Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0843 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.096 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0076 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0405 | 0.4283 | 0.4283 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0405 | 0.4283 | 0.4283 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.096 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.096 | 1 |
Onchocerca volvulus | 0.0076 | 0 | 0.5 | |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.096 | 1 |
Onchocerca volvulus | 0.0076 | 0 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.096 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0487 | 0.5358 | 0.5358 |
Brugia malayi | beta-lactamase | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.096 | 1 |
Trypanosoma brucei | beta lactamase | 0.0405 | 0.4283 | 1 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0405 | 0.4283 | 1 |
Onchocerca volvulus | 0.0076 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.34 | Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand | ChEMBL. | 9836623 |
Log Ki (binding) | = 8.34 | Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand | ChEMBL. | 9836623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.