Detailed information for compound 264020

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 702.826 | Formula: C34H42N10O5S
  • H donors: 8 H acceptors: 6 LogP: 0.89 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=NCCC[C@@H](C(=O)N[C@@H](C(=O)N)Cc1csc2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](Cc1nc[nH]c1)NC(=O)C)Cc1ccccc1)N
  • InChi: 1S/C34H42N10O5S/c1-20(45)41-28(16-23-17-38-19-40-23)33(49)44-27(14-21-8-3-2-4-9-21)32(48)42-25(11-7-13-39-34(36)37)31(47)43-26(30(35)46)15-22-18-50-29-12-6-5-10-24(22)29/h2-6,8-10,12,17-19,25-28H,7,11,13-16H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H,44,49)(H4,36,37,39)/t25-,26+,27-,28-/m0/s1
  • InChiKey: GDPLVOFFSHSVQV-PUHABZHSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus melanocortin 3 receptor Starlite/ChEMBL References
Mus musculus melanocortin 1 receptor Starlite/ChEMBL References
Mus musculus melanocortin 4 receptor Starlite/ChEMBL References
Mus musculus melanocortin 5 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 372 aa 314 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0882 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.1855 0.1971
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) tubulin beta-2A chain 0.0027 0.0563 0.0563
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1833 0.1948
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0042 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0563 0.6003
Schistosoma mansoni thyroid hormone receptor 0.0142 0.4124 0.4383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0882 1
Trichomonas vaginalis tubulin, putative 0.0027 0.0563 0.6003
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Schistosoma mansoni peroxidasin 0.0242 0.7241 0.7696
Giardia lamblia Beta tubulin 0.0027 0.0563 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.1855 0.1971
Entamoeba histolytica tubulin family protein 0.0027 0.0563 0.0514
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1833 0.1948
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1833 0.1948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.1833 0.1948
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Schistosoma mansoni neuropeptide receptor 0.0068 0.1833 0.1948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1246 0.1324
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1833 0.1948
Schistosoma mansoni amine GPCR 0.0068 0.1833 0.1948
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0882 1
Onchocerca volvulus Peroxidasin homolog 0.0242 0.7241 0.7686
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1246 0.1324
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0042 0.0045
Schistosoma mansoni opsin-like receptor 0.0068 0.1833 0.1948
Schistosoma mansoni biogenic amine receptor 0.0068 0.1833 0.1948
Echinococcus granulosus peroxidasin 0.0242 0.7241 0.7696
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0406 0.4039
Brugia malayi ecdysteroid receptor 0.0011 0.0042 0.0045
Echinococcus granulosus orexin receptor type 2 0.0068 0.1833 0.1948
Schistosoma mansoni tubulin subunit beta 0.0027 0.0563 0.0598
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Toxoplasma gondii beta-1 tubulin, putative 0.0027 0.0563 0.3201
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.1833 0.1948
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.1833 0.1948
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0042 0.0045
Loa Loa (eye worm) tubulin beta-1 chain 0.0027 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Plasmodium falciparum glutathione reductase 0.0066 0.1758 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1246 0.1324
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Trypanosoma brucei beta tubulin 0.0027 0.0563 0.2704
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.1833 0.1948
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0882 0.4505
Schistosoma mansoni opsin-like receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0953 0.1013
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0042 0.0045
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0423 0.1526
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0027 0.0563 0.0598
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.1833 0.1948
Loa Loa (eye worm) glutathione reductase 0.0066 0.1758 0.1758
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.1833 0.1833
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0563 0.0598
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.0563 0.6003
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1833 0.1948
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0042 0.0045
Echinococcus multilocularis orexin receptor type 2 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Trichomonas vaginalis esterase, putative 0.0038 0.0882 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0882 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1833 0.1948
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0882 1
Onchocerca volvulus 0.0038 0.0882 0.0896
Echinococcus multilocularis tubulin subunit beta 0.0027 0.0563 0.0598
Echinococcus granulosus g protein coupled receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.1758 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.1833 0.1948
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0042 0.0045
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.7241 0.7241
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Echinococcus granulosus tubulin beta 1 chain 0.0027 0.0563 0.0598
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Brugia malayi ORL1-like opioid receptor 0.0068 0.1833 0.1948
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.1833 0.1948
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.1758 0.1869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0042 0.0045
Onchocerca volvulus 0.0068 0.1833 0.1912
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.1758 0.9457
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Brugia malayi nuclear receptor NHR-88 0.0011 0.0042 0.0045
