TDR Targets

Basic information

Technical information

TDR Targets ID: 236498
Name: 7-chloro-N-[2-[4-(7-chloroquinolin-4-yl)piper azin-1-yl]ethyl]quinolin-4-amine
MW: 452.379 | Formula: C24H23Cl2N5
H donors: 1 H acceptors: 2 LogP: 5.33 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)nccc2NCCN1CCN(CC1)c1ccnc2c1ccc(c2)Cl
InChi: 1S/C24H23Cl2N5/c25-17-1-3-19-21(5-7-27-22(19)15-17)29-9-10-30-11-13-31(14-12-30)24-6-8-28-23-16-18(26)2-4-20(23)24/h1-8,15-16H,9-14H2,(H,27,29)
InChiKey: AXGJQYDQWXCHEV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-chloro-N-[2-[4-(7-chloro-4-quinolyl)piperazin-1-yl]ethyl]quinolin-4-amine
7-chloro-N-[2-[4-(7-chloro-4-quinolyl)-1-piperazinyl]ethyl]-4-quinolinamine
(7-chloro-4-quinolyl)-[2-[4-(7-chloro-4-quinolyl)piperazino]ethyl]amine
(7-chloro-4-quinolyl)-[2-[4-(7-chloro-4-quinolyl)piperazin-1-yl]ethyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	plasmepsin VIII, putative	0.0124793	0.0220237	1
Trichomonas vaginalis	CMGC family protein kinase	0.00796946	0.00722242	0.0497967
Toxoplasma gondii	aspartyl protease ASP1	0.0124793	0.0220237	1
Loa Loa (eye worm)	carboxylesterase	0.0499605	0.145038	0.152429
Loa Loa (eye worm)	carboxylesterase	0.0499605	0.145038	0.152429
Schistosoma mansoni	serine/threonine protein kinase	0.00899492	0.010588	0.010588
Plasmodium falciparum	protein serine/threonine kinase-1	0.00719255	0.00467259	0.212162
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.00796946	0.00722242	0.327939
Plasmodium vivax	plasmepsin IV, putative	0.0124793	0.0220237	1
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0124793	0.0220237	1
Trichomonas vaginalis	CMGC family protein kinase	0.00796946	0.00722242	0.0497967
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0499605	0.145038	0.145038
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.00719255	0.00467259	0.646957
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Loa Loa (eye worm)	hypothetical protein	0.0499605	0.145038	0.152429
Brugia malayi	Carboxylesterase family protein	0.0499605	0.145038	0.152429
Leishmania major	protein kinase, putative	0.00719255	0.00467259	0.646957
Entamoeba histolytica	casein kinase, putative	0.00796946	0.00722242	1
Toxoplasma gondii	aspartyl protease	0.0124793	0.0220237	1
Loa Loa (eye worm)	aspartyl protease 6	0.0124793	0.0220237	0.023146
Trichomonas vaginalis	CMGC family protein kinase	0.00796946	0.00722242	0.0497967
Brugia malayi	aspartic protease BmAsp-2, identical	0.0124793	0.0220237	0.023146
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0124793	0.0220237	0.023146
Mycobacterium ulcerans	carboxylesterase, LipT	0.0499605	0.145038	0.5
Toxoplasma gondii	aspartyl protease ASP3	0.0124793	0.0220237	1
Loa Loa (eye worm)	hypothetical protein	0.0499605	0.145038	0.152429
Loa Loa (eye worm)	hypothetical protein	0.0499605	0.145038	0.152429
Trypanosoma brucei	Casein kinase II	0.00796946	0.00722242	1
Plasmodium falciparum	plasmepsin I	0.0124793	0.0220237	1
Loa Loa (eye worm)	hypothetical protein	0.0499605	0.145038	0.152429
Schistosoma mansoni	memapsin-2 (A01 family)	0.310459	1	1
Giardia lamblia	Kinase, CDC7	0.00899492	0.010588	1
Plasmodium falciparum	plasmepsin V	0.0124793	0.0220237	1
Trichomonas vaginalis	CMGC family protein kinase	0.00796946	0.00722242	0.0497967
Brugia malayi	hypothetical protein	0.0124793	0.0220237	0.023146
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.295685	0.951512	0.951512
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0334764	0.0909368	0.0955709
Brugia malayi	Carboxylesterase family protein	0.295685	0.951512	1
Plasmodium vivax	aspartyl protease, putative	0.0124793	0.0220237	1
Toxoplasma gondii	CMGC kinase, CK2 family	0.00796946	0.00722242	0.327939
Loa Loa (eye worm)	hypothetical protein	0.0499605	0.145038	0.152429
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.00719255	0.00467259	0.00491071
Plasmodium falciparum	plasmepsin VII	0.0124793	0.0220237	1
Echinococcus granulosus	casein kinase ii subunit alpha	0.00796946	0.00722242	0.00759048
Brugia malayi	Protein kinase domain containing protein	0.00719255	0.00467259	0.00491071
Echinococcus granulosus	acetylcholinesterase	0.295685	0.951512	1
