Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.008 | 0.032 | 0.057 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0502 | 0.0895 |
Schistosoma mansoni | ferritin light chain | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.019 | 0.0794 |
Echinococcus multilocularis | expressed protein | 0.002 | 0.0018 | 0.0032 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.002 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0132 | 0.0576 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0151 | 0.0672 | 0.9913 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.0165 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0209 | 0.0876 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.002 | 0.0018 | 0.0018 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.2027 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Schistosoma mansoni | smad | 0.0018 | 0.0011 | 0.002 |
Echinococcus granulosus | geminin | 0.039 | 0.186 | 0.3314 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0099 | 0.0413 | 0.0413 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0046 | 0.0147 | 0.0262 |
Echinococcus multilocularis | Protein lozenge | 0.0062 | 0.023 | 0.0409 |
Loa Loa (eye worm) | runx1 | 0.0062 | 0.023 | 0.0963 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0151 | 0.0672 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0151 | 0.0672 | 0.1197 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0171 | 0.0768 | 0.1369 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.1197 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.186 | 0.3314 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0052 | 0.0179 | 0.1551 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0286 | 0.051 |
Trichomonas vaginalis | ferritin, putative | 0.002 | 0.0018 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0011 | 0.0048 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Echinococcus multilocularis | dnaJ subfamily B | 0.1145 | 0.5614 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0132 | 0.0576 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0089 | 0.0158 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0042 | 0.013 | 0.0544 |
Brugia malayi | jmjC domain containing protein | 0.0046 | 0.0147 | 0.0616 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Echinococcus granulosus | ferritin | 0.002 | 0.0018 | 0.0032 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0151 | 0.0672 | 0.0672 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Schistosoma mansoni | ferritin light chain | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.0772 | 0.3232 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0124 | 0.0221 |
Brugia malayi | MH2 domain containing protein | 0.0269 | 0.1257 | 0.5266 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0089 | 0.0158 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Brugia malayi | PAS domain containing protein | 0.0049 | 0.0165 | 0.0691 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.186 | 0.3314 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0101 | 0.0181 |
Echinococcus granulosus | expressed protein | 0.002 | 0.0018 | 0.0032 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0089 | 0.0158 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Schistosoma mansoni | apoferritin-2 | 0.002 | 0.0018 | 0.0032 |
Echinococcus granulosus | smad | 0.0018 | 0.0011 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0741 | 0.3103 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0011 | 0.0048 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0155 | 0.0276 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.019 | 0.0338 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.1583 | 0.7789 | 0.7789 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0132 | 0.0576 | 0.1025 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0772 | 0.3232 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0286 | 0.12 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.019 | 0.0794 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.013 | 0.0231 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.019 | 0.0338 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0049 | 0.0857 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0286 | 0.12 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0286 | 0.12 |
Brugia malayi | Smad1 | 0.0018 | 0.0011 | 0.0048 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0846 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.013 | 0.0231 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0672 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0918 | 0.4484 | 0.7988 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Mycobacterium leprae | Isocitrate lyase | 0.095 | 0.4645 | 0.4645 |
Loa Loa (eye worm) | histone methyltransferase | 0.0025 | 0.0044 | 0.0184 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.0472 | 0.1978 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.0089 | 0.0372 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.2027 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.008 | 0.032 | 0.1341 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.002 | 0.0035 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0155 | 0.0276 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0099 | 0.0413 | 0.0413 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.0772 | 0.3232 |
Onchocerca volvulus | 0.0036 | 0.0101 | 0.0055 | |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0046 | 0.0147 | 0.0262 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0672 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0215 | 0.09 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0089 | 0.0158 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.013 | 0.0544 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0011 | 0.0048 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0215 | 0.09 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0025 | 0.0044 | 0.0078 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0268 | 0.1124 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0286 | 0.12 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.019 | 0.0338 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.2027 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0152 | 0.0678 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.019 | 0.0338 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.1197 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0846 |
Brugia malayi | hypothetical protein | 0.0165 | 0.0741 | 0.3103 |
Brugia malayi | Probable ClpP-like protease | 0.0151 | 0.0672 | 0.2814 |
Echinococcus granulosus | peregrin | 0.0034 | 0.0089 | 0.0158 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0101 | 0.0181 |
Echinococcus granulosus | dnaJ subfamily B | 0.1145 | 0.5614 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0179 | 0.2645 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0502 | 0.2104 |
Schistosoma mansoni | hypothetical protein | 0.1145 | 0.5614 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0052 | 0.0179 | 0.1551 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.019 | 0.0794 |
