Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Bos taurus | Trypsin I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin I | 246 aa | 223 aa | 34.5 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin I | 246 aa | 243 aa | 28.8 % |
Onchocerca volvulus | Trypsin I | 246 aa | 247 aa | 21.1 % | |
Drosophila melanogaster | Jonah 65Aii | Trypsin I | 246 aa | 265 aa | 34.3 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin I | 246 aa | 305 aa | 23.9 % |
Onchocerca volvulus | Trypsin I | 246 aa | 266 aa | 22.2 % | |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin I | 246 aa | 259 aa | 26.6 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin I | 246 aa | 209 aa | 31.1 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin I | 246 aa | 287 aa | 27.5 % |
Echinococcus granulosus | Mastin | Trypsin I | 246 aa | 306 aa | 23.2 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin I | 246 aa | 235 aa | 29.8 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin I | 246 aa | 208 aa | 24.0 % |
Brugia malayi | Trypsin family protein | Trypsin I | 246 aa | 270 aa | 23.3 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin I | 246 aa | 301 aa | 23.9 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin I | 246 aa | 267 aa | 29.2 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin I | 246 aa | 208 aa | 23.1 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin I | 246 aa | 249 aa | 24.5 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 234 aa | 26.9 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 304 aa | 24.0 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin I | 246 aa | 269 aa | 31.6 % |
Neospora caninum | glycine cleavage T-protein domain containing protein, putative | Trypsin I | 246 aa | 203 aa | 21.7 % |
Drosophila melanogaster | Jonah 66Ci | Trypsin I | 246 aa | 272 aa | 30.5 % |
Echinococcus multilocularis | Mastin | Trypsin I | 246 aa | 306 aa | 23.2 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin I | 246 aa | 233 aa | 33.5 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 241 aa | 27.0 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin I | 246 aa | 261 aa | 28.0 % |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin I | 246 aa | 205 aa | 27.8 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin I | 246 aa | 299 aa | 23.4 % |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin I | 246 aa | 233 aa | 30.0 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin I | 246 aa | 299 aa | 21.7 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 287 aa | 27.9 % |
Echinococcus multilocularis | enteropeptidase | Trypsin I | 246 aa | 230 aa | 27.0 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin I | 246 aa | 246 aa | 38.2 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin I | 246 aa | 248 aa | 28.2 % |
Mycobacterium tuberculosis | Membrane-associated serine protease | Trypsin I | 246 aa | 203 aa | 20.7 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 241 aa | 27.0 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin I | 246 aa | 250 aa | 23.6 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin I | 246 aa | 272 aa | 31.6 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin I | 246 aa | 238 aa | 28.6 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin I | 246 aa | 260 aa | 27.7 % |
Echinococcus granulosus | enteropeptidase | Trypsin I | 246 aa | 230 aa | 27.0 % |
Drosophila melanogaster | Jonah 99Ci | Trypsin I | 246 aa | 237 aa | 32.9 % |
Schistosoma japonicum | Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative | Trypsin I | 246 aa | 207 aa | 24.6 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin I | 246 aa | 250 aa | 29.6 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin I | 246 aa | 251 aa | 33.9 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin I | 246 aa | 249 aa | 31.3 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin I | 246 aa | 233 aa | 33.9 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 262 aa | 34.0 % |
Loa Loa (eye worm) | hypothetical protein | Trypsin I | 246 aa | 217 aa | 24.0 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin I | 246 aa | 242 aa | 30.6 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin I | 246 aa | 235 aa | 34.9 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin I | 246 aa | 223 aa | 31.8 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin I | 246 aa | 234 aa | 32.5 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin I | 246 aa | 235 aa | 25.1 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin I | 246 aa | 264 aa | 24.6 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin I | 246 aa | 227 aa | 29.5 % |
Onchocerca volvulus | Trypsin I | 246 aa | 210 aa | 21.0 % | |
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin I | 246 aa | 262 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | integrin beta-2 | 0.1635 | 0.3228 | 0.3201 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.0225 | 0.0032 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0175 | 0.0205 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0424 | 0.0385 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2569 | 0.5162 | 0.5142 |
Schistosoma mansoni | integrin alpha-ps | 0.0103 | 0.0058 | 0.0017 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.0091 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.3839 | 0.779 | 0.7781 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2569 | 0.5162 | 0.5142 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0266 | 0.0395 | 0.0356 |
