TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 519.486 | Formula: C27H26N3O6P
H donors: 3 H acceptors: 6 LogP: 2.79 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1ccccc1c1ccc(cc1)CN1CCCC[C@@H](C1=O)NC(=O)c1ccc(cc1)OP(=O)(O)O
InChi: 1S/C27H26N3O6P/c28-17-22-5-1-2-6-24(22)20-10-8-19(9-11-20)18-30-16-4-3-7-25(27(30)32)29-26(31)21-12-14-23(15-13-21)36-37(33,34)35/h1-2,5-6,8-15,25H,3-4,7,16,18H2,(H,29,31)(H2,33,34,35)/t25-/m0/s1
InChiKey: LNOGZHMFVYZERW-VWLOTQADSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1683	0.1683
Schistosoma mansoni	ferritin light chain	0.001	0.0007	0.0023
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0139	0.0226
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.0567	0.0922
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0646	0.1052
Echinococcus granulosus	ecdysone induced protein 78C	0.0036	0.0484	0.0788
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0175	0.0175
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0484	0.0788
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.032	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0246	0.4248	0.6915
Brugia malayi	nuclear hormone receptor family member odr-7	0.0017	0.0139	0.0139
Brugia malayi	Steroid receptor seven-up type 2	0.0036	0.0484	0.0484
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0046	0.0656	0.1068
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0646	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.0646	0.1052
Echinococcus granulosus	tar DNA binding protein	0.0138	0.2303	0.375
Schistosoma mansoni	coup transcription factor	0.0036	0.0484	0.1577
Brugia malayi	cDNA sequence BC016226	0.0015	0.01	0.01
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0139	0.0226
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0138	0.2303	0.2303
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0646	0.1052
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0175	0.0175
Brugia malayi	protein-tyrosine kinase	0.0041	0.0567	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.005	0.0081
Schistosoma mansoni	survival motor neuron protein	0.005	0.0731	0.2384
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0036	0.0484	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0036	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0015	0.01	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0036	0.0484	0.0788
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0785	0.2559
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0014	0.0023
Schistosoma mansoni	nuclear receptor	0.0017	0.0139	0.0452
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0104	0.1693	0.1693
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Leishmania major	hypothetical protein, conserved	0.0027	0.032	0.1381
Schistosoma mansoni	ferritin	0.001	0.0007	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0484	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0484	0.0484
Brugia malayi	hypothetical protein	0.0017	0.0139	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0036	0.0484	0.0484
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.0485	0.079
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.005	0.0081
Schistosoma mansoni	NAD dehydrogenase	0.0015	0.01	0.0326
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0785	0.0785
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0646	0.1052
Brugia malayi	hypothetical protein	0.0018	0.0146	0.0146
Schistosoma mansoni	ferritin light chain	0.001	0.0007	0.0023
Loa Loa (eye worm)	glutamate receptor	0.0018	0.015	0.015
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0017	0.0139	0.0452
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0259	0.4477	0.4477
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.2303	0.751
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.001	0.0007	0.5
Brugia malayi	MH2 domain containing protein	0.0139	0.2322	0.2322
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.1309	0.2131
Brugia malayi	hypothetical protein	0.0019	0.0175	0.0175
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0045	0.0643	0.0643
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0015	0.01	0.0304
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0036	0.0484	0.0788
Schistosoma mansoni	jun-related protein	0.0067	0.1032	0.3364
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0646	0.1052
Brugia malayi	hypothetical protein	0.0246	0.4248	0.4248
Schistosoma mansoni	tyrosine kinase	0.001	0.0014	0.0047
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0139	0.0432
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0785	0.1278
Echinococcus granulosus	survival motor neuron protein 1	0.0246	0.4248	0.6915
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0139	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Loa Loa (eye worm)	SRC-1	0.0045	0.0646	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0015	0.01	0.01
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.0567	0.0922
Schistosoma mansoni	tyrosine kinase	0.0045	0.0646	0.2107
Schistosoma mansoni	apoferritin-2	0.001	0.0007	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0056	0.083	0.083
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0038	0.0511	0.0832
Trichomonas vaginalis	ferritin, putative	0.001	0.0007	0.5
