TDR Targets

Basic information

Technical information

TDR Targets ID: 211643
Name: O-butyl butoxycarbothioyldisulfanylmethanethi oate
MW: 298.509 | Formula: C10H18O2S4
H donors: 0 H acceptors: 0 LogP: 4.98 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOC(=S)SSC(=S)OCCCC
InChi: 1S/C10H18O2S4/c1-3-5-7-11-9(13)15-16-10(14)12-8-6-4-2/h3-8H2,1-2H3
InChiKey: QCAZHHXMIVSLMW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[butoxy(thioxo)methyl]disulfanylmethanethioic acid O-butyl ester
butoxycarbothioyldisulfanylmethanethioic acid O-butyl ester
(butoxy-thioxomethyl)disulfanylmethanethioic acid O-butyl ester
105-77-1
Bis-butylxanthogen
Butylxanthic disulfide
Butylxanthic disulfide ester
Di-n-Butyl xanthogen disulfide
Dibutyl dixanthogen
Dibutyl dixanthogenate
Dibutyl xanthogen disulfide
Dibutylxanthogen
Dithiobis[thionoformic acid] dibutyl ester
Formic acid, dithiobis[thio-, O,O-dibutyl ester
NSC5239
Thioperoxydicarbonic acid ([(HO)C(S)]2S2), dibutyl ester
Xanthogen, bis[butyl-
4-03-00-00417 (Beilstein Handbook Reference)
BRN 1792348
CPB (ester)
Di(butoxythiocarbonyl) disulfide
Dibutyl thioperoxydicarbonate
Dithiobis(thionoformic acid) dibutyl ester
EINECS 203-330-5
Formic acid, dithiobis(thio-, O,O-dibutyl ester
NSC 5239
Thioperoxydicarbonic acid (((HO)C(S))2S2), dibutyl ester
Thioperoxydicarbonic acid, dibutyl ester
Xanthogen, bisbutyl-
1,1'-{Dithiobis[(thioxomethylene)oxy]}dibutane
AIDS-032875
AIDS032875

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0118	0.1931	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0379	0.1962
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Toxoplasma gondii	facilitative glucose transporter GT1	0.0118	0.1931	0.3462
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0036	0.0545	0.2821
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0006	0.0032	0.0508
Brugia malayi	hypothetical protein	0.0022	0.03	0.1556
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0036	0.0545	0.0977
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0145	0.3815
Trypanosoma cruzi	hexose transporter, putative	0.002	0.0271	0.4299
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0035	0.0532	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0036	0.0545	0.0648
Trichomonas vaginalis	CAMK family protein kinase	0.0036	0.0545	0.2821
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0545	0.0545
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0312	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0026	0.0379	0.5997
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0552	0.8747
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0035	0.0532	0.2756
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0036	0.0545	0.2821
Trypanosoma brucei	histidyl-tRNA synthetase	0.0004	0	0.0005
Brugia malayi	cytoplasmic intermediate filament protein	0.0012	0.0144	0.0743
Plasmodium vivax	lysine--tRNA ligase, putative	0.0026	0.0379	0.045
Leishmania major	hypothetical protein, conserved	0.0006	0.0032	0.0508
Leishmania major	hypothetical protein, conserved	0.0006	0.0032	0.0508
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0007	0.0045	0.0234
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0214	0.0214
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0006	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0532	0.2756
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0037	0.0552	0.8747
Echinococcus granulosus	intermediate filament protein	0.0023	0.0326	0.0326
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0017	0.0214	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Echinococcus granulosus	solute carrier family 22	0.0017	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0145	1
Trypanosoma brucei	glucose transporter 2A	0.0037	0.0552	0.8747
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.03	0.0357
Trichomonas vaginalis	glucose transporter, putative	0.0037	0.0552	0.2861
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0532	0.0532
Leishmania major	lysyl-tRNA synthetase, putative	0.0026	0.0379	0.5997
Mycobacterium ulcerans	histidyl-tRNA synthetase	0.0004	0	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0017	0.0214	0.0214
Trypanosoma brucei	sugar transporter, putative	0.0017	0.0214	0.3384
Leishmania major	hypothetical protein, conserved	0.0017	0.0214	0.3384
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0028	0.0143
Mycobacterium ulcerans	hypothetical protein	0.0006	0.0032	0.0848
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.019	0.3161	0.5668
Plasmodium falciparum	hexose transporter	0.0118	0.1931	0.2295
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Loa Loa (eye worm)	histidyl-tRNA synthetase	0.0004	0	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0118	0.1931	0.1931
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Schistosoma mansoni	microtubule-associated protein tau	0.0594	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.03	0.1556
