Detailed information for compound 212410

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.42 | Formula: C18H24N6O5
  • H donors: 4 H acceptors: 6 LogP: -0.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)C1OC(C(C1O)O)n1cnc2c1ncnc2NC1CCC2C(C1)O2
  • InChi: 1S/C18H24N6O5/c1-2-19-17(27)14-12(25)13(26)18(29-14)24-7-22-11-15(20-6-21-16(11)24)23-8-3-4-9-10(5-8)28-9/h6-10,12-14,18,25-26H,2-5H2,1H3,(H,19,27)(H,20,21,23)
  • InChiKey: RAPHKNWQGUWSDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0511 0.1396
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0008 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0036 0.01
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0021
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0008 0.0021
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0034 0.0094
Echinococcus multilocularis ferritin 0.0008 0.0025 0.0025
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0036 0.0097
Brugia malayi hypothetical protein 0.0118 0.0877 0.2455
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.0035 0.0235 0.0641
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0444 0.1214
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.6572
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0444 0.1214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1066 0.1066
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0036 0.0324
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1066 0.2985
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Loa Loa (eye worm) nuclear factor I 0.0005 0.0001 0.0002
Echinococcus granulosus tar DNA binding protein 0.0063 0.0444 0.0444
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0036 0.0097
Schistosoma mansoni cpg binding protein 0.0035 0.0235 0.0641
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0268 0.0752
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0036 0.01
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0008 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0036 0.01
Schistosoma mansoni hypothetical protein 0.0478 0.366 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0008 0.0008
Brugia malayi MH1 domain containing protein 0.001 0.0034 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0036 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.6572
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0008 0.0021
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0006 0.0008 0.0008
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0008 0.0021
Schistosoma mansoni ferritin 0.0008 0.0025 0.0068
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0008 0.0008
Trichomonas vaginalis helicase, putative 0.0008 0.0019 0.6572
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0008 0.0021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0036 0.0097
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0021
Brugia malayi MH2 domain containing protein 0.0139 0.104 0.2913
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0008 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0103 0.0103
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0036 0.0036
Schistosoma mansoni smad1 5 8 and 0.001 0.0034 0.0092
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0452 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1066 0.2911
Mycobacterium ulcerans thymidine phosphorylase 0.1296 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0444 0.1244
Echinococcus granulosus Smad4 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0118 0.0877 0.2455
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0008 0.0021
Brugia malayi RNA binding protein 0.0063 0.0444 0.1244
Echinococcus multilocularis dnaJ subfamily B 0.0478 0.366 0.366
Brugia malayi TAR-binding protein 0.0063 0.0444 0.1244
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0036 0.01
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0034 0.0092
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0366 0.2794 0.2776
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0036 0.01
Loa Loa (eye worm) histone methyltransferase 0.001 0.004 0.0113
Echinococcus multilocularis muscleblind protein 1 0.0466 0.3571 0.3571
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0008 0.0021
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0008 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0025 0.0067
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1296 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0021
Brugia malayi Muscleblind-like protein 0.0466 0.3571 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0947 0.7296 0.7296
Schistosoma mansoni hypothetical protein 0.004 0.0268 0.0733
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0008 0.0008
Echinococcus granulosus GPCR family 2 0.0018 0.0103 0.0103
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Echinococcus granulosus expressed protein 0.0006 0.0008 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0036 0.01
Brugia malayi steroid hormone receptor 0.001 0.0036 0.01
Echinococcus granulosus ferritin 0.0008 0.0025 0.0025
Brugia malayi nuclear receptor NHR-88 0.001 0.0036 0.01
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0103 0.0103
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0034 0.0034
Brugia malayi G-protein alpha subunit 0.0006 0.0008 0.0021
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0036 0.01
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0286 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0288
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.104 0.2913
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0036 0.01
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Brugia malayi ecdysteroid receptor 0.001 0.0036 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0008 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0103 0.0103
Schistosoma mansoni cpg binding protein 0.0034 0.022 0.0601
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0286 0.078
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0006 0.0008 0.0008
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0118 0.0877 0.2455
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0036 0.0324
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0008 0.0021
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0008 0.0021
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0008 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0411 0.1151
Echinococcus multilocularis smad 0.001 0.0034 0.0034
Schistosoma mansoni ferritin 0.0008 0.0025 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1066 0.1066
Echinococcus granulosus dnaJ subfamily B 0.0478 0.366 0.366
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.6572
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0036 0.01
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0444 0.1214
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0008 0.0021
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0025 0.0025
Brugia malayi Smad1 0.001 0.0034 0.0094
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.022 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0036 0.01
Loa Loa (eye worm) RNA binding protein 0.0063 0.0444 0.1244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0036 0.01
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0019 0.6572
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0366 0.2794 0.2776
