TDR Targets

Basic information

Technical information

TDR Targets ID: 281632
Name: (4-methoxy-2,3-dipropylnaphthalen-1-yl) aceta te
MW: 300.392 | Formula: C19H24O3
H donors: 0 H acceptors: 1 LogP: 5.57 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1c(CCC)c(OC)c2c(c1OC(=O)C)cccc2
InChi: 1S/C19H24O3/c1-5-9-14-15(10-6-2)19(22-13(3)20)17-12-8-7-11-16(17)18(14)21-4/h7-8,11-12H,5-6,9-10H2,1-4H3
InChiKey: DOVGSQNKDIRAJZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4-methoxy-2,3-dipropyl-1-naphthyl) acetate
acetic acid (4-methoxy-2,3-dipropyl-1-naphthyl) ester
(4-methoxy-2,3-dipropyl-naphthalen-1-yl) ethanoate
123332-25-2
1-Naphthalenol, 4-methoxy-2,3-dipropyl-, acetate
1-naphthalenol, 4-Methoxy-2,3-dipropyl-1-naphthalenol acetate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0025	0.073	0.2082
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Schistosoma mansoni	ubiquitin-specific peptidase 14 (C19 family)	0.0003	0.002	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Schistosoma mansoni	ubiquitin-specific peptidase 42 (C19 family)	0.0003	0.002	0.0146
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0003	0.002	0.0048
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0039	0.1166	1
Brugia malayi	ubiquitin carboxyl-terminal hydrolase 46	0.0003	0.002	0.002
Schistosoma mansoni	peptidase	0.0003	0.002	0.0146
Loa Loa (eye worm)	tumor suppressor	0.0317	1	1
Echinococcus multilocularis	aminopeptidase N	0.0132	0.4138	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 20	0.0003	0.002	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Onchocerca volvulus		0.0039	0.1166	0.2818
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3702	0.3702
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase	0.0003	0.002	0.0048
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0014	0.0362	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Trypanosoma brucei	calpain, putative	0.011	0.3432	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1359	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 36	0.0003	0.002	0.0048
Schistosoma mansoni	ubiquitin-specific peptidase 10 (C19 family)	0.0003	0.002	0.0146
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0039	0.1166	0.336
Onchocerca volvulus		0.0003	0.002	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0003	0.002	0.0048
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 23	0.0003	0.002	0.0048
Trypanosoma brucei	calpain-like protein, putative	0.011	0.3432	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0003	0.002	0.5
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0014	0.0362	0.2665
Trypanosoma brucei	Aminopeptidase M1, putative	0.0039	0.1166	0.336
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 47	0.0003	0.002	0.0048
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.0003	0.002	0.0048
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 12	0.0003	0.002	0.0048
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0107	0.3334	0.3334
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0014	0.0362	0.1003
Schistosoma mansoni	hypothetical protein	0.0027	0.0778	0.5728
Trypanosoma cruzi	aminopeptidase, putative	0.0014	0.0362	0.1003
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0003	0.002	0.0048
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Echinococcus granulosus	5'partial\|Ubiquitin carboxyl terminal hydrolase 48	0.0003	0.002	0.0048
Schistosoma mansoni	ubiquitin-specific peptidase 30 (C19 family)	0.0003	0.002	0.0146
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0014	0.0362	0.0875
Brugia malayi	hypothetical protein	0.0003	0.002	0.002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1359	0.3284
Brugia malayi	hypothetical protein	0.0039	0.1166	0.1166
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0014	0.0362	0.0875
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 12	0.0003	0.002	0.0048
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0003	0.002	0.0146
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.011	0.3432	1
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase 46	0.0003	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0003	0.002	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2898	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0025	0.073	0.073
Echinococcus granulosus	protein quaking	0.0027	0.0778	0.1881
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1359	0.1359
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0039	0.1166	0.858
Echinococcus multilocularis	protein quaking	0.0027	0.0778	0.1881
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0003	0.002	0.0048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.011	0.3432	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0039	0.1166	0.336
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.0003	0.002	0.0048
Schistosoma mansoni	calpain-7 (C02 family)	0.0003	0.002	0.0146
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0003	0.002	0.0048
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0003	0.002	0.0146
Brugia malayi	ubiquitin specific protease 14	0.0003	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0779	0.0779
Toxoplasma gondii	aminopeptidase N protein	0.0014	0.0362	1
Echinococcus multilocularis	expressed protein	0.0003	0.002	0.0048
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.0003	0.002	0.0048
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0014	0.0362	0.1003
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.3432	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0014	0.0362	0.0875
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0039	0.1166	0.336
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0039	0.1166	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0003	0.002	0.0048
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0003	0.002	0.0048
Brugia malayi	Peptidase family M1 containing protein	0.0014	0.0362	0.0362
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 16	0.0003	0.002	0.0048
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1359	0.3284
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 5	0.0003	0.002	0.0048
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0014	0.0362	0.2665
Echinococcus granulosus	ubiquitin specific peptidase c family	0.0003	0.002	0.0048
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 14	0.0003	0.002	0.0048
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0039	0.1166	0.858
Schistosoma mansoni	ubiquitin-specific peptidase 22 (C19 family)	0.0003	0.002	0.0146
Echinococcus granulosus	ubiquitin specific protease 41	0.0003	0.002	0.0048
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0003	0.002	0.0048
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Schistosoma mansoni	hypothetical protein	0.0027	0.0778	0.5728
Schistosoma mansoni	family C19 unassigned peptidase (C19 family)	0.0003	0.002	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Onchocerca volvulus		0.0003	0.002	0.0048
Trypanosoma brucei	hypothetical protein	0.011	0.3432	1
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0014	0.0362	0.1003
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0003	0.002	0.0048