Chlamydia trachomatis | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0101 | 0.0425 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.2027 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0298 | 0.1401 | 0.1401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.0772 | 0.3232 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.1025 |
Onchocerca volvulus | 0.008 | 0.032 | 0.1006 | |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2388 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.002 | 0.0035 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0269 | 0.1257 | 0.5266 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.002 | 0.002 | 0.0035 |
Brugia malayi | CXXC zinc finger family protein | 0.008 | 0.032 | 0.1341 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.0472 | 0.0841 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.0472 | 0.0841 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0151 | 0.0672 | 0.9913 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0049 | 0.0207 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.002 | 0.0018 | 0.0018 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0089 | 0.1311 |
Mycobacterium ulcerans | hypothetical protein | 0.0298 | 0.1401 | 0.1401 |
Brugia malayi | hypoxia-induced factor 1 | 0.0152 | 0.0677 | 0.2837 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.0101 | 0.0101 |
Giardia lamblia | PHD finger protein 15 | 0.0034 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0672 | 0.2814 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0031 | 0.0075 | 0.0133 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0286 | 0.051 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0099 | 0.0413 | 0.0413 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0046 | 0.0147 | 0.0262 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.1575 | 0.775 | 1 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0089 | 0.0372 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0011 | 0.002 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 1 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.019 | 0.0338 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0099 | 0.0413 | 0.0736 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0286 | 0.12 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.002 | 0.0018 | 0.0018 |
Schistosoma mansoni | single-minded | 0.0049 | 0.0165 | 0.0294 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.002 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0046 | 0.0147 | 0.0616 |
Brugia malayi | hypothetical protein | 0.0496 | 0.2388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.019 | 0.0794 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 0.775 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.2027 | 1 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.1583 | 0.7789 | 0.7789 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) | 0.1583 | 0.7789 | 0.7789 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Schistosoma mansoni | apoferritin-2 | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0286 | 0.12 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0089 | 0.0372 |
Echinococcus multilocularis | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0025 | 0.0044 | 0.0078 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.0359 | 0.0639 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0099 | 0.0413 | 0.0736 |
Schistosoma mansoni | lozenge | 0.0062 | 0.023 | 0.0409 |
Echinococcus multilocularis | ferritin | 0.002 | 0.0018 | 0.0032 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.8492 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0036 | 0.0098 | 0.0408 |
Mycobacterium ulcerans | error-prone DNA polymerase | 0.1575 | 0.775 | 0.775 |
Echinococcus multilocularis | smad | 0.0018 | 0.0011 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2388 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.019 | 0.0338 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.013 | 0.0231 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.0089 | 0.0158 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0011 | 0.002 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0052 | 0.0179 | 0.0179 |
Onchocerca volvulus | 0.0496 | 0.2388 | 1 | |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0152 | 0.0677 | 0.2837 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0052 | 0.0179 | 0.0209 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.0502 | 0.2104 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0011 | 0.002 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.0049 | 0.0049 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.013 | 0.0231 |
Echinococcus multilocularis | geminin | 0.039 | 0.186 | 0.3314 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0089 | 0.0372 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0269 | 0.1257 | 0.5266 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.002 | 0.002 | 0.0035 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0089 | 0.1311 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 100000 nM | BindingDB_Patents: Enzyme Assay. The aim of this study was to evaluate TK-112690 in vivo as an inhibitor of uridine phosphorylase (UPase) enzyme activity. The range of TK-112690 doses studied for ability to prevent metabolic breakdown of uridine, through the in vitro inhibition of mouse and human small intestinal UPase enzyme, was 0, 0.1, 0.5, 1, 5, 10, 50, 100, 500, 1000, 5000 and 10000 uM). Detection of UPase activity was determined by HPLC analysis using UV detection of uracil concentration (UPase catabolizes uridine into uracil and ribose-1-phosphate).The UPase enzyme material was prepared from homogenized mouse and human being small intestinal tissue. TK-112690 was dissolved in water (50 mg/ml) and analyzed for UPase inhibition in aqueous solution containing 5 mM uridine, 0.01 M Tris, 0.01 M phosphate, 1 mM EDTA, and 1 mM DTT. Reactions were performed at 37 C. at pH of 7.3.TK-11260 inhibition of mouse and human UPase was analyzed by reverse phase HPLC using UV detection. | ChEMBL. | No reference |
IC50 (binding) | < 100000 nM | BindingDB_Patents: Enzyme Assay. The aim of this study was to evaluate TK-112690 in vivo as an inhibitor of uridine phosphorylase (UPase) enzyme activity. The range of TK-112690 doses studied for ability to prevent metabolic breakdown of uridine, through the in vitro inhibition of mouse and human small intestinal UPase enzyme, was 0, 0.1, 0.5, 1, 5, 10, 50, 100, 500, 1000, 5000 and 10000 uM). Detection of UPase activity was determined by HPLC analysis using UV detection of uracil concentration (UPase catabolizes uridine into uracil and ribose-1-phosphate).The UPase enzyme material was prepared from homogenized mouse and human being small intestinal tissue. TK-112690 was dissolved in water (50 mg/ml) and analyzed for UPase inhibition in aqueous solution containing 5 mM uridine, 0.01 M Tris, 0.01 M phosphate, 1 mM EDTA, and 1 mM DTT. Reactions were performed at 37 C. at pH of 7.3.TK-11260 inhibition of mouse and human UPase was analyzed by reverse phase HPLC using UV detection. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.