TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 507.17 | Formula: C14H5F16NO
H donors: 1 H acceptors: 1 LogP: 6.34 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: Fc1ccc(cc1)NC(=O)C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
InChi: 1S/C14H5F16NO/c15-5-1-3-6(4-2-5)31-7(32)8(16,17)9(18,19)10(20,21)11(22,23)12(24,25)13(26,27)14(28,29)30/h1-4H,(H,31,32)
InChiKey: MZTFEWGCRRDJJG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	myotubularin protein 13	0.006	0.0771	0.0336
Trypanosoma cruzi	cyclin 6, putative	0.0365	0.6152	1
Echinococcus multilocularis	serine threonine protein kinase	0.0523	0.894	0.889
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0112	0.1684	0.2164
Trichomonas vaginalis	cyclins, putative	0.0174	0.2772	0.4072
Schistosoma mansoni	cyclins	0.0174	0.2772	0.2431
Loa Loa (eye worm)	hypothetical protein	0.0192	0.3091	0.4022
Echinococcus multilocularis	unc 13 (munc13)	0.0073	0.0991	0.0567
Echinococcus multilocularis	cyclin b3	0.0174	0.2772	0.2431
Onchocerca volvulus		0.0365	0.6152	1
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Entamoeba histolytica	cyclin, domain containing protein	0.0042	0.0449	0.065
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0318	0.5314	0.6914
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0449	0.056
Entamoeba histolytica	cyclin C, putative	0.0042	0.0449	0.065
Echinococcus granulosus	unc 13 munc13	0.0073	0.0991	0.0567
Entamoeba histolytica	diacylglycerol kinase, putative	0.006	0.0771	0.1177
Schistosoma mansoni	unc-13 (munc13)	0.0073	0.0991	0.0567
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0718	0.0281
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0892	0.0464
Echinococcus granulosus	Diacylglycerol kinase theta	0.006	0.0771	0.0336
Loa Loa (eye worm)	cyclin domain-containing protein	0.0042	0.0449	0.0585
Echinococcus granulosus	cyclin dependent kinase 1	0.0095	0.1382	0.0977
Schistosoma mansoni	serine/threonine protein kinase	0.0119	0.1805	0.142
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0095	0.1382	0.1799
Brugia malayi	Protein kinase domain containing protein	0.0119	0.1805	0.2249
Trypanosoma brucei	cdc2-related kinase 3	0.0095	0.1382	0.1636
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0073	0.0991	0.0567
Trypanosoma brucei	cdc2-related kinase 1	0.0095	0.1382	0.1636
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0057	0.0718	0.0934
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0095	0.1382	0.1918
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0119	0.1805	0.2349
Schistosoma mansoni	cyclin B3	0.0403	0.6811	0.6661
Echinococcus granulosus	protein kinase c iota type	0.0179	0.2865	0.253
Entamoeba histolytica	protein kinase, putative	0.0119	0.1805	0.2874
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0119	0.1805	0.2349
Echinococcus multilocularis	myotubularin protein 13	0.006	0.0771	0.0336
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0403	0.6811	0.6661
Echinococcus granulosus	cyclin b3	0.0174	0.2772	0.2431
Schistosoma mansoni	protein kinase C mu	0.006	0.0771	0.0336
Trichomonas vaginalis	cyclins, putative	0.0365	0.6152	1
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0057	0.0718	0.0281
Echinococcus multilocularis	cyclin B	0.0365	0.6152	0.5971
Toxoplasma gondii	hypothetical protein	0.0132	0.2033	0.3255
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0318	0.5314	0.6914
Entamoeba histolytica	cyclin, putative	0.0365	0.6152	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0042	0.0449	0.0585
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0119	0.1805	0.2349
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Echinococcus granulosus	N chimaerin	0.0064	0.084	0.0409
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0119	0.1805	0.2378
Echinococcus multilocularis	cyclins	0.0174	0.2772	0.2431
Brugia malayi	C1-like domain containing protein	0.0067	0.0892	0.1112
