Detailed information for compound 232693

Basic information

Technical information
  • TDR Targets ID: 232693
  • Name: ethyl 3-(3-carbamimidoylphenyl)-2-[[2-[(4-car bamothioylphenyl)sulfonylamino]acetyl]amino]p ropanoate
  • MW: 491.584 | Formula: C21H25N5O5S2
  • H donors: 3 H acceptors: 4 LogP: 1.6 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(Cc1cccc(c1)C(=N)N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C(=N)S
  • InChi: 1S/C21H25N5O5S2/c1-2-31-21(28)17(11-13-4-3-5-15(10-13)19(22)23)26-18(27)12-25-33(29,30)16-8-6-14(7-9-16)20(24)32/h3-10,17,25H,2,11-12H2,1H3,(H3,22,23)(H2,24,32)(H,26,27)
  • InChiKey: YFHANJZAFYUYQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-carbamimidoylphenyl)-2-[[2-[(4-carbamothioylphenyl)sulfonylamino]-1-oxoethyl]amino]propanoic acid ethyl ester
  • ethyl 3-(3-carbamimidoylphenyl)-2-[2-[(4-carbamothioylphenyl)sulfonylamino]ethanoylamino]propanoate
  • 3-(3-amidinophenyl)-2-[[2-[(4-thiocarbamoylphenyl)sulfonylamino]acetyl]amino]propionic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Coagulation factor X Starlite/ChEMBL References
Homo sapiens kallikrein B, plasma (Fletcher factor) 1 Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References
Bos taurus Trypsin II Starlite/ChEMBL References
Bos taurus Thrombin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster CG33465 gene product from transcript CG33465-RC Trypsin II   247 aa 203 aa 20.7 %
Onchocerca volvulus Trypsin II   247 aa 258 aa 22.9 %
Schistosoma mansoni aminopeptidase PILS (M01 family) Trypsin II   247 aa 298 aa 24.5 %
Drosophila melanogaster Jonah 65Aii Trypsin II   247 aa 237 aa 35.4 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin II   247 aa 247 aa 34.0 %
Drosophila melanogaster CG13744 gene product from transcript CG13744-RA Trypsin II   247 aa 250 aa 31.6 %
Drosophila melanogaster CG32277 gene product from transcript CG32277-RA Trypsin II   247 aa 240 aa 32.9 %
Drosophila melanogaster Jonah 99Ci Trypsin II   247 aa 268 aa 32.5 %
Drosophila melanogaster CG3916 gene product from transcript CG3916-RA Trypsin II   247 aa 257 aa 33.5 %
Drosophila melanogaster CG17239 gene product from transcript CG17239-RB Trypsin II   247 aa 224 aa 34.4 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin II   247 aa 217 aa 23.0 %
Drosophila melanogaster CG11313 gene product from transcript CG11313-RC Trypsin II   247 aa 223 aa 33.2 %
Drosophila melanogaster CG4914 gene product from transcript CG4914-RA Trypsin II   247 aa 244 aa 37.3 %
Drosophila melanogaster CG31267 gene product from transcript CG31267-RA Trypsin II   247 aa 263 aa 32.7 %
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Trypsin II   247 aa 303 aa 24.8 %
Echinococcus multilocularis Mastin Trypsin II   247 aa 306 aa 25.5 %
Onchocerca volvulus Trypsin II   247 aa 257 aa 26.5 %
Drosophila melanogaster Jonah 66Ci Trypsin II   247 aa 237 aa 30.4 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin II   247 aa 239 aa 22.2 %
Echinococcus multilocularis transmembrane protease serine 3 Trypsin II   247 aa 233 aa 34.8 %
Drosophila melanogaster CG31220 gene product from transcript CG31220-RB Trypsin II   247 aa 224 aa 29.5 %
Drosophila melanogaster CG18420 gene product from transcript CG18420-RA Trypsin II   247 aa 233 aa 28.3 %
Drosophila melanogaster CG9673 gene product from transcript CG9673-RB Trypsin II   247 aa 258 aa 26.4 %
Echinococcus multilocularis enteropeptidase Trypsin II   247 aa 227 aa 26.0 %
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) Trypsin II   247 aa 287 aa 27.2 %
Echinococcus granulosus transmembrane protease serine 3 Trypsin II   247 aa 233 aa 34.3 %
Echinococcus granulosus Mastin Trypsin II   247 aa 306 aa 25.2 %
Schistosoma japonicum Transmembrane protease, serine 9, putative Trypsin II   247 aa 246 aa 24.8 %
Drosophila melanogaster Spatzle-Processing Enzyme Trypsin II   247 aa 269 aa 27.5 %
Drosophila melanogaster CG14990 gene product from transcript CG14990-RA Trypsin II   247 aa 238 aa 30.2 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin II   247 aa 302 aa 25.5 %
Drosophila melanogaster CG30287 gene product from transcript CG30287-RA Trypsin II   247 aa 251 aa 27.1 %
Drosophila melanogaster CG9733 gene product from transcript CG9733-RB Trypsin II   247 aa 262 aa 31.3 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin II   247 aa 217 aa 23.0 %
Drosophila melanogaster CG3505 gene product from transcript CG3505-RA Trypsin II   247 aa 236 aa 30.1 %
Drosophila melanogaster CG33458 gene product from transcript CG33458-RA Trypsin II   247 aa 255 aa 29.4 %
Echinococcus granulosus enteropeptidase Trypsin II   247 aa 227 aa 26.4 %
Echinococcus multilocularis glycoprotein Antigen 5 Trypsin II   247 aa 302 aa 23.2 %
Drosophila melanogaster CG5909 gene product from transcript CG5909-RA Trypsin II   247 aa 257 aa 28.8 %
Drosophila melanogaster CG30288 gene product from transcript CG30288-RC Trypsin II   247 aa 248 aa 28.6 %
Drosophila melanogaster CG10405 gene product from transcript CG10405-RB Trypsin II   247 aa 254 aa 33.1 %
Schistosoma japonicum ko:K09637 transmembrane protease, serine 6, putative Trypsin II   247 aa 242 aa 29.8 %