Echinococcus multilocularis | carbonic anhydrase | 0.2569 | 0.5162 | 0.5162 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0199 | 0.0255 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0091 | 0.0051 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2569 | 0.5162 | 0.5142 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3155 | 0.6374 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3155 | 0.6374 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0199 | 0.0255 | 0.0255 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.0395 | 0.0308 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.0395 | 0.0308 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.2019 | 0.4022 | 0.9902 |
Brugia malayi | Kelch motif family protein | 0.0281 | 0.0424 | 0.0385 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4906 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0058 | 0.0017 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0266 | 0.0395 | 0.0356 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2569 | 0.5162 | 0.5142 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4906 | 1 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0095 | 0.0041 | 0.0041 |
Schistosoma mansoni | integrin alpha-ps | 0.0199 | 0.0255 | 0.0215 |
Brugia malayi | follicle stimulating hormone receptor | 0.0291 | 0.0447 | 0.0408 |
Echinococcus multilocularis | carbonic anhydrase | 0.2569 | 0.5162 | 0.5162 |
Echinococcus granulosus | carbonic anhydrase | 0.2569 | 0.5162 | 0.5142 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0091 | 0.0051 |
Echinococcus granulosus | carbonic anhydrase | 0.2569 | 0.5162 | 0.5142 |
Brugia malayi | Integrin beta pat-3 precursor | 0.1635 | 0.3228 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.2569 | 0.5162 | 0.5142 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.0395 | 0.0308 |
Echinococcus granulosus | carbonic anhydrase | 0.2569 | 0.5162 | 0.5142 |
Schistosoma mansoni | integrin alpha-4 | 0.085 | 0.1603 | 0.1569 |
Echinococcus multilocularis | integrin alpha ps | 0.0199 | 0.0255 | 0.0255 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4906 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2569 | 0.5162 | 0.5142 |
Schistosoma mansoni | integrin beta subunit | 0.1088 | 0.2095 | 0.2063 |
Echinococcus multilocularis | carbonic anhydrase | 0.2569 | 0.5162 | 0.5162 |
Leishmania major | carbonic anhydrase-like protein | 0.4906 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.3146 | 0.6355 | 0.5 |
Onchocerca volvulus | 0.012 | 0.0091 | 0.195 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.2569 | 0.5162 | 0.5142 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.0225 | 0.0032 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.2027 | 0.404 | 1 |
Brugia malayi | Trypsin family protein | 0.012 | 0.0091 | 0.0051 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0712 | 0.1317 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0058 | 0.0017 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2569 | 0.5162 | 0.5142 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0837 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0199 | 0.0255 | 0.0215 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0281 | 0.0424 | 0.0385 |
Schistosoma mansoni | carbonic anhydrase | 0.3146 | 0.6355 | 0.6341 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0712 | 0.1317 | 0.1282 |
Echinococcus granulosus | carbonic anhydrase II | 0.4906 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2569 | 0.5162 | 0.5142 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0291 | 0.0447 | 0.0408 |
Mycobacterium ulcerans | carbonic anhydrase | 0.3155 | 0.6374 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4906 | 1 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0712 | 0.1317 | 0.1282 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.3146 | 0.6355 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2569 | 0.5162 | 0.5142 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4906 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4906 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0281 | 0.0424 | 0.0385 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.0395 | 0.0308 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4906 | 1 | 1 |
Schistosoma mansoni | integrin alpha | 0.0199 | 0.0255 | 0.0215 |
Echinococcus granulosus | integrin alpha ps | 0.0199 | 0.0255 | 0.0215 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.0395 | 0.0308 |
Echinococcus multilocularis | integrin alpha ps | 0.0095 | 0.0041 | 0.0041 |
Schistosoma mansoni | carbonic anhydrase | 0.2569 | 0.5162 | 0.5142 |
Plasmodium falciparum | carbonic anhydrase | 0.2569 | 0.5162 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2569 | 0.5162 | 0.5142 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4906 | 1 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.1368 | 0.2676 | 0.2676 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.0091 | 0.0051 |
Echinococcus granulosus | integrin beta 2 | 0.1368 | 0.2676 | 0.2646 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4906 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.2569 | 0.5162 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.0395 | 0.0308 |
Schistosoma mansoni | hypothetical protein | 0.2569 | 0.5162 | 0.5142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 120 nM | In vitro inhibition of human thrombin(FIIa). | ChEMBL. | 10639283 |
Ki (binding) | = 120 nM | In vitro inhibition of human thrombin(FIIa). | ChEMBL. | 10639283 |
Ki (binding) | = 260 nM | In vitro inhibition of bovine trypsin(Trp). | ChEMBL. | 10639283 |
Ki (binding) | = 260 nM | In vitro inhibition of bovine trypsin(Trp). | ChEMBL. | 10639283 |
Ki (binding) | = 420 nM | In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system. | ChEMBL. | 10639283 |
Ki (binding) | = 420 nM | In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system. | ChEMBL. | 10639283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.