Detailed information for compound 288841

Basic information

Technical information
  • TDR Targets ID: 288841
  • Name: N-(2-dimethylaminoethyl)-6-methylphenazine-1- carboxamide
  • MW: 308.378 | Formula: C18H20N4O
  • H donors: 1 H acceptors: 3 LogP: 2.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)c1cccc2c1nc1cccc(c1n2)C)C
  • InChi: 1S/C18H20N4O/c1-12-6-4-8-14-16(12)20-15-9-5-7-13(17(15)21-14)18(23)19-10-11-22(2)3/h4-9H,10-11H2,1-3H3,(H,19,23)
  • InChiKey: ODIILRLTODYZAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-dimethylaminoethyl)-6-methyl-phenazine-1-carboxamide
  • N-(2-dimethylaminoethyl)-6-methyl-1-phenazinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0406 0.0685 0.0643
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1662 0.3398 0.339
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0913 0.178 0.177
Schistosoma mansoni hypothetical protein 0.0131 0.0091 0.0078
Echinococcus multilocularis g-protein coupled receptor 0.0131 0.0091 0.0078
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0347 0.0556 0.0556
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.472 1 1
Leishmania major hypothetical protein, unknown function 0.0317 0.0493 0.045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.2565 0.5347 0.5326
Leishmania major phosphatidylinositol 4-kinase, putative 0.0317 0.0493 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.2822 0.5903 0.5884
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Echinococcus granulosus potassium voltage gated channel subfamily H 0.015 0.0132 0.0119
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0091 0.0078
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3767 0.7943 0.7933
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.011 0.0045 0.0045
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.178 0.1743
Loa Loa (eye worm) phosphatidylinositol 3 0.0317 0.0493 0.0493
Schistosoma mansoni hypothetical protein 0.0699 0.1318 0.1307
Echinococcus multilocularis dro:myosuppressin receptor 0.0131 0.0091 0.0078
Schistosoma mansoni amine GPCR 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0091 0.0078
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0498 0.0882 0.0871
Schistosoma mansoni neuropeptide receptor 0.0131 0.0091 0.0078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0438 0.0754 0.0712
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0347 0.0556 0.0513
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0317 0.0493 0.045
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0091 0.0078
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.472 1 1
Schistosoma mansoni myosin xvIII 0.0131 0.0091 0.0078
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.472 1 1
Schistosoma mansoni hypothetical protein 0.0131 0.0091 0.0078
Schistosoma mansoni apoptosis regulator bax 0.0151 0.0135 0.0123
Echinococcus multilocularis somatostatin receptor 0.0131 0.0091 0.0078
Echinococcus granulosus neuropeptide FF receptor 2 0.0131 0.0091 0.0078
Schistosoma mansoni neuropeptide receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Plasmodium vivax hypothetical protein 0.0317 0.0493 0.8759
Trypanosoma cruzi target of rapamycin kinase 3 0.3767 0.7943 0.7943
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.015 0.0132 0.0087
Echinococcus multilocularis serine protein kinase ATM 0.0913 0.178 0.177
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni opsin-like receptor 0.0131 0.0091 0.0078
Brugia malayi Tachykinin-like peptides receptor 99D 0.0131 0.0091 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.3522 0.7413 0.7401
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0091 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Echinococcus granulosus sex peptide receptor 0.0131 0.0091 0.0078
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0317 0.0493 0.0481
Schistosoma mansoni alpha-1 adrenergic receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis serotonin receptor 0.0131 0.0091 0.0078
Schistosoma mansoni hypothetical protein 0.0151 0.0135 0.0123
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0091 0.0091
Echinococcus multilocularis Zinc finger, PHD finger 0.0347 0.0556 0.0544
Brugia malayi G protein-coupled receptor 0.0131 0.0091 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0091 0.0078
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0131 0.0091 0.0046
Echinococcus granulosus neuropeptide receptor 0.0131 0.0091 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.06 0.1104 0.1064
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0161 0.0149
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0131 0.0091 0.0078
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0091 0.0078
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0317 0.0493 0.0493
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0151 0.0135 0.0123
Schistosoma mansoni neuropeptide receptor 0.0131 0.0091 0.0078
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0317 0.0493 0.045
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0091 0.0078
Loa Loa (eye worm) phosphatidylinositol 3 0.472 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0091 0.0078
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0699 0.1318 0.1279
Schistosoma mansoni amine GPCR 0.0131 0.0091 0.0078
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.1612 0.329 0.326
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0317 0.0493 0.0481
Echinococcus granulosus G protein coupled receptor 139 0.0131 0.0091 0.0078
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0317 0.0493 0.8759
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0317 0.0493 0.0493
Echinococcus granulosus serine protein kinase ATM 0.0913 0.178 0.177