Drosophila melanogaster CG31326 gene product from transcript CG31326-RA Trypsin II   247 aa 249 aa 23.7 %
Drosophila melanogaster CG30323 gene product from transcript CG30323-RB Trypsin II   247 aa 212 aa 23.6 %
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family Trypsin II   247 aa 287 aa 27.2 %
Drosophila melanogaster CG30083 gene product from transcript CG30083-RB Trypsin II   247 aa 205 aa 30.2 %
Drosophila melanogaster CG4815 gene product from transcript CG4815-RA Trypsin II   247 aa 208 aa 27.4 %
Drosophila melanogaster CG34436 gene product from transcript CG34436-RA Trypsin II   247 aa 213 aa 24.9 %
Drosophila melanogaster CG18180 gene product from transcript CG18180-RA Trypsin II   247 aa 234 aa 31.2 %
Schistosoma japonicum Enteropeptidase, putative Trypsin II   247 aa 267 aa 26.2 %
Echinococcus granulosus glycoprotein Antigen 5 Trypsin II   247 aa 301 aa 22.3 %
Drosophila melanogaster Jonah 65Aiii Trypsin II   247 aa 238 aa 32.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Protein patched homolog 1 0.0041 0.026 0.0647
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0124 0.0282
Loa Loa (eye worm) hypothetical protein 0.0098 0.0987 0.2246
Echinococcus multilocularis sodium channel protein 0.0022 0.0011 0.0011
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0135 0.0135
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0135 0.0335
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0022 0.0011 0.0025
Schistosoma mansoni P2X receptor subunit 0.0066 0.0574 0.1429
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Leishmania major hypothetical protein, conserved 0.0022 0.0011 0.0524
Schistosoma mansoni P2X receptor subunit 0.0066 0.0574 0.1429
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0135 0.0335
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0011 0.0011
Schistosoma mansoni calcium-activated potassium channel 0.0022 0.0011 0.0027
Echinococcus multilocularis voltage dependent calcium channel 0.0022 0.0011 0.0011
Echinococcus multilocularis potassium large conductance calcium activated 0.0022 0.0011 0.0011
Toxoplasma gondii subtilisin SUB12 0.0023 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0361 0.4397 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0011 0.0011
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Echinococcus multilocularis expressed conserved protein 0.009 0.0896 0.0896
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0011 0.0027
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0574 0.1429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0142 0.0324
Schistosoma mansoni transient receptor potential channel 0.0022 0.0011 0.0027
Schistosoma mansoni transient receptor potential channel 4 0.0022 0.0011 0.0027
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0135 0.0306
Loa Loa (eye worm) hypothetical protein 0.0128 0.1378 0.3134
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0022 0.0011 0.0524
Toxoplasma gondii microneme protein MIC17A 0.0023 0.0022 0.0049
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0049
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0022 0.0011 0.0025
Brugia malayi Fibulin-1 precursor 0.0032 0.0142 0.0324
Leishmania major hypothetical protein, unknown function 0.0022 0.0011 0.0524
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0022 0.0011 0.0027
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0128 0.1378 0.343
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0011 0.0027
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0205 0.5
Onchocerca volvulus 0.0023 0.0025 0.0181
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 1
Onchocerca volvulus 0.0106 0.1102 0.8001
Toxoplasma gondii hypothetical protein 0.0023 0.0022 0.0049
Brugia malayi voltage-dependent calcium channel 0.0022 0.0011 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.1219
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0142 0.0328
Echinococcus granulosus Tolloid protein 1 0.0032 0.0142 0.0354
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.1213
Onchocerca volvulus 0.0023 0.0022 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0124 0.0282
Schistosoma mansoni voltage-gated potassium channel 0.0038 0.0221 0.055
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0022 0.0011 0.0027
Echinococcus multilocularis laminin 0.0032 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0339 0.411 1
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0309
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0135 0.0335
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0351 0.0874
Brugia malayi olfactory channel protein osm-9 0.0022 0.0011 0.0025
Echinococcus multilocularis voltage gated potassium channel 0.0038 0.0221 0.0221
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0022 0.0156
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0588 0.1337
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0135 0.0306
Schistosoma mansoni vesicular amine transporter 0.0022 0.0011 0.0027
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0022 0.0011 0.0079
Echinococcus multilocularis fibrillin 1 0.0032 0.0142 0.0142
