Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1B | References | |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1D | References | |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0641 | 1 | 1 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0175 | 0.2113 | 0.1968 |
Echinococcus multilocularis | calpain A | 0.0175 | 0.2121 | 0.1976 |
Loa Loa (eye worm) | calpain | 0.0061 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1835 | 0.1835 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0641 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0272 | 0.3749 | 0.3634 |
Echinococcus multilocularis | serotonin receptor | 0.0159 | 0.1835 | 0.1685 |
Echinococcus multilocularis | cathepsin b | 0.0272 | 0.3749 | 0.3634 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0272 | 0.3749 | 0.3634 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.009 | 0.0668 | 0.0497 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0641 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0641 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0272 | 0.3749 | 0.3634 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.009 | 0.0668 | 0.0497 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.009 | 0.0668 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.085 | 0.085 |
Brugia malayi | calpain family protein 1 | 0.0161 | 0.188 | 0.188 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0159 | 0.1835 | 0.1685 |
Echinococcus granulosus | cathepsin b | 0.0272 | 0.3749 | 0.3634 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0272 | 0.3749 | 0.3634 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0175 | 0.2113 | 0.1968 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0641 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0641 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0272 | 0.3749 | 0.3634 |
Schistosoma mansoni | amine GPCR | 0.0411 | 0.6116 | 0.6045 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0641 | 1 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0641 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0161 | 0.188 | 0.188 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0641 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0417 | 0.6205 | 0.6136 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0641 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0272 | 0.3749 | 0.3634 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0175 | 0.2113 | 0.1968 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0641 | 1 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0119 | 0.116 | 0.116 |
Brugia malayi | calpain 7 | 0.0061 | 0.018 | 0.018 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0161 | 0.188 | 0.188 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0641 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.116 | 0.116 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0641 | 1 | 1 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0119 | 0.116 | 0.0998 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0641 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.157 | 0.157 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0161 | 0.188 | 0.1731 |
Echinococcus granulosus | calpain A | 0.0175 | 0.2121 | 0.1976 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0641 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.188 | 0.188 |
Echinococcus multilocularis | serotonin receptor | 0.0159 | 0.1835 | 0.1685 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0175 | 0.2113 | 0.1968 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1835 | 0.1835 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0159 | 0.1835 | 0.1685 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0641 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0641 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0272 | 0.3749 | 0.3634 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0641 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0641 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.3749 | 0.3749 |
Loa Loa (eye worm) | cathepsin B | 0.009 | 0.0668 | 0.0668 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0641 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0272 | 0.3749 | 0.3749 |
Plasmodium vivax | RNA helicase-1, putative | 0.0641 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0641 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.009 | 0.0668 | 0.0497 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | > 7 | Antagonistic activity at Alpha-1 adrenergic receptor was performed on ring segments of rabbit thoracic aortacontracted by noradrenaline. | ChEMBL. | 7731013 |
Ki (binding) | = 0.63 nM | In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex. | ChEMBL. | 7731013 |
Ki (binding) | = 0.63 nM | In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex. | ChEMBL. | 7731013 |
pA2 (functional) | < 7 | Antagonistic activity at Alpha-1 adrenergic receptor was performed on ring segments of rabbit thoracic aortacontracted by noradrenaline. | ChEMBL. | 7731013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.