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus dro:myosuppressin receptor 0.0131 0.0091 0.0078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0406 0.0685 0.0643
Brugia malayi larval opioid receptor 0.0131 0.0091 0.0046
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0347 0.0556 0.0513
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.472 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0131 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.013 0.0089 0.0089
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0317 0.0493 0.0481
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1973 0.4069 0.4042
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0347 0.0556 0.0544
Trichomonas vaginalis PIKK family atypical protein kinase 0.1612 0.329 0.326
Brugia malayi Serotonin receptor 0.0131 0.0091 0.0046
Brugia malayi G-protein coupled receptor 0.0131 0.0091 0.0046
Schistosoma mansoni opsin-like receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0091 0.0078
Echinococcus multilocularis neuropeptide receptor A26 0.0131 0.0091 0.0078
Brugia malayi Serotonin receptor 0.0131 0.0091 0.0046
Brugia malayi AKH receptor 0.0131 0.0091 0.0046
Echinococcus multilocularis allatostatin A receptor 0.0131 0.0091 0.0078
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0317 0.0493 0.0481
Loa Loa (eye worm) hypothetical protein 0.0103 0.003 0.003
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Brugia malayi FAT domain containing protein 0.0699 0.1318 0.1279
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0377 0.0622 0.0579
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.472 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.1612 0.329 0.326
Loa Loa (eye worm) hypothetical protein 0.0699 0.1318 0.1318
Loa Loa (eye worm) hypothetical protein 0.0953 0.1865 0.1865
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.06 0.1104 0.1104
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Entamoeba histolytica hypothetical protein 0.0541 0.0976 0.0935
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0091 0.0078
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0257 0.0363 0.0319
Echinococcus granulosus orexin receptor type 2 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.281 0.5877 0.5858
Trichomonas vaginalis PIKK family atypical protein kinase 0.127 0.255 0.2516
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis G-protein coupled receptor, putative 0.0131 0.0091 0.0078
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0151 0.0135 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0406 0.0685 0.0643
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Schistosoma mansoni neuropeptide receptor 0.0131 0.0091 0.0078
Echinococcus granulosus 7TM GPCR rhodopsin 0.0131 0.0091 0.0078
Echinococcus granulosus peptide allatostatin:somatostatin 0.0131 0.0091 0.0078
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0091 0.0078
Schistosoma mansoni growth hormone secretagogue receptor 0.0131 0.0091 0.0078
Brugia malayi putative neuropeptide receptor 0.0131 0.0091 0.0046
Brugia malayi G-protein coupled receptor 0.0131 0.0091 0.0046
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0913 0.178 0.177
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0347 0.0556 0.0513
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Entamoeba histolytica hypothetical protein 0.0317 0.0493 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.1095 0.1054
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0347 0.0556 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.1623 0.3313 0.3283
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0347 0.0556 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.472 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.011 0.0045 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0347 0.0556 0.0544
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0347 0.0556 0.0513
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0317 0.0493 0.8759
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.011 0.0065
Echinococcus granulosus g protein coupled receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.402 0.849 0.8483
Echinococcus granulosus hypothetical protein 0.0131 0.0091 0.0078
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0317 0.0493 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.3763 0.7934 0.7925
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0347 0.0556 0.0544
Schistosoma mansoni adenoreceptor 0.0131 0.0091 0.0078
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0857 0.166 0.1649
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0913 0.178 0.178
Echinococcus granulosus neuropeptide receptor A26 0.0131 0.0091 0.0078
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0131 0.0091 0.0091
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0699 0.1318 0.1307
Toxoplasma gondii target of rapamycin (TOR), putative 0.3522 0.7413 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2569 0.5356 0.5335
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.06 0.1104 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.2569 0.5356 0.5335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0913 0.178 0.1743
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.472 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0317 0.0493 0.0481
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.3522 0.7413 0.7401
Echinococcus multilocularis orexin receptor type 2 0.0131 0.0091 0.0078
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0131 0.0091 0.0078
Schistosoma mansoni biogenic amine receptor 0.0131 0.0091 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.0003 0.0003
Loa Loa (eye worm) phosphatidylinositol 3 0.0317 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0317 0.0493 0.0493
Brugia malayi GnHR receptor homolog 0.0131 0.0091 0.0046
Brugia malayi Dopamine receptor 0.0131 0.0091 0.0046
