Detailed information for compound 252528

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.591 | Formula: C29H34N2O4
  • H donors: 1 H acceptors: 2 LogP: 4.45 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CC(COc1ccccc1C(=O)CCc1ccccc1)O
  • InChi: 1S/C29H34N2O4/c1-34-29-14-8-6-12-26(29)31-19-17-30(18-20-31)21-24(32)22-35-28-13-7-5-11-25(28)27(33)16-15-23-9-3-2-4-10-23/h2-14,24,32H,15-22H2,1H3
  • InChiKey: DZZBQXHAEAPAHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0877 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.302 1
Onchocerca volvulus 0.0023 0.302 0.2509
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.302 1
Echinococcus granulosus neuropeptide s receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.2576 0.436
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Schistosoma mansoni biogenic amine receptor 0.0023 0.302 1
Echinococcus multilocularis allatostatin A receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Schistosoma mansoni amine GPCR 0.0023 0.302 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.302 0.2786
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0019 0.2258 0.2941
Brugia malayi Dopamine receptor protein 2 0.0023 0.302 0.302
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0877 1
Onchocerca volvulus 0.0023 0.302 0.2509
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.302 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.302 1
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0877 0.5
Onchocerca volvulus 0.0023 0.302 0.2509
Echinococcus granulosus fmrfamide receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0031 0.4773 0.6357
Onchocerca volvulus 0.0027 0.3971 0.3623
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0877 0.0039
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.302 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.4383 0.5834
Onchocerca volvulus 0.0023 0.302 0.2509
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.302 0.2786
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.302 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.218 0.3343
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.302 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.3337 0.4459
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0877 1
Onchocerca volvulus 0.0023 0.302 0.2509
Echinococcus multilocularis sex peptide receptor 0.0023 0.302 1
Brugia malayi AKH receptor 0.0023 0.302 0.302
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0877 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.302 1
Brugia malayi Serotonin receptor 0.0023 0.302 0.302
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0877 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.302 1
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.302 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.302 1
Echinococcus multilocularis neuropeptide receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0023 0.3157 0.4188
Schistosoma mansoni multidrug resistance protein 0.0013 0.0877 0.2904
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Schistosoma mansoni myosin xvIII 0.0023 0.302 1
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.302 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.302 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.302 1
Brugia malayi ORL1-like opioid receptor 0.0023 0.302 0.302
Brugia malayi G-protein coupled receptor 0.0023 0.302 0.302
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0877 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.302 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.302 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0877 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.302 0.302
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0031 0.4773 0.6337
Mycobacterium ulcerans polyketide synthase Pks9 0.0019 0.2258 0.2981
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.302 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.4191 0.5599
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0877 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.302 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.302 0.302
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.302 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0877 1
Schistosoma mansoni biogenic amine receptor 0.0023 0.302 1
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.302 1
Brugia malayi Dopamine receptor protein 1 0.0023 0.302 0.302
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.302 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0043 0.7486 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0877 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Leishmania major p-glycoprotein 0.0013 0.0877 1
Echinococcus multilocularis g protein coupled receptor 0.0023 0.302 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0877 1
Onchocerca volvulus 0.0023 0.302 0.2509
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.302 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.302 1
Echinococcus multilocularis neuropeptide receptor 0.0023 0.302 1
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0009 0.0039 0.0052
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.302 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.4191 0.5599
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0995 0.019
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Echinococcus multilocularis fmrfamide receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Brugia malayi AMP-binding enzyme family protein 0.0027 0.3971 0.3971
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0877 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0877 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus neuropeptide receptor 0.0023 0.302 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.302 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0877 0.2805
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0877 0.2805
Onchocerca volvulus 0.0023 0.302 0.2509
Toxoplasma gondii type I fatty acid synthase, putative 0.0031 0.4773 1
Onchocerca volvulus 0.0023 0.302 0.2509
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.2616 0.3495
Schistosoma mansoni smdr2 0.0013 0.0877 0.2904
Mycobacterium ulcerans polyketide synthase Pks13 0.0043 0.7486 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0877 0.2805
Brugia malayi sulfakinin receptor protein 0.0023 0.302 0.302
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.302 0.302
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0043 0.7486 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0877 0.2805
Loa Loa (eye worm) hypothetical protein 0.0013 0.0877 0.0039
