Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 3 (5-HT3) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neuroligin | 0.0024 | 0.0723 | 0.0723 |
Echinococcus granulosus | carboxylesterase 5A | 0.0144 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0723 | 0.0723 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.0723 | 0.0723 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0723 | 0.0723 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0723 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0723 | 0.0723 |
Onchocerca volvulus | 0.0024 | 0.0723 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0144 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | carboxylesterase | 0.0144 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Onchocerca volvulus | 0.0024 | 0.0723 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.0723 | 0.0723 |
Onchocerca volvulus | 0.0024 | 0.0723 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0723 | 0.0723 |
Onchocerca volvulus | 0.0024 | 0.0723 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Onchocerca volvulus | 0.0024 | 0.0723 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0144 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.0723 | 0.0723 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.0723 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0723 | 0.0723 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.0723 | 0.0723 |
Echinococcus multilocularis | acetylcholinesterase | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.0723 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0723 | 0.0723 |
Echinococcus multilocularis | acetylcholinesterase | 0.0144 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0144 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0723 | 0.0723 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.0723 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0723 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.0723 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.0723 | 0.0723 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.0723 | 0.0723 |
Echinococcus granulosus | acetylcholinesterase | 0.0144 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.0723 | 0.0723 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Inhibition of 5-HT induced bradycardia [Benzold-Jarisch (BJ) reflex test] in rats at 5 min administered intravenously; not tested | ChEMBL. | 1479589 |
Ki (binding) | > 100 nM | Ability to displace [3H]-quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15. | ChEMBL. | 1479589 |
Ki (binding) | > 100 nM | Ability to displace [3H]-quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15. | ChEMBL. | 1479589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.