Detailed information for compound 300435

Basic information

Technical information
  • TDR Targets ID: 300435
  • Name: 1-[5-[bis(2,2-dimethylaziridin-1-yl)phosphory loxymethyl]-4-hydroxyoxolan-2-yl]-5-methylpyr imidine-2,4-dione
  • MW: 428.42 | Formula: C18H29N4O6P
  • H donors: 2 H acceptors: 4 LogP: -0.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CC(OC1CO[P+](N1CC1(C)C)(N1CC1(C)C)[O-])n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C18H29N4O6P/c1-11-7-20(16(25)19-15(11)24)14-6-12(23)13(28-14)8-27-29(26,21-9-17(21,2)3)22-10-18(22,4)5/h7,12-14,23H,6,8-10H2,1-5H3,(H,19,24,25)
  • InChiKey: GBGGASNAWLREPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[5-[bis(2,2-dimethylaziridin-1-yl)phosphoryloxymethyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
  • 1-[5-[bis(2,2-dimethyl-1-aziridinyl)phosphoryloxymethyl]-4-hydroxy-2-tetrahydrofuranyl]-5-methylpyrimidine-2,4-dione
  • 1-[5-[bis(2,2-dimethylaziridin-1-yl)phosphoryloxymethyl]-4-hydroxy-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
  • 1-[5-[bis(2,2-dimethylethylenimin-1-yl)phosphoryloxymethyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
  • 77887-10-6
  • NSC200729

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Toxoplasma gondii hypothetical protein 0.031 0.0596 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.031 0.0596 1
Echinococcus granulosus transient receptor potential cation channel 0.031 0.0596 0.0591
Echinococcus multilocularis shaker cognate 0.031 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Echinococcus multilocularis transient receptor potential cation channel 0.031 0.0596 0.0589
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.031 0.0596 0.2158
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.031 0.0596 0.0589
Trypanosoma cruzi hypothetical protein, conserved 0.02 0.0366 0.6141
Echinococcus multilocularis conserved hypothetical protein 0.031 0.0596 0.0589
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.031 0.0596 0.0589
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.031 0.0596 0.0589
Echinococcus multilocularis voltage dependent calcium channel 0.031 0.0596 0.0589
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.02 0.0366 0.6141
Echinococcus multilocularis potassium voltage gated channel protein 0.031 0.0596 0.0589
Schistosoma mansoni inositol 145-trisphosphate receptor 0.031 0.0596 0.2137
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.031 0.0596 0.0589
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.031 0.0596 0.0589
Schistosoma mansoni calcium-activated potassium channel 0.031 0.0596 0.2137
Toxoplasma gondii transporter, cation channel family protein 0.031 0.0596 1
Echinococcus granulosus short transient receptor potential channel 6 0.031 0.0596 0.0591
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.031 0.0596 0.2158
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.02 0.0366 0.0361
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.02 0.0366 0.6141
Echinococcus granulosus cyclic nucleotide gated cation channel 0.031 0.0596 0.0591
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.031 0.0596 0.0589
Leishmania major carnitine/choline acetyltransferase, putative 0.02 0.0366 0.0366
Brugia malayi ion channel NompC 0.031 0.0596 0.2158
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Echinococcus multilocularis ryanodine receptor 44f 0.031 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Brugia malayi hypothetical protein 0.0037 0.0023 0.0084
Loa Loa (eye worm) voltage-gated potassium channel 0.031 0.0596 0.2158
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Schistosoma mansoni two-pore calcium channel 0.031 0.0596 0.2137
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Loa Loa (eye worm) voltage-gated calcium channel 0.031 0.0596 0.2158
Trypanosoma cruzi hypothetical protein, conserved 0.02 0.0366 0.6141
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.02 0.0366 0.1325
Echinococcus granulosus voltage dependent calcium channel 0.031 0.0596 0.0591
Echinococcus granulosus voltage dependent calcium channel 0.031 0.0596 0.0591
Onchocerca volvulus 0.02 0.0366 0.6053
Echinococcus granulosus ryanodine receptor 44f 0.031 0.0596 0.0591
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Brugia malayi Choline O-acetyltransferase 0.1343 0.2761 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.031 0.0596 0.2137
Onchocerca volvulus 0.0234 0.0437 0.7256
Schistosoma mansoni transient receptor potential channel 4 0.031 0.0596 0.2137
Leishmania major hypothetical protein, conserved 0.031 0.0596 0.0596
Echinococcus granulosus shaker cognate 0.031 0.0596 0.0591
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.031 0.0596 0.0589
Echinococcus multilocularis transfer RNA-Gly 0.031 0.0596 0.0589
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.031 0.0596 0.2137
Echinococcus multilocularis transient receptor potential gamma protein 0.031 0.0596 0.0589
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.02 0.0366 0.1325
Echinococcus granulosus transient receptor potential cation channel 0.031 0.0596 0.0591
Plasmodium vivax SET domain protein, putative 0.003 0.0007 1
Echinococcus granulosus voltage gated potassium channel 0.031 0.0596 0.0591
