0.0163 0.0109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.1161 0.1113
Leishmania major hypothetical protein, conserved 0.012 0.3388 1
Schistosoma mansoni nAChR subunit 0.0023 0.0425 0.0373
Schistosoma mansoni hypothetical protein 0.0015 0.0188 0.0134
Brugia malayi PHD-finger family protein 0.0023 0.0435 0.0382
Echinococcus granulosus nAChR subunit 0.0023 0.0425 0.0373
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.017 0.0116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Brugia malayi Cation transporter family protein 0.0023 0.0425 0.0373
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.017 0.0116
Trichomonas vaginalis glutaminase, putative 0.0256 0.7546 0.7543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0083 0.0074
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0042 0.1027 1
Toxoplasma gondii ran binding protein 0.012 0.3388 0.3382
Schistosoma mansoni hypothetical protein 0.0015 0.0188 0.0134
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0425 0.0373
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 0.0425 0.0373
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0425 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1027 0.1019
Schistosoma mansoni tar DNA-binding protein 0.006 0.1556 0.151
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.012 0.3388 1
Echinococcus multilocularis tar DNA binding protein 0.006 0.1556 0.151
Schistosoma mansoni TRABID protein (C64 family) 0.012 0.3388 0.3352
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.05 0.0492
Brugia malayi Cation transporter family protein 0.0023 0.0425 0.0373
Toxoplasma gondii PHD-finger domain-containing protein 0.0023 0.0435 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0697 0.0688
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0337 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0508 0.05
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.012 0.3388 0.3352
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.05 0.0492
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.012 0.3388 0.3087
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0594 0.0543
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0042 0.1027 0.2665
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0108 0.0054
Onchocerca volvulus 0.0223 0.6539 0.652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0508 0.05
Schistosoma mansoni hypothetical protein 0.012 0.3388 0.3352
Loa Loa (eye worm) hypothetical protein 0.0015 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0047 0.1173 0.1173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.1161 0.1161
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Schistosoma mansoni nAChR subunit 0.0023 0.0425 0.0373
Onchocerca volvulus 0.0023 0.0425 0.0373
Trypanosoma brucei hypothetical protein, conserved 0.012 0.3388 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0435 0.0435
Echinococcus granulosus PHD finger protein rhinoceros 0.0023 0.0435 0.0382
Brugia malayi jmjC domain containing protein 0.0015 0.0207 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0763 0.0755
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0425 0.0373
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0273 0.0321
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 0.0425 0.0373
Onchocerca volvulus 0.0028 0.0594 0.0543
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 0.0425 0.0425
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0337 1 1
Loa Loa (eye worm) brahma associated protein 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0594 0.0543
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 0.0425 0.0425
Leishmania major hypothetical protein, conserved 0.012 0.3388 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Echinococcus multilocularis enhancer of polycomb 0.0014 0.0163 0.0109
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.012 0.3388 0.3352
Onchocerca volvulus 0.0337 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0434 0.0425
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0435 0.0435
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0425 0.0373
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.017 0.0161
Brugia malayi TAR-binding protein 0.006 0.1556 0.151
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0337 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0337 1 1
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0425 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0697 0.0688
Echinococcus granulosus ring and YY1 binding protein 0.012 0.3388 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.017 0.0161
Echinococcus granulosus GPCR family 2 0.0015 0.0188 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0594 0.0543
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0425 0.0373
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0425 0.0425
Schistosoma mansoni enhancer of polycomb 0.0014 0.0163 0.0109
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0337 1 1
Brugia malayi glutaminase DH11.1 0.0256 0.7546 0.7532
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.012 0.3388 0.3352
Schistosoma mansoni fusion 0.012 0.3388 0.3352
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0594 0.0586
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.1004 0.1004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0434 0.0425
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0594 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0697 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0839 0.0831
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0425 0.0373
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 0.0425 0.0373

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.23 Displacement of [3H]epibatidine from rat neuronal acetylcholine receptor subunit alpha4beta2 expressed in HEK293 cell membranes incubated for 4 hrs by scintillation counting method ChEMBL. 26298493
Ki (binding) = 5.8 uM Displacement of [3H]epibatidine from rat neuronal acetylcholine receptor subunit alpha4beta2 expressed in HEK293 cell membranes incubated for 4 hrs by scintillation counting method ChEMBL. 26298493

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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