TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 463.527 | Formula: C29H25N3O3
H donors: 2 H acceptors: 4 LogP: 5.02 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc2c(c1)n(Cc1ccc3c(n1)cccc3)cc2C)NCCc1ccc(cc1)C(=O)O
InChi: 1S/C29H25N3O3/c1-19-17-32(18-24-12-10-21-4-2-3-5-26(21)31-24)27-16-23(11-13-25(19)27)28(33)30-15-14-20-6-8-22(9-7-20)29(34)35/h2-13,16-17H,14-15,18H2,1H3,(H,30,33)(H,34,35)
InChiKey: FZIFQZJGCBRYHJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0112	0.0648	0.4498
Schistosoma mansoni	hypothetical protein	0.0018	0.0073	0.0483
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0123	0.0307
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0008	0.0008	0.0047
Schistosoma mansoni	DNA ligase IV	0.0011	0.0028	0.017
Onchocerca volvulus		0.0008	0.0008	0.051
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0123	0.085
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0008	0.0047
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0028	0.0186
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0011	0.0028	0.0186
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.0251	0.0658
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.024	0.1436	0.9232
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0008	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0316	0.2195
Mycobacterium ulcerans	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0083	0.0473	0.1238
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0028	0.0024
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0008	0.0047
Onchocerca volvulus		0.0027	0.0123	0.9137
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0073	0.0499
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0008	0.0054
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0008	0.0018
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, putative	0.0083	0.0473	0.3003
Trypanosoma cruzi	FHA domain containing protein, putative	0.0011	0.0028	0.0128
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.024	0.1436	0.9232
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0073	0.0499
Echinococcus multilocularis	nibrin	0.0011	0.0028	0.0024
Wolbachia endosymbiont of Brugia malayi	deoxycytidine triphosphate deaminase	0.0083	0.0473	0.3158
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0028	0.0181
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.024	0.1436	0.9232
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0181
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0316	0.2194
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0123	0.0745
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0123	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0008	0.0047
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.024	0.1436	0.9232
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0008	0.0018
Echinococcus multilocularis	neuropeptide s receptor	0.0482	0.2924	0.2921
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0123	0.0745
Entamoeba histolytica	deoxycytidine triphosphate deaminase, putative	0.0083	0.0473	0.3003
Giardia lamblia	Thymidine kinase	0.026	0.1555	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0563
Trypanosoma cruzi	thymidine kinase, putative	0.026	0.1555	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0241	0.1653
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0008	0.0008	0.0047
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0028	0.017
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0563
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0275	0.0722
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0008	0.0012
Schistosoma mansoni	hypothetical protein	0.004	0.0204	0.1395
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0181
Echinococcus granulosus	Niemann Pick C1 protein	0.0158	0.0928	0.2462
Schistosoma mansoni	topbp1	0.0011	0.0028	0.017
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0123	0.0307
Brugia malayi	dUTP diphosphatase	0.024	0.1436	1
Entamoeba histolytica	hypothetical protein	0.0011	0.0028	0.0128
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0008	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0316	0.2194
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0175	0.1032	0.2744
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0275	0.1894
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0123	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0073	0.0499
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0028	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0123	0.085
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0082	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0181
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0217	0.149
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0028	0.0181
Brugia malayi	Niemann-Pick C1 protein precursor	0.011	0.0638	0.4433
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0123	0.0307
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0008	0.0047
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0135	0.0931
Echinococcus granulosus	dUTP pyrophosphatase	0.024	0.1436	0.3815
Echinococcus granulosus	GPCR family 2	0.0018	0.0073	0.0184
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.0251	0.1739
Mycobacterium leprae	PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	0.0083	0.0473	0.4535
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0028	0.0128
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0014	0.0011
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0008	0.0047
Entamoeba histolytica	hypothetical protein	0.0042	0.0217	0.1351