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0291	0.4842	0.46
Echinococcus multilocularis	RNA directed DNA polymerase	0.0392	0.6625	0.6467
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0064	0.084	0.0409
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Brugia malayi	hypothetical protein	0.0042	0.0449	0.056
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0991	0.1289
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Echinococcus granulosus	cyclin B	0.0365	0.6152	0.5971
Brugia malayi	protein kinase C3,putative	0.0067	0.0892	0.1112
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0119	0.1805	0.142
Schistosoma mansoni	serine/threonine protein kinase	0.0584	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Echinococcus granulosus	protein kinase C gamma type	0.0523	0.894	0.889
Trypanosoma cruzi	cyclin, putative	0.0365	0.6152	1
Plasmodium falciparum	cyclin	0.0174	0.2772	0.4774
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0318	0.5314	0.5093
Trichomonas vaginalis	cyclins, putative	0.0365	0.6152	1
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0057	0.0718	0.0281
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0095	0.1382	0.1636
Echinococcus multilocularis	cyclins	0.0174	0.2772	0.2431
Trichomonas vaginalis	cyclin B, putative	0.0365	0.6152	1
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0718	0.0894
Echinococcus granulosus	cyclins	0.0174	0.2772	0.2431
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0318	0.5314	0.5093
Giardia lamblia	Kinase, CMGC CDK	0.0095	0.1382	0.1636
Giardia lamblia	Kinase, CMGC CDK	0.0095	0.1382	0.1636
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0318	0.5314	0.5093
Echinococcus granulosus	cyclins	0.0174	0.2772	0.2431
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Brugia malayi	Hr1 repeat family protein	0.0119	0.1805	0.2249
Echinococcus multilocularis	cyclins	0.0174	0.2772	0.2431
Brugia malayi	Cyclin C	0.0042	0.0449	0.056
Echinococcus granulosus	cyclin B3 1	0.0174	0.2772	0.2431
Entamoeba histolytica	diacylglycerol kinase, putative	0.006	0.0771	0.1177
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0095	0.1382	0.1799
Trypanosoma cruzi	cdc2-related kinase 3	0.0095	0.1382	0.1636
Entamoeba histolytica	protein kinase, putative	0.0057	0.0718	0.109
Leishmania major	cyclin	0.0365	0.6152	1
Trichomonas vaginalis	CMGC family protein kinase	0.0095	0.1382	0.1636
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0067	0.0892	0.1161
Trichomonas vaginalis	cyclin A, putative	0.0365	0.6152	1
Entamoeba histolytica	protein kinase, putative	0.0119	0.1805	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0365	0.6152	0.8005
Schistosoma mansoni	diacylglycerol kinase theta	0.006	0.0771	0.0336
Loa Loa (eye worm)	cyclin domain-containing protein	0.0042	0.0449	0.0585
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0892	0.0464
Brugia malayi	p70 ribosomal S6 kinase beta	0.0119	0.1805	0.2249
Echinococcus multilocularis	cyclin dependent kinase 1	0.0095	0.1382	0.0977
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.2772	0.4072
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0064	0.084	0.1093
Echinococcus granulosus	NDR protein kinase	0.0119	0.1805	0.142
Schistosoma mansoni	unc-13 (munc13)	0.0073	0.0991	0.0567
Trichomonas vaginalis	cyclins, putative	0.0365	0.6152	1
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0318	0.5314	1
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.006	0.0771	0.1003
Trichomonas vaginalis	CMGC family protein kinase	0.0095	0.1382	0.1636
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0073	0.0991	0.0567
Schistosoma mansoni	protein kinase C	0.0073	0.0991	0.0567
Schistosoma mansoni	hypothetical protein	0.006	0.0771	0.0336
Echinococcus granulosus	cyclins	0.0174	0.2772	0.2431
Trichomonas vaginalis	cyclin B, putative	0.0365	0.6152	1
Trichomonas vaginalis	cyclins, putative	0.0234	0.383	0.5928
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0449	0.056
