Detailed information for compound 273765

Basic information

Technical information
  • TDR Targets ID: 273765
  • Name: 2-amino-9-[(4-hydroxy-4-oxo-3,5-dioxa-4$l^{5} -phosphacyclohex-1-yl)oxymethyl]-3H-purin-6-o ne
  • MW: 317.195 | Formula: C9H12N5O6P
  • H donors: 3 H acceptors: 4 LogP: -2.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1[nH]c(=O)c2c(n1)n(COC1COP(=O)(OC1)O)cn2
  • InChi: 1S/C9H12N5O6P/c10-9-12-7-6(8(15)13-9)11-3-14(7)4-18-5-1-19-21(16,17)20-2-5/h3,5H,1-2,4H2,(H,16,17)(H3,10,12,13,15)
  • InChiKey: MWPCMYIIXPYDAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-azanyl-9-[(4-hydroxy-4-oxo-3,5-dioxa-4$l^{5}-phosphacyclohex-1-yl)oxymethyl]-3H-purin-6-one
  • 2-amino-9-[(4-hydroxy-4-keto-3,5-dioxa-4$l^{5}-phosphacyclohex-1-yl)oxymethyl]-3H-purin-6-one
  • 9-((2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl)guanine P-oxide
  • 2-amino-9-[(2-hydroxy-2-oxo-1,3-dioxa-2$l^{5}-phosphacyclohex-5-yl)oxymethyl]-3H-purin-6-one
  • 2-amino-9-[(2-hydroxy-2-keto-1,3-dioxa-2$l^{5}-phosphacyclohex-5-yl)oxymethyl]-3H-purin-6-one
  • 91516-85-7
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(((2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy)methyl)-
  • 9((2-Hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxy-methyl)guanine-P-oxide
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-
  • 9[(2-Hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxy-methyl]guanine-P-oxide
  • AIDS-003016
  • AIDS003016
  • DHPG-CP