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0008	0.0047
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0028	0.0128
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0008	0.0005
Leishmania major	thymidine kinase, putative	0.026	0.1555	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0123	0.0307
Entamoeba histolytica	hypothetical protein	0.0042	0.0217	0.1351
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0181
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0563
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0014	0.0028
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0186
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0082	0.0197
Onchocerca volvulus		0.0028	0.0135	1
Echinococcus granulosus	cpg binding protein	0.003	0.0145	0.0376
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0008	0.0008	0.0047
Brugia malayi	hypothetical protein	0.0042	0.0217	0.1504
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0123	0.085
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0135	0.0931
Echinococcus multilocularis	protein patched	0.0047	0.0251	0.0247
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0028	0.0128
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0028	0.0128
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0028	0.0186
Trichomonas vaginalis	thymidine kinase, putative	0.026	0.1555	1
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0028	0.0186
Schistosoma mansoni	hypothetical protein	0.0042	0.0217	0.149
Schistosoma mansoni	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.024	0.1436	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0082	0.0563
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0123	0.0307
Schistosoma mansoni	hypothetical protein	0.0046	0.0241	0.1653
Toxoplasma gondii	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.024	0.1436	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0275	0.1894
Entamoeba histolytica	hypothetical protein	0.0042	0.0217	0.1351
Entamoeba histolytica	hypothetical protein	0.0042	0.0217	0.1351
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0008	0.0018
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0082	0.0563
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0123	0.0324
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0014	0.009
Wolbachia endosymbiont of Brugia malayi	dUTPase	0.024	0.1436	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.011	0.0638	0.0634
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0123	0.085
Mycobacterium ulcerans	deoxycytidine triphosphate deaminase	0.0083	0.0473	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0008	0.0047
Onchocerca volvulus		0.0008	0.0008	0.051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0275	0.0271
Echinococcus multilocularis	Niemann Pick C1 protein	0.0158	0.0928	0.0925
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0014	0.0085
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.024	0.1436	0.9232
Trichomonas vaginalis	thymidine kinase, putative	0.026	0.1555	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0316	0.2194
Schistosoma mansoni	hypothetical protein	0.0046	0.0241	0.1653
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0291	0.2019
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0076	0.0197
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0123	0.0745
Entamoeba histolytica	thymidine kinase, putative	0.026	0.1555	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0028	0.0181
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0123	0.0745
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0073	0.0069
Schistosoma mansoni	cpg binding protein	0.003	0.0145	0.0985
Onchocerca volvulus		0.0008	0.0008	0.051
Echinococcus granulosus	neuropeptide s receptor	0.0482	0.2924	0.7778
Echinococcus multilocularis	thymidine phosphorylase	0.0618	0.3758	0.3756
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0316	0.2194
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0073	0.0069
Echinococcus granulosus	thymidine phosphorylase	0.0618	0.3758	1
Schistosoma mansoni	cpg binding protein	0.003	0.0145	0.0985
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0082	0.0384
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0008	0.0018
Mycobacterium tuberculosis	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)	0.0083	0.0473	0.1254
Echinococcus multilocularis	protein dispatched 1	0.0054	0.0292	0.0288
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0008	0.0018
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0618	0.3758	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0241	0.1653
Brugia malayi	CHE-14 protein	0.0047	0.0251	0.1739
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0275	0.1894
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0175	0.1032	0.2731
Entamoeba histolytica	hypothetical protein	0.0157	0.0924	0.592
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0011	0.0028	0.0053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0275	0.0271
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0123	0.1125
Plasmodium falciparum	replication factor C subunit 1, putative	0.0011	0.0028	0.0186
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0076	0.0197
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0028	0.0181
Plasmodium vivax	replication factor C subunit 1, putative	0.0011	0.0028	0.0186
Schistosoma mansoni	cpg binding protein	0.0028	0.0135	0.0916
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0076	0.0197
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0204	0.1409