Brugia malayi sulfakinin receptor protein 0.0131 0.0091 0.0046
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.06 0.1104 0.1064
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0406 0.0685 0.0643
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0091 0.0078
Echinococcus granulosus allatostatin A receptor 0.0131 0.0091 0.0078
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0347 0.0556 0.0556
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0699 0.1318 0.1307
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.085 0.1643 0.1632
Schistosoma mansoni amine GPCR 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.2822 0.5903 0.5884
Trichomonas vaginalis conserved hypothetical protein 0.0596 0.1095 0.1054
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.0091 0.0078
Brugia malayi ORL1-like opioid receptor 0.0131 0.0091 0.0046
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.281 0.5877 0.5858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.011 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0317 0.0493 0.8759
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0406 0.0685 0.0643
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.06 0.1104 0.1064
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0572 0.1043 0.1032
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0283 0.0419 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.2565 0.5347 0.5326
Leishmania major phosphatidylinositol 3-kinase, putative 0.1612 0.329 0.326
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1662 0.3398 0.3398
Loa Loa (eye worm) TYRA-2 protein 0.0131 0.0091 0.0091
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0131 0.0091 0.0078
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0913 0.178 0.177
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0317 0.0493 0.0481
Loa Loa (eye worm) hypothetical protein 0.0151 0.0135 0.0135
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0449 0.0778 0.0737
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0091 0.0091
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.011 0.0045 0.0033
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0131 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.1016 0.2003 0.1967
Echinococcus granulosus serotonin receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0091 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Loa Loa (eye worm) phosphatidylinositol 3 0.0317 0.0493 0.0493
Echinococcus multilocularis serotonin receptor 0.0131 0.0091 0.0078
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis G protein coupled receptor 139 0.0131 0.0091 0.0078
Loa Loa (eye worm) phosphatidylinositol 3 0.0798 0.1531 0.1531
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0131 0.0091 0.0078
Entamoeba histolytica protein kinase rad3, putative 0.0913 0.178 0.1743
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.011 0.0045 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.472 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0913 0.178 0.178
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0131 0.0091 0.0078
Onchocerca volvulus 0.0317 0.0493 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1662 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0095 0.0012 0.0012
Echinococcus granulosus fmrfamide receptor 0.0131 0.0091 0.0078
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0317 0.0493 0.8759
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0131 0.0091 0.0078
Loa Loa (eye worm) FKBP5 protein 0.011 0.0045 0.0045
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0131 0.0091 0.0046
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0347 0.0556 0.0556
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0347 0.0556 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.3522 0.7413 0.7401
Entamoeba histolytica hypothetical protein 0.0317 0.0493 0.045
Schistosoma mansoni neuropeptide f receptor 76f 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0317 0.0493 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.3522 0.7413 0.7401
Trichomonas vaginalis PIKK family atypical protein kinase 0.3522 0.7413 0.7401
Loa Loa (eye worm) phosphatidylinositol 3 0.0317 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus alpha 1A adrenergic receptor 0.0131 0.0091 0.0078
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.0091 0.0078
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1016 0.2003 0.2182
Schistosoma mansoni opsin-like receptor 0.0131 0.0091 0.0078
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.472 1 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0131 0.0091 0.0078
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.06 0.1104 0.1064
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0317 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.011 0.0045 0.0033
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0131 0.0091 0.0046
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0317 0.0493 0.8759
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0596 0.1095 0.1095
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.015 0.0132 0.0119
Echinococcus granulosus neuropeptide s receptor 0.0131 0.0091 0.0078
Schistosoma mansoni biogenic amine receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0091 0.0078
Schistosoma mansoni histamine h1 receptor 0.0131 0.0091 0.0078
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.472 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0857 0.166 0.1649
Loa Loa (eye worm) phosphatidylinositol kinase 0.0317 0.0493 0.0493
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.1016 0.2003 0.2003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Brugia malayi Dopamine receptor protein 2 0.0131 0.0091 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0924 0.1803 0.1766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0493 0.045
