Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0102 | 0.0102 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.2846 | 0.2916 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0439 | 0.0392 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1848 | 0.1848 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0088 | 0.2846 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0088 | 0.2846 | 0.4322 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6584 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1848 | 0.1848 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0439 | 0.0392 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1848 | 0.1848 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0088 | 0.2846 | 0.4322 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0223 | 0.8693 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0439 | 0.0392 |
Echinococcus multilocularis | geminin | 0.0174 | 0.6584 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0088 | 0.2846 | 0.3194 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0653 | 0.0992 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Echinococcus granulosus | geminin | 0.0174 | 0.6584 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0088 | 0.2846 | 0.4322 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0439 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1848 | 0.1848 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2846 | 0.2846 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0542 | 0.0542 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0102 | 0.0102 |
Onchocerca volvulus | Huntingtin homolog | 0.0253 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0088 | 0.2846 | 0.4322 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0088 | 0.2846 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0223 | 0.8693 | 0.8693 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0439 | 0.0392 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.3194 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0439 | 0.0392 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1246 | 0.1246 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0088 | 0.2846 | 0.3266 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.8693 | 0.8693 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2846 | 0.2846 |
Mycobacterium ulcerans | hypothetical protein | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1246 | 0.1246 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1848 | 0.1848 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0439 | 0.1228 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.1848 | 0.2807 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.2916 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0542 | 0.0823 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0653 | 0.0992 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.2846 | 0.2916 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0439 | 0.0439 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0223 | 0.8693 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0088 | 0.2846 | 0.4322 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0542 | 0.0542 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0439 | 0.0439 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0439 | 0.1228 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Onchocerca volvulus | Huntingtin homolog | 0.0253 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0088 | 0.2846 | 0.4322 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.001 | 0.001 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0439 | 0.0392 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0088 | 0.2846 | 0.3194 |
Onchocerca volvulus | 0.0088 | 0.2846 | 0.2846 | |
Entamoeba histolytica | hypothetical protein | 0.0088 | 0.2846 | 0.3266 |
Plasmodium vivax | polyprenol reductase, putative | 0.0088 | 0.2846 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0653 | 0.0992 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0439 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1246 | 0.1246 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6584 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0088 | 0.2846 | 0.3266 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.3194 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0653 | 0.0992 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.014 | 0.0213 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0653 | 0.0653 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1848 | 0.2807 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0439 | 0.0392 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0088 | 0.2846 | 0.2846 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1246 | 0.1246 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1848 | 0.1848 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0439 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP (ADMET) | = 3.89 | Partition coefficient of the compound | ChEMBL. | 1331457 |
ED50 (functional) | = 4 mg kg-1 | Dose of the compound required to induce convulsions in 50% of the mice.(In vivo convulsant activity.) | ChEMBL. | 1331457 |
IC50 (binding) | = 1 nM | In vitro affinity at the Benzodiazepine receptor (BzR) is its ability to displace [3H]-diazepam from BzR. | ChEMBL. | 1331457 |
S | < 0.2 mg ml-1 | Solubility of the compound in water. | ChEMBL. | 1331457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.