Schistosoma mansoni	topbp1	0.0011	0.0028	0.017
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0008	0.0018
Onchocerca volvulus		0.0011	0.0028	0.1996
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0563
Echinococcus granulosus	neuropeptide receptor A26	0.0482	0.2924	0.7778
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0186
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0076	0.0197
Plasmodium vivax	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.024	0.1436	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0073	0.0483
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0251	0.1614
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0186
Onchocerca volvulus		0.0008	0.0008	0.051
Toxoplasma gondii	propionate-CoA ligase	0.0008	0.0008	0.0047
Loa Loa (eye worm)	dUTP diphosphatase	0.024	0.1436	1
Trypanosoma brucei	thymidine kinase	0.026	0.1555	1
Chlamydia trachomatis	deoxycytidine triphosphate deaminase	0.0083	0.0473	0.3158
Plasmodium falciparum	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.024	0.1436	1
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0028	0.0186
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0275	0.1907
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0028	0.0128
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0008	0.0018
Entamoeba histolytica	hypothetical protein	0.0157	0.0924	0.592
Loa Loa (eye worm)	hypothetical protein	0.004	0.0204	0.1409
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0175	0.1032	1
Treponema pallidum	deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)	0.024	0.1436	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0008	0.0047
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0008	0.0047
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0073	0.0069
Trichomonas vaginalis	thymidine kinase, putative	0.026	0.1555	1
Entamoeba histolytica	hypothetical protein	0.024	0.1436	0.9232
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0008	0.0047
Chlamydia trachomatis	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.024	0.1436	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0008	0.0031
Echinococcus multilocularis	cpg binding protein	0.003	0.0145	0.0141
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0186
Entamoeba histolytica	hypothetical protein	0.0083	0.0473	0.3003
Brugia malayi	topoisomerase	0.0011	0.0028	0.0186
Echinococcus granulosus	expressed conserved protein	0.0104	0.0596	0.1578
Trypanosoma cruzi	thymidine kinase, putative	0.026	0.1555	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0123	0.085
Schistosoma mansoni	hypothetical protein	0.0018	0.0073	0.0483
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0123	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0186
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.0251	0.0658
Schistosoma mansoni	hypothetical protein	0.0018	0.0073	0.0483
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0008	0.0008	0.0047
Trichomonas vaginalis	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.024	0.1436	0.9236
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0217	0.0568
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0073	0.0499
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0123	0.0307
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0123	0.0307
Echinococcus granulosus	Niemann Pick C1 protein	0.011	0.0638	0.1688
Echinococcus multilocularis	dUTP pyrophosphatase	0.024	0.1436	0.1433
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0028	0.0181
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.0251	0.0247
Schistosoma mansoni	patched 1	0.0047	0.0251	0.1726
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0008	0.0018
Entamoeba histolytica	hypothetical protein	0.024	0.1436	0.9232
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0123	0.085
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0251	0.1739
Echinococcus multilocularis	expressed conserved protein	0.0104	0.0596	0.0593
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0123	0.0745
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0275	0.0722
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0275	0.1907
Mycobacterium ulcerans	thymidine phosphorylase	0.0618	0.3758	1
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.024	0.1436	0.9232
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0186
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0073	0.0184
Loa Loa (eye worm)	hypothetical protein	0.011	0.0638	0.4433
Echinococcus granulosus	nibrin	0.0011	0.0028	0.0065
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0331	0.2282
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0008	0.0018
Echinococcus multilocularis	neuropeptide receptor A26	0.0482	0.2924	0.2921
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.011	0.0638	0.4069
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0008	0.0018
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0186
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0008	0.0008	0.0047
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0011	0.0028	0.0194
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0073	0.0184
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0217	0.0213
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0123	0.1125

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	0 nM	In vitro binding affinity towards Cysteinyl leukotriene D4 receptor by using [3H]-LTD4 binding assay in guinea pig lung membranes; IA means inactive	ChEMBL.	10669566

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 224733