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.1833 0.1948
Onchocerca volvulus 0.0068 0.1833 0.1912
Toxoplasma gondii beta tubulin 0.0027 0.0563 0.3201
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.1833 0.1948
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1833 0.1948
Brugia malayi Dopamine receptor protein 1 0.0068 0.1833 0.1948
Brugia malayi beta-lactamase family protein 0.0038 0.0882 0.0937
Schistosoma mansoni tubulin subunit beta 0.0027 0.0563 0.0598
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.1833 0.1948
Giardia lamblia Beta tubulin 0.0027 0.0563 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1246 0.1324
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0042 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0423 0.2404
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0038 0.0882 0.0882
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.1833 0.1948
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0882 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0882 0.068
Brugia malayi sulfakinin receptor protein 0.0068 0.1833 0.1948
Brugia malayi Dopamine receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.1833 0.1833
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0423 0.4246
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0042 0.0045
Brugia malayi RE15519p 0.0068 0.1833 0.1948
Schistosoma mansoni hypothetical protein 0.0177 0.5208 0.5536
Entamoeba histolytica tubulin family protein 0.0027 0.0563 0.0514
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Echinococcus granulosus neuropeptide receptor 0.0068 0.1833 0.1948
Echinococcus granulosus geminin 0.0177 0.5208 0.5536
Onchocerca volvulus Peroxidase homolog 0.0242 0.7241 0.7686
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0882 0.4505
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.1833 0.1948
Echinococcus granulosus beta tubulin 0.0027 0.0563 0.0598
Brugia malayi G-protein coupled receptor 0.0068 0.1833 0.1948
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.1833 0.1948
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1833 0.1948
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.1833 0.1948
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0042 0.0045
Onchocerca volvulus Peroxidasin homolog 0.0242 0.7241 0.7686
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Onchocerca volvulus 0.0068 0.1833 0.1912
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.1833 0.1948
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0042 0.0045
Mycobacterium tuberculosis Conserved protein 0.0038 0.0882 0.068
Mycobacterium tuberculosis Conserved protein 0.0038 0.0882 0.068
Brugia malayi hypothetical protein 0.0242 0.7241 0.7696
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0423 0.1913
Trichomonas vaginalis tubulin gamma chain, putative 0.0027 0.0563 0.6003
Brugia malayi Tubulin beta-1 chain 0.0027 0.0563 0.0598
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0042 0.0045
Giardia lamblia Beta tubulin 0.0027 0.0563 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0423 0.1913
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.1833 0.1833
Onchocerca volvulus 0.0068 0.1833 0.1912
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0882 0.4505
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0882 0.068
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1833 0.1948
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1855 1
Brugia malayi beta-tubulin, identical 0.0027 0.0563 0.0598
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.1833 0.1948
Echinococcus granulosus sex peptide receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.1758 0.1758
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1833 0.1833
Onchocerca volvulus 0.0068 0.1833 0.1912
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0882 1
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0563 0.0598
Onchocerca volvulus 0.0068 0.1833 0.1912
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.7241 0.7241
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0322 0.1832
Onchocerca volvulus 0.0068 0.1833 0.1912
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0563 0.0563
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Plasmodium falciparum thioredoxin reductase 0.0066 0.1758 1
Brugia malayi steroid hormone receptor 0.0011 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Brugia malayi Serotonin receptor 0.0068 0.1833 0.1948
Schistosoma mansoni tubulin subunit beta 0.0027 0.0563 0.0598
Schistosoma mansoni amine GPCR 0.0068 0.1833 0.1948
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.1833 0.1833
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0423 0.4246
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0423 0.1913
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1246 0.1324
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0423 0.1913
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.1833 0.1912
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.1833 0.1948
Schistosoma mansoni amine GPCR 0.0068 0.1833 0.1948
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0423 0.1526
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Plasmodium falciparum glutathione reductase 0.0023 0.0423 0.2404
Schistosoma mansoni biogenic amine receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.1833 0.1948
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0042 0.0045
Onchocerca volvulus Peroxidase homolog 0.0242 0.7241 0.7686
Loa Loa (eye worm) hypothetical protein 0.0038 0.0882 0.0882
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1833 0.1948
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0042 0.0045
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Schistosoma mansoni hypothetical protein 0.0068 0.1833 0.1948
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0882 0.068
Echinococcus granulosus tubulin subunit beta 0.0027 0.0563 0.0598
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.1758 0.1869
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0563 0.6003