Schistosoma mansoni hypothetical protein 0.0037 0.0023 0.0058
Echinococcus granulosus transient receptor potential cation channel 0.031 0.0596 0.0591
Echinococcus granulosus hypothetical protein 0.031 0.0596 0.0591
Echinococcus granulosus voltage gated potassium channel 0.031 0.0596 0.0591
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.031 0.0596 0.0591
Toxoplasma gondii hypothetical protein 0.031 0.0596 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.031 0.0596 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.031 0.0596 0.0591
Echinococcus granulosus potassium voltage gated channel subfamily A 0.031 0.0596 0.0591
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.031 0.0596 0.2137
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Brugia malayi Muscleblind-like protein 0.0154 0.0269 0.0974
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.031 0.0596 0.2158
Echinococcus granulosus sodium leak channel non selective protein 0.031 0.0596 0.0591
Echinococcus multilocularis calcium activated potassium channel 0.031 0.0596 0.0589
Echinococcus granulosus potassium voltage gated channel subfamily D 0.031 0.0596 0.0591
Echinococcus granulosus potassium voltage gated channel subfamily H 0.031 0.0596 0.0591
Echinococcus granulosus voltage gated hydrogen channel 1 0.031 0.0596 0.0591
Entamoeba histolytica hypothetical protein 0.0037 0.0023 0.5
Echinococcus granulosus choline O acetyltransferase 0.1343 0.2761 0.2758
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.02 0.0366 0.6141
Onchocerca volvulus 0.02 0.0366 0.6053
Schistosoma mansoni hypothetical protein 0.031 0.0596 0.2137
Echinococcus multilocularis potassium large conductance calcium activated 0.031 0.0596 0.0589
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.02 0.0366 0.1325
Leishmania major hypothetical protein, unknown function 0.031 0.0596 0.0596
Trypanosoma cruzi hypothetical protein, conserved 0.02 0.0366 0.6141
Echinococcus multilocularis potassium voltage gated channel protein 0.031 0.0596 0.0589
Schistosoma mansoni 60S ribosomal protein L21 0.031 0.0596 0.2137
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Brugia malayi cation channel family protein 0.031 0.0596 0.2158
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.031 0.0596 0.2158
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.031 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.4794 1 1
Echinococcus granulosus calcium activated potassium channel 0.031 0.0596 0.0591
Loa Loa (eye worm) calcium channel 0.031 0.0596 0.2158
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.031 0.0596 0.0591
Schistosoma mansoni choline o-acyltransferase 0.1343 0.2761 1
Echinococcus multilocularis potassium voltage gated channel protein 0.031 0.0596 0.0589
Leishmania major carnitine palmitoyltransferase-like protein 0.02 0.0366 0.0366
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.031 0.0596 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Brugia malayi Choline O-acetyltransferase 0.1343 0.2761 1
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.02 0.0366 0.0359
Echinococcus multilocularis hyperpolarization activated cyclic 0.031 0.0596 0.0589
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.02 0.0366 0.6141
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.031 0.0596 0.0591
Brugia malayi voltage-dependent calcium channel 0.031 0.0596 0.2158
Echinococcus multilocularis sodium channel protein 0.4794 1 1
Loa Loa (eye worm) hypothetical protein 0.1343 0.2761 1
Trypanosoma cruzi hypothetical protein, conserved 0.02 0.0366 0.6141
Schistosoma mansoni hypothetical protein 0.0175 0.0312 0.1107
Loa Loa (eye worm) choline O-acetyltransferase 0.1343 0.2761 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.031 0.0596 0.0591
Toxoplasma gondii transporter, cation channel family protein 0.031 0.0596 1
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0269 0.0262
Echinococcus granulosus geminin 0.0175 0.0312 0.0307
Echinococcus multilocularis muscleblind protein 0.0154 0.0269 0.0262
Entamoeba histolytica hypothetical protein 0.0037 0.0023 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.031 0.0596 0.0589
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.031 0.0596 0.2158
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Schistosoma mansoni voltage-dependent calcium channel 0.031 0.0596 0.2137
Brugia malayi Pre-SET motif family protein 0.003 0.0007 0.0027
Onchocerca volvulus 0.02 0.0366 0.6053
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.02 0.0366 0.6141
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.031 0.0596 0.2137
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.02 0.0366 0.1325
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.02 0.0366 0.1325
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.031 0.0596 0.2158
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.02 0.0366 0.0366
Schistosoma mansoni transient receptor potential channel 0.031 0.0596 0.2137
Echinococcus multilocularis two pore calcium channel protein 2 0.031 0.0596 0.0589
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.02 0.0366 0.0361
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.031 0.0596 0.0589
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.031 0.0596 0.9935