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0014	0.0362	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1359	0.3284
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Brugia malayi	Temporarily assigned gene name protein 44	0.0027	0.0779	0.0779
Loa Loa (eye worm)	TATA binding protein associated factor	0.0014	0.0362	0.0362
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0025	0.073	0.5373
Entamoeba histolytica	aminopeptidase, putative	0.0039	0.1166	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0025	0.073	0.1765
Loa Loa (eye worm)	hypothetical protein	0.0025	0.073	0.073
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0014	0.0362	0.1003
Giardia lamblia	DUB-1	0.0003	0.002	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 46 (C19 family)	0.0003	0.002	0.0146
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Schistosoma mansoni	ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold	0.0003	0.002	0.0146
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0039	0.1166	0.336
Brugia malayi	Peptidase family M1 containing protein	0.0132	0.4138	0.4138
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0014	0.0362	0.2987
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.3432	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.3432	1
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0014	0.0362	0.0362
Onchocerca volvulus		0.0014	0.0362	0.0875
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Schistosoma mansoni	ubiquitin-specific peptidase 7 (C19 family)	0.0003	0.002	0.0146
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0014	0.0362	0.1003
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.0003	0.002	0.0146
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Schistosoma mansoni	ubiquitin-specific peptidase 48 (C19 family)	0.0003	0.002	0.0146
Schistosoma mansoni	ubiquitin-specific peptidase 24 (C19 family)	0.0003	0.002	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0362	0.0362
Echinococcus granulosus	ubiquitin specific peptidase 30 (C19 family)	0.0003	0.002	0.0048
Echinococcus multilocularis	Ubiquitin carboxyl terminal hydrolase 48	0.0003	0.002	0.0048
Schistosoma mansoni	calpain-7 (C02 family)	0.0003	0.002	0.0146
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.011	0.3432	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0003	0.002	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0003	0.002	0.0146
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 47	0.0003	0.002	0.0048
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 14	0.0003	0.002	0.0048
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.3432	1
Schistosoma mansoni	ubiquitin-specific peptidase 16 (C19 family)	0.0003	0.002	0.0146
Trypanosoma cruzi	aminopeptidase, putative	0.0039	0.1166	0.336
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0039	0.1166	0.336
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.0003	0.002	0.0048
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Giardia lamblia	Hypothetical protein	0.0003	0.002	0.5
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0014	0.0362	0.1003
Loa Loa (eye worm)	aminopeptidase N	0.0039	0.1166	0.1166
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0003	0.002	0.0048
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.0003	0.002	0.002
Trypanosoma brucei	aminopeptidase, putative	0.0014	0.0362	0.1003
Onchocerca volvulus		0.0003	0.002	0.0048
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 36	0.0003	0.002	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0362	0.0362
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0039	0.1166	0.2818
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0014	0.0362	0.2665
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0.002	0.002
Echinococcus granulosus	Ubiquitin carboxyl terminal hydrolase 48	0.0003	0.002	0.0048
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.0003	0.002	0.0146
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0003	0.002	0.5
Toxoplasma gondii	aminopeptidase N, putative	0.0014	0.0362	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0003	0.002	0.0048
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0003	0.002	0.0048
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1359	0.3284
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0362	0.0362
Onchocerca volvulus		0.0132	0.4138	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 24	0.0003	0.002	0.0048
Schistosoma mansoni	ubiquitin-specific peptidase 4 (C19 family)	0.0003	0.002	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0003	0.002	0.0146
Schistosoma mansoni	ubiquitin-specific peptidase 45 (C19 family)	0.0003	0.002	0.0146
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.0003	0.002	0.0048
Brugia malayi	TATA binding protein associated factor	0.0014	0.0362	0.0362
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.0003	0.002	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1359	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Echinococcus granulosus	aminopeptidase N	0.0132	0.4138	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0039	0.1166	0.2818
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase	0.0003	0.002	0.0048
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 20	0.0003	0.002	0.0048
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0014	0.0362	0.0875
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0014	0.0362	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0003	0.002	0.0048
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0003	0.002	0.5
Brugia malayi	hypothetical protein	0.0027	0.0779	0.0779
Brugia malayi	hypothetical protein	0.0014	0.0362	0.0362
Mycobacterium ulcerans	aminopeptidase N PepN	0.0039	0.1166	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1359	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.3432	1
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0039	0.1166	0.336
Echinococcus multilocularis	ubiquitin specific peptidase 42 (C19 family)	0.0003	0.002	0.0048
Brugia malayi	Peptidase family M1 containing protein	0.0039	0.1166	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0003	0.002	0.002
Echinococcus multilocularis	ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase	0.0003	0.002	0.0048
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0.002	0.002
Toxoplasma gondii	aminopeptidase n, putative	0.0014	0.0362	1
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0014	0.0362	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 16	0.0003	0.002	0.0048
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1359	0.1359
Echinococcus granulosus	hypothetical protein	0.0027	0.0778	0.1881
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 24	0.0003	0.002	0.0048
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0003	0.002	0.0048
Schistosoma mansoni	hypothetical protein	0.0003	0.002	0.0146

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.43 uM	In vitro inhibition of LTC4/D4 (leukotriene) production in rat peritoneal mononuclear cells.	ChEMBL.	2153828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 183623

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 281632