Loa Loa (eye worm) tubulin beta-4 chain 0.0027 0.0563 0.0563
Echinococcus granulosus beta tubulin 0.0027 0.0563 0.0598
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0423 0.0449
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.1833 0.1948
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0423 0.1913
Echinococcus multilocularis beta tubulin 0.0027 0.0563 0.0598
Plasmodium vivax glutathione reductase, putative 0.0066 0.1758 1
Echinococcus multilocularis peroxidasin 0.0242 0.7241 0.7696
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.1855 0.1855
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.1833 0.1948
Onchocerca volvulus Chorion peroxidase homolog 0.0242 0.7241 0.7686
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1833 0.1948
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 0.1833 0.1948
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.3796 0.4035
Loa Loa (eye worm) blistered cuticle protein 3 0.0242 0.7241 0.7241
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0312 0.9408 0.9408
Schistosoma mansoni opsin-like receptor 0.0068 0.1833 0.1948
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0042 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0042 0.0045
Echinococcus granulosus tubulin beta 4A class IVa 0.0027 0.0563 0.0598
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0563 0.0598
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0563 0.0598
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Echinococcus granulosus transcription factor Dp 1 0.004 0.0953 0.1013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1833 0.1948
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0042 0.0045
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0042 0.0042
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0423 0.751
Brugia malayi hypothetical protein 0.0127 0.3661 0.3891
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.1833 0.1948
Onchocerca volvulus 0.0068 0.1833 0.1912
Schistosoma mansoni hypothetical protein 0.0177 0.5208 0.5536
Schistosoma mansoni thyroid hormone receptor 0.0142 0.4124 0.4383
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0882 0.068
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.1833 0.1948
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0423 0.0449
Brugia malayi AKH receptor 0.0068 0.1833 0.1948
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0042 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1833 0.1948
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0042 0.0045
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1833 0.1948
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0042 0.0045
Schistosoma mansoni hypothetical protein 0.0068 0.1833 0.1948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1246 0.1324
Brugia malayi hypothetical protein 0.0312 0.9408 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1833 0.1948
Onchocerca volvulus 0.0068 0.1833 0.1912
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.1855 0.1971
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Onchocerca volvulus 0.0068 0.1833 0.1912
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0423 0.1913
Brugia malayi glutathione reductase 0.0066 0.1758 0.1869
Echinococcus multilocularis somatostatin receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis serotonin receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0563 0.0598
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0563 0.0598
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1833 0.1833
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0882 0.0937
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Onchocerca volvulus 0.0242 0.7241 0.7686
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0042 0.0042
Schistosoma mansoni neuropeptide receptor 0.0068 0.1833 0.1948
Leishmania major hypothetical protein, conserved 0.0038 0.0882 0.4505
Echinococcus multilocularis geminin 0.0177 0.5208 0.5536
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0042 0.0045
Echinococcus multilocularis tubulin beta 1 chain 0.0027 0.0563 0.0598
Loa Loa (eye worm) tubulin beta chain 0.0027 0.0563 0.0563
Brugia malayi Peroxidasin 0.0242 0.7241 0.7696
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1855 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.1833 0.1948
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Loa Loa (eye worm) beta-tubulin 0.0027 0.0563 0.0563
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0423 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0042 0.0045
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0042 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.1833 0.1833
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0423 0.0449
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.7241 0.7241
Mycobacterium ulcerans lipase LipD 0.0038 0.0882 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1246 0.1246
Schistosoma mansoni neuropeptide receptor 0.0068 0.1833 0.1948
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0235 0.0249
Trypanosoma brucei beta tubulin 0.0027 0.0563 0.2704
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0042 0.0045
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0882 1
Plasmodium falciparum thioredoxin reductase 0.0023 0.0423 0.2404
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.3796 0.4035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0882 0.0937
Echinococcus granulosus neuropeptide s receptor 0.0068 0.1833 0.1948
Schistosoma mansoni amine GPCR 0.0068 0.1833 0.1948
Brugia malayi Animal haem peroxidase family protein 0.0242 0.7241 0.7696
Echinococcus granulosus hypothetical protein 0.0068 0.1833 0.1948
Schistosoma mansoni hypothetical protein 0.0068 0.1833 0.1948
Schistosoma mansoni tubulin subunit beta 0.0027 0.0563 0.0598
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.1855 1
Onchocerca volvulus 0.0068 0.1833 0.1912
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0042 0.0045
Treponema pallidum NADH oxidase 0.0023 0.0423 0.5
