Detailed information for compound 25180

Basic information

Technical information
  • TDR Targets ID: 25180
  • Name: 7-chloro-5-phenyl-3-(phenylmethoxymethyl)-1,3 -dihydro-1,4-benzodiazepin-2-one
  • MW: 390.862 | Formula: C23H19ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.42 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C(=NC(C(=O)N2)COCc1ccccc1)c1ccccc1
  • InChi: 1S/C23H19ClN2O2/c24-18-11-12-20-19(13-18)22(17-9-5-2-6-10-17)25-21(23(27)26-20)15-28-14-16-7-3-1-4-8-16/h1-13,21H,14-15H2,(H,26,27)
  • InChiKey: ZDUTWTMGYFHWON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(benzyloxymethyl)-7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
  • 3-(benzoxymethyl)-7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0104 0.0024 0.0153
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0515 0.0372 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Toxoplasma gondii aspartyl protease ASP3 0.0101 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0227 0.0128 0.014
Echinococcus multilocularis tissue type plasminogen activator 0.0167 0.0078 0.0078
Giardia lamblia Hypothetical protein 0.0238 0.0138 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.1026 0.0805 0.1967
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0157 0.0069 0.0069
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.1026 0.0805 0.1967
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0157 0.0069 0.0439
Schistosoma mansoni histone deacetylase hda2 0.0135 0.0051 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.1026 0.0805 0.1967
Trypanosoma cruzi histone deacetylase 1, putative 0.0356 0.0238 0.0582
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0227 0.0128 0.0313
Trypanosoma cruzi hypothetical protein, conserved 0.0515 0.0372 0.0909
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0088 0.0011 0.0027
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0238 0.0138 0.0337
Loa Loa (eye worm) TK/ROR protein kinase 0.0167 0.0078 0.0085
Plasmodium vivax histone deacetylase, putative 0.0245 0.0144 0.1783
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.4267 0.3551 0.3551
Loa Loa (eye worm) hypothetical protein 0.0115 0.0034 0.0037
Schistosoma mansoni histone deacetylase hda2 0.0251 0.0149 0.0363
Toxoplasma gondii histone deacetylase HDAC4 0.0135 0.0051 0.0124
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.1952 0.159 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1936 0.1577 0.385
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0088 0.0011 0.0011
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0109 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.4908 0.4095 0.4485
Brugia malayi Protein kinase domain containing protein 0.0167 0.0078 0.0078
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1026 0.0805 0.1967
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.4267 0.3551 0.3551
Loa Loa (eye worm) hypothetical protein 0.0366 0.0246 0.027
Plasmodium vivax histone deacetylase 1, putative 0.0356 0.0238 0.2957
Loa Loa (eye worm) PDE1B protein 0.1026 0.0805 0.0882
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.1026 0.0805 0.5109
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Toxoplasma gondii hypothetical protein 0.0515 0.0372 0.0909
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1026 0.0805 0.0805
Leishmania major hypothetical protein, conserved 0.1026 0.0805 0.1967
Schistosoma mansoni hypothetical protein 0.0227 0.0128 0.0313
Echinococcus multilocularis prolyl endopeptidase 0.4908 0.4095 0.4095
Trichomonas vaginalis conserved hypothetical protein 0.091 0.0707 0.4487
Schistosoma mansoni histone deacetylase 4 5 0.0245 0.0144 0.0351
Onchocerca volvulus Cell death protein 3 homolog 0.0091 0.0014 0.0033
Echinococcus granulosus apoptotic protease activating factor 1 0.0091 0.0014 0.0014
Onchocerca volvulus Histone deacetylase 10 homolog 0.0135 0.0051 0.0124
Brugia malayi Cell death protein 3 precursor 0.0091 0.0014 0.0014
Giardia lamblia Alanyl dipeptidyl peptidase 0.0515 0.0372 0.0987
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.091 0.0707 0.1552
Loa Loa (eye worm) histone deacetylase 1 0.0356 0.0238 0.0261
Toxoplasma gondii cathepsin B 0.0104 0.0024 0.0059
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0157 0.0069 0.0439
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.091 0.0707 0.3805
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1026 0.0805 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.1026 0.0805 0.5109
Brugia malayi cathepsin B-like cysteine proteinase 0.0289 0.0181 0.0181
Trypanosoma brucei hypothetical protein, conserved 0.1026 0.0805 0.1967
Trypanosoma cruzi hypothetical protein, conserved 0.1026 0.0805 0.1967
Loa Loa (eye worm) histone deacetylase 7A 0.0245 0.0144 0.0157
Loa Loa (eye worm) hypothetical protein 0.0167 0.0078 0.0085
