Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0181 | 0.1174 | 0.1024 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0684 | 0.6718 | 0.7628 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0181 | 0.1174 | 0.1174 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.0903 | 0.0701 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0264 | 0.2087 | 0.2087 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0181 | 0.1174 | 0.0347 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 0.0903 | 0.4328 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.0903 | 0.0701 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0248 | 0.1187 |
Leishmania major | delta-5 fatty acid desaturase | 0.0181 | 0.1174 | 0.0347 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0181 | 0.1174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1174 | 0.1174 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0181 | 0.1174 | 0.1174 |
Leishmania major | delta-4 fatty acid desaturase | 0.0181 | 0.1174 | 0.0347 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0181 | 0.1174 | 0.5625 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0475 | 0.0475 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0181 | 0.1174 | 0.1174 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0181 | 0.1174 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0982 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0865 | 0.8709 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0248 | 0.1187 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0181 | 0.1174 | 0.1024 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0181 | 0.1174 | 0.0347 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0181 | 0.1174 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0181 | 0.1174 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.0903 | 0.0701 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0684 | 0.6718 | 1 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0181 | 0.1174 | 0.1024 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0684 | 0.6718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0475 | 0.0475 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 0.0903 | 0.4328 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0181 | 0.1174 | 0.5625 |
Schistosoma mansoni | fatty acid desaturase | 0.0181 | 0.1174 | 0.5625 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0181 | 0.1174 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0098 | 0.0266 | 0.1275 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0684 | 0.6718 | 0.7628 |
Schistosoma mansoni | nephrin | 0.0093 | 0.0209 | 0.0999 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0181 | 0.1174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0266 | 0.0266 |
Brugia malayi | Adenosylhomocysteinase | 0.0156 | 0.0903 | 0.0903 |
Leishmania major | fatty acid desaturase, putative | 0.0181 | 0.1174 | 0.0347 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.0903 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0181 | 0.1174 | 0.1174 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0181 | 0.1174 | 1 |
Leishmania major | delta-12 fatty acid desaturase | 0.0181 | 0.1174 | 0.0347 |
Mycobacterium ulcerans | hypothetical protein | 0.0181 | 0.1174 | 1 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0181 | 0.1174 | 0.1024 |
Leishmania major | stearic acid desaturase, putative | 0.0865 | 0.8709 | 1 |
Echinococcus multilocularis | neuroglian | 0.0093 | 0.0209 | 0.0999 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0248 | 0.1187 |
Echinococcus granulosus | neuroglian | 0.0093 | 0.0209 | 0.0999 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0181 | 0.1174 | 0.5625 |
Mycobacterium ulcerans | hypothetical protein | 0.0181 | 0.1174 | 1 |
Onchocerca volvulus | 0.0879 | 0.8862 | 0.9668 | |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0156 | 0.0903 | 0.5 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0181 | 0.1174 | 0.1024 |
Leishmania major | delta-6 fatty acid desaturase | 0.0181 | 0.1174 | 0.0347 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 0.0903 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.0248 | 0.1187 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0181 | 0.1174 | 0.5625 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 0.0903 | 0.4328 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0903 | 0.9126 | 1 |
Onchocerca volvulus | 0.0865 | 0.8709 | 0.9476 | |
Brugia malayi | Fatty acid desaturase family protein | 0.0181 | 0.1174 | 0.1174 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0181 | 0.1174 | 0.1024 |
Leishmania major | fatty-acid desaturase, putative | 0.0865 | 0.8709 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0264 | 0.2087 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0181 | 0.1174 | 1 |
Onchocerca volvulus | 0.0865 | 0.8709 | 0.9476 | |
Brugia malayi | acyl-CoA desaturase | 0.0684 | 0.6718 | 0.6718 |
Leishmania major | fatty acid desaturase, putative | 0.0181 | 0.1174 | 0.0347 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0181 | 0.1174 | 0.1024 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0264 | 0.2087 | 0.2087 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0181 | 0.1174 | 0.1024 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0865 | 0.8709 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0181 | 0.1174 | 0.5625 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0181 | 0.1174 | 0.1024 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0156 | 0.0903 | 0.0903 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0181 | 0.1174 | 0.0347 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0098 | 0.0266 | 0.1275 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0181 | 0.1174 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0117 | 0.0475 | 0.2274 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0181 | 0.1174 | 0.1024 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0264 | 0.2087 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.0903 | 0.5 |
Echinococcus granulosus | twitchin | 0.0093 | 0.0209 | 0.0999 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0181 | 0.1174 | 0.0347 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0264 | 0.2087 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0117 | 0.0475 | 0.2274 |
Loa Loa (eye worm) | FAT-3 protein | 0.0181 | 0.1174 | 0.1174 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0684 | 0.6718 | 0.6718 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.3 ug ml-1 | Antiretroviral activity in the XC-plaque assay using Moloney leukemia virus (MoLV) as a model for human immunodeficiency virus (HIV). | ChEMBL. | 1995889 |
K inact (binding) | NA 0 min-1 | Activity of the compound determined in mouse liver S-adenosyl-L-homocysteine hydrolase and expressed as Kinactivator values; NA= not applicable | ChEMBL. | 1995889 |
K inact (binding) | NA 0 min-1 | Competitive inhibitory activity against rat liver S-adenosyl-L-homocysteine hydrolase | ChEMBL. | 1995889 |
Ki (binding) | NA 0 uM | Activity of the compound determined in mouse liver S-adenosyl-L-homocysteine hydrolase and expressed as KI values; NA= not applicable | ChEMBL. | 1995889 |
Ki (binding) | NA 0 uM | Activity of the compound determined in rat liver S-adenosyl-L-homocysteine hydrolase and expressed as KI values; NA= not applicable | ChEMBL. | 1995889 |
Ki (binding) | = 1.6 uM | Activity of the compound determined in rat liver S-adenosyl-L-homocysteine hydrolase and expressed as Kinactivator values; NA= not applicable | ChEMBL. | 1995889 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.