Detailed information for compound 325480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.469 | Formula: C25H26O9
  • H donors: 4 H acceptors: 4 LogP: 3.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cc(cc1OC)CO[C@@H]1Cc2c(O)cc(cc2O[C@@H]1c1ccc(c(c1)O)O)O
  • InChi: 1S/C25H26O9/c1-30-21-6-13(7-22(31-2)25(21)32-3)12-33-23-11-16-18(28)9-15(26)10-20(16)34-24(23)14-4-5-17(27)19(29)8-14/h4-10,23-24,26-29H,11-12H2,1-3H3/t23-,24-/m1/s1
  • InChiKey: ATDKJUKVGVOGDN-DNQXCXABSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0216 0.0093
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.077 0.0656
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0111 0.0406
Loa Loa (eye worm) hypothetical protein 0.0203 0.2095 0.8385
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.03 0.1544
Onchocerca volvulus 0.0053 0.0473 0.2221
Mycobacterium ulcerans hypothetical protein 0.0352 0.37 1
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.077 0.0656
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0026 0.0016
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0473 0.1019
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.077 0.1008
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0212
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.077 0.0656
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0214 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0523 0.2065
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0026 0.0056
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0026 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.008 0.077 1
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0026 0.0028
Leishmania major hypothetical protein, conserved 0.008 0.077 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.03 0.1544
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.001 0.0021
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0327 0.1275
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0072 0.011
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0212
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0757 0.1321
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.2152 0.2144
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0026 0.0064
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0216 0.0038
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.0056
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.03 0.0513
Loa Loa (eye worm) hypothetical protein 0.008 0.077 0.3058
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0473 0.0464
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0026 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0458 0.0448
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0216 0.0038
Brugia malayi mbt repeat family protein 0.0053 0.0473 0.1862
Schistosoma mansoni hypothetical protein 0.0039 0.0327 0.0704
Loa Loa (eye worm) hypothetical protein 0.0053 0.0473 0.1862
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0113 0.0104
Loa Loa (eye worm) fli-1 protein 0.024 0.2496 1
Echinococcus granulosus protein C ets 2 0.0011 0.0026 0.0028
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.077 0.1346
Brugia malayi mbt repeat family protein 0.0053 0.0473 0.1862
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0214 0.1717
Brugia malayi beta-lactamase family protein 0.008 0.077 0.3058
Brugia malayi beta-lactamase 0.008 0.077 0.3058
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.077 0.1959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0458 0.0985
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0216 0.0093
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0026 0.0028
Echinococcus granulosus tar DNA binding protein 0.0068 0.0636 0.1109
Mycobacterium tuberculosis Conserved protein 0.008 0.077 0.0656
Echinococcus multilocularis geminin 0.0384 0.4051 0.4045
Echinococcus granulosus flap endonuclease 1 0.0029 0.0214 0.0361
Onchocerca volvulus 0.0063 0.0586 0.2761
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0026 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0458 0.0448
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0026 0.0028
Schistosoma mansoni hypothetical protein 0.0439 0.4644 1
Plasmodium vivax ornithine aminotransferase, putative 0.005 0.0442 0.4099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.077 0.3058
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0352 0.37 1
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0552 0.0959
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.005 0.0442 0.5
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0552 0.1189
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0473 0.0464
Schistosoma mansoni z-protein (S1r protein) 0.001 0.001 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0636 0.137
Schistosoma mansoni hypothetical protein 0.0384 0.4051 0.8724
Loa Loa (eye worm) hypothetical protein 0.0058 0.0523 0.2065
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0636 0.0627
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0064
Schistosoma mansoni dep domain containing protein 0.001 0.001 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0099 0.0157
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0043 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0216 0.0828
Echinococcus granulosus Aminotransferase class III 0.005 0.0442 0.0765
Loa Loa (eye worm) histone methyltransferase 0.002 0.0113 0.0416
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0458 0.1801
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0636 0.2519
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.03 0.3767
Plasmodium vivax hypothetical protein, conserved 0.008 0.077 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0633 0.2504
Mycobacterium tuberculosis Probable hydrolase 0.008 0.077 0.0656
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0214 0.0431
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0072 0.0062
Schistosoma mansoni ets 0.0011 0.0026 0.0056
Loa Loa (eye worm) hypothetical protein 0.008 0.077 0.3058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0458 0.0985
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0113 0.0183
Schistosoma mansoni cpg binding protein 0.0067 0.0624 0.1345
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0099 0.0357
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0552 0.0543
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0473 0.082
Brugia malayi Ets-domain containing protein 0.0011 0.0026 0.0064
Mycobacterium tuberculosis Conserved protein 0.008 0.077 0.0656
Trichomonas vaginalis esterase, putative 0.008 0.077 0.1959
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0072 0.0062
Schistosoma mansoni elf1 0.0011 0.0026 0.0056
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0026 0.0028
Toxoplasma gondii ABC1 family protein 0.008 0.077 0.6406
Schistosoma mansoni dishevelled 0.001 0.001 0.0021
Mycobacterium ulcerans hypothetical protein 0.008 0.077 0.1008
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0352 0.37 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0043 0.0058
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.005 0.0442 0.1737
Echinococcus multilocularis ets variant gene 4 0.0011 0.0026 0.0016
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0473 0.1019
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.077 0.1959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0458 0.0985
Brugia malayi beta-lactamase family protein 0.008 0.077 0.3058
Schistosoma mansoni hypothetical protein 0.0321 0.3373 0.7264
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0473 0.1019
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0636 0.137
