TDR Targets

Basic information

Technical information

TDR Targets ID: 289161
Name: 2-[[3-[4-amino-5-(3-methoxyphenyl)pyrrolo[2,3 -d]pyrimidin-7-yl]cyclobutyl]methylamino]etha nol
MW: 367.445 | Formula: C20H25N5O2
H donors: 3 H acceptors: 3 LogP: 1.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCNCC1CC(C1)n1cc(c2c1ncnc2N)c1cccc(c1)OC
InChi: 1S/C20H25N5O2/c1-27-16-4-2-3-14(9-16)17-11-25(20-18(17)19(21)23-12-24-20)15-7-13(8-15)10-22-5-6-26/h2-4,9,11-13,15,22,26H,5-8,10H2,1H3,(H2,21,23,24)
InChiKey: TWUSYQHQSFRUMW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[3-[4-amino-5-(3-methoxyphenyl)-7-pyrrolo[2,3-d]pyrimidinyl]cyclobutyl]methylamino]ethanol
2-[[3-[4-azanyl-5-(3-methoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]methylamino]ethanol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Gallus gallus	Tyrosine-protein kinase SRC	Starlite/ChEMBL	References
Homo sapiens	ABL proto-oncogene 2, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	c src tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	513 aa	33.9 %
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Tyrosine-protein kinase SRC	533 aa	500 aa	35.0 %
Onchocerca volvulus	Cyclin-H homolog	Tyrosine-protein kinase SRC	533 aa	453 aa	44.8 %
Schistosoma mansoni	serine/threonine protein kinase	Tyrosine-protein kinase SRC	533 aa	473 aa	24.5 %
Echinococcus granulosus	tyrosine protein kinase Btk29A	Tyrosine-protein kinase SRC	533 aa	500 aa	35.0 %
Echinococcus granulosus	c src tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	513 aa	33.7 %
Echinococcus multilocularis	tyrosine protein kinase Abl	Tyrosine-protein kinase SRC	533 aa	506 aa	36.6 %
Schistosoma mansoni	tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	501 aa	35.3 %
Onchocerca volvulus		Tyrosine-protein kinase SRC	533 aa	435 aa	27.4 %
Echinococcus multilocularis	tyrosine protein kinase ABL1	Tyrosine-protein kinase SRC	533 aa	473 aa	39.1 %
Brugia malayi	Tyrosine-protein kinase abl-1	Tyrosine-protein kinase SRC	533 aa	455 aa	44.4 %
Echinococcus granulosus	tyrosine protein kinase ABL1	Tyrosine-protein kinase SRC	533 aa	473 aa	39.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	NCK adaptor protein	0.0022	0.0214	0.0238
Echinococcus multilocularis	insulin receptor	0.0175	0.4058	0.6259
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.027	0.6447	1
Brugia malayi	Protein kinase domain containing protein	0.002	0.0157	0.0242
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0032	0.0452	0.073
Brugia malayi	hypothetical protein	0.0021	0.0174	0.0271
Echinococcus granulosus	tyrosine protein kinase Srms	0.0021	0.0174	0.0175
Trypanosoma cruzi	polo-like protein kinase, putative	0.0082	0.1705	0.3148
Schistosoma mansoni	protein kinase	0.005	0.0898	0.1454
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0081	0.1677	0.2529
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0191	0.0375
Echinococcus granulosus	MAM	0.0024	0.0245	0.0287
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0154	0.3537	0.5442
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3327	0.3317
Echinococcus granulosus	serine threonine protein kinase nrc	0.002	0.0148	0.0135
Loa Loa (eye worm)	AGC/NDR protein kinase	0.002	0.0157	0.0142
Echinococcus granulosus	serine:threonine protein kinase N2	0.0108	0.2376	0.3624
Entamoeba histolytica	protein kinase domain containing protein	0.005	0.0898	0.1761
Brugia malayi	Serine/threonine-protein kinase Nek7	0.0176	0.4073	0.6911
Entamoeba histolytica	protein kinase 2, putative	0.002	0.0148	0.029
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0082	0.1705	0.5525
Trypanosoma brucei	histone deacetylase 1	0.0216	0.5096	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.002	0.0157	0.0148
Trichomonas vaginalis	AGC family protein kinase	0.002	0.0157	0.013
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Loa Loa (eye worm)	TK/ALK protein kinase	0.0207	0.4861	0.4854
Toxoplasma gondii	aurora kinase	0.005	0.0898	0.0581
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0136	0.3067	0.3057
