Detailed information for compound 21905

Basic information

Technical information
  • TDR Targets ID: 21905
  • Name: N-(1,10-phenanthrolin-2-yl)benzamide
  • MW: 299.326 | Formula: C19H13N3O
  • H donors: 1 H acceptors: 3 LogP: 3.63 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1ccc2c(n1)c1ncccc1cc2
  • InChi: 1S/C19H13N3O/c23-19(15-5-2-1-3-6-15)22-16-11-10-14-9-8-13-7-4-12-20-17(13)18(14)21-16/h1-12H,(H,21,22,23)
  • InChiKey: IMYKVLLBPSJPGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • AIDS-033092
  • AIDS033092
  • Benzamide, N-1,10-phenanthrolin-2-yl-
  • VUF8827

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.1662
Loa Loa (eye worm) DR-78 0.001 0.0011 0.0029
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0325
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0406 0.135
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0042 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0047 0.1662
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0002 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0042 0.1486
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0088 0.0273 0.0906
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0047 0.0151
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0151
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0216
Brugia malayi ecdysone receptor 0.001 0.0011 0.0325
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0014 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.1541
Entamoeba histolytica hypothetical protein, conserved 0.0088 0.0273 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.1662
Echinococcus granulosus dnaJ subfamily B 0.0412 0.1351 0.4507
Brugia malayi nuclear receptor RXR 0.0011 0.0014 0.0468
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0029
Toxoplasma gondii hypothetical protein 0.0088 0.0273 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0002 0.0001
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0088 0.0273 0.0906
Schistosoma mansoni zinc finger protein 0.001 0.0011 0.0029
Echinococcus granulosus cpg binding protein 0.0031 0.008 0.0262
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0014 0.0042
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0273 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0047 0.0151
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0047 0.0151
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0088 0.0273 0.0906
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0273 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0001
Trypanosoma cruzi glycerol uptake protein, putative 0.0088 0.0273 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0029
Schistosoma mansoni hypothetical protein 0.0088 0.0273 0.0906
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0042
Onchocerca volvulus 0.001 0.0011 0.0325
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0088 0.0273 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0014 0.0468
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0011 0.0029
Treponema pallidum alginate O-acetylation protein (algI) 0.0088 0.0273 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0088 0.0273 0.0906
Schistosoma mansoni sterol O-acyltransferase 1 0.0905 0.2995 1
Schistosoma mansoni cpg binding protein 0.0031 0.008 0.0262
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0029
Trichomonas vaginalis porcupine, putative 0.0088 0.0273 1
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 0.3005 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.1662
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0047 0.0151
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0088 0.0273 0.0906
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0088 0.0273 0.0906
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.1662
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0047 0.0151
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0047 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0151
Brugia malayi ecdysteroid receptor 0.0021 0.0047 0.1662
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0088 0.0273 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.1662
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0042
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0011 0.0325
Echinococcus granulosus o acyltransferase membrane bound domain 0.0088 0.0273 0.0906
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0088 0.0273 0.0906
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0047 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0047 0.1662
Brugia malayi diacylglycerol acyltransferase 0.0088 0.0273 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0088 0.0273 1
Brugia malayi MBOAT family protein 0.0088 0.0273 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0406 0.135
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0042
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0088 0.0273 0.0906
Brugia malayi MBOAT family protein 0.0088 0.0273 1
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0011 0.0029
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0088 0.0273 0.0906
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0151
Echinococcus multilocularis cpg binding protein 0.0031 0.008 0.0262
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0088 0.0273 0.0906
Brugia malayi nuclear hormone receptor 0.0021 0.0047 0.1662
Echinococcus multilocularis sterol O acyltransferase 1 0.0905 0.2995 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0047 0.0151
Echinococcus multilocularis microtubule associated protein 2 0.0703 0.2322 0.775
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.1662
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0011 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0047 0.0151
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.1541
Mycobacterium ulcerans histidinol dehydrogenase 0.3005 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0273 0.0906
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0047 0.0151
Entamoeba histolytica vacuolar protein sorting 26 0.0088 0.0273 1
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0011 0.0029
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0088 0.0273 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0075 0.0243
Loa Loa (eye worm) MBOAT family protein 0.0088 0.0273 0.0906
Leishmania major glycerol uptake protein, putative 0.0088 0.0273 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Leishmania major glycerol uptake protein, putative 0.0088 0.0273 1
Schistosoma mansoni cpg binding protein 0.0029 0.0075 0.0243
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.0474 0.1579
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0011 0.0325
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0088 0.0273 0.0906
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0014 0.0468
Leishmania major glycerol uptake protein, putative 0.0088 0.0273 1
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0011 0.0325
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0088 0.0273 0.0906
Brugia malayi hypothetical protein 0.001 0.0011 0.0325
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0325
Echinococcus granulosus sterol O acyltransferase 1 0.0905 0.2995 1
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0088 0.0273 0.0906
Brugia malayi nuclear receptor NHR-88 0.0021 0.0047 0.1662
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0047 0.1662
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0151
Entamoeba histolytica hypothetical protein 0.0088 0.0273 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0325