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Onchocerca volvulus 0.0242 0.7241 0.7686
Trypanosoma brucei beta tubulin 0.0027 0.0563 0.2704
Leishmania major trypanothione reductase 0.0066 0.1758 0.9457
Echinococcus granulosus neuropeptide receptor 0.0068 0.1833 0.1948
Mycobacterium leprae Probable lipase LipE 0.0038 0.0882 1
Schistosoma mansoni hypothetical protein 0.0131 0.3796 0.4035
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Schistosoma mansoni hypothetical protein 0.0312 0.9408 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0042 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0423 0.2404
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1833 0.1948
Onchocerca volvulus Protein cereblon homolog 0.0312 0.9408 1
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0563 0.0598
Loa Loa (eye worm) RecQ helicase 0.0022 0.0406 0.0406
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.1833 0.1948
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0406 0.0432
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0882 0.4438
Onchocerca volvulus 0.0068 0.1833 0.1912
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0042 0.0045
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Brugia malayi beta-lactamase family protein 0.0038 0.0882 0.0937
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0042 0.0042
Schistosoma mansoni tubulin subunit beta 0.0027 0.0563 0.0598
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1833 0.1948
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0042 0.0045
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1833 0.1948
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.4124 0.4383
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.1855 1
Schistosoma mansoni coup transcription factor 0.0011 0.0042 0.0045
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0235 0.0249
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0423 0.2404
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0563 0.0598
Loa Loa (eye worm) hypothetical protein 0.0038 0.0882 0.0882
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0042 0.0045
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0882 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0563 0.0598
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0406 0.4039
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Trypanosoma brucei beta tubulin 0.0027 0.0563 0.2704
Entamoeba histolytica hypothetical protein, conserved 0.0312 0.9408 1
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1833 0.1948
Brugia malayi Melatonin receptor type 1A 0.0068 0.1833 0.1948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1833 0.1948
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0042 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Onchocerca volvulus 0.0068 0.1833 0.1912
Brugia malayi larval opioid receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.1833 0.1948
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0042 0.0045
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0882 0.0937
Brugia malayi GnHR receptor homolog 0.0068 0.1833 0.1948
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Onchocerca volvulus Dual oxidase homolog 0.0242 0.7241 0.7686
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0563 0.0563
Onchocerca volvulus 0.0068 0.1833 0.1912
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.1833 0.1948
Echinococcus granulosus fmrfamide receptor 0.0068 0.1833 0.1948
Brugia malayi Dopamine receptor protein 2 0.0068 0.1833 0.1948
Echinococcus granulosus somatostatin receptor 0.0068 0.1833 0.1948
Schistosoma mansoni hypothetical protein 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1246 0.1324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1246 0.1324
Brugia malayi Animal haem peroxidase family protein 0.0242 0.7241 0.7696
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.1833 0.1948
Echinococcus granulosus g protein coupled receptor 0.0068 0.1833 0.1948
Brugia malayi Blistered cuticle protein 3 0.0242 0.7241 0.7696
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.1833 0.1948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0042 0.0042
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.1833 0.1948
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 0.1833 0.1948
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0038 0.0882 0.0882
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1833 0.1948
Schistosoma mansoni peroxidasin 0.0242 0.7241 0.7696
Brugia malayi Thioredoxin reductase 0.0066 0.1758 0.1869
Plasmodium vivax tubulin beta chain, putative 0.0027 0.0563 0.2415
Brugia malayi Animal haem peroxidase family protein 0.0242 0.7241 0.7696
Brugia malayi follicle stimulating hormone receptor 0.0308 0.9291 0.9875
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1833 0.1948
Brugia malayi nuclear hormone receptor 0.0011 0.0042 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.1833 0.1912
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Echinococcus multilocularis sex peptide receptor 0.0068 0.1833 0.1948
Schistosoma mansoni amine GPCR 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.1855 0.1971
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.1833 0.1948
Schistosoma mansoni tubulin subunit beta 0.0027 0.0563 0.0598
Loa Loa (eye worm) hypothetical protein 0.0038 0.0882 0.0882
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0177 0.1005
Onchocerca volvulus 0.0068 0.1833 0.1912
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.1833 0.1948
Echinococcus multilocularis serotonin receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0308 0.9291 0.9291
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0042 0.0045
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.1833 0.1948
Brugia malayi putative neuropeptide receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0423 0.2404
Echinococcus granulosus serotonin receptor 0.0068 0.1833 0.1948
Toxoplasma gondii beta-tubulin, putative 0.0027 0.0563 0.3201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0423 0.1913