Plasmodium falciparum	protein kinase 5	0.0095	0.1382	0.1918
Onchocerca volvulus		0.006	0.0771	0.0563
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0318	0.5314	0.853
Brugia malayi	RhoGEF domain containing protein	0.006	0.0771	0.096
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0119	0.1805	0.142
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0449	0.0585
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Echinococcus multilocularis	protein kinase shaggy	0.0318	0.5314	0.5093
Schistosoma mansoni	cyclin B	0.0365	0.6152	0.5971
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0318	0.5314	0.853
Schistosoma mansoni	serine/threonine protein kinase	0.0119	0.1805	0.142
Toxoplasma gondii	AGC kinase	0.0119	0.1805	0.2788
Brugia malayi	cell division control protein 2 homolog	0.0095	0.1382	0.1722
Loa Loa (eye worm)	hypothetical protein	0.0452	0.7685	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0412	0.6967	0.9066
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0119	0.1805	0.2349
Entamoeba histolytica	cyclin, putative	0.0174	0.2772	0.4458
Brugia malayi	cyclin fold protein 1 variant b	0.0042	0.0449	0.056
Trichomonas vaginalis	CMGC family protein kinase	0.0095	0.1382	0.1636
Giardia lamblia	Kinase, CMGC GSK	0.0318	0.5314	0.853
Echinococcus multilocularis	protein kinase c eta type	0.006	0.0771	0.0336
Loa Loa (eye worm)	cyclin domain-containing protein	0.0403	0.6811	0.8862
Trypanosoma cruzi	cdc2-related kinase 3	0.0095	0.1382	0.1636
Brugia malayi	diacylglycerol kinase	0.006	0.0771	0.096
Schistosoma mansoni	diacylglycerol kinase theta	0.006	0.0771	0.0336
Echinococcus granulosus	cyclin dependent kinase 5	0.0095	0.1382	0.0977
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0095	0.1382	0.1636
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0119	0.1805	0.142
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Echinococcus multilocularis	Diacylglycerol kinase theta	0.006	0.0771	0.0336
Entamoeba histolytica	protein kinase domain containing protein	0.0318	0.5314	0.8626
Echinococcus granulosus	RNA directed DNA polymerase	0.0392	0.6625	0.6467
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0067	0.0892	0.1112
Toxoplasma gondii	diacylglycerol kinase, putative	0.006	0.0771	0.0661
Trypanosoma cruzi	cdc2-related kinase 1	0.0095	0.1382	0.1636
Echinococcus multilocularis	protein kinase c iota type	0.0179	0.2865	0.253
Entamoeba histolytica	hypothetical protein	0.006	0.0771	0.1177
Echinococcus multilocularis	protein kinase c epsilon type	0.0191	0.3085	0.276
Echinococcus multilocularis	cyclin dependent kinase 1	0.0095	0.1382	0.0977
Echinococcus granulosus	protein kinase shaggy	0.0318	0.5314	0.5093
Brugia malayi	Protein kinase domain containing protein	0.0119	0.1805	0.2249
Trichomonas vaginalis	cyclin B, putative	0.0365	0.6152	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0064	0.084	0.0409
Entamoeba histolytica	cyclin family protein	0.0174	0.2772	0.4458
Trichomonas vaginalis	CMGC family protein kinase	0.0318	0.5314	0.853
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0449	0.056
Brugia malayi	Protein kinase c protein 2	0.0472	0.8027	1
Echinococcus multilocularis	cyclins	0.0174	0.2772	0.2431
Giardia lamblia	Kinase, AGC AKT	0.0179	0.2869	0.4244
Brugia malayi	Protein kinase domain containing protein	0.0095	0.1382	0.1722
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.006	0.0771	0.1003
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0318	0.5314	1
Plasmodium vivax	protein kinase Crk2	0.0095	0.1382	0.1918
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0403	0.6811	0.8485
Echinococcus granulosus	cyclins	0.0174	0.2772	0.2431
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0365	0.6152	0.7664
Schistosoma mansoni	atypical protein kinase C	0.0179	0.2865	0.253
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0064	0.084	0.0409
Loa Loa (eye worm)	cyclin C	0.0042	0.0449	0.0585