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0574 0.0574
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0987 0.2246
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0 0.5
Toxoplasma gondii hypothetical protein 0.0022 0.0011 0.0025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0032 0.0142 0.0324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0142 0.0324
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0574 0.0574
Echinococcus multilocularis voltage dependent calcium channel 0.0022 0.0011 0.0011
Echinococcus granulosus tumor protein p63 0.0331 0.4006 0.9972
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0022 0.0011 0.0025
Toxoplasma gondii PAN domain-containing protein 0.0356 0.4339 1
Schistosoma mansoni ryanodine receptor related 0.0022 0.0011 0.0027
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0022 0.0011 0.0027
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0022 0.0011 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0135 0.0335
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0025 0.1219
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0022 0.0011 0.0011
Schistosoma mansoni 60S ribosomal protein L21 0.0029 0.0097 0.0241
Toxoplasma gondii hypothetical protein 0.0023 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0282
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0022 0.0011 0.0011
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.009 0.0887 0.0887
Onchocerca volvulus 0.0048 0.0351 0.2549
Brugia malayi cation channel family protein 0.0022 0.0011 0.0025
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0022 0.0011 0.0027
Loa Loa (eye worm) ion channel NompC 0.0022 0.0011 0.0025
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0309
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0022 0.0011 0.0524
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0022 0.0011 0.0027
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Echinococcus granulosus transient receptor potential gamma protein 0.0022 0.0011 0.0027
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0011 0.0027
Loa Loa (eye worm) voltage-dependent calcium channel 0.0022 0.0011 0.0025
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0135 0.0335
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0599
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0205 0.0177
Echinococcus granulosus sodium leak channel non selective protein 0.0022 0.0011 0.0027
Echinococcus multilocularis GPCR, family 2 0.0031 0.0124 0.0124
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0022 0.0011 0.0025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0011 0.0025
Echinococcus granulosus short transient receptor potential channel 6 0.0022 0.0011 0.0027
Schistosoma mansoni inositol monophosphatase 0.0037 0.0205 0.051
Echinococcus granulosus shaker cognate 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0351 0.0799
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.0067 0.0588 0.1463
Onchocerca volvulus 0.0023 0.0022 0.0156
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0601 0.1172
Echinococcus multilocularis short transient receptor potential channel 6 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0987 0.2246
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0221 0.0221
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0142 0.0324
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0057
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0135 0.0335
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0022 0.0011 0.0011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0972 1
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0192 0.0192
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0011 0.0027
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0135 0.0135
Schistosoma mansoni voltage-gated ion channel 0.0022 0.0011 0.0027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0025 0.1219
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0205 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0022 0.0011 0.0027
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0972 0.242
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.0973 0.2422
Toxoplasma gondii PAN/Apple domain-containing protein 0.0023 0.0022 0.0049
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0011 0.0027
Brugia malayi ion channel NompC 0.0022 0.0011 0.0025
Schistosoma mansoni patched 1 0.0041 0.026 0.0647
Echinococcus granulosus voltage dependent calcium channel 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0049
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0049
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0599
Echinococcus granulosus two pore calcium channel protein 2 0.0022 0.0011 0.0027
Toxoplasma gondii microneme protein MIC17B 0.0023 0.0022 0.0049
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0011 0.0027
Echinococcus multilocularis tumor protein p63 0.0331 0.4006 0.4006
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0011 0.0027
Entamoeba histolytica hypothetical protein 0.0036 0.0192 0.1768
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0022 0.0011 0.0025
