Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0199 | 0.0305 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1533 | 0.6061 | 1 |
Onchocerca volvulus | 0.1496 | 0.5908 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.043 | 0.0688 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0175 | 0.0289 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.25 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.25 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1533 | 0.6061 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1496 | 0.5908 | 0.9546 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1533 | 0.6061 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0152 | 0.043 | 0.0709 |
Echinococcus granulosus | hypothetical protein | 0.0678 | 0.2572 | 0.4072 |
Brugia malayi | hypothetical protein | 0.0712 | 0.2711 | 0.4285 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.25 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1533 | 0.6061 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.25 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.0199 | 0.0328 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0673 | 0.2551 | 0.4209 |
Schistosoma mansoni | dihydrofolate reductase | 0.1533 | 0.6061 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.0366 | 0.0324 |
Echinococcus granulosus | thymidylate synthase | 0.1496 | 0.5908 | 0.9741 |
Brugia malayi | thymidylate synthase | 0.1496 | 0.5908 | 0.974 |
Loa Loa (eye worm) | thymidylate synthase | 0.1496 | 0.5908 | 0.9748 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0712 | 0.2711 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1533 | 0.6061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.043 | 0.0688 |
Echinococcus multilocularis | thymidylate synthase | 0.1496 | 0.5908 | 0.9749 |
Brugia malayi | dihydrofolate reductase family protein | 0.1533 | 0.6061 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1496 | 0.5908 | 0.974 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.0199 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0152 | 0.043 | 0.0384 |
Echinococcus granulosus | dihydrofolate reductase | 0.1533 | 0.6061 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.25 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.0199 | 0.004 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.0366 | 0.0604 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1533 | 0.6061 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0152 | 0.043 | 0.0709 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1533 | 0.6061 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0152 | 0.043 | 0.0433 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 55.71 nM | In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex. | ChEMBL. | 7731013 |
Ki (binding) | = 55.71 nM | In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex. | ChEMBL. | 7731013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.