Echinococcus multilocularis	Rac GTPase activating protein 1	0.006	0.0771	0.0336
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0291	0.4842	0.6301
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.1382	0.0977
Echinococcus multilocularis	cyclins	0.0174	0.2772	0.2431
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0449	0.056
Onchocerca volvulus		0.006	0.0771	0.0563
Echinococcus multilocularis	cyclin B3 1	0.0174	0.2772	0.2431
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0449	0.056
Echinococcus granulosus	serine:threonine protein kinase N2	0.0119	0.1805	0.142
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0064	0.084	0.0409
Brugia malayi	protein kinase C II.	0.0191	0.3085	0.3844
Loa Loa (eye worm)	cyclin domain-containing protein	0.0042	0.0449	0.0585
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Loa Loa (eye worm)	cyclin domain-containing protein	0.0042	0.0449	0.0585
Loa Loa (eye worm)	hypothetical protein	0.006	0.0771	0.1003
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0095	0.1382	0.1799
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0392	0.6625	0.6467
Schistosoma mansoni	serine/threonine protein kinase	0.0119	0.1805	0.142
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0119	0.1805	0.142
Trichomonas vaginalis	CMGC family protein kinase	0.0318	0.5314	0.853
Echinococcus multilocularis	N chimaerin	0.0064	0.084	0.0409
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0365	0.6152	0.7664
Loa Loa (eye worm)	cyclin domain-containing protein	0.0042	0.0449	0.0585
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0365	0.6152	1
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0403	0.6811	0.6661
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0057	0.0718	0.0934
Entamoeba histolytica	cyclin family protein	0.0174	0.2772	0.4458
Plasmodium falciparum	glycogen synthase kinase 3	0.0318	0.5314	1
Echinococcus granulosus	cyclin dependent kinase	0.0095	0.1382	0.0977
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0718	0.047
Trichomonas vaginalis	cyclin B3, putative	0.0174	0.2772	0.4072
Brugia malayi	Ras association domain family 1 isoform A	0.006	0.0771	0.096
Entamoeba histolytica	protein kinase, putative	0.0318	0.5314	0.8626
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0067	0.0892	0.0464
Echinococcus multilocularis	cyclins	0.0174	0.2772	0.2431
Loa Loa (eye worm)	raf kinase	0.006	0.0771	0.1003
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.1382	0.0977
Entamoeba histolytica	cell division protein kinase 2, putative	0.0095	0.1382	0.218
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.079	0.0357
Schistosoma mansoni	serine/threonine protein kinase	0.0584	1	1
Echinococcus granulosus	cyclins	0.0174	0.2772	0.2431
Schistosoma mansoni	serine/threonine protein kinase	0.0191	0.3085	0.276
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0584	1	1
Loa Loa (eye worm)	CYL-1 protein	0.0042	0.0449	0.0585
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0119	0.1805	0.2349
Loa Loa (eye worm)	RasGEF domain-containing protein	0.006	0.0771	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1805	0.2349
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0119	0.1805	0.2349
Brugia malayi	hypothetical protein	0.0042	0.0449	0.056
Echinococcus granulosus	protein kinase c eta type	0.006	0.0771	0.0336
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0449	0.056
Echinococcus multilocularis	cyclin dependent kinase 5	0.0095	0.1382	0.0977
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0119	0.1805	0.142
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0119	0.1805	0.142
Schistosoma mansoni	serine/threonine kinase	0.0119	0.1805	0.142
Onchocerca volvulus		0.0073	0.0991	0.0949
Giardia lamblia	G2/mitotic-specific cyclin B	0.0365	0.6152	1
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0179	0.2869	0.4244
Giardia lamblia	Kinase, CMGC GSK	0.0318	0.5314	0.853