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0238 0.1511
Trypanosoma brucei cysteine peptidase C (CPC) 0.0104 0.0024 0.0059
Entamoeba histolytica hypothetical protein, conserved 0.0515 0.0372 1
Toxoplasma gondii histone deacetylase HDAC3 0.0356 0.0238 0.0582
Toxoplasma gondii histone deacetylase HDAC1 0.0245 0.0144 0.0351
Giardia lamblia Alanyl dipeptidyl peptidase 0.0515 0.0372 0.0987
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0356 0.0238 0.1511
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0238 0.1511
Brugia malayi prolyl oligopeptidase family protein 0.0515 0.0372 0.0372
Schistosoma mansoni histone deacetylase 0.0356 0.0238 0.0582
Schistosoma mansoni histone deacetylase 4 5 0.0245 0.0144 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.1936 0.1577 1
Loa Loa (eye worm) hypothetical protein 0.0356 0.0238 0.0261
Echinococcus multilocularis cathepsin b 0.0289 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0109 0.0029 0.0032
Echinococcus multilocularis histone deacetylase 6 0.0245 0.0144 0.0144
Mycobacterium tuberculosis Probable peptidase 0.1952 0.159 0.4078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Plasmodium falciparum plasmepsin IX 0.0101 0.0022 0.0275
Giardia lamblia Hypothetical protein 0.1026 0.0805 0.2215
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Trypanosoma cruzi Aph-1 protein, putative 0.0101 0.0022 0.0053
Echinococcus granulosus acylamino acid releasing enzyme 0.0515 0.0372 0.0372
Brugia malayi Histone deacetylase family protein 0.0245 0.0144 0.0144
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0157 0.0069 0.0128
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0238 0.0138 0.0874
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.1026 0.0805 0.0805
Echinococcus multilocularis caspase 2 0.0091 0.0014 0.0014
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0109 0.0028 0.0028
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.1026 0.0805 0.1967
Schistosoma mansoni chromatin regulatory protein sir2 0.0238 0.0138 0.0337
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0227 0.0128 0.0128
Trypanosoma brucei Aph-1 protein, putative 0.0101 0.0022 0.0053
Leishmania major silent information regulator 2, putative 0.0238 0.0138 0.0337
Loa Loa (eye worm) hypothetical protein 0.9942 0.836 0.9155
Echinococcus granulosus tissue type plasminogen activator 0.0167 0.0078 0.0078
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0157 0.0069 0.0439
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0238 0.1511
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.1952 0.159 0.4078
Loa Loa (eye worm) hypothetical protein 0.0088 0.0011 0.0012
Echinococcus multilocularis histone deacetylase 7 0.0245 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0108 0.0028 0.003
Echinococcus multilocularis inhibitor of apoptosis protein 0.0227 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.091 0.0707 0.4487
Echinococcus granulosus gamma secretase subunit aph 1 0.0258 0.0155 0.0155
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0515 0.0372 0.0909
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.1936 0.1577 0.385
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.3241 0.2682 0.2682
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1936 0.1577 0.385
Loa Loa (eye worm) histone deacetylase 0.0245 0.0144 0.0157
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1026 0.0805 0.0805
Schistosoma mansoni hypothetical protein 0.0091 0.0014 0.0033
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0356 0.0238 0.1511
Trypanosoma cruzi hypothetical protein, conserved 0.0167 0.0078 0.0189
Leishmania major C-8 sterol isomerase-like protein 0.0716 0.0543 0.1326
Echinococcus granulosus tm gpcr rhodopsin 0.0561 0.0411 0.0411
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0238 0.1511
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0157 0.0069 0.0069
Echinococcus multilocularis chromatin regulatory protein sir2 0.0238 0.0138 0.0138
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.1026 0.0805 0.0805
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0515 0.0372 0.0909
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 0.5109
Trypanosoma brucei histone deacetylase, putative 0.0245 0.0144 0.0351
Loa Loa (eye worm) hypothetical protein 0.0716 0.0543 0.0595
Toxoplasma gondii prolyl endopeptidase 0.4908 0.4095 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0238 0.0138 0.0337
Trypanosoma brucei histone deacetylase 2 0.0135 0.0051 0.0124
Loa Loa (eye worm) hypothetical protein 0.0091 0.0014 0.0015
Loa Loa (eye worm) norepinephrine transporter 0.0088 0.0011 0.0012
Leishmania major histone deacetylase, putative 0.0245 0.0144 0.0351
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 0.1967
Onchocerca volvulus 0.0167 0.0078 0.0189