Brugia malayi	major facilitator superfamily protein	0.0017	0.0214	0.1107
Brugia malayi	Sugar transporter family protein	0.0017	0.0214	0.1107
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.019	0.3161	0.3758
Echinococcus granulosus	synaptic vesicle 2 protein	0.0017	0.0214	0.0214
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Schistosoma mansoni	glycyl-tRNA synthetase	0.0007	0.0045	0.0045
Treponema pallidum	threonyl-tRNA synthetase	0.0007	0.0045	0.3127
Plasmodium vivax	hexose transporter	0.0118	0.1931	0.2295
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0006	0.0037	0.0037
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0036	0.0545	0.0648
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0017	0.0214	0.0214
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0036	0.0545	0.0648
Echinococcus granulosus	solute carrier family 22	0.0017	0.0214	0.0214
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0006	0.0032	0.0508
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Plasmodium vivax	ataxin-2 like protein, putative	0.0022	0.03	0.0357
Schistosoma mansoni	hypothetical protein	0.001	0.0098	0.0098
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0545	0.0545
Loa Loa (eye worm)	histone methyltransferase	0.0008	0.0062	0.0323
Onchocerca volvulus		0.0025	0.0352	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Schistosoma mansoni	hypothetical protein	0.0352	0.59	0.59
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0324	0.1677
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0319	0.1652
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0007	0.0045	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0007	0.0045	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0214	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Echinococcus granulosus	glycyl tRNA synthetase	0.0007	0.0045	0.0045
Mycobacterium ulcerans	sugar transporter	0.0017	0.0214	0.5643
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Schistosoma mansoni	protein kinase	0.0036	0.0545	0.0545
Loa Loa (eye worm)	sugar transporter	0.0118	0.1931	1
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Onchocerca volvulus		0.0023	0.0326	0.8149
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0006	0.0032	0.0058
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0007	0.0045	0.0468
Plasmodium vivax	CDK-related protein kinase 6, putative	0.05	0.8413	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0545	0.0545
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0632	1
Trichomonas vaginalis	glucose transporter, putative	0.0037	0.0552	0.2861
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0026	0.0379	0.6932
Toxoplasma gondii	sugar transporter ST1	0.0017	0.0214	0.0383
Toxoplasma gondii	histidyl-tRNA synthetase (HisRS), putative	0.0004	0	0.0001
Schistosoma mansoni	protein kinase	0.0036	0.0545	0.0545
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0312	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0036	0.0545	0.0648
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0032	0.0166
Trichomonas vaginalis	interferon-induced, double-stranded RNA-activated protein kinase, putative	0.0004	0	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Brugia malayi	hypothetical protein	0.0017	0.0214	0.1107
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0052	0.0821	0.0821
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0028	0.0143
Trypanosoma brucei	PAB1-binding protein , putative	0.0022	0.03	0.4758
Trypanosoma cruzi	glucose transporter, putative	0.0017	0.0214	0.3384
Schistosoma mansoni	lamin	0.0023	0.0326	0.0326
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0037	0.0552	0.8747
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0041	0.0632	0.1132
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0145	0.3815
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0041	0.0632	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0026	0.0379	0.7117
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0032	0.0508
Plasmodium falciparum	lysine--tRNA ligase	0.0026	0.0379	0.045
Echinococcus granulosus	cpg binding protein	0.0026	0.0376	0.0376
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0007	0.0045	0.0045
Echinococcus multilocularis	musashi	0.0023	0.0326	0.0326
Giardia lamblia	Threonyl-tRNA synthetase	0.0007	0.0045	0.0849
Loa Loa (eye worm)	intermediate filament protein	0.0023	0.0326	0.1689
Schistosoma mansoni	hypothetical protein	0.0118	0.1931	0.1931
Plasmodium falciparum	mitogen-activated protein kinase 2	0.019	0.3161	0.3758
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0011	0.0123	0.0123
Schistosoma mansoni	glucose transport protein	0.0118	0.1931	0.1931
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0545	0.0545
Echinococcus granulosus	dnaJ subfamily B	0.0352	0.59	0.59
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0545	0.0545