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major carbonic anhydrase family protein, putative 0.1543 0.287 0.287
Toxoplasma gondii ABC1 family protein 0.0035 0.002 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0032 0.0032
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0024 0.0024
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0001
Brugia malayi MH2 domain containing protein 0.012 0.0181 0.0175
Mycobacterium ulcerans hypothetical protein 0.0035 0.002 0.0051
Mycobacterium tuberculosis Conserved protein 0.0035 0.002 0.0073
Brugia malayi hypoxia-induced factor 1 0.0155 0.0247 0.0241
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0226 0.0807
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.001 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Mycobacterium tuberculosis Conserved protein 0.0035 0.002 0.0073
Brugia malayi Pre-SET motif family protein 0.003 0.001 0.0004
Toxoplasma gondii hypothetical protein 0.1965 0.3667 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0024 0.0024
Onchocerca volvulus 0.0035 0.002 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.2114 0.3948 1
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.0511 0.5
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0024 0.0024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.002 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.0511 0.1712
Brugia malayi Putative carbonic anhydrase 5 precursor 0.5317 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0024 0.006
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0023 0.0018
Echinococcus granulosus carbonic anhydrase 0.1965 0.3667 0.3667
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.0511 0.1712
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0226 0.0571
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0023 0.0023
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.002 0.0073
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0072 0.009 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.002 0.0051
Echinococcus multilocularis carbonic anhydrase 0.1965 0.3667 0.3667
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0015
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1543 0.287 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0226 0.072
Brugia malayi beta-lactamase family protein 0.0035 0.002 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0032 0.0032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.002 0.0015
Brugia malayi hypothetical protein 0.0037 0.0023 0.0018
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0072 0.009 0.0323
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0023 0.0023
Echinococcus granulosus carbonic anhydrase II 0.5317 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.002 0.0073
Echinococcus multilocularis lamin 0.0028 0.0006 0.0006
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0024 0.0024
Entamoeba histolytica ankyrin, putative 0.0072 0.009 0.0235
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1965 0.3667 0.3663
Mycobacterium ulcerans lipase LipD 0.0035 0.002 0.0051
Onchocerca volvulus 0.0035 0.002 0.0362
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.007 0.0085 0.0215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.002 0.002
Entamoeba histolytica carbonic anhydrase, putative 0.1543 0.287 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0024 0.006
Plasmodium vivax hypothetical protein, conserved 0.0035 0.002 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0085 0.0215
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0023 0.0059
Schistosoma mansoni carbonic anhydrase 0.1543 0.287 0.2866
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0042 0.0032 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.002 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.2114 0.3948 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.002 0.0051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0006 0.0001
Onchocerca volvulus 0.0037 0.0023 0.0441
Leishmania major hypothetical protein, conserved 0.0035 0.002 0.002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1965 0.3667 0.3663
Leishmania major hypothetical protein, conserved 0.0042 0.0032 0.0032
Mycobacterium ulcerans carbonic anhydrase 0.2114 0.3948 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0024 0.0004
Echinococcus multilocularis carbonic anhydrase 0.1965 0.3667 0.3667
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0381 0.1364
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0042 0.0032 0.0114
Loa Loa (eye worm) hypothetical protein 0.3185 0.5971 0.5969
Brugia malayi PAS domain containing protein 0.005 0.0048 0.0042
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0072 0.009 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.001 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0008 0.0008
Echinococcus multilocularis musashi 0.0028 0.0006 0.0006
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.002 0.0073
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0024 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0015
Echinococcus granulosus intermediate filament protein 0.0028 0.0006 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0181 0.0176
Trypanosoma brucei hypothetical protein, conserved 0.0215 0.0359 0.0339
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0024 0.006
Echinococcus multilocularis lamin dm0 0.0028 0.0006 0.0006
Onchocerca volvulus 0.007 0.0085 0.1985
Echinococcus multilocularis carbonic anhydrase II 0.5317 1 1
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.061 0.1105 0.3954
Plasmodium falciparum carbonic anhydrase 0.1965 0.3667 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0836 0.1533 0.1533
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0048 0.0042
Schistosoma mansoni carbonic anhydrase-related 0.1965 0.3667 0.3663
Echinococcus multilocularis carbonic anhydrase 0.1965 0.3667 0.3667
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.5317 1 1
Mycobacterium ulcerans transferase 0.007 0.0085 0.0215
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1965 0.3667 0.3663
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0015
Trichomonas vaginalis set domain proteins, putative 0.0239 0.0405 0.1026
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0015
Echinococcus granulosus single minded 2 0.0037 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.0359 0.0359
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.002 0.0051
Loa Loa (eye worm) carbonic anhydrase 3 0.5317 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.5317 1 1
Trypanosoma brucei carbonic anhydrase-like protein 0.5317 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.002 0.0051
Echinococcus granulosus carbonic anhydrase 0.1965 0.3667 0.3667
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.5317 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0024 0.0018
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.002 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0032 0.0012
Echinococcus granulosus carbonic anhydrase 0.1965 0.3667 0.3667
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0006 0.0001
Loa Loa (eye worm) beta-lactamase 0.0035 0.002 0.0015
Brugia malayi beta-lactamase family protein 0.0035 0.002 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Echinococcus granulosus lamin dm0 0.0028 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0037 0.0023 0.0018
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0024 0.0018
Onchocerca volvulus 0.003 0.001 0.011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.002 0.0051
Entamoeba histolytica acetyltransferase, putative 0.0072 0.009 0.0235
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1965 0.3667 0.3664
Schistosoma mansoni single-minded 0.005 0.0048 0.0042
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.002 0.002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1965 0.3667 0.3663
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.002 0.0014
Schistosoma mansoni carbonic anhydrase-related 0.1965 0.3667 0.3663
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.5317 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.002 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.002 0.0051
Loa Loa (eye worm) hypothetical protein 0.1965 0.3667 0.3664
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Loa Loa (eye worm) hypothetical protein 0.0168 0.0271 0.0266
Schistosoma mansoni carbonic anhydrase 0.1965 0.3667 0.3663
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.0511 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.035 0.0345
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1965 0.3667 0.3663
Schistosoma mansoni carbonic anhydrase-related 0.1965 0.3667 0.3663
Mycobacterium tuberculosis Conserved protein 0.0035 0.002 0.0073
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1504 0.2796 1
Brugia malayi hypothetical protein 0.0168 0.0271 0.0266
Mycobacterium ulcerans carbonic anhydrase 0.1543 0.287 0.7269
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.5317 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.002 0.0051
Onchocerca volvulus 0.0239 0.0405 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.002 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0005
Trichomonas vaginalis esterase, putative 0.0035 0.002 0.0051
Leishmania major carbonic anhydrase-like protein 0.5317 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.002 0.0014
Onchocerca volvulus 0.0035 0.002 0.0362
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0511 0.1293
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.0359 0.0359
Leishmania major hypothetical protein, conserved 0.0215 0.0359 0.0359
Brugia malayi Pre-SET motif family protein 0.021 0.035 0.0345
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0024 0.0002
Mycobacterium ulcerans beta-lactamase 0.0035 0.002 0.0051
Brugia malayi beta-lactamase 0.0035 0.002 0.0014
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0024 0.0018
Echinococcus granulosus dynactin 5 p25 0.0072 0.009 0.009
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.1965 0.3667 0.3664
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0019
Mycobacterium leprae PROBABLE TRANSFERASE 0.007 0.0085 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.001 0.0004
Schistosoma mansoni hypothetical protein 0.1965 0.3667 0.3663
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0023 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0023 0.0023
Echinococcus granulosus lamin 0.0028 0.0006 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0181 0.0176
Mycobacterium ulcerans hypothetical protein 0.0042 0.0032 0.0081
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0934 0.1718 0.6143