Echinococcus granulosus TRP transient receptor potential channel 0.031 0.0596 0.0591
Echinococcus multilocularis short transient receptor potential channel 6 0.031 0.0596 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.031 0.0596 0.2137
Brugia malayi olfactory channel protein osm-9 0.031 0.0596 0.2158
Loa Loa (eye worm) ryanodine receptor 0.031 0.0596 0.2158
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.031 0.0596 0.2158
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.02 0.0366 0.0359
Echinococcus multilocularis hyperpolarization activated cyclic 0.031 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.0312 0.06 0.2172
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Loa Loa (eye worm) hypothetical protein 0.02 0.0366 0.1325
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.031 0.0596 0.2137
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.031 0.0596 0.2158
Onchocerca volvulus 0.0312 0.06 1
Echinococcus multilocularis voltage gated potassium channel 0.031 0.0596 0.0589
Brugia malayi cation channel family protein 0.031 0.0596 0.2158
Echinococcus granulosus potassium voltage gated channel protein 0.031 0.0596 0.0591
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Brugia malayi MH2 domain containing protein 0.0123 0.0204 0.0738
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.031 0.0596 0.2137
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.031 0.0596 0.2158
Brugia malayi hypothetical protein 0.0312 0.06 0.2172
Echinococcus granulosus transient receptor potential gamma protein 0.031 0.0596 0.0591
Schistosoma mansoni choline o-acyltransferase 0.02 0.0366 0.1302
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Loa Loa (eye worm) voltage-dependent calcium channel 0.031 0.0596 0.2158
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Echinococcus multilocularis transient receptor potential cation channel 0.031 0.0596 0.0589
Echinococcus granulosus potassium voltage gated channel subfamily D 0.031 0.0596 0.0591
Echinococcus multilocularis two pore calcium channel protein 1 0.031 0.0596 0.0589
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.02 0.0366 0.6141
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.031 0.0596 0.0591
Brugia malayi Cyclic-nucleotide gated cation channel 0.031 0.0596 0.2158
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.031 0.0596 0.2158
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0007 0.0002
Echinococcus granulosus potassium large conductance calcium activated 0.031 0.0596 0.0591
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.031 0.0596 0.2158
Schistosoma mansoni voltage-gated ion channel 0.031 0.0596 0.2137
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.031 0.0596 0.2137
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.02 0.0366 0.6141
Echinococcus multilocularis sodium leak channel non selective protein 0.031 0.0596 0.0589
Brugia malayi Transient-receptor-potential like protein 0.031 0.0596 0.2158
Schistosoma mansoni hypothetical protein 0.0175 0.0312 0.1107
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.031 0.0596 1
Echinococcus granulosus hyperpolarization activated cyclic 0.031 0.0596 0.0591
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Loa Loa (eye worm) voltage-gated potassium channel 0.031 0.0596 0.2158
Brugia malayi hypothetical protein 0.031 0.0596 0.2158
Echinococcus granulosus hyperpolarization activated cyclic 0.031 0.0596 0.0591
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Echinococcus granulosus transient receptor potential cation channel 0.031 0.0596 0.0591
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.031 0.0596 0.2158
Trypanosoma brucei hypothetical protein, conserved 0.02 0.0366 0.6141
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.031 0.0596 0.9935
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.031 0.0596 0.0589
Schistosoma mansoni transient receptor potential channel 0.031 0.0596 0.2137
Schistosoma mansoni voltage-gated cation channel 0.031 0.0596 0.2137
Echinococcus granulosus potassium voltage gated channel protein 0.031 0.0596 0.0591
Schistosoma mansoni transient receptor potential channel 0.031 0.0596 0.2137
Echinococcus granulosus cyclic nucleotide gated cation channel 0.031 0.0596 0.0591
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.02 0.0366 0.6141
Echinococcus multilocularis transient receptor potential cation channel 0.031 0.0596 0.0589
Echinococcus granulosus muscleblind protein 0.0154 0.0269 0.0264
Echinococcus multilocularis TRP (transient receptor potential) channel 0.031 0.0596 0.0589
Toxoplasma gondii transporter, cation channel family protein 0.031 0.0596 1
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.031 0.0596 0.2158
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Echinococcus multilocularis short transient receptor potential channel 6 0.031 0.0596 0.0589
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.02 0.0366 0.6141
Leishmania major calcium channel protein, putative,ion transporter, putative 0.4794 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.031 0.0596 0.2137
Echinococcus multilocularis geminin 0.0175 0.0312 0.0305
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Echinococcus granulosus short transient receptor potential channel 6 0.031 0.0596 0.0591