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Entamoeba histolytica prolyl oligopeptidase family protein 0.0515 0.0372 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.1026 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.0227 0.0128 0.014
Loa Loa (eye worm) hypothetical protein 0.0289 0.0181 0.0199
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0104 0.0024 0.0059
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0515 0.0372 0.0372
Schistosoma mansoni cathepsin D (A01 family) 0.0116 0.0035 0.0085
Schistosoma mansoni chromatin regulatory protein sir2 0.0238 0.0138 0.0337
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.1952 0.159 0.3883
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0509 0.0367 0.0896
Trypanosoma cruzi histone deacetylase, putative 0.0135 0.0051 0.0124
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.4267 0.3551 0.8673
Giardia lamblia hypothetical protein 0.1026 0.0805 0.2215
Toxoplasma gondii kringle domain-containing protein 0.0167 0.0078 0.0189
Trypanosoma cruzi histone deacetylase, putative 0.0245 0.0144 0.0351
Entamoeba histolytica prolyl oligopeptidase family protein 0.0515 0.0372 1
Echinococcus multilocularis histone deacetylase 3 0.0356 0.0238 0.0238
Onchocerca volvulus Deterin homolog 0.0227 0.0128 0.0313
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.1952 0.159 0.3883
Echinococcus granulosus histone deacetylase 6 0.0245 0.0144 0.0144
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Brugia malayi hypothetical protein 0.0091 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.1026 0.0805 0.1967
Trypanosoma cruzi hypothetical protein, conserved 0.1026 0.0805 0.1967
Loa Loa (eye worm) hypothetical protein 0.0088 0.0011 0.0012
Echinococcus multilocularis gamma secretase subunit aph 1 0.0258 0.0155 0.0155
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Echinococcus multilocularis histone deacetylase 1 0.0356 0.0238 0.0238
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.1026 0.0805 0.1967
Trypanosoma cruzi histone deacetylase, putative 0.0245 0.0144 0.0351
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.1026 0.0805 0.5109
Echinococcus multilocularis histone deacetylase 6 0.0245 0.0144 0.0144
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1936 0.1577 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.1026 0.0805 0.0805
Mycobacterium ulcerans putative regulatory protein 0.091 0.0707 0.3805
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Toxoplasma gondii hypothetical protein 0.091 0.0707 0.1728
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Entamoeba histolytica histone deacetylase, putative 0.0356 0.0238 0.6395
Trypanosoma brucei histone deacetylase 3 0.0245 0.0144 0.0351
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 1
Trypanosoma cruzi histone deacetylase, putative 0.0135 0.0051 0.0124
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.4267 0.3551 1
Trypanosoma cruzi histone deacetylase, putative 0.0245 0.0144 0.0351
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.1952 0.159 0.3883
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1026 0.0805 0.1967
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.4267 0.3551 0.3551
Echinococcus granulosus histone deacetylase 3 0.0356 0.0238 0.0238
Echinococcus multilocularis histone deacetylase 6 0.0251 0.0149 0.0149
Toxoplasma gondii GAF domain-containing protein 0.091 0.0707 0.1728
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1026 0.0805 0.5109
Plasmodium vivax histone deacetylase 2, putative 0.0245 0.0144 0.1783
Echinococcus multilocularis apoptotic protease activating factor 1 0.0091 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.9323 0.7835 0.8581
Loa Loa (eye worm) solute carrier family 6 member 4 0.0088 0.0011 0.0012
Trypanosoma cruzi Aph-1 protein, putative 0.0101 0.0022 0.0053
Loa Loa (eye worm) hypothetical protein 1.0852 0.9131 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0356 0.0238 0.0582
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 0.5109
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.4267 0.3551 0.8673
Echinococcus granulosus Dipeptidyl peptidase 9 0.0515 0.0372 0.0372
Treponema pallidum sodium- and chloride- dependent transporter 0.0088 0.0011 0.5
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0515 0.0372 0.0909
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.1026 0.0805 0.1967
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0716 0.0543 0.0543
Brugia malayi Subtilase family protein 0.029 0.0182 0.0182
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0515 0.0372 0.0909
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0227 0.0128 0.0128
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 0.5109
Onchocerca volvulus 0.0088 0.0011 0.0027
Brugia malayi prolyl oligopeptidase family protein 0.4908 0.4095 0.4095
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0515 0.0372 0.0909
