Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0174 | 0.6584 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6584 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1848 | 0.1848 |
Echinococcus granulosus | geminin | 0.0174 | 0.6584 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0088 | 0.2846 | 0.4322 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0439 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0223 | 0.8693 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1848 | 0.1848 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.3194 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0088 | 0.2846 | 0.4322 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0088 | 0.2846 | 0.3266 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0088 | 0.2846 | 0.4322 |
Onchocerca volvulus | Huntingtin homolog | 0.0253 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0542 | 0.0823 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0439 | 0.0392 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1848 | 0.1848 |
Entamoeba histolytica | hypothetical protein | 0.0088 | 0.2846 | 0.3266 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0439 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0653 | 0.0992 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0439 | 0.0392 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0653 | 0.0992 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0088 | 0.2846 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1848 | 0.2807 |
Mycobacterium ulcerans | hypothetical protein | 0.0223 | 0.8693 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1848 | 0.1848 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.001 | 0.001 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0223 | 0.8693 | 0.8693 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0439 | 0.0439 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1246 | 0.1246 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1246 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0542 | 0.0542 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1246 | 0.1246 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6584 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0253 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0439 | 0.1228 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.1848 | 0.2807 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0439 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2846 | 0.2846 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0439 | 0.0392 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0223 | 0.8693 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0439 | 0.0439 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0088 | 0.2846 | 0.3194 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0439 | 0.0392 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0102 | 0.0102 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1848 | 0.1848 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.3194 |
Plasmodium vivax | polyprenol reductase, putative | 0.0088 | 0.2846 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0088 | 0.2846 | 1 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0439 | 0.0392 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.8693 | 0.8693 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.001 | 0.001 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0439 | 0.0392 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0653 | 0.0992 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0542 | 0.0542 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0088 | 0.2846 | 0.4322 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0088 | 0.2846 | 0.2846 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.2846 | 0.2916 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 1 |
Onchocerca volvulus | 0.0088 | 0.2846 | 0.2846 | |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0223 | 0.8693 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0088 | 0.2846 | 0.4322 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0439 | 0.1228 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1246 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2846 | 0.2846 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0088 | 0.2846 | 0.4322 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.2846 | 0.2916 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0439 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0102 | 0.0102 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0223 | 0.8693 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0653 | 0.0992 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.014 | 0.0213 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0653 | 0.0653 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0088 | 0.2846 | 0.3266 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0088 | 0.2846 | 0.3194 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1848 | 0.1848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP (ADMET) | = 3.89 | Partition coefficient of the compound | ChEMBL. | 1331457 |
ED50 (functional) | = 4 mg kg-1 | Dose of the compound required to induce convulsions in 50% of the mice.(In vivo convulsant activity.) | ChEMBL. | 1331457 |
IC50 (binding) | = 1 nM | In vitro affinity at the Benzodiazepine receptor (BzR) is its ability to displace [3H]-diazepam from BzR. | ChEMBL. | 1331457 |
S | < 0.2 mg ml-1 | Solubility of the compound in water. | ChEMBL. | 1331457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.