Echinococcus granulosus	tyrosine kinase	0.0021	0.0174	0.0175
Entamoeba histolytica	protein kinase, putative	0.0039	0.0633	0.1243
Loa Loa (eye worm)	histone deacetylase	0.0196	0.4592	0.4584
Loa Loa (eye worm)	TK protein kinase	0.0081	0.1677	0.1665
Echinococcus multilocularis	histone deacetylase 6	0.0196	0.4592	0.7095
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.002	0.0157	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0633	0.1083
Giardia lamblia	Kinase, NEK	0.0089	0.1884	0.3509
Trypanosoma brucei	histone deacetylase 4	0.0196	0.4592	0.8871
Echinococcus granulosus	histone deacetylase 6	0.0196	0.4592	0.7095
Echinococcus granulosus	plexin a4	0.0017	0.0081	0.0031
Echinococcus multilocularis	histone deacetylase 6	0.0196	0.4592	0.7095
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0136	0.3075	0.5211
Trichomonas vaginalis	CAMK family protein kinase	0.0082	0.1705	0.3225
Loa Loa (eye worm)	plexin A	0.0017	0.0081	0.0067
Trichomonas vaginalis	STE family protein kinase	0.0089	0.1884	0.3582
Leishmania major	histone deacetylase, putative	0.0196	0.4592	0.88
Loa Loa (eye worm)	hypothetical protein	0.002	0.0157	0.0142
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0022	0.0214	0.0343
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0127	0.2851	0.4368
Giardia lamblia	Kinase, NEK	0.0089	0.1884	0.3509
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0094	0.202	0.3068
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0191	0.0088
Brugia malayi	Histone deacetylase 1	0.0216	0.5096	0.8653
Echinococcus granulosus	growth factor receptor bound protein 2	0.0022	0.0214	0.0238
Echinococcus multilocularis		0.007	0.1415	0.2119
Schistosoma mansoni	tyrosine kinase	0.0021	0.0174	0.0278
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.005	0.0898	0.1761
Brugia malayi	Protein kinase domain containing protein	0.0207	0.4863	0.8256
Trypanosoma cruzi	aurora B kinase, putative	0.005	0.0898	0.1515
Echinococcus multilocularis	histone deacetylase 3	0.0216	0.5096	0.7884
Echinococcus multilocularis	tyrosine protein kinase shark	0.0021	0.0174	0.0175
Schistosoma mansoni	tyrosine kinase	0.0145	0.3298	0.5351
Trichomonas vaginalis	CAMK family protein kinase	0.0042	0.0697	0.1209
Loa Loa (eye worm)	TK/INSR protein kinase	0.0175	0.4058	0.405
Loa Loa (eye worm)	histone deacetylase 7A	0.0196	0.4592	0.4584
Brugia malayi	histone deacetylase 1 (HD1)	0.0216	0.5096	0.8653
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0071	0.1438	0.2156
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Schistosoma mansoni	plexin	0.0015	0.0015	0.002
Brugia malayi	Tyrosine-protein kinase abl-1	0.0127	0.2851	0.4829
Entamoeba histolytica	histone deacetylase, putative	0.0216	0.5096	1
Trypanosoma cruzi	histone deacetylase, putative	0.0196	0.4592	0.8981
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0216	0.5096	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.2209	0.2198
Brugia malayi	serine/threonine kinase 12	0.005	0.0898	0.1503
Echinococcus granulosus	Protein kinase C brain isozyme	0.002	0.0157	0.0148
Echinococcus multilocularis	tyrosine kinase	0.0021	0.0174	0.0175
Echinococcus multilocularis	NCK adaptor protein	0.0022	0.0214	0.0238
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0136	0.3075	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0092	0.1955	0.2966
Echinococcus multilocularis	epidermal growth factor receptor	0.0154	0.3537	0.5442
Echinococcus granulosus	tyrosine protein kinase shark	0.0021	0.0174	0.0175
Schistosoma mansoni	tyrosine kinase	0.0175	0.4058	0.6586
Echinococcus multilocularis	MAM	0.0024	0.0245	0.0287
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0898	0.1611
Schistosoma mansoni	tyrosine kinase	0.0154	0.3537	0.5739
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0092	0.1955	0.2966
Schistosoma mansoni	atypical protein kinase C	0.002	0.0157	0.0251
Trichomonas vaginalis	CAMK family protein kinase	0.0082	0.1705	0.3225
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0021	0.0174	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0105	0.2286	0.2275