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0038	0.0511	0.0832
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0484	0.1577
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0139	0.0226
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0041	0.0566	0.0566
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0015	0.01	0.0163
Echinococcus granulosus	expressed protein	0.001	0.0007	0.0012
Loa Loa (eye worm)	nuclear hormone receptor	0.0017	0.0139	0.0139
Onchocerca volvulus		0.0051	0.0754	0.7339
Brugia malayi	hypothetical protein	0.0017	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.0012	0.005	0.0163
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.0646	0.1052
Brugia malayi	orphan nuclear receptor NR2E1	0.0017	0.0139	0.0139
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.2322	0.2322
Schistosoma mansoni	tyrosine kinase	0.001	0.0014	0.0047
Schistosoma mansoni	hypothetical protein	0.005	0.0731	0.2384
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0014	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.0646	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0754	0.0754
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0036	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.0039
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0175	0.0175
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0036	0.0484	0.1577
Entamoeba histolytica	protein kinase, putative	0.0104	0.1693	1
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.1693	0.5519
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.018	0.3067	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.0484	0.0484
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0014	0.0023
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0015	0.01	0.0163
Brugia malayi	nuclear receptor NHR-67	0.0017	0.0139	0.0139
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0785	0.2559
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0036	0.0484	0.0484
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0017	0.0139	0.0139
Schistosoma mansoni	ferritin	0.001	0.0007	0.0023
Schistosoma mansoni	fad oxidoreductase	0.0015	0.01	0.0326
Mycobacterium leprae	Possible thiamine biosynthesis oxidoreductase ThiO	0.0015	0.01	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0484	0.0484
Schistosoma mansoni	tyrosine kinase	0.0045	0.0646	0.2107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus multilocularis	tar DNA binding protein	0.0138	0.2303	0.375
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0175	0.0572
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0036	0.0484	0.0484
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0017	0.0139	0.0139
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0014	0.0023
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0036	0.0484	0.1577
Schistosoma mansoni	metabotropic glutamate receptor	0.0022	0.0226	0.0738
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0014	0.0023
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0036	0.0484	0.1577
Entamoeba histolytica	protein kinase domain containing protein	0.0104	0.1693	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Echinococcus multilocularis	ecdysone induced protein 78C	0.0036	0.0484	0.0788
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.0646	0.1052
Brugia malayi	nuclear receptor RXR	0.0019	0.0175	0.0175
Schistosoma mansoni	hypothetical protein	0.0067	0.1032	0.3364
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.0646	0.1052
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0139	0.0139
Onchocerca volvulus	Protein ultraspiracle homolog	0.0036	0.0484	0.4305
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0036	0.0484	0.0788
Echinococcus multilocularis	dual specificity	0.0104	0.1693	0.2756
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0015	0.01	0.0326
Onchocerca volvulus		0.0036	0.0484	0.4305
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.0646	0.1052
Schistosoma mansoni	nuclear receptor nhr-48	0.0017	0.0139	0.0452
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0785	0.2559
Loa Loa (eye worm)	hypothetical protein	0.008	0.1268	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0175	0.0175
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.1309	0.2131
Brugia malayi	ecdysteroid receptor	0.0036	0.0484	0.0484
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0139	0.0226
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0014	0.0047
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0015	0.01	0.0326
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0036	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0175	0.0175
Brugia malayi	nuclear hormone receptor	0.0036	0.0484	0.0484
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.2322	0.2322
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0139	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus multilocularis	jun protein	0.0082	0.1309	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0175	0.0175
Schistosoma mansoni	ferritin	0.001	0.0007	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0175	0.0175
Loa Loa (eye worm)	TAR-binding protein	0.0138	0.2303	0.2303
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.032	1