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0214	0.3384
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0028	0.0143
Brugia malayi	CXXC zinc finger family protein	0.0025	0.0352	0.1822
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0028	0.0143
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0118	0.1931	0.1931
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0028	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0214	0.1107
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0032	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0115	0.0598
Trichomonas vaginalis	myo-inositol transporter, putative	0.0017	0.0214	0.1107
Entamoeba histolytica	hypothetical protein	0.0026	0.0379	0.6955
Echinococcus granulosus	lamin	0.0023	0.0326	0.0326
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.001	0.0098	0.0098
Treponema pallidum	glycyl-tRNA synthetase	0.0004	0	0.002
Schistosoma mansoni	cpg binding protein	0.0026	0.0376	0.0376
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Entamoeba histolytica	histidyl-tRNA synthetase, putative	0.0004	0	0.0005
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0312	0.5587
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0045	0.0234
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0036	0.0545	0.2821
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.083
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0006	0.0037	0.0037
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0006	0.0037	0.0037
Plasmodium falciparum	protein kinase 6	0.05	0.8413	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0036	0.0545	0.0977
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0007	0.0045	0.0715
Plasmodium falciparum	proline--tRNA ligase	0.0041	0.0632	0.0751
Schistosoma mansoni	cpg binding protein	0.0025	0.0352	0.0352
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0715
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0032	0.0166
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0379	0.5997
Schistosoma mansoni	cpg binding protein	0.0026	0.0376	0.0376
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0007	0.0045	0.1193
Chlamydia trachomatis	lysine--tRNA ligase	0.0026	0.0379	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0008	0.0061	0.0315
Schistosoma mansoni	sugar transporter	0.0017	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0532	0.2756
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0379	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0035	0.0532	0.2756
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0036	0.0545	0.8623
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0532	0.0532
Brugia malayi	hypothetical protein	0.0014	0.017	0.0881
Leishmania major	histidyl-tRNA synthetase, putative	0.0004	0	0.0005
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0545	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0115	0.0598
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0017	0.0214	0.1107
Echinococcus multilocularis	lamin	0.0023	0.0326	0.0326
Brugia malayi	intermediate filament protein	0.0023	0.0326	0.1689
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Onchocerca volvulus		0.0023	0.0326	0.8149
Echinococcus granulosus	solute carrier family 22	0.0017	0.0214	0.0214
Leishmania major	protein kinase, putative	0.0036	0.0545	0.8623
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.1931	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0036	0.0545	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0123	0.0635
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Toxoplasma gondii	sugar transporter ST2	0.0017	0.0214	0.0383
Brugia malayi	Intermediate filament tail domain containing protein	0.0023	0.0326	0.1689
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0007	0.0045	0.083
Plasmodium falciparum	threonine--tRNA ligase	0.0007	0.0045	0.0054
Schistosoma mansoni	sugar transporter	0.0017	0.0214	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0037	0.0552	0.2861
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.03	0.4758
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Trypanosoma cruzi	sugar transporter, putative	0.0017	0.0214	0.3384
Wolbachia endosymbiont of Brugia malayi	histidyl-tRNA synthetase	0.0004	0	0.0014
Entamoeba histolytica	protein kinase, putative	0.0036	0.0545	1
Brugia malayi	major facilitator superfamily protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Brugia malayi	glycyl-tRNA synthetase	0.0007	0.0045	0.0234
Toxoplasma gondii	lysine-tRNA ligase	0.0026	0.0379	0.0679
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Plasmodium vivax	glycine--tRNA ligase, putative	0.0007	0.0045	0.0054
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0379	0.0379
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0012	0.0144	0.0743
Loa Loa (eye worm)	sugar transporter	0.0017	0.0214	0.1107