Mycobacterium ulcerans hypothetical protein 0.0023 0.0025 0.1219
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0032 0.0142 0.0324
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0011 0.0011
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0022 0.0011 0.0027
Loa Loa (eye worm) ryanodine receptor 0.0022 0.0011 0.0025
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Echinococcus multilocularis geminin 0.0331 0.4017 0.4017
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0011 0.0027
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.026 0.026
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0972 0.2211
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0025 0.1219
Echinococcus multilocularis two pore calcium channel protein 2 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0096 0.0973 0.2422
Echinococcus multilocularis Tolloid protein 1 0.0032 0.0142 0.0142
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0032 0.0142 0.0354
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0022 0.0011 0.0027
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0049
Loa Loa (eye worm) voltage-gated potassium channel 0.0022 0.0011 0.0025
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0991 0.2468
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0309
Toxoplasma gondii PAN domain-containing protein 0.0356 0.4339 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0011 0.0027
Echinococcus multilocularis calcium activated potassium channel 0.0022 0.0011 0.0011
Echinococcus granulosus voltage gated potassium channel 0.0038 0.0221 0.055
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0025 0.1219
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0574 0.1429
Schistosoma mansoni two-pore calcium channel 0.0022 0.0011 0.0027
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0221 0.055
Echinococcus multilocularis sodium leak channel non selective protein 0.0022 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0022 0.0156
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0022 0.0011 0.0027
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0205 0.0205
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Echinococcus multilocularis shaker cognate 0.0022 0.0011 0.0011
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0022 0.0011 0.0011
Echinococcus multilocularis conserved hypothetical protein 0.0022 0.0011 0.0011
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0135 0.0335
Echinococcus granulosus GPCR family 2 0.0031 0.0124 0.0309
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus multilocularis transient receptor potential gamma protein 0.0022 0.0011 0.0011
Echinococcus granulosus two pore calcium channel protein 1 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.026 0.0591
Onchocerca volvulus 0.0021 0 0.0001
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Schistosoma mansoni P2X receptor subunit 0.0066 0.0574 0.1429
Echinococcus multilocularis protein dispatched 1 0.0047 0.0336 0.0336
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0502
Schistosoma mansoni egf-like domain protein 0.0032 0.0142 0.0354
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Onchocerca volvulus 0.0023 0.0022 0.0156
Echinococcus granulosus expressed conserved protein 0.009 0.0896 0.2231
Loa Loa (eye worm) hypothetical protein 0.0067 0.0588 0.1337
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0135 0.0335
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0192 0.0479
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0205 0.0177
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.009 0.0887 0.2017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Brugia malayi Inositol-1 0.0037 0.0205 0.0466
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0124 0.0282
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Echinococcus granulosus potassium large conductance calcium activated 0.0022 0.0011 0.0027
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0022 0.0011 0.0011
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0155 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0011 0.0027
Onchocerca volvulus 0.0023 0.0022 0.0156
Echinococcus granulosus laminin 0.0032 0.0142 0.0354
Entamoeba histolytica hypothetical protein 0.0036 0.0192 0.1768
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0011 0.0025
Echinococcus multilocularis ryanodine receptor 44f 0.0022 0.0011 0.0011
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.1219
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0601 0.1172
Entamoeba histolytica hypothetical protein 0.0036 0.0192 0.1768
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0011 0.0027
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0096 0.0972 0.2211
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0022 0.0011 0.0011
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0022 0.0011 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1507 0.1507
Schistosoma mansoni voltage-dependent calcium channel 0.0022 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0599
Echinococcus granulosus ryanodine receptor 44f 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.008 0.0763 0.1736