Brugia malayi GnHR receptor homolog 0.0023 0.302 0.302
Schistosoma mansoni neuropeptide receptor 0.0023 0.302 1
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.302 1
Mycobacterium ulcerans fatty acid synthase Fas 0.0009 0.0081 0.0056
Brugia malayi ABC transporter family protein 0.0013 0.0877 0.0877
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0877 0.2805
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.1281 0.1036
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0877 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.3337 0.4398
Loa Loa (eye worm) hypothetical protein 0.0016 0.1625 0.0997
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Schistosoma mansoni multidrug resistance protein 0.0013 0.0877 0.2904
Schistosoma mansoni opsin-like receptor 0.0023 0.302 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0029 0.4383 0.581
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.302 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.4383 0.5834
Echinococcus granulosus g protein coupled receptor 0.0023 0.302 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Echinococcus multilocularis orexin receptor type 2 0.0023 0.302 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.302 0.2786
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.4383 0.5834
Echinococcus multilocularis somatostatin receptor 0.0023 0.302 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.302 1
Mycobacterium ulcerans polyketide synthase 0.0029 0.4383 0.5834
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.302 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0023 0.3157 0.4155
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.302 1
Echinococcus granulosus g-protein coupled receptor 0.0023 0.302 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.4383 0.5856
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.302 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.302 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.302 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0031 0.4773 0.6337
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.302 1
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0877 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0877 0.5
Schistosoma mansoni opsin-like receptor 0.0023 0.302 1
Schistosoma mansoni adenoreceptor 0.0023 0.302 1
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.302 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.302 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.302 0.302
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.302 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.302 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0877 1
Schistosoma mansoni amine GPCR 0.0023 0.302 1
Loa Loa (eye worm) fatty acid synthase 0.0028 0.43 0.4426
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.302 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Brugia malayi G protein-coupled receptor 0.0023 0.302 0.302
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.302 0.2786
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0877 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.302 1
Echinococcus multilocularis fmrfamide receptor 0.0023 0.302 1
Brugia malayi neuropeptide F receptor 0.0023 0.302 0.302
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0877 0.2805
Mycobacterium leprae Polyketide synthase Pks13 0.0043 0.7486 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0877 0.2805
Brugia malayi G-protein coupled receptor 0.0023 0.302 0.302
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0031 0.4773 0.6376
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0877 0.0039
Brugia malayi follicle stimulating hormone receptor 0.0023 0.302 0.302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.302 1
Echinococcus granulosus neuropeptide receptor 0.0023 0.302 1
Echinococcus granulosus orexin receptor type 2 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.302 0.302
Echinococcus granulosus g protein coupled receptor 0.0023 0.302 1
Onchocerca volvulus 0.005 0.9028 0.9544
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0877 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.302 1
Schistosoma mansoni opsin-like receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.302 1
Onchocerca volvulus 0.0023 0.302 0.2509
Onchocerca volvulus 0.0023 0.302 0.2509
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0877 0.0039
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.302 0.2786
Echinococcus granulosus g protein coupled receptor 0.0023 0.302 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0877 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.302 0.2786
Schistosoma mansoni amine GPCR 0.0023 0.302 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0877 1
Echinococcus granulosus allatostatin A receptor 0.0023 0.302 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0029 0.4383 0.4383
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.302 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Brugia malayi Dopamine receptor 0.0023 0.302 0.302
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus multilocularis serotonin receptor 0.0023 0.302 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0877 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0031 0.4773 0.6376
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0019 0.2258 0.2981
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0039 0.0039
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.302 1
Mycobacterium ulcerans thioesterase TesA 0.0024 0.3337 0.443
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0877 0.2805
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.302 1
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.001 0.0267 0.0356
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus somatostatin receptor 0.0023 0.302 1
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8648 1
Schistosoma mansoni amine GPCR 0.0023 0.302 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0877 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.3971 0.4005
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.302 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0877 0.2904
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.302 0.302
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Schistosoma mansoni histamine h1 receptor 0.0023 0.302 1
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0847 0.2704
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0877 1
Schistosoma mansoni hypothetical protein 0.0023 0.302 1
Giardia lamblia Methyltransferase like 2 0.0009 0 0.5
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0009 0.0081 0.0108