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0632	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0017	0.0214	0.0214
Chlamydia trachomatis	threonine--tRNA ligase	0.0007	0.0045	0.1193
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0379	0.0379
Plasmodium vivax	proline--tRNA ligase, putative	0.0041	0.0632	0.0751
Giardia lamblia	Hexose transporter	0.0017	0.0214	0.4016
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0017	0.0214	0.0214
Trichomonas vaginalis	glycyl-tRNA synthetase, putative	0.0004	0	0.0002
Echinococcus multilocularis	calcium dependent protein kinase	0.0034	0.0507	0.0507
Leishmania major	glucose transporter, lmgt2	0.0037	0.0552	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0036	0.0545	0.0545
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Toxoplasma gondii	sugar transporter ST3	0.0017	0.0214	0.0383
Plasmodium vivax	threonine--tRNA ligase, putative	0.0007	0.0045	0.0054
Schistosoma mansoni	intermediate filament proteins	0.0023	0.0326	0.0326
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.03	0.4758
Trichomonas vaginalis	sugar transport protein, putative	0.0017	0.0214	0.1107
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0036	0.0545	0.0648
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0023	0.0326	0.1689
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0026	0.0379	0.1962
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0552	0.2861
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0118	0.1931	0.1931
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0028	0.0143
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Trypanosoma cruzi	hexose transporter	0.0037	0.0552	0.8747
Giardia lamblia	Prolyl-tRNA synthetase	0.0035	0.0532	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0062	0.0062
Toxoplasma gondii	LsmAD domain-containing protein	0.0022	0.03	0.0539
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0017	0.0214	0.6499
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0037	0.0552	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Brugia malayi	Sugar transporter family protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.001	0.0098	0.0098
Echinococcus granulosus	lysyl tRNA synthetase	0.0026	0.0379	0.0379
Schistosoma mansoni	sugar transporter	0.0017	0.0214	0.0214
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.03	0.0357
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus granulosus	solute carrier family 22	0.0017	0.0214	0.0214
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Schistosoma mansoni	sugar transporter	0.0017	0.0214	0.0214
Leishmania major	hypothetical protein, conserved	0.0022	0.03	0.4758
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0017	0.0214	0.0254
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0017	0.0214	0.5643
Trichomonas vaginalis	sugar transporter, putative	0.0037	0.0552	0.2861
Echinococcus multilocularis	dnaJ subfamily B	0.0352	0.59	0.59
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0036	0.0545	0.0648
Trichomonas vaginalis	helicase, putative	0.0006	0.0028	0.0143
Toxoplasma gondii	transporter, major facilitator family protein	0.0017	0.0214	0.0383
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0118	0.1931	0.1931
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0007	0.0045	0.2114
Schistosoma mansoni	glucose transport protein	0.0118	0.1931	0.1931
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0011	0.0123	0.0123
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0017	0.0214	0.5643
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0007	0.0045	0.0234
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0007	0.0045	0.0234
Echinococcus granulosus	calcium dependent protein kinase	0.0034	0.0507	0.0507
Schistosoma mansoni	lamin	0.0023	0.0326	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0552	0.2861
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0532	0.0532
Echinococcus multilocularis	cpg binding protein	0.0026	0.0376	0.0376
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0032	0.0166
Trichomonas vaginalis	glucose transporter, putative	0.0017	0.0214	0.1107
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0715
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0004	0	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0214	0.1107
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0017	0.0214	0.3384
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus granulosus	General substrate transporter	0.0101	0.165	0.165
Echinococcus multilocularis	glycyl tRNA synthetase	0.0007	0.0045	0.0045
Mycobacterium ulcerans	integral membrane transport protein	0.0017	0.0214	0.5643
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0028	0.0143
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0025	0.0352	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0017	0.0214	0.6499
Schistosoma mansoni	glucose transport protein	0.0118	0.1931	0.1931