Trichomonas vaginalis	CAMK family protein kinase	0.0042	0.0697	0.1209
Plasmodium falciparum	histone deacetylase 2	0.0196	0.4592	0.8981
Plasmodium vivax	NIMA-related protein kinase (Pfnek-1), putative	0.0089	0.1884	0.3026
Onchocerca volvulus	Tyrosine kinase homolog	0.0127	0.2857	0.9287
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.005	0.0898	0.1309
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.5096	1
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.005	0.0898	0.1761
Schistosoma mansoni	growth factor receptor-bound protein	0.0022	0.0214	0.0343
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.5096	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0082	0.1705	0.2574
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0174	0.0271
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0898	0.1611
Loa Loa (eye worm)	SRC-1	0.0092	0.1955	0.1944
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.002	0.0148	0.0135
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0157	0.0251
Echinococcus multilocularis	histone deacetylase 7	0.0196	0.4592	0.7095
Echinococcus granulosus	Glutaredoxin protein 5	0.0017	0.0083	0.0033
Entamoeba histolytica	protein kinase, putative	0.005	0.0898	0.1761
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0021	0.0174	0.0175
Loa Loa (eye worm)	NEK/NEK6 protein kinase	0.0176	0.4073	0.4064
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0081	0.1677	0.2529
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0082	0.1705	0.2574
Chlamydia trachomatis	serine/threonine protein kinase	0.0176	0.4073	0.5
Echinococcus granulosus	histone deacetylase	0.0196	0.4592	0.7095
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0157	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0633	0.1083
Onchocerca volvulus		0.0116	0.2568	0.8343
Plasmodium vivax	histone deacetylase 2, putative	0.0196	0.4592	0.7743
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0082	0.1705	0.1693
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0021	0.0174	0.034
Echinococcus granulosus	nervana 2	0.0017	0.0083	0.0033
Onchocerca volvulus		0.0021	0.0174	0.0519
Entamoeba histolytica	protein kinase, putative	0.005	0.0898	0.1761
Schistosoma mansoni	tyrosine kinase	0.0259	0.6161	1
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0157	0.0251
Brugia malayi	p70 ribosomal S6 kinase beta	0.0037	0.059	0.098
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0092	0.1955	0.2966
Echinococcus multilocularis	serine threonine protein kinase	0.002	0.0157	0.0148
Echinococcus multilocularis	rac serine:threonine kinase	0.0022	0.0191	0.0203
Brugia malayi	SH2 domain containing protein	0.0021	0.0174	0.0271
Echinococcus multilocularis	protein kinase c iota type	0.002	0.0157	0.0148
Echinococcus multilocularis	plexin a4	0.0017	0.0081	0.0031
Schistosoma mansoni	serine/threonine protein kinase	0.0082	0.1705	0.2765
Leishmania major	histone deacetylase, putative	0.0216	0.5096	1
Onchocerca volvulus		0.0021	0.0174	0.0519
Trypanosoma brucei	histone deacetylase 2	0.0102	0.2209	0.3532
Brugia malayi	histone deacetylase 11	0.0248	0.5887	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0179	0.416	0.6418
Brugia malayi	Protein kinase domain containing protein	0.0223	0.5273	0.8954
Loa Loa (eye worm)	TK/ABL protein kinase	0.027	0.6447	0.6442
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.002	0.0157	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0245	0.0231
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0032	0.0452	0.0611
Brugia malayi	plexin A	0.0017	0.0081	0.0114
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.5096	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0017	0.0083	0.0033
Echinococcus multilocularis	protein tyrosine kinase	0.0221	0.521	0.8062
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.002	0.0157	0.0148
Plasmodium falciparum	histone deacetylase 1	0.0216	0.5096	1
Schistosoma mansoni	tyrosine kinase	0.0021	0.0174	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0245	0.0231
Schistosoma mansoni	tyrosine kinase	0.0154	0.3537	0.5739