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0015	0.01	0.0304
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0017	0.0139	0.0139
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0036	0.0484	0.1577
Brugia malayi	conserved hypotetical protein	0.0017	0.0139	0.0139
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0015	0.01	0.01
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0139	0.0226
Echinococcus granulosus	dual specificity	0.0104	0.1693	0.2756
Loa Loa (eye worm)	hypothetical protein	0.0567	1	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0051	0.0754	0.2459
Onchocerca volvulus		0.005	0.0731	0.7083
Brugia malayi	nuclear receptor NHR-88	0.0036	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus granulosus	nuclear receptor nhr 48	0.0017	0.0139	0.0226
Onchocerca volvulus		0.0017	0.0139	0.0432
Schistosoma mansoni	RAR-like nuclear receptor	0.0036	0.0484	0.1577
Brugia malayi	hypothetical protein	0.0019	0.0175	0.0175
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0484	0.0788
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.032	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.032	0.1381
Brugia malayi	nuclear hormone receptor	0.0017	0.0139	0.0139
Brugia malayi	metabotropic glutamate receptor type 2	0.0022	0.0226	0.0226
Echinococcus granulosus	thyroid hormone receptor alpha	0.0017	0.0139	0.0226
Brugia malayi	ecdysone receptor	0.0017	0.0139	0.0139
Brugia malayi	Protein kinase domain containing protein	0.0104	0.1693	0.1693
Loa Loa (eye worm)	steroid hormone receptor	0.0036	0.0484	0.0484
Brugia malayi	Receptor family ligand binding region containing protein	0.0012	0.0039	0.0039
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0056	0.083	0.1352
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0036	0.0484	0.0484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0036	0.0484	0.0484
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0785	0.1278
Echinococcus multilocularis	nuclear receptor nhr 48	0.0017	0.0139	0.0226
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0015	0.01	0.0163
Mycobacterium leprae	Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)	0.0015	0.01	0.0304
Schistosoma mansoni	retinoic acid receptor RXR	0.0036	0.0484	0.1577
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0017	0.0139	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0015	0.01	0.01
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0015	0.01	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0036	0.0484	0.0484
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0484	0.0484
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0017	0.0139	0.0139
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.2303	0.751
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0014	0.0014
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0015	0.01	0.0163
Loa Loa (eye worm)	hypothetical protein	0.018	0.3067	0.3067
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0036	0.0484	0.0788
Brugia malayi	nuclear receptor RXR	0.0017	0.0139	0.0139
Brugia malayi	TAR-binding protein	0.0138	0.2303	0.2303
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.0484	0.1577
Echinococcus multilocularis	tumor protein p63	0.0352	0.6142	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.01	0.01
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0484	0.0788
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0036	0.0484	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0036	0.0484	0.0788
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0017	0.0139	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0036	0.0484	0.0484
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.0484	0.1577
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0785	0.1278
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0036	0.0484	0.0788
Entamoeba histolytica	protein kinase, putative	0.0104	0.1693	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0175	0.0286
Schistosoma mansoni	fad oxidoreductase	0.0015	0.01	0.0326
Brugia malayi	tailless protein	0.0017	0.0139	0.0139
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0017	0.0139	0.0226
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0015	0.01	0.01
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.018	0.3067	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.0484	0.1577
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0036	0.0484	0.1577
Brugia malayi	hypothetical protein	0.0027	0.032	0.032
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0484	0.0484
Onchocerca volvulus	Bile acid receptor homolog	0.0036	0.0484	0.4305
Loa Loa (eye worm)	hypothetical protein	0.0027	0.032	0.032
Onchocerca volvulus		0.0065	0.0991	1
Brugia malayi	hypothetical protein	0.0065	0.0991	0.0991
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.032	0.1381
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0036	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0246	0.4248	0.4248
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0015	0.01	0.0304
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0567	0.0922
Brugia malayi	RNA recognition motif domain containing protein	0.0138	0.2303	0.2303
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0015	0.01	0.01