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0515 0.0372 0.0909
Brugia malayi histone deacetylase 1 (HD1) 0.0356 0.0238 0.0238
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1936 0.1577 0.385
Schistosoma mansoni chromatin regulatory protein sir2 0.0238 0.0138 0.0337
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1026 0.0805 0.1967
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.1026 0.0805 0.1967
Schistosoma mansoni caspase-7 (C14 family) 0.0091 0.0014 0.0033
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Echinococcus granulosus serotonin transporter 0.0088 0.0011 0.0011
Echinococcus granulosus prolyl endopeptidase 0.4908 0.4095 0.4095
Loa Loa (eye worm) cathepsin B 0.0104 0.0024 0.0026
Trypanosoma brucei histone deacetylase 1 0.0356 0.0238 0.0582
Leishmania major oligopeptidase b 0.1952 0.159 0.3883
Echinococcus multilocularis cathepsin b 0.0289 0.0181 0.0181
Trypanosoma cruzi oligopeptidase b 0.1952 0.159 0.3883
Loa Loa (eye worm) prolyl oligopeptidase 0.0515 0.0372 0.0408
Onchocerca volvulus Prolyl endopeptidase homolog 0.4908 0.4095 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.1026 0.0805 0.1967
Schistosoma mansoni chromatin regulatory protein sir2 0.0157 0.0069 0.0169
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Loa Loa (eye worm) hypothetical protein 0.1026 0.0805 0.0882
Echinococcus granulosus cathepsin b 0.0289 0.0181 0.0181
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.1026 0.0805 0.1967
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0356 0.0238 0.1511
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 0.5109
Schistosoma mansoni hypothetical protein 0.0167 0.0078 0.0189
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0515 0.0372 0.0909
Loa Loa (eye worm) hypothetical protein 0.0088 0.0011 0.0012
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0258 0.0155 0.017
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.1026 0.0805 0.1967
Toxoplasma gondii histone deacetylase HDAC5 0.0135 0.0051 0.0124
Loa Loa (eye worm) subtilase 0.029 0.0182 0.0199
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.1026 0.0805 0.0805
Echinococcus granulosus histone deacetylase 6 0.0251 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0509 0.0367 0.0402
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0515 0.0372 0.0909
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0515 0.0372 0.2362
Toxoplasma gondii hypothetical protein 0.091 0.0707 0.1728
Brugia malayi NAD-dependent deacetylase SIRT1 0.0157 0.0069 0.0069
Echinococcus granulosus histone deacetylase 7 0.0245 0.0144 0.0144
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1026 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.4267 0.3551 0.389
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0515 0.0372 0.0408
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0289 0.0181 0.0443
Plasmodium falciparum phosphodiesterase gamma, putative 0.1026 0.0805 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1026 0.0805 0.1967
Trypanosoma brucei prolyl endopeptidase 0.4908 0.4095 1
Trichomonas vaginalis conserved hypothetical protein 0.091 0.0707 0.4487
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Toxoplasma gondii histone deacetylase HDAC2 0.0356 0.0238 0.0582
Onchocerca volvulus 0.0227 0.0128 0.0313
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0289 0.0181 0.0443
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.9323 0.7835 0.7835
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1936 0.1577 0.385
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Echinococcus multilocularis histone deacetylase 8 0.0135 0.0051 0.0051
Echinococcus multilocularis serotonin transporter 0.0088 0.0011 0.0011
Trypanosoma brucei histone deacetylase 4 0.0245 0.0144 0.0351
Plasmodium falciparum histone deacetylase, putative 0.0245 0.0144 0.1783
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.1936 0.1577 0.385
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0515 0.0372 0.0909
Echinococcus multilocularis histone deacetylase 0.0245 0.0144 0.0144
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Echinococcus granulosus chromatin regulatory protein sir2 0.0238 0.0138 0.0138
Loa Loa (eye worm) serotonin transporter b 0.0088 0.0011 0.0012
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.1026 0.0805 0.1967
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.3241 0.2682 0.2938
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0104 0.0024 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Loa Loa (eye worm) hypothetical protein 0.0157 0.0069 0.0076
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.1936 0.1577 0.1577
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0051 0.0056
Brugia malayi Trypsin family protein 0.0509 0.0367 0.0367