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0633	0.1083
Echinococcus multilocularis	histone deacetylase 6	0.0201	0.4722	0.7299
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0092	0.1955	0.2966
Brugia malayi	serine/threonine-protein kinase plk-2	0.0082	0.1705	0.2879
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2032	0.202
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.5096	1
Loa Loa (eye worm)	TK protein kinase	0.0069	0.1391	0.1379
Echinococcus granulosus	tyrosine protein kinase Blk	0.0081	0.1677	0.2529
Echinococcus granulosus	epidermal growth factor receptor	0.0154	0.3537	0.5442
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0245	0.0231
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Toxoplasma gondii	histone deacetylase HDAC4	0.0248	0.5887	1
Trypanosoma brucei	polo-like protein kinase	0.0082	0.1705	0.2402
Echinococcus granulosus	protein kinase c iota type	0.002	0.0157	0.0148
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.5096	1
Loa Loa (eye worm)	histone deacetylase 3	0.0216	0.5096	0.5089
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0128	0.2883	0.2873
Onchocerca volvulus		0.0021	0.0174	0.0519
Echinococcus granulosus	histone deacetylase 6	0.0201	0.4722	0.7299
Trichomonas vaginalis	CAMK family protein kinase	0.0082	0.1705	0.3225
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0071	0.1438	0.2156
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0069	0.1391	0.2082
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.5096	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0039	0.0633	0.062
Echinococcus multilocularis	histone deacetylase	0.0196	0.4592	0.7095
Loa Loa (eye worm)	AUR protein kinase	0.005	0.0898	0.0884
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.002	0.0157	0.0148
Entamoeba histolytica	protein kinase, putative	0.0037	0.059	0.1158
Schistosoma mansoni	hypothetical protein	0.0024	0.0245	0.0394
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0191	0.0307
Brugia malayi	serine/threonine protein kinase 6	0.005	0.0898	0.1503
Trypanosoma brucei	histone deacetylase 3	0.0196	0.4592	0.8871
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0157	0.0251
Brugia malayi	histone deacetylase 3 (HD3)	0.0216	0.5096	0.8653
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.002	0.0157	0.0142
Giardia lamblia	Kinase, NEK	0.0089	0.1884	0.3509
Trichomonas vaginalis	AGC family protein kinase	0.002	0.0157	0.013
Echinococcus multilocularis	histone deacetylase 1	0.0216	0.5096	0.7884
Schistosoma mansoni	tyrosine kinase	0.0032	0.0452	0.073
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0191	0.0307
Onchocerca volvulus		0.0028	0.0346	0.1084
Schistosoma mansoni	histone deacetylase 1 2 3	0.0102	0.2209	0.3584
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.1884	0.3582
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.002	0.0148	0.0135
Trypanosoma brucei	aurora B kinase	0.005	0.0898	0.0592
Plasmodium falciparum	histone deacetylase, putative	0.0196	0.4592	0.8981
Schistosoma mansoni	serine/threonine kinase	0.002	0.0157	0.0251
Brugia malayi	Protein kinase domain containing protein	0.0069	0.1397	0.2355
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0082	0.1705	0.1924
Plasmodium vivax	histone deacetylase 1, putative	0.0216	0.5096	0.8621
Schistosoma mansoni	tyrosine kinase	0.0145	0.3298	0.5351
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0214	0.0199
Schistosoma mansoni	histone deacetylase hda2	0.0102	0.2209	0.3584
Echinococcus multilocularis	protein kinase c epsilon type	0.002	0.0157	0.0148
Leishmania major	histone deacetylase, putative	0.0216	0.5096	1
Loa Loa (eye worm)	histone deacetylase 11	0.0248	0.5887	0.5881
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0071	0.1437	0.2423
Brugia malayi	SRC-1	0.0092	0.1955	0.3305
Echinococcus granulosus	histone deacetylase 8	0.0102	0.2209	0.3364
Plasmodium falciparum	NIMA related kinase 1	0.0089	0.1884	0.3509
Schistosoma mansoni	tyrosine kinase	0.0092	0.1955	0.3171
