Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.272 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.1771 | 0.3379 | 0.3331 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.3696 | 0.7306 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3545 | 0.6997 | 0.6975 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.1771 | 0.3379 | 0.3742 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.8164 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.1473 | 0.2771 | 0.272 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.1771 | 0.3379 | 0.3331 |
Giardia lamblia | UPL-1 | 0.1473 | 0.2771 | 0.272 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0679 | 0.1152 | 0.1089 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.8164 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.5018 | 1 | 1 |
Loa Loa (eye worm) | uridine phosphorylase | 0.1473 | 0.2771 | 0.2692 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Brugia malayi | uridine phosphorylase family protein | 0.1473 | 0.2771 | 0.272 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0709 | 0.1215 | 0.1152 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0709 | 0.1215 | 0.1152 |
Trypanosoma brucei | uridine phosphorylase | 0.1473 | 0.2771 | 0.8164 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.272 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0709 | 0.1215 | 0.1152 |
Chlamydia trachomatis | AMP nucleosidase | 0.1473 | 0.2771 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.272 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.1473 | 0.2771 | 0.272 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.5018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3545 | 0.6997 | 1 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.0298 | 0.0376 | 0.0376 |
Toxoplasma gondii | phosphorylase family protein | 0.1473 | 0.2771 | 0.3733 |
Treponema pallidum | uridine phosphorylase (udp) | 0.3696 | 0.7306 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.1473 | 0.2771 | 0.272 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.5018 | 1 | 1 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.1771 | 0.3379 | 0.3331 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.272 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.1473 | 0.2771 | 0.2771 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.8164 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1473 | 0.2771 | 0.272 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.3696 | 0.7306 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.3696 | 0.7306 | 0.7287 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.5018 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.1473 | 0.2771 | 0.272 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.1771 | 0.3379 | 0.3331 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1473 | 0.2771 | 0.2771 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.1771 | 0.3379 | 1 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.1473 | 0.2771 | 0.272 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.3696 | 0.7306 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0709 | 0.1215 | 0.1152 |
Mycobacterium leprae | probable uridine phosphorylase | 0.1473 | 0.2771 | 0.2771 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.1771 | 0.3379 | 0.3331 |
Schistosoma mansoni | uridine phosphorylase | 0.1473 | 0.2771 | 0.272 |
Leishmania major | nucleoside phosphorylase-like protein | 0.1473 | 0.2771 | 0.8164 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.3696 | 0.7306 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0709 | 0.1215 | 0.1152 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.1473 | 0.2771 | 0.272 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.3696 | 0.7306 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0709 | 0.1215 | 0.1152 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1473 | 0.2771 | 0.272 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1473 | 0.2771 | 0.2771 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.5018 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.1771 | 0.3379 | 1 |
Brugia malayi | MTAP | 0.1771 | 0.3379 | 0.3331 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.3696 | 0.7306 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1473 | 0.2771 | 0.272 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.1771 | 0.3379 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.1473 | 0.2771 | 0.3733 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.3545 | 0.6997 | 0.6975 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.3696 | 0.7306 | 0.7287 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.1473 | 0.2771 | 0.272 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.5018 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3545 | 0.6997 | 0.6975 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.1771 | 0.3379 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -7.154 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.986 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.273 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | Indirect antitumour effect was measured as cytotoxicity against murine macrophages; not detected | ChEMBL. | 12904070 | |
IC50 (functional) | = 212.7 uM | Indirect antitumour effect was measured as cytotoxicity with human monocytes pretreated with compounds | ChEMBL. | 12904070 |
ND (functional) | 0 | In vitro cytotoxicity against the selected tumour cell line LoVoS arising from human colon adenocarcinoma was determined; not detected | ChEMBL. | 12904070 |
ND (functional) | 0 | In vitro cytotoxicity against the selected tumour cell line LoVoR arising from human colon adenocarcinoma was determined; not detected | ChEMBL. | 12904070 |
ND (functional) | 0 | Direct cytotoxicity against the selected tumour cell line 2008 was determined especially on ovarian adenocarcinoma derived cells; not detected | ChEMBL. | 12904070 |
ND (functional) | 0 | Direct cytotoxicity against the selected tumour cell line c13* was determined especially on ovarian adenocarcinoma derived cells; not detected | ChEMBL. | 12904070 |
ND (functional) | 0 | Indirect antitumour effect was measured as cytotoxicity against murine macrophages; not detected | ChEMBL. | 12904070 |
Potency ratio (functional) | = 0.6 | Potency ratio was determined against human monocytes versus DMXAA (Dimethylxanthenone-4-acetic acid); less potent | ChEMBL. | 12904070 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.