Schistosoma mansoni	serine/threonine protein kinase	0.00719255	0.00467259	0.00467259
Brugia malayi	Carboxylesterase family protein	0.0499605	0.145038	0.152429
Echinococcus multilocularis	neuroligin	0.0499605	0.145038	0.152429
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0499605	0.145038	0.5
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Plasmodium falciparum	plasmepsin III	0.0124793	0.0220237	1
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0334764	0.0909368	0.0955709
Trichomonas vaginalis	CMGC family protein kinase	0.00796946	0.00722242	0.0497967
Brugia malayi	Protein kinase domain containing protein	0.00899492	0.010588	0.0111276
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Trichomonas vaginalis	CMGC family protein kinase	0.00899492	0.010588	0.0730015
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0499605	0.145038	0.145038
Loa Loa (eye worm)	hypothetical protein	0.295685	0.951512	1
Entamoeba histolytica	protein kinase domain containing protein	0.00796946	0.00722242	1
Echinococcus multilocularis	acetylcholinesterase	0.295685	0.951512	1
Schistosoma mansoni	serine/threonine protein kinase	0.0334764	0.0909368	0.0909368
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0124793	0.0220237	0.151847
Trichomonas vaginalis	spcc417.12 protein, putative	0.0499605	0.145038	1
Plasmodium falciparum	plasmepsin VI	0.0124793	0.0220237	1
Brugia malayi	Carboxylesterase family protein	0.295685	0.951512	1
Trichomonas vaginalis	CMGC family protein kinase	0.00796946	0.00722242	0.0497967
Brugia malayi	hypothetical protein	0.0499605	0.145038	0.152429
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0124793	0.0220237	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0499605	0.145038	0.5
Giardia lamblia	Kinase, CMGC CLK	0.00719255	0.00467259	0.44131
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0124793	0.0220237	0.023146
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0334764	0.0909368	0.0955709
Loa Loa (eye worm)	hypothetical protein	0.295685	0.951512	1
Trichomonas vaginalis	CMGC family protein kinase	0.00719255	0.00467259	0.0322163
Loa Loa (eye worm)	carboxylesterase	0.295685	0.951512	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Schistosoma mansoni	BC026374 protein (S09 family)	0.0499605	0.145038	0.145038
Plasmodium falciparum	plasmepsin X	0.0124793	0.0220237	1
Onchocerca volvulus		0.0124793	0.0220237	0.151847
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.00719255	0.00467259	0.646957
Plasmodium vivax	aspartyl proteinase, putative	0.0124793	0.0220237	1
Echinococcus multilocularis	CDC7 cell division cycle 7	0.00899492	0.010588	0.0111276
Brugia malayi	hypothetical protein	0.0124793	0.0220237	0.023146
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.00719255	0.00467259	0.212162
Loa Loa (eye worm)	hypothetical protein	0.00688117	0.00365063	0.00383667
Echinococcus granulosus	acetylcholinesterase	0.295685	0.951512	1
Leishmania major	casein kinase II, putative	0.00796946	0.00722242	1
Echinococcus granulosus	carboxylesterase 5A	0.295685	0.951512	1
Trichomonas vaginalis	CMGC family protein kinase	0.00796946	0.00722242	0.0497967
Schistosoma mansoni	protein kinase	0.00796946	0.00722242	0.00722242
Loa Loa (eye worm)	hypothetical protein	0.0124793	0.0220237	0.023146
Brugia malayi	Carboxylesterase family protein	0.0499605	0.145038	0.152429
Trypanosoma cruzi	casein kinase II, putative	0.00796946	0.00722242	1
Loa Loa (eye worm)	hypothetical protein	0.0124793	0.0220237	0.023146
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0334764	0.0909368	0.626985
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0124793	0.0220237	0.023146
Schistosoma mansoni	acetylcholinesterase	0.0499605	0.145038	0.145038
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0334764	0.0909368	0.0955709
Schistosoma mansoni	gliotactin	0.0499605	0.145038	0.145038
Echinococcus multilocularis	acetylcholinesterase	0.295685	0.951512	1
Plasmodium falciparum	plasmepsin II	0.0124793	0.0220237	1
Echinococcus granulosus	CDC7 cell division cycle 7	0.00899492	0.010588	0.0111276
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Loa Loa (eye worm)	hypothetical protein	0.0499605	0.145038	0.152429
Onchocerca volvulus		0.00899492	0.010588	0.0730015