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0157	0.0251
Onchocerca volvulus		0.0021	0.0174	0.0519
Schistosoma mansoni	serine/threonine protein kinase	0.0128	0.2883	0.4678
Leishmania major	histone deacetylase, putative	0.0196	0.4592	0.88
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0108	0.2376	0.3624
Brugia malayi	Histone deacetylase family protein	0.0196	0.4592	0.7794
Plasmodium vivax	histone deacetylase, putative	0.0248	0.5887	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.002	0.0157	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0159
Loa Loa (eye worm)	hypothetical protein	0.006	0.1159	0.1146
Echinococcus granulosus	tyrosine protein kinase HCK	0.0069	0.1391	0.2082
Loa Loa (eye worm)	thyroid receptor interactor	0.0071	0.1437	0.1425
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0136	0.3067	0.5198
Schistosoma mansoni	histone deacetylase	0.0216	0.5096	0.827
Echinococcus granulosus	protein kinase c epsilon type	0.002	0.0157	0.0148
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.02	0.0217
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.1955	0.2966
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0633	0.1083
Echinococcus multilocularis	Glutaredoxin protein 5	0.0017	0.0083	0.0033
Schistosoma mansoni	histone deacetylase 4 5	0.0196	0.4592	0.7452
Brugia malayi	protein-tyrosine kinase	0.0081	0.1677	0.2831
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0037	0.059	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0174	0.4027	0.4018
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0191	0.0375
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0092	0.1955	0.2966
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0081	0.1677	0.2529
Echinococcus granulosus	epidermal growth factor receptor	0.0238	0.5635	0.8729
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.005	0.0898	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0216	0.5096	0.5089
Schistosoma mansoni	adapter molecule crk	0.0022	0.0214	0.0343
Echinococcus granulosus	histone deacetylase 3	0.0216	0.5096	0.7884
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0092	0.1955	0.2966
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.1955	0.2966
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0128	0.2883	0.4419
Echinococcus granulosus	insulin receptor	0.0175	0.4058	0.6259
Entamoeba histolytica	protein kinase , putative	0.005	0.0898	0.1761
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0157	0.0251
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0898	0.1611
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0082	0.1705	0.3346
Brugia malayi	Furin-like cysteine rich region family protein	0.0238	0.5635	0.9571
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0081	0.1677	0.2529
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0633	0.1083
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.3524	0.5976
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0214	0.0339
Plasmodium falciparum	serine/threonine protein kinase, putative	0.005	0.0898	0.1515
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0174	0.0271
Echinococcus granulosus	tyrosine protein kinase ABL1	0.027	0.6447	1
Brugia malayi	Protein kinase domain containing protein	0.002	0.0157	0.0242
Brugia malayi	protein kinase C II.	0.002	0.0157	0.0242
Schistosoma mansoni	hypothetical protein	0.0024	0.0245	0.0394
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0216	0.5096	1
Onchocerca volvulus		0.0021	0.0174	0.0519
Brugia malayi	serine/threonine-protein kinase 6	0.005	0.0898	0.1503
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0174	0.0271
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.002	0.0157	0.0142
Schistosoma mansoni	growth factor receptor-bound protein	0.0022	0.0214	0.0343
Echinococcus granulosus	histone deacetylase 7	0.0196	0.4592	0.7095
Trypanosoma cruzi	Protein kinase B	0.0022	0.0191	0.0088
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0633	0.1083
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0898	0.1611
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0022	0.0214	0.0199