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.01
Brugia malayi nuclear hormone receptor 0.001 0.0036 0.01
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0039 0.011
Brugia malayi MH2 domain containing protein 0.001 0.0034 0.0094
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0021
Schistosoma mansoni apoferritin-2 0.0008 0.0025 0.0068
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0008 0.0021
Onchocerca volvulus 0.0034 0.022 0.2443
Echinococcus multilocularis GPCR, family 2 0.0018 0.0103 0.0103
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0008 0.0021
Schistosoma mansoni smad 0.001 0.0034 0.0092
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0036 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0444 0.1244
Loa Loa (eye worm) Smad1 0.001 0.0034 0.0094
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0103 0.0288
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Echinococcus multilocularis expressed protein 0.0006 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0002
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0008 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1066 0.2985
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0008 0.0008
Echinococcus multilocularis thymidine phosphorylase 0.1296 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0444 0.1214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1066 0.1066
Echinococcus granulosus cpg binding protein 0.0035 0.0235 0.0235
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0008 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.6572
Echinococcus multilocularis cpg binding protein 0.0035 0.0235 0.0235
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.004 0.004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0036 0.01
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0036 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0036 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Echinococcus granulosus expressed protein 0.0008 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0036 0.01
Echinococcus multilocularis Smad4 0.001 0.0034 0.0034
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0036 0.0097
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0411 0.1151
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0019 0.6572
Schistosoma mansoni ferritin 0.0008 0.0025 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1066 0.2911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1066 0.2911
Schistosoma mansoni ferritin 0.0008 0.0025 0.0068
Onchocerca volvulus 0.001 0.0036 0.0324
Echinococcus multilocularis muscleblind protein 0.0466 0.3571 0.3571
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0008 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0036 0.01
Loa Loa (eye worm) hypothetical protein 0.0058 0.0411 0.1151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1066 0.1066
Brugia malayi MH1 domain containing protein 0.0005 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0036 0.01
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0008 0.0021
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0103 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Echinococcus multilocularis expressed protein 0.0008 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.004 0.0268 0.0752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0036 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Schistosoma mansoni nuclear hormone receptor 0.001 0.0036 0.0097
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Schistosoma mansoni coup transcription factor 0.001 0.0036 0.0097
Schistosoma mansoni hypothetical protein 0.0042 0.0286 0.078
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.6572
Schistosoma mansoni smad1 5 8 and 0.001 0.0034 0.0092
Echinococcus granulosus muscleblind protein 0.0466 0.3571 0.3571
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.104 0.2913
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0366 0.2794 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Echinococcus granulosus smad 0.001 0.0034 0.0034
Onchocerca volvulus Huntingtin homolog 0.0118 0.0877 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0036 0.0097
Schistosoma mansoni ferritin light chain 0.0008 0.0025 0.0068
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0286 0.0286
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0008 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0036 0.01
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0025 0.0025
Brugia malayi MH1 domain containing protein 0.001 0.0034 0.0094
Schistosoma mansoni thyroid hormone receptor 0.001 0.0036 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0444 0.1214
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Brugia malayi MH2 domain containing protein 0.001 0.0034 0.0094
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0008 0.0021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0466 0.3571 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0034 0.0034
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0008 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0034 0.0094
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0444 0.0444
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0025 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0036 0.0097
Loa Loa (eye worm) hypothetical protein 0.0466 0.3571 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.01
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0444 0.1244
Schistosoma mansoni ferritin light chain 0.0008 0.0025 0.0068
Trichomonas vaginalis ferritin, putative 0.0008 0.0025 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.6572
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.01
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0036 0.01
Brugia malayi hypothetical protein 0.0006 0.0008 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Brugia malayi MH1 domain containing protein 0.0005 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.01
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0036 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.01
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0025 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0103 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.6572
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.004 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0103 0.0103
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0008 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0036 0.0324
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0036 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0008 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0036 0.0036
Schistosoma mansoni apoferritin-2 0.0008 0.0025 0.0068
Schistosoma mansoni Smad4 0.001 0.0034 0.0092
Onchocerca volvulus Huntingtin homolog 0.0118 0.0877 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0411 0.1151
Schistosoma mansoni smad1 5 8 and 0.001 0.0034 0.0092
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0008 0.0021
Brugia malayi CXXC zinc finger family protein 0.0034 0.022 0.0616
Brugia malayi hypothetical protein 0.0042 0.0286 0.08

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.9 nM Potency to inhibit A1-adenosine receptor mediated cAMP accumulation in DDT1 MF-2 cells ChEMBL. 9934487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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