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Trypanosoma cruzi prolyl endopeptidase 0.4908 0.4095 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0515 0.0372 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0515 0.0372 0.0909
Echinococcus granulosus caspase 2 0.0091 0.0014 0.0014
Mycobacterium ulcerans putative regulatory protein 0.091 0.0707 0.3805
Schistosoma mansoni histone deacetylase 0.0356 0.0238 0.0582
Plasmodium falciparum cysteine repeat modular protein 1 0.0167 0.0078 0.0963
Plasmodium vivax hypothetical protein, conserved 0.0515 0.0372 0.4624
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.1026 0.0805 0.1967
Brugia malayi Histone deacetylase family protein 0.0245 0.0144 0.0144
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.1936 0.1577 0.1577
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.4908 0.4095 1
Trichomonas vaginalis conserved hypothetical protein 0.091 0.0707 0.4487
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0515 0.0372 0.0909
Brugia malayi Kringle domain containing protein 0.0167 0.0078 0.0078
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0716 0.0543 0.1326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0238 0.0138 0.0138
Onchocerca volvulus 0.0509 0.0367 0.0896
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0238 0.0138 0.0138
Brugia malayi prolyl oligopeptidase family protein 0.0515 0.0372 0.0372
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.029 0.0182 0.0444
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0244 0.0143 0.3837
Echinococcus granulosus histone deacetylase 0.0245 0.0144 0.0144
Leishmania major histone deacetylase, putative 0.0245 0.0144 0.0351
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1026 0.0805 0.5109
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.4908 0.4095 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0104 0.0024 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Loa Loa (eye worm) hypothetical protein 0.8297 0.6966 0.7629
Toxoplasma gondii hypothetical protein 0.091 0.0707 0.1728
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0515 0.0372 0.0909
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1026 0.0805 0.5109
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1026 0.0805 0.1967
Giardia lamblia Histone deacetylase 0.0356 0.0238 0.0607
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0157 0.0069 0.0439
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.4267 0.3551 0.3551
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0515 0.0372 0.0909
Trichomonas vaginalis conserved hypothetical protein 0.1026 0.0805 0.5109
Schistosoma mansoni gamma-secretase subunit aph-1 0.0258 0.0155 0.0379
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0238 0.0138 0.0874
Plasmodium vivax aspartyl protease, putative 0.0101 0.0022 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0515 0.0372 0.2362
Plasmodium falciparum GAF domain-related protein, putative 0.091 0.0707 0.8783
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.1026 0.0805 0.5109
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1026 0.0805 0.1967
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0289 0.0181 0.0443
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0515 0.0372 1
Brugia malayi Histone deacetylase 1 0.0356 0.0238 0.0238
Loa Loa (eye worm) histone deacetylase 11 0.0135 0.0051 0.0056
Trypanosoma brucei oligopeptidase b 0.1952 0.159 0.3883
Leishmania major hypothetical protein, conserved 0.0167 0.0078 0.0189
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1026 0.0805 0.5109
Schistosoma mansoni sodium/chloride dependent transporter 0.0088 0.0011 0.0027
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1936 0.1577 0.1577
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.4908 0.4095 1
Trypanosoma cruzi oligopeptidase b 0.1952 0.159 0.3883
Loa Loa (eye worm) transcriptional regulator 0.0238 0.0138 0.0151
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.1026 0.0805 0.0805
Leishmania major hypothetical protein, conserved 0.1026 0.0805 0.1967
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0227 0.0128 0.0128
Leishmania major histone deacetylase, putative 0.0356 0.0238 0.0582
Plasmodium falciparum peptidase, putative 0.0515 0.0372 0.4624
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0515 0.0372 0.0372
Brugia malayi prolyl oligopeptidase family protein 0.0515 0.0372 0.0372
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1026 0.0805 0.1967
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.1952 0.159 0.3883
Trypanosoma brucei prolyl oligopeptidase, putative 0.1952 0.159 0.3883
Trypanosoma brucei C-8 sterol isomerase, putative 0.0716 0.0543 0.1326
Leishmania major histone deacetylase, putative 0.0356 0.0238 0.0582
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.1952 0.159 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Loa Loa (eye worm) hypothetical protein 0.0515 0.0372 0.0408