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0633	0.1083
Trichomonas vaginalis	AGC family protein kinase	0.002	0.0157	0.013
Schistosoma mansoni	nck2/grb4	0.0022	0.0214	0.0343
Onchocerca volvulus		0.0024	0.0245	0.0753
Trypanosoma brucei	histone deacetylase, putative	0.0196	0.4592	0.8871
Trypanosoma cruzi	histone deacetylase, putative	0.0196	0.4592	0.8981
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0166	0.0267
Toxoplasma gondii	NIMA-related protein kinase NIMA1	0.0089	0.1884	0.2443
Echinococcus granulosus	serine/threonine protein kinase	0.0022	0.0191	0.0203
Loa Loa (eye worm)	histone deacetylase 1	0.0216	0.5096	0.5089
Echinococcus multilocularis	histone deacetylase 8	0.0102	0.2209	0.3364
Trypanosoma cruzi	histone deacetylase 1, putative	0.0216	0.5096	1
Schistosoma mansoni	histone deacetylase	0.0216	0.5096	0.827
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0216	0.5096	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0092	0.1955	0.2966
Schistosoma mansoni	tyrosine kinase	0.0032	0.0452	0.073
Schistosoma mansoni	tyrosine kinase	0.0145	0.3298	0.5351
Entamoeba histolytica	protein kinase, putative	0.0069	0.1391	0.273
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0179	0.416	0.6418
Echinococcus granulosus	protein kinase C gamma type	0.002	0.0157	0.0148
Brugia malayi	Histone deacetylase family protein	0.0196	0.4592	0.7794
Echinococcus granulosus	c src tyrosine kinase	0.0032	0.0452	0.0611
Giardia lamblia	Histone deacetylase	0.0216	0.5096	1
Echinococcus granulosus	nervana 2	0.0017	0.0083	0.0033
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0092	0.1955	0.2966
Brugia malayi	Protein kinase domain containing protein	0.0039	0.0633	0.1054
Brugia malayi	hypothetical protein	0.0024	0.0245	0.0392
Echinococcus granulosus	aurora kinase A	0.005	0.0898	0.1309
Echinococcus granulosus	NDR protein kinase	0.002	0.0157	0.0148
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.1955	0.2966
Trichomonas vaginalis	CAMK family protein kinase	0.0082	0.1705	0.3225
Echinococcus granulosus	protein tyrosine kinase	0.0221	0.521	0.8062
Trypanosoma cruzi	polo-like protein kinase, putative	0.0082	0.1705	0.3148
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0898	0.1454
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0136	0.3075	0.3065
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0136	0.3075	0.4719
Brugia malayi	Sex muscle abnormal protein 5	0.0022	0.0214	0.0339
Loa Loa (eye worm)	AUR protein kinase	0.005	0.0898	0.0884
Loa Loa (eye worm)	hypothetical protein	0.01	0.2162	0.2151
Schistosoma mansoni	tyrosine kinase	0.0092	0.1955	0.3171
Giardia lamblia	Kinase, PLK	0.0082	0.1705	0.3148
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0238	0.5635	0.5629
Echinococcus multilocularis	serine:threonine protein kinase N2	0.002	0.0157	0.0148
Entamoeba histolytica	protein kinase, putative	0.0039	0.0633	0.1243
Schistosoma mansoni	tyrosine kinase	0.0221	0.521	0.8455
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.002	0.0157	0.0148
Schistosoma mansoni	tyrosine kinase	0.0175	0.4058	0.6586
Toxoplasma gondii	histone deacetylase HDAC5	0.0102	0.2209	0.3057
Schistosoma mansoni	kinase	0.0043	0.0723	0.117
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.005	0.0898	0.1306
Trichomonas vaginalis	CAMK family protein kinase	0.0082	0.1705	0.3225
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0022	0.0214	0.0238
Brugia malayi	Hr1 repeat family protein	0.0128	0.2883	0.4885
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0174	0.0159
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0174	0.0271
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0092	0.1955	0.2966
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.002	0.0157	0.0148
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0092	0.1955	0.2966
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0032	0.0452	0.0611
Trichomonas vaginalis	CAMK family protein kinase	0.0082	0.1705	0.3225
Entamoeba histolytica	protein kinase, putative	0.002	0.0157	0.0307