Echinococcus granulosus g protein coupled receptor 0.0068 0.1833 0.1948
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.1833 0.1948
Schistosoma mansoni biogenic amine receptor 0.0068 0.1833 0.1948
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0423 0.1913
Brugia malayi Animal haem peroxidase family protein 0.0242 0.7241 0.7696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0042 0.0042
Onchocerca volvulus 0.0038 0.0882 0.0896
Echinococcus multilocularis allatostatin A receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0882 0.0882
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1833 0.1948
Brugia malayi hypothetical protein 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Echinococcus granulosus protein cereblon 0.0312 0.9408 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0882 0.068
Onchocerca volvulus 0.0068 0.1833 0.1912
Echinococcus multilocularis beta tubulin 0.0027 0.0563 0.0598
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.1833 0.1833
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0423 0.1913
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.7241 0.7241
Mycobacterium ulcerans beta-lactamase 0.0038 0.0882 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0882 0.068
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0882 0.0937
Brugia malayi beta-lactamase 0.0038 0.0882 0.0937
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.1855 0.1899
Loa Loa (eye worm) hypothetical protein 0.0018 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1833 0.1948
Echinococcus granulosus g-protein coupled receptor 0.0068 0.1833 0.1948
Toxoplasma gondii thioredoxin reductase 0.0066 0.1758 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0042 0.0045
Onchocerca volvulus 0.0242 0.7241 0.7686
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Plasmodium falciparum tubulin beta chain 0.0027 0.0563 0.3201
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0423 0.1913
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0423 0.0449
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0882 0.0937
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0042 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0882 0.068
Loa Loa (eye worm) beta-lactamase 0.0038 0.0882 0.0882
Brugia malayi G-protein coupled receptor 0.0068 0.1833 0.1948
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.1833 0.1948
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.1758 0.1979
Loa Loa (eye worm) hypothetical protein 0.0038 0.0882 0.0882
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0042 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0042 0.0045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0042 0.0045
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0042 0.0045
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0406 0.0432
Brugia malayi Serotonin receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1833 0.1948
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0261 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0068 0.1833 0.1833
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0042 0.0045
Echinococcus granulosus allatostatin A receptor 0.0068 0.1833 0.1948
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0882 0.068
Trypanosoma brucei trypanothione reductase 0.0066 0.1758 0.9457
Brugia malayi G protein-coupled receptor 0.0068 0.1833 0.1948
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1833 0.1948
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0423 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1833 0.1948
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Brugia malayi neuropeptide F receptor 0.0068 0.1833 0.1948
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Loa Loa (eye worm) hypothetical protein 0.0242 0.7241 0.7241
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0563 0.6003
Echinococcus granulosus bloom syndrome protein 0.0022 0.0406 0.0432
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0563 0.0598
Brugia malayi Animal haem peroxidase family protein 0.0242 0.7241 0.7696
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1833 0.1833
Onchocerca volvulus 0.0068 0.1833 0.1912
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1833 0.1948
Toxoplasma gondii ABC1 family protein 0.0038 0.0882 0.5014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0042 0.0042
Schistosoma mansoni adenoreceptor 0.0068 0.1833 0.1948
Trypanosoma cruzi beta tubulin, putative 0.0027 0.0563 0.2704
Schistosoma mansoni myosin xvIII 0.0068 0.1833 0.1948
Brugia malayi neuropeptide F receptor 0.0068 0.1833 0.1948
Echinococcus multilocularis protein cereblon 0.0312 0.9408 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.7172 1
Onchocerca volvulus 0.0038 0.0882 0.0896
Leishmania major beta tubulin 0.0027 0.0563 0.2704
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0423 0.5
Schistosoma mansoni histamine h1 receptor 0.0068 0.1833 0.1948

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 47.7 nM Activity in mouse melanocortin-5 receptor stably expressed in HEK-293 cells ChEMBL. 12477357
EC50 (binding) = 47.7 nM Activity in mouse melanocortin-5 receptor stably expressed in HEK-293 cells ChEMBL. 12477357
EC50 (binding) = 79.9 nM Activity in mouse melanocortin-1 receptor stably expressed in HEK-293 cells ChEMBL. 12477357
EC50 (binding) = 79.9 nM Activity in mouse melanocortin-1 receptor stably expressed in HEK-293 cells ChEMBL. 12477357
EC50 (binding) = 143 nM Activity in mouse melanocortin-4 receptor stably expressed in HEK-293 cells ChEMBL. 12477357
EC50 (binding) = 143 nM Activity in mouse melanocortin-4 receptor stably expressed in HEK-293 cells ChEMBL. 12477357
EC50 (binding) = 3700 nM Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK-293 cells ChEMBL. 12477357
EC50 (binding) = 3700 nM Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK-293 cells ChEMBL. 12477357

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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