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0104	0.1693	1
Entamoeba histolytica	hypothetical protein	0.0104	0.1693	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0139	0.0452
Echinococcus granulosus	jun protein	0.0082	0.1309	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.0646	0.1052
Onchocerca volvulus		0.0017	0.0139	0.0432
Brugia malayi	steroid hormone receptor	0.0036	0.0484	0.0484
Echinococcus multilocularis	expressed protein	0.001	0.0007	0.0012
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.032	1
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0015	0.01	0.0333
Echinococcus granulosus	tumor protein p63	0.0352	0.6142	1
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0104	0.1693	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0544	0.0885
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0785	0.1278
Loa Loa (eye worm)	glutamate receptor	0.0045	0.0643	0.0643
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.0646	0.1052
Brugia malayi	follicle stimulating hormone receptor	0.0259	0.4477	0.4477
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.0567	0.0922
Echinococcus multilocularis	ferritin	0.001	0.0007	0.0012
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0567	0.0567
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0036	0.0484	0.0788
Brugia malayi	SRC-1	0.0045	0.0646	0.0646
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0139	0.0139
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0544	0.0885
Brugia malayi	bZIP transcription factor family protein	0.0082	0.1309	0.1309
Loa Loa (eye worm)	DR-78	0.0017	0.0139	0.0139
Brugia malayi	RE18450p	0.0015	0.01	0.01
Echinococcus granulosus	FTZ F1 alpha	0.0036	0.0484	0.0788
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0036	0.0484	0.0484
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0104	0.1693	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0785	0.0785
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0036	0.0484	0.0484
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0484	0.0788
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0017	0.0139	0.0226
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0485	0.0485
Echinococcus multilocularis	FTZ F1 alpha	0.0036	0.0484	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0175	0.0175
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.0646	0.1052
Treponema pallidum	bacterioferrin (TpF1)	0.001	0.0007	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.2303	0.751
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0175	0.0286
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.0567	0.0922
Brugia malayi	RNA binding protein	0.0138	0.2303	0.2303
Schistosoma mansoni	apoferritin-2	0.001	0.0007	0.0023
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0036	0.0484	0.4305
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.0485	0.079
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0139	0.0139
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0646	0.1052
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.0646	0.1052
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0036	0.0484	0.0788
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0012	0.0039	0.0039
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0104	0.1693	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1683	0.1683
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0036	0.0484	0.0788
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0036	0.0484	0.1577
Schistosoma mansoni	ferritin	0.001	0.0007	0.0023
Schistosoma mansoni	nuclear receptor	0.0017	0.0139	0.0452
Echinococcus granulosus	ferritin	0.001	0.0007	0.0012
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0056	0.083	0.1352
Brugia malayi	photoreceptor-specific nuclear receptor	0.0036	0.0484	0.0484
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0175	0.0572
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0731	0.0731
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0015	0.01	0.5
Echinococcus granulosus	tyrosine kinase	0.0041	0.0567	0.0922
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0165	0.2797	1
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0012	0.0039	0.0039
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0139	0.0226
Schistosoma mansoni	zinc finger protein	0.0017	0.0139	0.0452
Loa Loa (eye worm)	RNA binding protein	0.0138	0.2303	0.2303
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0484	0.0484
Entamoeba histolytica	protein kinase, putative	0.0036	0.0485	0.2417
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.032	0.1381
Schistosoma mansoni	metabotropic glutamate receptor	0.0038	0.0511	0.1666
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.2303	0.751
Schistosoma mansoni	d-amino acid oxidase	0.018	0.3067	1
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.2303	0.751
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0754	0.2459

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2110 nM	Binding affinity towards p60 Src tyrosine kinase using scintillation proximity assay	ChEMBL.	11965373
IC50 (binding)	= 2110 nM	Binding affinity towards p60 Src tyrosine kinase using scintillation proximity assay	ChEMBL.	11965373

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 31116