Echinococcus granulosus histone deacetylase 1 0.0356 0.0238 0.0238
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Plasmodium vivax phosphodiesterase gamma, putative 0.1026 0.0805 1
Loa Loa (eye worm) hypothetical protein 0.1936 0.1577 0.1727
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0093 0.0015 0.0037
Plasmodium falciparum cGMP-specific phosphodiesterase 0.1026 0.0805 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0289 0.0181 0.0443
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1026 0.0805 0.5109
Plasmodium vivax histone deacetylase, putative 0.0135 0.0051 0.0632
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0167 0.0078 0.0963
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0515 0.0372 0.2362
Echinococcus granulosus inhibitor of apoptosis protein 0.0227 0.0128 0.0128
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0509 0.0367 0.0896
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Brugia malayi prolyl oligopeptidase family protein 0.0515 0.0372 0.0372
Schistosoma mansoni inhibitor of apoptosis protein 0.0227 0.0128 0.0313
Brugia malayi gamma-secretase subunit aph-1 0.0258 0.0155 0.0155
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0238 0.1511
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1936 0.1577 1
Loa Loa (eye worm) histone deacetylase 3 0.0356 0.0238 0.0261
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0227 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0515 0.0372 0.0408
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.091 0.0707 0.1552
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.3241 0.2682 0.2682
Plasmodium falciparum histone deacetylase 1 0.0356 0.0238 0.2957
Echinococcus granulosus histone deacetylase 6 0.0245 0.0144 0.0144
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0515 0.0372 0.0372
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0238 0.0138 0.37
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3241 0.2682 0.2682
Plasmodium falciparum histone deacetylase 2 0.0245 0.0144 0.1783
Echinococcus granulosus histone deacetylase 8 0.0135 0.0051 0.0051
Echinococcus multilocularis acylamino acid releasing enzyme 0.0515 0.0372 0.0372
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0014 0.0015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1936 0.1577 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.4394 0.3659 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Trypanosoma cruzi hypothetical protein, conserved 0.1026 0.0805 0.1967
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0561 0.0411 0.0411
Plasmodium vivax aspartyl protease, putative 0.0101 0.0022 0.0275
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.1026 0.0805 0.0882
Brugia malayi histone deacetylase 3 (HD3) 0.0356 0.0238 0.0238
Onchocerca volvulus 0.0454 0.0321 0.0783
Brugia malayi histone deacetylase 11 0.0135 0.0051 0.0051
Plasmodium falciparum cGMP-specific phosphodiesterase 0.1026 0.0805 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.1026 0.0805 0.1967
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1026 0.0805 0.0805
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Schistosoma mansoni cathepsin D (A01 family) 0.0116 0.0035 0.0085
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0289 0.0181 0.0443
Plasmodium falciparum plasmepsin X 0.0101 0.0022 0.0275
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1026 0.0805 0.1967
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0238 0.1511
Brugia malayi transcriptional regulator, Sir2 family protein 0.0238 0.0138 0.0138
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 1.1878 1 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0238 0.0138 0.0337
Schistosoma mansoni histone deacetylase 1 2 3 0.0135 0.0051 0.0124
Echinococcus granulosus cathepsin b 0.0289 0.0181 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0515 0.0372 0.0909
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 1.1878 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1936 0.1577 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1936 0.1577 0.385
Plasmodium falciparum phosphodiesterase delta, putative 0.1026 0.0805 1
Onchocerca volvulus 0.0091 0.0014 0.0033
Plasmodium vivax hypothetical protein, conserved 0.091 0.0707 0.8783
Loa Loa (eye worm) hypothetical protein 0.0509 0.0367 0.0402

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 13 uM Half-maximal inhibition of binding of [125I]-gastrin to guinea pig gastric glands ChEMBL. 2885419
IC50 (binding) = 60 uM Half-maximal inhibition of [125I]-CCK-33 binding to rat pancreas cholecystokinin receptor ChEMBL. 2885419
IC50 (binding) = 80 uM Half-maximal inhibition of [125I]-CCK-33 binding to guinea pig brain(cortex) cholecystokinin receptor ChEMBL. 2885419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.