Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | shaker cognate | potassium voltage-gated channel, shaker-related subfamily, member 3 | 575 aa | 465 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Synaptic glycoprotein SC2 | 0.0043 | 0.3597 | 0.3597 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0059 | 0.5303 | 0.5303 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0059 | 0.5303 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0059 | 0.5303 | 1 |
Onchocerca volvulus | 0.0043 | 0.3597 | 0.5 | |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0059 | 0.5303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3597 | 0.3597 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3597 | 0.3597 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0059 | 0.5303 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0043 | 0.3597 | 0.3597 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0059 | 0.5303 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0059 | 0.5303 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0043 | 0.3597 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0059 | 0.5303 | 1 |
Schistosoma mansoni | immunophilin | 0.0059 | 0.5303 | 0.5303 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0059 | 0.5303 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0059 | 0.5303 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0043 | 0.3597 | 0.3597 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0099 | 0.9524 | 0.9524 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0059 | 0.5303 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0051 | 0.4451 | 0.4451 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0043 | 0.3597 | 0.3597 |
Loa Loa (eye worm) | FKBP5 protein | 0.0059 | 0.5303 | 0.5303 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0043 | 0.3597 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0051 | 0.4451 | 0.4451 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0059 | 0.5303 | 0.5303 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0043 | 0.3597 | 0.3597 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0043 | 0.3597 | 0.3597 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0059 | 0.5303 | 0.5303 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0059 | 0.5303 | 0.5303 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0059 | 0.5303 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0059 | 0.5303 | 0.5303 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0059 | 0.5303 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0059 | 0.5303 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0059 | 0.5303 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0104 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 1 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0043 | 0.3597 | 0.3597 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0051 | 0.4451 | 0.4451 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0059 | 0.5303 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0059 | 0.5303 | 0.5303 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0059 | 0.5303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4451 | 0.4451 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0059 | 0.5303 | 0.5303 |
Schistosoma mansoni | immunophilin | 0.0059 | 0.5303 | 0.5303 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0104 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0059 | 0.5303 | 0.5303 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0059 | 0.5303 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0043 | 0.3597 | 0.3597 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0059 | 0.5303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3597 | 0.3597 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0043 | 0.3597 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0059 | 0.5303 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0059 | 0.5303 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 19 nM | Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cells | ChEMBL. | 15603971 |
IC50 (functional) | = 19 nM | Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cells | ChEMBL. | 15603971 |
IC50 (functional) | = 131 nM | Inhibitory activity against voltage-gated potassium channel subunit Kv1.3 of human T cells | ChEMBL. | 15603971 |
IC50 (functional) | = 131 nM | Inhibitory activity against voltage-gated potassium channel subunit Kv1.3 of human T cells | ChEMBL. | 15603971 |
Ratio (functional) | = 1.4 | Relative T cell IC50 compared to IC50 for correolide assay | ChEMBL. | 15603971 |
Ratio (functional) | = 1.4 | Relative T cell IC50 compared to IC50 for correolide assay | ChEMBL. | 15603971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.