Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0439 | 0.0439 |
Mycobacterium ulcerans | hypothetical protein | 0.0223 | 0.8693 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0653 | 0.0992 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0088 | 0.2846 | 0.4322 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1246 | 0.1246 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Echinococcus multilocularis | geminin | 0.0174 | 0.6584 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1848 | 0.1848 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1848 | 0.1848 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0653 | 0.0992 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0088 | 0.2846 | 0.3266 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.2846 | 0.2916 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0088 | 0.2846 | 0.4322 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1848 | 0.1848 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0439 | 0.0392 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.3194 |
Onchocerca volvulus | Huntingtin homolog | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2846 | 0.2846 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0439 | 0.0392 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.2916 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Plasmodium vivax | polyprenol reductase, putative | 0.0088 | 0.2846 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0439 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0653 | 0.0992 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.8693 | 0.8693 |
Entamoeba histolytica | hypothetical protein | 0.0088 | 0.2846 | 0.3266 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0088 | 0.2846 | 0.4322 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.001 | 0.001 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.1848 | 0.2807 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1246 | 0.1246 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2846 | 0.2846 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0653 | 0.0992 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0439 | 0.0392 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0088 | 0.2846 | 0.3194 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0088 | 0.2846 | 0.4322 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1848 | 0.2807 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6584 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1848 | 0.1848 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.001 | 0.001 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0223 | 0.8693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0542 | 0.0823 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0088 | 0.2846 | 0.2846 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0102 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.6584 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 0.3194 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Onchocerca volvulus | Huntingtin homolog | 0.0253 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0439 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0088 | 0.2846 | 0.4322 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0542 | 0.0542 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0439 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0439 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0439 | 0.1228 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1848 | 0.1848 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0088 | 0.2846 | 0.3194 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0439 | 0.0392 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0088 | 0.2846 | 0.2916 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0223 | 0.8693 | 0.8693 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0439 | 0.1228 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0102 | 0.0102 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0088 | 0.2846 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1246 | 0.1246 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0439 | 0.0666 |
Echinococcus granulosus | geminin | 0.0174 | 0.6584 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0088 | 0.2846 | 0.4322 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0223 | 0.8693 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1848 | 0.1848 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0542 | 0.0542 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.014 | 0.0213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1848 | 0.2807 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0439 | 0.0392 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0653 | 0.0653 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0088 | 0.2846 | 0.3266 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1246 | 0.1246 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0088 | 0.2846 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0653 | 0.0741 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0223 | 0.8693 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0223 | 0.8693 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0439 | 0.0439 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0088 | 0.2846 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0439 | 0.0392 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.2846 | 0.2916 |
Onchocerca volvulus | 0.0088 | 0.2846 | 0.2846 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP (ADMET) | = 3.89 | Partition coefficient of the compound | ChEMBL. | 1331457 |
ED50 (functional) | = 4 mg kg-1 | Dose of the compound required to induce convulsions in 50% of the mice.(In vivo convulsant activity.) | ChEMBL. | 1331457 |
IC50 (binding) | = 1 nM | In vitro affinity at the Benzodiazepine receptor (BzR) is its ability to displace [3H]-diazepam from BzR. | ChEMBL. | 1331457 |
S | < 0.2 mg ml-1 | Solubility of the compound in water. | ChEMBL. | 1331457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.