Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0029 | 0.0357 | 0.0349 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.3271 | 0.3265 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.106 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0525 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0029 | 0.0357 | 0.0349 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0525 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0029 | 0.0357 | 0.0349 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.2366 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0008 | 0.0014 |
Echinococcus multilocularis | lamin | 0.0056 | 0.106 | 0.1053 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0357 | 0.0349 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0525 | 0.09 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0238 | 0.5834 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0029 | 0.0357 | 0.0611 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0357 | 0.0378 |
Schistosoma mansoni | thyroid hormone receptor | 0.0396 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0525 | 0.0887 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.0374 | 0.0628 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0029 | 0.0357 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0525 | 0.0887 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0357 | 0.0378 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0357 | 0.0598 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0525 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0357 | 0.0611 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0029 | 0.0357 | 0.0598 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.2366 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0029 | 0.0357 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.106 | 0.1806 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0357 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0106 | 0.2366 | 0.236 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0525 | 0.6755 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0238 | 0.5834 | 1 |
Brugia malayi | Smad1 | 0.0016 | 0.0008 | 0.0014 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0525 | 0.09 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0357 | 0.0611 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0525 | 0.0887 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0525 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0029 | 0.0357 | 0.0349 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0106 | 0.2366 | 0.236 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.3271 | 0.5607 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.0357 | 0.0611 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.9226 | 0.9225 |
Brugia malayi | hypothetical protein | 0.0106 | 0.2366 | 0.4056 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.106 | 0.1806 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0357 | 0.0611 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0357 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0525 | 0.0887 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.0667 | 0.0715 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0577 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.2366 | 0.236 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.0667 | 1 |
Onchocerca volvulus | 0.0036 | 0.0525 | 0.2393 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0525 | 0.0887 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0525 | 0.0561 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0357 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0357 | 0.0611 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.106 | 0.1053 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0008 | 0.0014 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0029 | 0.0357 | 0.0611 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.0374 | 0.0641 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.3271 | 0.3265 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0357 | 0.0611 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0525 | 0.09 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0106 | 0.2366 | 0.2558 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.0357 | 0.0611 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0525 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.2366 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.0667 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0367 | 0.9226 | 1 |
Echinococcus multilocularis | musashi | 0.0056 | 0.106 | 0.1053 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0525 | 0.5 |
Schistosoma mansoni | lamin | 0.0056 | 0.106 | 0.1053 |
Onchocerca volvulus | 0.0056 | 0.106 | 1 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0367 | 0.9226 | 0.9225 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0525 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0269 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0296 | 0.0493 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.0667 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0357 | 0.0378 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0357 | 0.0611 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0357 | 0.0598 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.0667 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0357 | 0.0378 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0525 | 0.0887 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.106 | 0.1818 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0029 | 0.0357 | 0.0349 |
Echinococcus granulosus | lamin | 0.0056 | 0.106 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0229 | 0.0379 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0029 | 0.0357 | 0.0378 |
Onchocerca volvulus | 0.0036 | 0.0525 | 0.2393 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0525 | 0.09 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0357 | 0.0349 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0029 | 0.0357 | 0.0349 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0029 | 0.0357 | 0.0378 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0029 | 0.0357 | 0.0611 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0525 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0525 | 0.0517 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0029 | 0.0357 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0525 | 0.6755 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0525 | 0.0517 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.3168 | 0.3427 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0525 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.106 | 1 | |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0029 | 0.0357 | 0.0349 |
Brugia malayi | steroid hormone receptor | 0.0029 | 0.0357 | 0.0611 |
Echinococcus granulosus | FTZ F1 alpha | 0.0029 | 0.0357 | 0.0378 |
Brugia malayi | ecdysteroid receptor | 0.0029 | 0.0357 | 0.0611 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.2366 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0029 | 0.0357 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0525 | 0.0887 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0357 | 0.0611 |
Onchocerca volvulus | 0.0036 | 0.0525 | 0.2393 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0029 | 0.0357 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1033 | 0.176 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.0296 | 0.0288 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0029 | 0.0357 | 0.0378 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0525 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.0667 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.0296 | 0.0312 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0008 | 0.0014 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.5605 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0357 | 0.0349 |
Schistosoma mansoni | lamin | 0.0056 | 0.106 | 0.1053 |
Brugia malayi | MH2 domain containing protein | 0.0238 | 0.5834 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0525 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0269 | 0.0447 |
Schistosoma mansoni | coup transcription factor | 0.0029 | 0.0357 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0357 | 0.0611 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0357 | 0.0598 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.106 | 0.1818 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0357 | 0.0378 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0525 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0577 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0029 | 0.0357 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0357 | 0.0611 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0357 | 0.0611 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0008 | 0.0014 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.106 | 0.1806 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.3271 | 0.5601 |
Schistosoma mansoni | thyroid hormone receptor | 0.0396 | 1 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0525 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.106 | 0.1053 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0357 | 0.0598 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.106 | 0.1141 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0357 | 0.0349 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 0.0357 | 0.0349 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0357 | 0.0611 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0029 | 0.0357 | 0.0611 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0229 | 0.0393 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0357 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0357 | 0.0598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.