TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 301.297 | Formula: C15H15N3O4
H donors: 1 H acceptors: 3 LogP: 1.18 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1C1OC(=O)NC1=O)CCn1cncc1
InChi: 1S/C15H15N3O4/c1-21-12-3-2-10(4-6-18-7-5-16-9-18)8-11(12)13-14(19)17-15(20)22-13/h2-3,5,7-9,13H,4,6H2,1H3,(H,17,19,20)
InChiKey: GDBYOFWRAXQWEK-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0025	0.0029	0.0651
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0017	0.0003	0.0068
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0029	0.0095
Echinococcus granulosus	sodium and chloride dependent glycine	0.0025	0.0029	0.0128
Brugia malayi	Steroid receptor seven-up type 2	0.0017	0.0003	0.0004
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0024	0.0033
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0025	0.0029	0.004
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0003	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0024	0.0102
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0024	0.0485
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0003	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0088	0.1969
Brugia malayi	Telomerase reverse transcriptase	0.213	0.7253	1
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0088	0.0314
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1639	0.5568	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0088	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0088	0.1969
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0017	0.0003	0.0068
Loa Loa (eye worm)	norepinephrine transporter	0.0146	0.0446	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0651
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0029	0.0651
Plasmodium vivax	amine transporter, putative	0.0025	0.0029	0.0095
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0017	0.0003	0.0005
Loa Loa (eye worm)	serotonin transporter b	0.0146	0.0446	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0088	0.0388
Brugia malayi	nuclear hormone receptor	0.0017	0.0003	0.0004
Entamoeba histolytica	hypothetical protein	0.0035	0.0065	0.2047
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0088	0.0388
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0042	0.0088	0.0158
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0065	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0118	0.2648
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0122	0.0168
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0088	0.0314
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0255	0.0459
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0017	0.0003	0.0068
Schistosoma mansoni	ap endonuclease	0.002	0.0011	0.0242
Schistosoma mansoni	patched 1	0.0041	0.0086	0.193
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0003	0.0004
Echinococcus multilocularis	FTZ F1 alpha	0.0017	0.0003	0.0005
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0024	0.0048
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0418	0.1848
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0017	0.0003	0.0004
Mycobacterium ulcerans	oxidoreductase	0.0042	0.0088	0.0425
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0003	0.0068
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0065	0.009
Brugia malayi	hypothetical protein	0.0042	0.0088	0.0121
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0003	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0651
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0025	0.0029	0.3033
Echinococcus granulosus	ecdysone induced protein 78C	0.0017	0.0003	0.0013
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0042	0.0088	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0276	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0596	0.199	1
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0042	0.0088	0.0158
Entamoeba histolytica	hypothetical protein	0.0035	0.0065	0.2047
Brugia malayi	steroid hormone receptor	0.0017	0.0003	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0017	0.0003	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0651
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0122	0.0168
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0003	0.0004
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0024	0.0127
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0025	0.0029	0.0052
Onchocerca volvulus		0.0025	0.0029	0.0026
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0017	0.0003	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0086	0.193
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0024	0.0102
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0024	0.0033
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0065	0.0287
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0029	0.0651
Giardia lamblia	Telomerase catalytic subunit	0.08	0.2691	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0024	0.0048
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0017	0.0003	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0088	0.1969
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0017	0.0003	0.0068
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0024	0.0485
Trypanosoma brucei	telomerase reverse transcriptase	0.08	0.2691	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0024	0.0102
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0011	0.0242
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0003	0.0068
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0017	0.0003	0.0068
Onchocerca volvulus		0.0025	0.0029	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0088	0.1969
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0017	0.0003	0.0004
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.0068
Echinococcus multilocularis	serotonin transporter	0.0146	0.0446	0.0801
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0025	0.0029	0.0651
Schistosoma mansoni	amine oxidase	0.0042	0.0088	0.1969
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.0068
Schistosoma mansoni	retinoic acid receptor RXR	0.0017	0.0003	0.0068
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.08	0.2691	1
Onchocerca volvulus		0.0023	0.0024	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0446	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0029	0.0651
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0017	0.0003	0.0005
Schistosoma mansoni	hypothetical protein	0.004	0.0081	0.1815
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0088	0.1969
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.08	0.2691	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0065	0.2047
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0088	0.1969
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0017	0.0003	0.0013
Toxoplasma gondii	hypothetical protein	0.0025	0.0029	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0042	0.0088	1
Brugia malayi	ecdysteroid receptor	0.0017	0.0003	0.0004
Echinococcus granulosus	serotonin transporter	0.0146	0.0446	0.1973
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0011	0.0015
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0017	0.0003	0.0068
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0088	0.0287
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0042	0.0088	0.0425
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0017	0.0003	0.0013
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0042	0.0088	0.1969
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0024	0.053
Schistosoma mansoni	RAR-like nuclear receptor	0.0017	0.0003	0.0068
Mycobacterium ulcerans	monoamine oxidase	0.0042	0.0088	0.0425
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0017	0.0003	0.0013
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0065	0.0117
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0024	0.0127
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0017	0.0003	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0065	0.1463
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.004
Echinococcus multilocularis		0.0042	0.0088	0.0158
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0003	0.0004
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0024	0.0485
Loa Loa (eye worm)	steroid hormone receptor	0.0017	0.0003	0.0068
Schistosoma mansoni	amine oxidase	0.0042	0.0088	0.1969
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0024	0.0102
Echinococcus multilocularis	conserved hypothetical protein	0.0669	0.2238	0.402
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0086	0.0155
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0042	0.0088	0.0314