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0317 0.0493 0.045
Loa Loa (eye worm) hypothetical protein 0.0596 0.1095 0.1095
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0857 0.166 0.1649
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0151 0.0135 0.0123
Echinococcus granulosus 7tm_1 domain containing protein 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.3522 0.7413 0.7401
Trichomonas vaginalis PIKK family atypical protein kinase 0.3167 0.6647 0.6632
Echinococcus multilocularis 0.0317 0.0493 0.0481
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Echinococcus granulosus g protein coupled receptor 0.0131 0.0091 0.0078
Schistosoma mansoni biogenic amine receptor 0.0131 0.0091 0.0078
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0317 0.0493 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.3522 0.7413 0.7401
Schistosoma mansoni fkbp-rapamycin associated protein 0.0913 0.178 0.177
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0347 0.0556 0.0544
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0091 0.0078
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.06 0.1104 0.1064
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Entamoeba histolytica hypothetical protein 0.0913 0.178 0.1743
Brugia malayi Melatonin receptor type 1A 0.0131 0.0091 0.0046
Echinococcus granulosus somatostatin receptor 0.0131 0.0091 0.0078
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0131 0.0091 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0498 0.0882 0.0841
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0091 0.0078
Schistosoma mansoni hypothetical protein 0.0151 0.0135 0.0123
Loa Loa (eye worm) hypothetical protein 0.0498 0.0882 0.0882
Schistosoma mansoni immunophilin 0.011 0.0045 0.0033
Echinococcus multilocularis sex peptide receptor 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.2565 0.5347 0.5326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0493 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.2569 0.5356 0.5335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0317 0.0493 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.3763 0.7934 0.7925
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0151 0.0135 0.0123
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0317 0.0493 0.045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0091 0.0078
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1623 0.3313 0.3283
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0913 0.178 0.1743
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0091 0.0078
Schistosoma mansoni immunophilin 0.011 0.0045 0.0033
Leishmania major phosphatidylinositol kinase related protein, putative 0.0317 0.0493 0.045
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0541 0.0976 0.0935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.0091 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0091 0.0078
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Schistosoma mansoni hypothetical protein 0.0131 0.0091 0.0078
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.085 0.1643 0.1632
Echinococcus granulosus tachykinin peptides receptor 99D 0.0131 0.0091 0.0078
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0924 0.1803 0.1766
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.011 0.0045 0.5
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.011 0.0045 0.0045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0131 0.0091 0.0078
Brugia malayi Dopamine receptor protein 1 0.0131 0.0091 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0317 0.0493 0.8759
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0131 0.0091 0.0046
Schistosoma mansoni hypothetical protein 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.3064 0.6424 0.6408
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0161 0.0149
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0347 0.0556 0.0513
Brugia malayi follicle stimulating hormone receptor 0.0131 0.0091 0.0046
Entamoeba histolytica hypothetical protein 0.0317 0.0493 0.045
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Brugia malayi RE15519p 0.0131 0.0091 0.0046
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.011 0.0045 0.0033
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1612 0.329 0.326
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.011 0.0045 0.0033
Mycobacterium leprae conserved hypothetical protein 0.0317 0.0493 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0347 0.0556 0.0544
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0091 0.0078
Brugia malayi putative neuropeptide receptor NPR1 0.0131 0.0091 0.0046
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0091 0.0078
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.472 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.011 0.0045 0.0045
Schistosoma mansoni amine GPCR 0.0131 0.0091 0.0078
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0091 0.0078
Brugia malayi G protein-coupled receptor F59B2.13 0.0131 0.0091 0.0046
Leishmania major hypothetical protein, conserved 0.0408 0.0688 0.0646
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1623 0.3313 0.3283
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.011 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.472 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.3763 0.7934 0.7925
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2226 0.4616 0.4591
Leishmania major phosphatidylinositol 3-kinase, putative 0.0347 0.0556 0.0513
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0509 0.0907 0.0866
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0091 0.0078
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis fk506 binding protein 0.011 0.0045 0.0033