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0499605	0.145038	0.152429
Loa Loa (eye worm)	hypothetical protein	0.0499605	0.145038	0.152429
Loa Loa (eye worm)	CDC7 protein kinase	0.00899492	0.010588	0.0111276
Schistosoma mansoni	cathepsin D (A01 family)	0.0124793	0.0220237	0.0220237
Onchocerca volvulus		0.00899492	0.010588	0.0730015
Plasmodium vivax	serine/threonine kinase-1, putative	0.00719255	0.00467259	0.212162
Onchocerca volvulus		0.0499605	0.145038	1
Trichomonas vaginalis	CMGC family protein kinase	0.00899492	0.010588	0.0730015
Echinococcus multilocularis	para nitrobenzyl esterase	0.0499605	0.145038	0.152429
Onchocerca volvulus		0.0499605	0.145038	1
Brugia malayi	aspartic protease BmAsp-1, identical	0.0124793	0.0220237	0.023146
Echinococcus granulosus	BC026374 protein S09 family	0.0499605	0.145038	0.152429
Echinococcus granulosus	dual specificity protein kinase clk2	0.00719255	0.00467259	0.00491071
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.00719255	0.00467259	0.646957
Trichomonas vaginalis	CMGC family protein kinase	0.00899492	0.010588	0.0730015
Echinococcus multilocularis	casein kinase ii subunit alpha	0.00796946	0.00722242	0.00759048
Brugia malayi	Protein kinase domain containing protein	0.0334764	0.0909368	0.0955709
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0334764	0.0909368	0.0955709
Plasmodium falciparum	plasmepsin IX	0.0124793	0.0220237	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0499605	0.145038	0.152429
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0124793	0.0220237	0.023146
Onchocerca volvulus		0.0499605	0.145038	1
Plasmodium falciparum	casein kinase 2, alpha subunit	0.00796946	0.00722242	0.327939
Onchocerca volvulus		0.0124793	0.0220237	0.151847
Loa Loa (eye worm)	hypothetical protein	0.0124793	0.0220237	0.023146
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0499605	0.145038	0.145038
Plasmodium vivax	plasmepsin V, putative	0.0124793	0.0220237	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.00796946	0.00722242	0.00759048
Echinococcus granulosus	hypothetical protein	0.00688117	0.00365063	0.00383667
Schistosoma mansoni	serine/threonine protein kinase	0.00719255	0.00467259	0.00467259
Loa Loa (eye worm)	acetylcholinesterase 1	0.295685	0.951512	1
Echinococcus multilocularis		0.00688117	0.00365063	0.00383667
Onchocerca volvulus		0.0499605	0.145038	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0499605	0.145038	1
Plasmodium vivax	aspartyl proteinase, putative	0.0124793	0.0220237	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0499605	0.145038	0.152429
Echinococcus multilocularis	dual specificity protein kinase clk2	0.00719255	0.00467259	0.00491071
Schistosoma mansoni	cathepsin D (A01 family)	0.0124793	0.0220237	0.0220237
Plasmodium vivax	aspartyl protease, putative	0.0124793	0.0220237	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0499605	0.145038	0.152429
Plasmodium vivax	unspecified product	0.00796946	0.00722242	0.327939
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0499605	0.145038	0.145038
Echinococcus multilocularis	carboxylesterase 5A	0.295685	0.951512	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0499605	0.145038	0.5
Brugia malayi	Casein kinase II, alpha chain	0.00796946	0.00722242	0.00759048
Onchocerca volvulus		0.0499605	0.145038	1
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0124793	0.0220237	0.023146
Plasmodium falciparum	plasmepsin IV	0.0124793	0.0220237	1
Giardia lamblia	Kinase, CMGC CK2	0.00796946	0.00722242	0.682133
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0124793	0.0220237	0.0220237
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.00719255	0.00467259	0.646957
Brugia malayi	Pepsin A precursor	0.0124793	0.0220237	0.023146
Plasmodium vivax	aspartyl protease, putative	0.0124793	0.0220237	1
Leishmania major	protein kinase, putative	0.00719255	0.00467259	0.646957
Echinococcus granulosus	neuroligin	0.0499605	0.145038	0.152429
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.00719255	0.00467259	0.646957
Brugia malayi	Carboxylesterase family protein	0.0499605	0.145038	0.152429
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.00719255	0.00467259	0.646957