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0877 0.2805
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.302 0.2786
Onchocerca volvulus 0.0023 0.302 0.2509
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.302 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0877 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0877 0.5
Mycobacterium leprae Probable polyketide synthase Pks1 0.0031 0.4773 0.6337
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.3971 0.5305
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.302 1
Brugia malayi Melatonin receptor type 1A 0.0023 0.302 0.302
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.302 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.302 0.2509
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0029 0.4383 0.5856
Onchocerca volvulus 0.0023 0.302 0.2509
Onchocerca volvulus 0.0023 0.302 0.2509
Brugia malayi putative neuropeptide receptor 0.0023 0.302 0.302
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.302 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0877 0.2805
Echinococcus multilocularis serotonin receptor 0.0023 0.302 1
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0877 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0877 1
Schistosoma mansoni amine GPCR 0.0023 0.302 1
Onchocerca volvulus Fatty acid synthase homolog 0.0052 0.9418 1
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.302 1
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.302 0.2786
Onchocerca volvulus 0.0023 0.302 0.2509
Onchocerca volvulus 0.0023 0.302 0.2509
Schistosoma mansoni neuropeptide receptor 0.0023 0.302 1
Schistosoma mansoni hypothetical protein 0.0023 0.302 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0877 0.2805
Schistosoma mansoni neuropeptide receptor 0.0023 0.302 1
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.302 0.2786
Brugia malayi multidrug resistance protein 3 0.0013 0.0877 0.0877
Brugia malayi RE15519p 0.0023 0.302 0.302
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0031 0.4773 0.6357
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.302 1
Echinococcus granulosus serotonin receptor 0.0023 0.302 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0877 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.302 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.302 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.4383 0.5856
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.302 0.2509
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0877 0.2805
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.302 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0877 0.1172
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.302 1
Brugia malayi larval opioid receptor 0.0023 0.302 0.302
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.302 1
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.302 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.302 1
Schistosoma mansoni biogenic amine receptor 0.0023 0.302 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.302 0.2786
Brugia malayi Serotonin receptor 0.0023 0.302 0.302
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0023 0.3157 0.4188
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.1676 0.224
Schistosoma mansoni hypothetical protein 0.0023 0.302 1
Brugia malayi hypothetical protein 0.0023 0.302 0.302
Trichomonas vaginalis taga, putative 0.0013 0.0877 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.302 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0847 0.2704
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0029 0.4383 0.581
Echinococcus granulosus hypothetical protein 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Brugia malayi neuropeptide F receptor 0.0023 0.302 0.302
Echinococcus multilocularis g protein coupled receptor 0.0023 0.302 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.302 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0877 0.2805
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.302 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.302 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.302 0.302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Onchocerca volvulus 0.0023 0.302 0.2509
Schistosoma mansoni neuropeptide receptor 0.0023 0.302 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0877 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.302 1
Echinococcus granulosus sex peptide receptor 0.0023 0.302 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.302 0.302
Mycobacterium ulcerans thioesterase 0.0024 0.3337 0.443
Schistosoma mansoni hypothetical protein 0.0023 0.302 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.302 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0647 0.0864
Trichomonas vaginalis abcb9, putative 0.0013 0.0877 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0877 1
Onchocerca volvulus 0.0023 0.302 0.2509
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0024 0.324 0.4329
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.302 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.4383 0.5834
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0877 0.2805
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.302 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.302 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.302 0.2786
Mycobacterium ulcerans polyketide synthase 0.0031 0.4773 0.6357
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0031 0.4773 0.6376
Loa Loa (eye worm) hypothetical protein 0.0023 0.302 0.2786
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.302 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.0042 0.0475
Echinococcus multilocularis g protein coupled receptor 0.0023 0.302 1

Activities

Activity type Activity value Assay description Source Reference
clogP = 4.89 Calculated partition coefficient (clogP) (Molgen) ChEMBL. 14584949
clogP = 6.62 Calculated partition coefficient (clogP) (HINT) ChEMBL. 14584949
EC50 (binding) = 0.23 uM Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay ChEMBL. 17352460
EC50 (binding) = 0.23 uM Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay ChEMBL. 17352460
IC50 (functional) = 0.11 uM In vitro multi drug resistance (MDR) reversal inhibitory activity against CCRF-CEM/VCR-1000 cell line ChEMBL. 14584949
IC50 (functional) = 0.11 uM In vitro multi drug resistance (MDR) reversal inhibitory activity against CCRF-CEM/VCR-1000 cell line ChEMBL. 14584949

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 14584949

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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