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0131 0.0091 0.0091
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0091 0.0091
Loa Loa (eye worm) melatonin receptor type 1A 0.0131 0.0091 0.0091
Onchocerca volvulus 0.0317 0.0493 1
Toxoplasma gondii FATC domain-containing protein 0.0913 0.178 0.186
Loa Loa (eye worm) phosphatidylinositol 3 0.1623 0.3313 0.3313
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0406 0.0685 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.2569 0.5356 0.5335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0913 0.178 0.1743
Giardia lamblia Phosphatidylinositol 4-kinase 0.0317 0.0493 0.045
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0317 0.0493 0.045
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.472 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0406 0.0685 0.0685
Leishmania major phosphatidylinositol kinase, putative 0.0317 0.0493 0.045
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0347 0.0556 0.0513
Brugia malayi neuropeptide F receptor 0.0131 0.0091 0.0046
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Mycobacterium tuberculosis Conserved hypothetical protein 0.0317 0.0493 0.5
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.015 0.0132 0.0132
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0572 0.1043 0.1032
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0347 0.0556 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0317 0.0493 0.045
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0913 0.178 0.1743
Schistosoma mansoni hypothetical protein 0.0317 0.0493 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.3763 0.7934 0.7925
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0913 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0347 0.0556 0.0092
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3767 0.7943 0.7933
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0131 0.0091 0.0078
Echinococcus granulosus g-protein coupled receptor 0.0131 0.0091 0.0078
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0317 0.0493 0.0481
Schistosoma mansoni hypothetical protein 0.0151 0.0135 0.0123
Brugia malayi neuropeptide F receptor 0.0131 0.0091 0.0046
Echinococcus multilocularis neuropeptide FF receptor 2 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1662 0.3398 0.339
Trichomonas vaginalis PIKK family atypical protein kinase 0.2822 0.5903 0.5884
Loa Loa (eye worm) apoptosis regulator protein 0.0151 0.0135 0.0135
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0406 0.0685 0.0643
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.472 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0091 0.0078
Echinococcus granulosus neuropeptide receptor 0.0131 0.0091 0.0078
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0131 0.0091 0.0078
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0406 0.0685 0.0673
Schistosoma mansoni amine GPCR 0.0131 0.0091 0.0078
Brugia malayi hypothetical protein 0.0131 0.0091 0.0046
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0509 0.0907 0.0866
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Giardia lamblia GTOR 0.472 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0317 0.0493 0.045
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0091 0.0078
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1662 0.3398 0.3368
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0131 0.0091 0.0046
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0498 0.0882 0.0871
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0347 0.0556 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1662 0.3398 0.339
Loa Loa (eye worm) hypothetical protein 0.0131 0.0091 0.0091
Echinococcus granulosus g protein coupled receptor 0.0131 0.0091 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.3763 0.7934 0.7925
Giardia lamblia Hypothetical protein 0.0317 0.0493 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.1612 0.329 0.326

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 820 nM Nanomolar concentration required to reduce the growth of L1210 cells in culture to 50% of control values after 70 h (in vitro) ChEMBL. 3572972
IC50 (functional) = 820 nM Nanomolar concentration required to reduce the growth of L1210 cells in culture to 50% of control values after 70 h (in vitro) ChEMBL. 3572972
ILS max (functional) NA 0 Average increase in life span of treated animals over control groups of tumor-bearing untreated animals when given at optimal dose; NA means no significant activity (in vivo) ChEMBL. 3572972
ILS max (functional) = 58 Average increase in life span of treated animals over control groups of tumor-bearing untreated animals when given at optimal dose (in vivo) ChEMBL. 3572972
Log K (binding) = 6.68 Logarithm of association constant (K) for binding to DNA by ethidium displacement ChEMBL. 3572972
Log K (binding) = 6.74 Logarithm of association constant (K) for binding to DNA by ethidium displacement ChEMBL. 3572972
OD (functional) = 150 mg kg-1 day-1 Optimal dose in mg/kg administered intraperitoneally on days 1,5 and 9 required to inhibit the growth of P388 leukemia cells was determined (in vivo) ChEMBL. 3572972
OD (functional) = 150 mg kg-1 day-1 Optimal dose required after intraperitoneal administration on days 5,9 and 13 to inhibit the growth of lewis lung carcinoma (LL) cells was determined (in vivo) ChEMBL. 3572972
OD (functional) = 150 mg kg-1 day-1 Optimal dose in mg/kg administered intraperitoneally on days 1,5 and 9 required to inhibit the growth of P388 leukemia cells was determined (in vivo) ChEMBL. 3572972
Rm = -0.01 Lipophilicity (HPLC) ChEMBL. 3572972

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 3572972

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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