Schistosoma mansoni hypothetical protein 0.0036 0.0192 0.0479
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0987 0.2246
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0011 0.0027
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0022 0.0011 0.0027
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0135 0.0135
Onchocerca volvulus 0.0128 0.1378 1
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0205 0.0177
Toxoplasma gondii microneme protein MIC4 0.0023 0.0022 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus granulosus geminin 0.0331 0.4017 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0142 0.0324
Loa Loa (eye worm) hypothetical protein 0.0051 0.038 0.0865
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0142 0.0324
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0128 0.1378 0.3134
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0049
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Echinococcus granulosus voltage gated hydrogen channel 1 0.0022 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0309
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0135 0.0335
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0124 0.0124
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0135 0.0335
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0097 0.0241
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.004 0.0241 0.0599
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0011 0.0011
Toxoplasma gondii hypothetical protein 0.0022 0.0011 0.0025
Schistosoma mansoni voltage-gated cation channel 0.0022 0.0011 0.0027
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0022 0.0011 0.0011
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0142 0.0328
Loa Loa (eye worm) calcium channel 0.0022 0.0011 0.0025
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0022 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.026 0.0315
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0027
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.009 0.0887 0.2017
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.1213
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0022 0.0011 0.0524
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Onchocerca volvulus 0.0022 0.0011 0.0079
Brugia malayi CHE-14 protein 0.0041 0.026 0.0591
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0192 0.0479
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0205 0.19
Toxoplasma gondii microneme protein, putative 0.0023 0.0022 0.0049
Brugia malayi Transient-receptor-potential like protein 0.0022 0.0011 0.0025
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0135 0.0135
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0022 0.0011 0.0027
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0205 0.0472
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0022 0.0011 0.0025
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0022 0.0011 0.0025
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.026 0.0647
Brugia malayi follicle stimulating hormone receptor 0.0233 0.2737 0.6225
Onchocerca volvulus Arrow homolog 0.0032 0.0142 0.1033
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0011 0.0011
Echinococcus granulosus calcium activated potassium channel 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0022 0.0011 0.0011
Echinococcus multilocularis short transient receptor potential channel 6 0.0022 0.0011 0.0011
Onchocerca volvulus 0.0023 0.0022 0.0156
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Onchocerca volvulus 0.0023 0.0022 0.0156
Schistosoma mansoni P2X receptor subunit 0.0066 0.0574 0.1429
Loa Loa (eye worm) hypothetical protein 0.0041 0.026 0.0591
Loa Loa (eye worm) hypothetical protein 0.0032 0.0142 0.0324
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0142 0.0324
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0011 0.0027
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0361 0.4397 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0022 0.0011 0.0025
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0135 0.0306
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus multilocularis protein patched 0.0041 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0049
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0038 0.0221 0.0502
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0049
Schistosoma mansoni transient receptor potential channel 0.0022 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.0331 0.4017 1
Echinococcus multilocularis two pore calcium channel protein 1 0.0022 0.0011 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0124 0.0309
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Entamoeba histolytica hypothetical protein 0.0036 0.0192 0.1768
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0022 0.0011 0.0079
Echinococcus granulosus sodium channel protein 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) voltage-gated calcium channel 0.0022 0.0011 0.0025
Echinococcus multilocularis transfer RNA-Gly 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.1213
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.1219