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0017	0.0003	0.0005
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0146	0.0446	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0276	0.6175
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0276	0.1218
Plasmodium falciparum	telomerase reverse transcriptase	0.08	0.2691	1
Brugia malayi	SWIRM domain containing protein	0.0042	0.0088	0.0121
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0042	0.0088	0.0314
Schistosoma mansoni	hypothetical protein	0.004	0.0081	0.1815
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0024	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0077
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0042	0.0088	0.0314
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0017	0.0003	0.0013
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0003	0.0005
Brugia malayi	hypothetical protein	0.0035	0.0065	0.009
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0025	0.0029	0.0052
Plasmodium falciparum	amino acid transporter, putative	0.0025	0.0029	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0003	0.0004
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0025	0.0029	0.0128
Brugia malayi	Serotonin receptor	0.0453	0.1497	0.2064
Onchocerca volvulus		0.0042	0.0088	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0651
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0003	0.0004
Schistosoma mansoni	sodium/chloride dependent transporter	0.0025	0.0029	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Toxoplasma gondii	RNA-directed DNA polymerase	0.08	0.2691	1
Leishmania major	telomerase reverse transcriptase, putative	0.08	0.2691	1
Schistosoma mansoni	hypothetical protein	0.004	0.0081	0.1815
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0106	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0446	1
Echinococcus granulosus	expressed conserved protein	0.0091	0.0255	0.1129
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0011	0.0058
Onchocerca volvulus		0.0025	0.0029	0.0026
Treponema pallidum	sodium- and chloride- dependent transporter	0.0146	0.0446	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0065	0.2047
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0554	0.1846	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0025	0.0029	0.0128
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0017	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.0068
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0011	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0446	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0017	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0651
Brugia malayi	photoreceptor-specific nuclear receptor	0.0017	0.0003	0.0004
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0086	0.0381
Brugia malayi	hypothetical protein	0.0025	0.0029	0.004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0024	0.053
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0276	0.038
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0024	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0086	0.193
Mycobacterium tuberculosis	Possible oxidoreductase	0.0042	0.0088	0.0475
Plasmodium falciparum	protoporphyrinogen oxidase	0.0042	0.0088	0.0314
Schistosoma mansoni	ap endonuclease	0.002	0.0011	0.0242
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0011	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0086	1
Plasmodium falciparum	transporter, putative	0.0025	0.0029	0.0095
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0025	0.0029	0.0052
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0017	0.0003	0.0004
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.0651
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0029	0.0651
Schistosoma mansoni	hypothetical protein	0.004	0.0081	0.1815
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0017	0.0003	0.0004
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.0651
Onchocerca volvulus		0.0146	0.0446	0.0443
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0281	0.629
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0017	0.0003	0.0068
Schistosoma mansoni	coup transcription factor	0.0017	0.0003	0.0068
Brugia malayi	CHE-14 protein	0.0041	0.0086	0.0119
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0017	0.0003	0.0068
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0418	0.0751
Mycobacterium ulcerans	dehydrogenase	0.0042	0.0088	0.0425
Echinococcus granulosus	FTZ F1 alpha	0.0017	0.0003	0.0013
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0024	0.0102
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0042	0.0088	0.1969
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0017	0.0003	0.0068
Toxoplasma gondii	hypothetical protein	0.0025	0.0029	0.0068
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0042	0.0088	0.0314
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0011	0.0037
Schistosoma mansoni	sodium/chloride dependent transporter	0.0146	0.0446	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0017	0.0003	0.0068
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0024	0.0102
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0017	0.0003	0.0005
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0011	0.0027
Plasmodium vivax	telomerase reverse transcriptase, putative	0.08	0.2691	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.004
Schistosoma mansoni	hypothetical protein	0.0035	0.0065	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0077
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0276	0.0495
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0017	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0077
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0003	0.0068
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Echinococcus multilocularis	ecdysone induced protein 78C	0.0017	0.0003	0.0005
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0025	0.0029	0.0128
Toxoplasma gondii	histone lysine-specific demethylase	0.0042	0.0088	0.0287
Schistosoma mansoni	hypothetical protein	0.0035	0.0065	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0122	0.2723
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0029	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0042	0.0088	0.0287
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0003	0.0004
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0024	0.0048
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0029	0.0651
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0596	0.199	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0042	0.0088	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0025	0.0029	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0024	0.053
Schistosoma mansoni	sodium/chloride dependent transporter	0.0025	0.0029	0.0651
Echinococcus granulosus	sodium and chloride dependent glycine	0.0025	0.0029	0.0128
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0024	0.0102
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0077
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0003	0.0018
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0011	0.0048
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0025	0.0029	0.0651
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0029	0.004
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0086	0.0381
Leishmania major	UDP-galactopyranose mutase	0.0042	0.0088	0.0287
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0003	0.0004
Echinococcus multilocularis	protein patched	0.0041	0.0086	0.0155
Echinococcus granulosus	hypothetical protein	0.0676	0.2262	1
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0025	0.0029	0.0052
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0146	0.0446	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0068
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0122	0.2723
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.0088	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0651
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0146	0.0446	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0077
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0025	0.0029	0.0128
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0017	0.0003	0.0004

Activities

Activity type	Activity value	Assay description	Source	Reference
Blood sugar lowering (functional)	0 %	Ability to lower blood sugar level at the dose of 25 mg/kg in fasted rats, by using glucose tolerance test(GTT); NA=Inactive	ChEMBL.	3701788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 283895