Onchocerca volvulus 0.02 0.0366 0.6053
Entamoeba histolytica hypothetical protein 0.0037 0.0023 0.5
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.031 0.0596 0.0591
Echinococcus granulosus two pore calcium channel protein 1 0.031 0.0596 0.0591
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Echinococcus granulosus two pore calcium channel protein 2 0.031 0.0596 0.0591
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.031 0.0596 0.2137
Echinococcus multilocularis voltage dependent calcium channel 0.031 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Schistosoma mansoni vesicular amine transporter 0.031 0.0596 0.2137
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0023 0.0058
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.031 0.0596 0.2158
Entamoeba histolytica hypothetical protein 0.0037 0.0023 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0023 0.0018
Echinococcus multilocularis transient receptor potential cation channel 0.031 0.0596 0.0589
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.02 0.0366 0.6141
Echinococcus multilocularis transient receptor potential cation channel 0.031 0.0596 0.0589
Echinococcus granulosus potassium voltage gated channel protein 0.031 0.0596 0.0591
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.02 0.0366 0.6141
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.031 0.0596 0.2137
Echinococcus multilocularis voltage gated potassium channel 0.031 0.0596 0.0589
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.031 0.0596 0.0589
Echinococcus granulosus potassium voltage gated channel protein 0.031 0.0596 0.0591
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0377 0.1367
Echinococcus granulosus potassium voltage gated channel subfamily D 0.031 0.0596 0.0591
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.031 0.0596 0.2137
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.031 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Brugia malayi Pre-SET motif family protein 0.0206 0.0377 0.1367
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.031 0.0596 0.2158
Echinococcus multilocularis voltage gated hydrogen channel 1 0.031 0.0596 0.0589
Echinococcus granulosus transient receptor potential cation channel 0.031 0.0596 0.0591
Echinococcus multilocularis transient receptor potential cation channel 0.031 0.0596 0.0589
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.031 0.0596 1
Onchocerca volvulus 0.031 0.0596 0.9935
Trypanosoma cruzi hypothetical protein, conserved 0.02 0.0366 0.6141
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Echinococcus granulosus potassium voltage gated channel protein 0.031 0.0596 0.0591
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.031 0.0596 0.0589
Loa Loa (eye worm) ion channel NompC 0.031 0.0596 0.2158
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0204 0.0738
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0204 0.0738
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.031 0.0596 0.2137
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.031 0.0596 0.2158
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0007 0.0124
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Schistosoma mansoni ryanodine receptor related 0.031 0.0596 0.2137
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.031 0.0596 0.2137
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.031 0.0596 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.031 0.0596 0.2158
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.031 0.0596 0.2158
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.031 0.0596 0.0591
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.031 0.0596 0.2137
Loa Loa (eye worm) hypothetical protein 0.031 0.0596 0.2158
Schistosoma mansoni voltage-gated potassium channel 0.031 0.0596 0.2137
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.031 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.0154 0.0269 0.0974
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.031 0.0596 0.0591
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.031 0.0596 0.2137
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.02 0.0366 0.6141
Echinococcus multilocularis choline O acetyltransferase 0.1343 0.2761 0.2756
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.031 0.0596 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.031 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0269 0.0974
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.031 0.0596 0.0589
Echinococcus granulosus transient receptor potential cation channel 0.031 0.0596 0.0591

Activities

Activity type Activity value Assay description Source Reference
T/C (functional) = 94 % Compound was evaluated for antitumour activity against L1210 leukemia in mice by NCI screener test at a dose of 50 mg/kg ChEMBL. 7277400
T/C (functional) = 105 % Compound was evaluated for antitumour activity against L1210 leukemia in mice by NCI screener test at a dose of 100 mg/kg ChEMBL. 7277400
T/C (functional) = 124 % Compound was evaluated for antitumour activity against L1210 leukemia in mice by NCI screener test at a dose of 200 mg/kg ChEMBL. 7277400

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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