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 0.5 uM In vitro antiviral activity was measured against HSV-1 (F delta 305) in Vero cells ChEMBL. 3009811
ID50 (functional) = 2 uM In vitro antiviral activity was measured against HSV-1(F) in Vero cells ChEMBL. 3009811
ID50 (functional) = 6 uM In vitro antiviral activity was measured against HSV-2(G) in Vero cells ChEMBL. 3009811
ID50 (functional) = 6 uM In vitro antiviral activity was measured against HCMV(AD-169) in MRC5 cells ChEMBL. 3009811
ID50 (functional) = 6 uM In vitro antiviral activity was measured against HCMV(AD-169) in MRC5 cells ChEMBL. 3009811
ID50 (functional) = 7 uM In vitroantiviral activity was measured against HSV-1 (MP-PAA/DHPG) in Vero cells ChEMBL. 3009811
ID50 (functional) = 40 uM In vitro anticellular activity was measured against vero cells ChEMBL. 3009811
MST (functional) = 10.4 day Effect of of the compound on mean survival time upon oral treatment on HSV-2 induced mortality in mice at 5 mg/kg dose ChEMBL. 3009811
MST (functional) = 10.4 day Effect of of the compound on mean survival time upon oral treatment on HSV-2 induced mortality in mice at 5 mg/kg dose ChEMBL. 3009811
MST (functional) = 10.6 day Effect of of the compound on mean survival time upon oral treatment on HSV-2 induced mortality in mice at 10 mg/kg dose ChEMBL. 3009811
MST (functional) = 10.6 day Effect of of the compound on mean survival time upon oral treatment on HSV-2 induced mortality in mice at 10 mg/kg dose ChEMBL. 3009811
MST (functional) = 11.6 day Effect of of the compound on mean survival time upon oral treatment on HSV-2 induced mortality in mice at 20 mg/kg dose ChEMBL. 3009811
MST (functional) = 11.6 day Effect of of the compound on mean survival time upon oral treatment on HSV-2 induced mortality in mice at 20 mg/kg dose ChEMBL. 3009811
MST increase (functional) 0 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 10 mg/kg dose; NS=Not significant ChEMBL. 3009811
MST increase (functional) 0 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 5 mg/kg dose; NS=Not significant ChEMBL. 3009811
MST increase (functional) < 0.01 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 20 mg/kg dose ChEMBL. 3009811
Survivor increase (functional) 0 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 10 mg/kg dose; NS=Not significant ChEMBL. 3009811
Survivor increase (functional) 0 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 5 mg/kg dose; NS=Not significant ChEMBL. 3009811
Survivor increase (functional) = 0.01 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 20 mg/kg dose ChEMBL. 3009811
Survivors (functional) = 3 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 10 mg/kg dose; 3/20 ChEMBL. 3009811
Survivors (functional) = 8 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 5 mg/kg dose; 8/20 ChEMBL. 3009811
Survivors (functional) = 10 Effect of oral treatment with compound on HSV-2 induced mortality in mice at 20 mg/kg dose; 10/20 ChEMBL. 3009811

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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