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 0.067 nM min-1 (mg of protein)-1	In vitro effect of the compound on methemoglobin reductase activity in blood of dog at 33 uM concentration	ChEMBL.	10201823
Activity (binding)	= 0.067 nM min-1 (mg of protein)-1	In vitro effect of the compound on methemoglobin reductase activity in blood of dog at 166 uM concentration	ChEMBL.	10201823
Activity (binding)	= 0.067 nM min-1 (mg of protein)-1	In vitro effect of the compound on methemoglobin reductase activity in blood of dog at 33 uM concentration	ChEMBL.	10201823
Activity (binding)	= 0.067 nM min-1 (mg of protein)-1	In vitro effect of the compound on methemoglobin reductase activity in blood of dog at 166 uM concentration	ChEMBL.	10201823
IC50 (functional)	= 1.2 nM	Antimalarial activity against D6 clone of P. falciparum was determined in vitro.	ChEMBL.	9784111
IC50 (functional)	= 1.2 nM	Antimalarial activity against D6 clone of P. falciparum was determined in vitro.	ChEMBL.	9784111
IC50 (functional)	= 9 nM	Antimalarial activity against chloroquine-resistant W2 clone of P. falciparum was determined in vitro.	ChEMBL.	9784111
IC50 (functional)	= 9 nM	Antimalarial activity against chloroquine-resistant W2 clone of P. falciparum was determined in vitro.	ChEMBL.	9784111
IC50 (functional)	= 5 uM	Ability of the compound to inhibit hematin polymerization was determined against Plasmodium falciparum.	ChEMBL.	9784111
IC50 (functional)	= 5 uM	Ability of the compound to inhibit hematin polymerization was determined against Plasmodium falciparum.	ChEMBL.	9784111
Methemoglobin (functional)	Nil 0 %	In vitro effect of the compound on methemoglobin formation in blood of dog at 1 mM concentration; Nil	ChEMBL.	10201823
Methemoglobin (functional)	Nil 0 %	In vitro effect of the compound on methemoglobin formation in blood of dog at 5 mM concentration	ChEMBL.	10201823
Number (functional)	= 1	Number of P. berghei infected mice died on day 8 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 22 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 18 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 9 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died at 640 mg/kg; Curative	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 17 at 160 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 20 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 14 at 160 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 16 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died at 160 mg/kg; Curative	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 12 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 2	Number of P. berghei infected mice died on day 13 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 3	Number of P. berghei infected mice died on day 13 at 160 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 8 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 9 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 12 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 14 at 160 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 17 at 160 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died at 160 mg/kg; Curative	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 16 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 18 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 20 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died on day 22 at 640 mg/kg	ChEMBL.	9784111
Number (functional)	= 1	Number of P. berghei infected mice died at 640 mg/kg; Curative	ChEMBL.	9784111
Number (functional)	= 2	Number of P. berghei infected mice died on day 13 at 40 mg/kg	ChEMBL.	9784111
Number (functional)	= 3	Number of P. berghei infected mice died on day 13 at 160 mg/kg	ChEMBL.	9784111

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	9784111

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL343320
PubChem: 10049515

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 236498