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0061	0.079	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0365	0.6152	0.8005
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0067	0.0892	0.0464
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0718	0.047
Brugia malayi	RhoGAP domain containing protein	0.0064	0.084	0.1046
Trichomonas vaginalis	cyclins, putative	0.0365	0.6152	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0095	0.1382	0.218
Entamoeba histolytica	hypothetical protein	0.0042	0.0449	0.065
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0449	0.0585
Schistosoma mansoni	serine/threonine protein kinase	0.0291	0.4842	0.46
Schistosoma mansoni	rac gtpase activating protein	0.006	0.0771	0.0336
Giardia lamblia	Cyclin A	0.0174	0.2772	0.4072
Echinococcus granulosus	Rac GTPase activating protein 1	0.006	0.0771	0.0336
Brugia malayi	diacylglycerol kinase	0.006	0.0771	0.096
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.0179	0.2869	0.3575
Entamoeba histolytica	protein kinase, putative	0.0119	0.1805	0.2874
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0042	0.0449	0.0585
Entamoeba histolytica	protein kinase, putative	0.0119	0.1805	0.2874
Schistosoma mansoni	vav2	0.0064	0.084	0.0409
Schistosoma mansoni	protein kinase C mu	0.0067	0.0892	0.0464
Trypanosoma brucei	protein kinase, putative	0.0318	0.5314	0.853
Entamoeba histolytica	cyclin, domain containing protein	0.0042	0.0449	0.065
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0191	0.3085	0.4015
Trichomonas vaginalis	cyclin D, putative	0.0174	0.2772	0.4072
Trichomonas vaginalis	cyclin B, putative	0.0174	0.2772	0.4072
Brugia malayi	intracellular kinase	0.0318	0.5314	0.662
Echinococcus granulosus	protein kinase c epsilon type	0.0191	0.3085	0.276
Trypanosoma cruzi	cyclin, putative	0.0365	0.6152	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1261	0.164
Brugia malayi	Pleckstrin Homology Domain	0.006	0.0771	0.096
Trypanosoma brucei	mitotic cyclin 6	0.0365	0.6152	1
Entamoeba histolytica	protein kinase domain containing protein	0.0318	0.5314	0.8626
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0067	0.0892	0.1161
Trichomonas vaginalis	cyclin D, putative	0.0174	0.2772	0.4072
Echinococcus granulosus	raf serine:threonine protein kinase	0.0061	0.079	0.0357
Brugia malayi	RhoGAP domain containing protein	0.006	0.0771	0.096
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0718	0.047
Giardia lamblia	Hypothetical protein	0.0174	0.2772	0.4072
Echinococcus multilocularis	cyclin dependent kinase	0.0095	0.1382	0.0977
Trypanosoma cruzi	cdc2-related kinase 1	0.0095	0.1382	0.1636
Onchocerca volvulus		0.0318	0.5314	0.853
Loa Loa (eye worm)	hypothetical protein	0.0392	0.6625	0.8621
Trichomonas vaginalis	cyclin B, putative	0.0365	0.6152	1
Echinococcus multilocularis	cyclins	0.0174	0.2772	0.2431
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0291	0.4842	0.46
Brugia malayi	Protein kinase domain containing protein	0.0067	0.0892	0.1112
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0057	0.0718	0.0894
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0365	0.6152	1
Trichomonas vaginalis	AGC family protein kinase	0.0119	0.1805	0.2378
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0095	0.1382	0.0977
Brugia malayi	Variant SH3 domain containing protein	0.0064	0.084	0.1046
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0119	0.1805	0.142
Brugia malayi	Protein kinase domain containing protein	0.0119	0.1805	0.2249
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0449	0.056

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 91 %	Percent plasma glucose concentration of drug treated mice (ob/ob) relative to vehicle control animals	ChEMBL.	1548684
Activity (functional)	= 91 %	Percent plasma glucose concentration of drug treated mice (ob/ob) relative to vehicle control animals	ChEMBL.	1548684

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 306678