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0042
Trypanosoma cruzi GUP1, putative 0.0088 0.0273 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.1662
Brugia malayi nuclear receptor NHR-67 0.001 0.0011 0.0325
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0047 0.0151
Onchocerca volvulus 0.0029 0.0075 0.2685
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.1662
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Leishmania major glycerol uptake protein, putative 0.0088 0.0273 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.1662
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0135
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0151
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0088 0.0273 1
Trypanosoma brucei glycerol uptake protein, putative 0.0088 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0011 0.0325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0273 1
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0474 0.1579
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0011 0.0029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0011 0.0029
Brugia malayi tailless protein 0.001 0.0011 0.0325
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0088 0.0273 0.0906
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Trichomonas vaginalis transmembrane protein nessy, putative 0.0088 0.0273 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0011 0.0029
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0088 0.0273 0.0906
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Leishmania major hypothetical protein, conserved 0.0088 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.1662
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0047 0.1662
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0047 0.1662
Brugia malayi Hhat protein 0.0088 0.0273 1
Trypanosoma brucei glycerol uptake protein, putative 0.0088 0.0273 1
Schistosoma mansoni coup transcription factor 0.0021 0.0047 0.0151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0042 0.0135
Schistosoma mansoni microtubule-associated protein tau 0.0703 0.2322 0.775
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0151
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.1351 0.4507
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0047 0.0151
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0088 0.0273 1
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0088 0.0273 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.0151
Brugia malayi hypothetical protein 0.001 0.0011 0.0325
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0042 0.5
Onchocerca volvulus 0.0088 0.0273 1
Echinococcus granulosus microtubule associated protein 2 0.0703 0.2322 0.775
Brugia malayi steroid hormone receptor 0.0021 0.0047 0.1662
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0029
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0011 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.1662
Loa Loa (eye worm) hhat protein 0.0088 0.0273 0.0906
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0088 0.0273 0.0906
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0151
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0011 0.0325
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0088 0.0273 0.0906
Leishmania major glycerol uptake protein, putative 0.0088 0.0273 1
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0474 0.1579
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.1662
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Loa Loa (eye worm) hhat protein 0.0088 0.0273 0.0906
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0088 0.0273 0.0906
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0161 0.5143
Loa Loa (eye worm) hypothetical protein 0.0088 0.0273 0.0906
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0047 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.0151
Loa Loa (eye worm) hypothetical protein 0.0905 0.2995 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0008 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0042
Brugia malayi MBOAT family protein 0.0088 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0047 0.0151
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0047 0.1662
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0011 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0047 0.0151
Brugia malayi conserved hypotetical protein 0.001 0.0011 0.0325
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0047 0.0151
Brugia malayi hypothetical protein 0.0011 0.0014 0.0468
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0014 0.0042
Brugia malayi nuclear receptor RXR 0.001 0.0011 0.0325
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0151
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0014 0.0042
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0042 0.5
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0088 0.0273 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0047 0.0151
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0151
Schistosoma mansoni hypothetical protein 0.0128 0.0406 0.135
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0088 0.0273 0.0906
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0088 0.0273 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0183 0.0604
Brugia malayi MBOAT family protein 0.0088 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0029
Brugia malayi CXXC zinc finger family protein 0.0029 0.0075 0.2685
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0047 0.1662
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0029
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0011 0.0029
Onchocerca volvulus 0.001 0.0011 0.0325
Schistosoma mansoni zinc finger protein 0.0088 0.0273 0.0906
Trypanosoma cruzi GUP1, putative 0.0088 0.0273 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0151
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0088 0.0273 0.0906
Brugia malayi MBOAT family protein 0.0088 0.0273 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.0151
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0088 0.0273 0.0906
Brugia malayi hypothetical protein 0.0011 0.0014 0.0468
Onchocerca volvulus 0.0021 0.0047 0.1662
Schistosoma mansoni hypothetical protein 0.0412 0.1351 0.4507
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0088 0.0273 0.0906
Loa Loa (eye worm) MBOAT family protein 0.0088 0.0273 0.0906
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0029
Trypanosoma cruzi glycerol uptake protein, putative 0.0088 0.0273 1
Schistosoma mansoni cpg binding protein 0.0031 0.008 0.0262
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0042 0.0135
Loa Loa (eye worm) hypothetical protein 0.0816 0.2701 0.9016
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0011 0.0325
Echinococcus granulosus o acyltransferase membrane bound domain 0.0088 0.0273 0.0906
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0325
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0014 0.0042
Loa Loa (eye worm) MBOAT family protein 0.0088 0.0273 0.0906

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.023 uM Minimum inhibitory concentration measured against M. gallisepticum K514 in the presence of extra copper ChEMBL. 2002460
MIC (functional) > 100 uM Minimum inhibitory concentration measured against M. gallisepticum K514 in the absence of extra copper ChEMBL. 2002460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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