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0028	0.0143
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0007	0.0045	0.0045
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0552	0.8747
Leishmania major	glycyl tRNA synthetase, putative	0.0004	0	0.0005
Brugia malayi	Cam kinase protein 1	0.0036	0.0545	0.2821
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0007	0.0045	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0545	0.2821
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0035	0.0532	0.2756
Chlamydia trachomatis	histidine--tRNA ligase	0.0004	0	0.0008
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0545	0.0545
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0036	0.0545	0.0648
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0036	0.0545	0.0648
Entamoeba histolytica	protein kinase, putative	0.0036	0.0545	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0035	0.0532	0.9773
Echinococcus multilocularis	General substrate transporter	0.0101	0.165	0.165
Leishmania major	glucose transporter, lmgt3	0.0037	0.0552	0.8747
Leishmania major	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0715
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0006	0.0032	0.0508
Leishmania major	myo-inositol/proton symporter (MIT)	0.0017	0.0214	0.3384
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0715
Plasmodium falciparum	protein kinase 7	0.0333	0.5578	0.663
Brugia malayi	Sugar transporter family protein	0.0118	0.1931	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0062	0.0062
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0632	1
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0041	0.0632	1
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0007	0.0045	0.1193
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0017	0.0214	0.1107
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0234
Trichomonas vaginalis	sugar transporter, putative	0.0037	0.0552	0.2861
Toxoplasma gondii	protein kinase, putative	0.0333	0.5578	1
Echinococcus multilocularis	microtubule associated protein 2	0.0594	1	1
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0007	0.0045	0.0081
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0552	0.8747
Schistosoma mansoni	glucose transporter	0.0017	0.0214	0.0214
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0006	0.0037	0.0037
Leishmania major	glucose transporter, lmgt1	0.0037	0.0552	0.8747
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0118	0.1931	0.1931
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0532	0.0532
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Brugia malayi	hypothetical protein	0.0017	0.0214	0.1107
Giardia lamblia	Glycyl-tRNA synthetase	0.0007	0.0045	0.0849
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0028	0.0143
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0047	0.0727	0.1303
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0379	1
Giardia lamblia	Sugar-proton symporter	0.0017	0.0214	0.4016
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0118	0.1931	0.1931
Echinococcus multilocularis	lysyl tRNA synthetase	0.0026	0.0379	0.0379
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0004	0	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Trypanosoma brucei	glucose transporter 1E	0.0037	0.0552	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Brugia malayi	lysyl-tRNA synthetase	0.0026	0.0379	0.1962
Toxoplasma gondii	anticodon binding domain-containing protein	0.0004	0	0.0001
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0037	0.0552	0.8747
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0545	0.0545
Plasmodium vivax	sugar transporter, putative	0.0017	0.0214	0.0254
Trypanosoma cruzi	histidyl-tRNA synthetase	0.0004	0	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.1689
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0552	0.8747
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0118	0.1931	0.1931
Schistosoma mansoni	protein kinase	0.0036	0.0545	0.0545
Toxoplasma gondii	glycyl-tRNA synthetase	0.0007	0.0045	0.0081
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0015	0.0179	0.0926
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0036	0.0545	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0214	0.1107
Echinococcus multilocularis	lamin dm0	0.0023	0.0326	0.0326
Brugia malayi	hypothetical protein	0.0017	0.0214	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0214	0.1107
Echinococcus granulosus	lamin dm0	0.0023	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0029	0.042	0.2174

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Inhibition of HIV-1 replication in human T-cell by using XTT assay; Inactive	ChEMBL.	8809151
IC50 (functional)	= 13.4	Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay.	ChEMBL.	8809151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL332367
PubChem: 66926

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 211643