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0092	0.1955	0.2966
Plasmodium vivax	histone deacetylase, putative	0.0196	0.4592	0.7743
Schistosoma mansoni	cell adhesion molecule	0.0014	0.0012	0.0015
Giardia lamblia	Aurora kinase	0.005	0.0898	0.1515
Echinococcus multilocularis	aurora kinase A	0.005	0.0898	0.1309
Schistosoma mansoni	serine/threonine protein kinase	0.0176	0.4073	0.6609
Echinococcus multilocularis	c src tyrosine kinase	0.0032	0.0452	0.0611
Echinococcus granulosus	histone deacetylase 6	0.0196	0.4592	0.7095
Schistosoma mansoni	histone deacetylase 4 5	0.0196	0.4592	0.7452
Trypanosoma cruzi	histone deacetylase 1, putative	0.0216	0.5096	1
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.005	0.0898	0.1309
Loa Loa (eye worm)	AUR protein kinase	0.005	0.0898	0.0884
Trypanosoma cruzi	histone deacetylase, putative	0.0102	0.2209	0.4167
Onchocerca volvulus		0.0021	0.0174	0.0519
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0174	0.0271
Schistosoma mansoni	tyrosine kinase	0.0238	0.5635	0.9146
Echinococcus granulosus	histone deacetylase 1	0.0216	0.5096	0.7884
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.002	0.0157	0.0142
Echinococcus multilocularis	nervana 2	0.0017	0.0083	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0175	0.4058	0.6886
Schistosoma mansoni	histone deacetylase hda2	0.0201	0.4722	0.7664
Trichomonas vaginalis	CAMK family protein kinase	0.0082	0.1705	0.3225
Schistosoma mansoni	serine/threonine protein kinase	0.0136	0.3075	0.4989
Echinococcus granulosus	tyrosine kinase	0.0081	0.1677	0.2529
Toxoplasma gondii	histone deacetylase HDAC3	0.0216	0.5096	0.8506
Brugia malayi	SH2 domain containing protein	0.0021	0.0174	0.0271
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0136	0.3075	0.4719
Toxoplasma gondii	histone deacetylase HDAC1	0.0196	0.4592	0.7555
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0092	0.1955	0.2966
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0092	0.1955	0.2966
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0017	0.0083	0.0033
Toxoplasma gondii	histone deacetylase HDAC2	0.0216	0.5096	0.8506
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0214	0.0339
Echinococcus multilocularis	nervana 2	0.0017	0.0083	0.0033
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0136	0.3075	0.3065
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0102	0.2209	0.7172
Echinococcus multilocularis	serine:threonine protein kinase 38	0.002	0.0157	0.0148
Trypanosoma cruzi	histone deacetylase, putative	0.0196	0.4592	0.8981
Echinococcus multilocularis	epidermal growth factor receptor	0.0238	0.5635	0.8729
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0022	0.0214	0.0199
Trypanosoma cruzi	histone deacetylase, putative	0.0102	0.2209	0.4167
Loa Loa (eye worm)	TK/FAK protein kinase	0.0223	0.5273	0.5266
Echinococcus granulosus	serine:threonine protein kinase N2	0.0128	0.2883	0.4419
Brugia malayi	Protein kinase domain containing protein	0.0136	0.3075	0.5211

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.02 uM	Inhibition of p60 c-Src tyrosine kinase activity	ChEMBL.	11277535
IC50 (binding)	= 0.02 uM	Inhibition of p60 c-Src tyrosine kinase activity	ChEMBL.	11277535
IC50 (functional)	= 0.3 uM	Inhibition of p60 c-Src tyrosine kinase mediated phosphorylation of Fak in IC8.1 fibroblasts	ChEMBL.	11277535
IC50 (functional)	= 0.3 uM	Inhibition of p60 c-Src tyrosine kinase mediated phosphorylation of Fak in IC8.1 fibroblasts	ChEMBL.	11277535
IC50 (binding)	= 0.42 uM	Inhibition of v-Abl tyrosine kinase activity	ChEMBL.	11277535
IC50 (binding)	= 0.42 uM	Inhibition of v-Abl tyrosine kinase activity	ChEMBL.	11277535
IC50 (binding)	= 0.49 uM	Inhibition of Epidermal growth factor receptor (EGF-R) tyrosine kinase activity	ChEMBL.	11277535
IC50 (binding)	= 0.49 uM	Inhibition of Epidermal growth factor receptor (EGF-R) tyrosine kinase activity	ChEMBL.	11277535

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL168550
PubChem: 10067548

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 289161