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Echinococcus granulosus TRP transient receptor potential channel 0.0022 0.0011 0.0027
Brugia malayi hypothetical protein 0.0036 0.0192 0.0438
Loa Loa (eye worm) hypothetical protein 0.0032 0.0135 0.0306
Brugia malayi hypothetical protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0057
Schistosoma mansoni transient receptor potential channel 0.0022 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0972 0.0972
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0049
Echinococcus granulosus hypothetical protein 0.0022 0.0011 0.0027
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0023 0.0022 0.0049
Brugia malayi Trypsin family protein 0.0128 0.1378 0.3134
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0022 0.0011 0.0027
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0022 0.0011 0.0025
Schistosoma mansoni inositol monophosphatase 0.0037 0.0205 0.051
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus granulosus short transient receptor potential channel 6 0.0022 0.0011 0.0027
Toxoplasma gondii microneme protein MIC17C 0.0023 0.0022 0.0049
Schistosoma mansoni hypothetical protein 0.0331 0.4017 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0022 0.0011 0.0027
Echinococcus granulosus voltage dependent calcium channel 0.0022 0.0011 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Brugia malayi cation channel family protein 0.0022 0.0011 0.0025
Onchocerca volvulus 0.0023 0.0022 0.0156
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0135 0.0335
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0124 0.0309
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0022 0.0011 0.0027
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0135 0.0335
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0011 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.2737 0.6225
Onchocerca volvulus 0.0023 0.0022 0.0156
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0011 0.0027
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0205 0.051
Schistosoma mansoni voltage-gated potassium channel 0.0038 0.0221 0.055
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0022 0.0011 0.0027
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0011 0.0027
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0049
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0011 0.0011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0128 0.1378 0.343
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0025
Echinococcus granulosus potassium voltage gated channel subfamily H 0.009 0.0887 0.2208
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0124 0.0124
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0027
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0574 0.0574
Loa Loa (eye worm) voltage-gated potassium channel 0.0022 0.0011 0.0025
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0022 0.0011 0.0027
Onchocerca volvulus 0.0023 0.0022 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0142 0.0324
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1507 0.3752
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0011 0.0027
Loa Loa (eye worm) inositol-1 0.0037 0.0205 0.0466
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0135 0.0135
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0574 0.1429

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 21 uM Inhibitory concentration of the compound against Tryptase. ChEMBL. 9784099
IC50 (binding) = 21 uM Inhibitory concentration of the compound against Tryptase. ChEMBL. 9784099
Ki (binding) = 0.58 uM Inhibitory activity against Coagulation factor X ChEMBL. 9784099
Ki (binding) = 0.58 uM Inhibitory activity against Coagulation factor X ChEMBL. 9784099
Ki (binding) = 0.64 uM Inhibitory activity against Coagulation factor X ChEMBL. 9784099
Ki (binding) = 0.64 uM Inhibitory activity against Coagulation factor X ChEMBL. 9784099
Ki (binding) = 12 uM Inhibitory activity against plasma kallikrein ChEMBL. 9784099
Ki (binding) = 12 uM Inhibitory activity against plasma kallikrein ChEMBL. 9784099
Ki (binding) = 13 uM Inhibitory activity against Trypsin. ChEMBL. 9784099
Ki (binding) = 13 uM Inhibitory activity against Trypsin. ChEMBL. 9784099
Ki (binding) = 15 uM Inhibitory activity against Thrombin. ChEMBL. 9784099
Ki (binding) = 15 uM Inhibitory activity against Thrombin. ChEMBL. 9784099
Ki (binding) = 48 uM Inhibitory activity against the anticoagulant Activated protein C ChEMBL. 9784099
Ki (binding) = 48 uM Inhibitory activity against the anticoagulant Activated protein C ChEMBL. 9784099
Ki (binding) = 52 uM Inhibitory activity against Plasmin. ChEMBL. 9784099
Ki (binding) = 52 uM Inhibitory activity against Plasmin. ChEMBL. 9784099
Ki (binding) > 1000 uM Inhibitory activity against microPa. ChEMBL. 9784099
Ki (binding) > 1000 uM Inhibitory activity against sc-tissue plasminogen activator purified from CHO cells ChEMBL. 9784099
Ki (binding) > 1000 uM Inhibitory activity against microPa. ChEMBL. 9784099

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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