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.1197 1
Echinococcus multilocularis cpg binding protein 0.0067 0.0624 0.0615
Echinococcus multilocularis ornithine aminotransferase 0.005 0.0442 0.0432
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.077 0.0656
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0636 0.137
Brugia malayi RNA binding protein 0.0068 0.0636 0.2519
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.2152 0.3791
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0757 0.0747
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0552 0.0543
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0072 0.0155
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0352 0.37 0.6505
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0212
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0214 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0099 0.0357
Plasmodium falciparum ornithine aminotransferase 0.005 0.0442 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.03 0.1544
Brugia malayi CXXC zinc finger family protein 0.0063 0.0586 0.2315
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0216 0.0038
Echinococcus multilocularis ornithine aminotransferase 0.005 0.0442 0.0432
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0552 0.0959
Leishmania major hypothetical protein, conserved 0.0029 0.0216 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0636 0.2519
Brugia malayi TAR-binding protein 0.0068 0.0636 0.2519
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0026 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.077 1
Echinococcus granulosus neuropeptide receptor A26 0.0533 0.5661 1
Loa Loa (eye worm) beta-lactamase 0.008 0.077 0.3058
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.077 0.3058
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0216 0.1735
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0458 0.0792
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.077 0.0656
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.077 0.0656
Echinococcus granulosus neuropeptide s receptor 0.0533 0.5661 1
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.077 1
Echinococcus granulosus dnaJ subfamily B 0.0439 0.4644 0.8201
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0552 0.218
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.077 0.1959
Schistosoma mansoni ornithine--oxo-acid transaminase 0.005 0.0442 0.0952
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0064
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.03 0.029
Echinococcus multilocularis neuropeptide s receptor 0.0533 0.5661 0.5656
Brugia malayi hypothetical protein 0.0019 0.0105 0.0381
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0473 0.1862
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0352 0.37 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0552 0.218
Loa Loa (eye worm) RNA binding protein 0.0068 0.0636 0.2519
Mycobacterium ulcerans lipase LipD 0.008 0.077 0.1008
Echinococcus multilocularis Aminotransferase class III 0.005 0.0442 0.0432
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0026 0.0016
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.03 0.2441
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0586 0.2315
Schistosoma mansoni cpg binding protein 0.0067 0.0624 0.1345
Loa Loa (eye worm) hypothetical protein 0.008 0.077 0.3058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.077 0.1008
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.077 0.1959
Brugia malayi Augmenter of liver regeneration 0.0037 0.03 0.1165
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0026 0.0064
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0636 0.2519
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0216 0.0038
Schistosoma mansoni hypothetical protein 0.0013 0.0043 0.0092
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.03 0.1544
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0026 0.0064
Schistosoma mansoni ets-related 0.024 0.2496 0.5375
Onchocerca volvulus 0.008 0.077 0.3647
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0099 0.0157
Mycobacterium tuberculosis Probable aminotransferase 0.0352 0.37 0.6505
Schistosoma mansoni gabp alpha 0.0079 0.0757 0.1629
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.077 0.1959
Brugia malayi transcription factor E74 isoform 0.0011 0.0026 0.0064
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.005 0.0442 0.5
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0072 0.011
Mycobacterium leprae conserved hypothetical protein 0.008 0.077 0.1008
Brugia malayi Flap endonuclease-1 0.0029 0.0214 0.082
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.005 0.0442 0.3639
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0514 0.545 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0473 0.2221
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.03 0.1544
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0214 0.5
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0026 0.0016
Brugia malayi Ets-domain containing protein 0.0079 0.0757 0.3003
Leishmania major hypothetical protein, conserved 0.0037 0.03 0.1544
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0473 0.082
Echinococcus granulosus ornithine aminotransferase 0.005 0.0442 0.0765
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0458 0.1801
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0203 0.2095 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0636 0.137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.077 0.1659
Schistosoma mansoni flap endonuclease-1 0.0026 0.0184 0.0396
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.077 0.0761
Loa Loa (eye worm) MBCTL1 0.006 0.0552 0.218
Echinococcus granulosus geminin 0.0384 0.4051 0.7152
Echinococcus multilocularis protein C ets 2 0.0011 0.0026 0.0016
Brugia malayi Fli-1 protein 0.024 0.2496 1
Brugia malayi hypothetical protein 0.0029 0.0216 0.0828
Schistosoma mansoni cpg binding protein 0.0063 0.0586 0.1261
Echinococcus multilocularis GPCR, family 2 0.0018 0.0099 0.0089
Schistosoma mansoni hypothetical protein 0.0384 0.4051 0.8724
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.1352 0.2911
Schistosoma mansoni ets-related 0.0011 0.0026 0.0056
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0026 0.0028
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.03 0.1165
Schistosoma mansoni dishevelled 0.001 0.001 0.0021
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0026 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.4644 0.4639
Loa Loa (eye worm) hypothetical protein 0.008 0.077 0.3058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0099 0.0089
Echinococcus granulosus cpg binding protein 0.0067 0.0624 0.1088
Loa Loa (eye worm) hypothetical protein 0.0039 0.0327 0.1275
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0458 0.0792
Echinococcus granulosus GPCR family 2 0.0018 0.0099 0.0157
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0026 0.0064
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.0056
Onchocerca volvulus 0.008 0.077 0.3647
Mycobacterium tuberculosis Conserved protein 0.008 0.077 0.0656
Echinococcus multilocularis neuropeptide receptor A26 0.0533 0.5661 0.5656
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0099 0.0357
Brugia malayi Ets-domain containing protein 0.0079 0.0757 0.3003
Loa Loa (eye worm) hypothetical protein 0.008 0.077 0.3058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0523 0.2065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.077 0.1659
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.03 0.2441
Loa Loa (eye worm) hypothetical protein 0.0018 0.0099 0.0357
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0214 0.082
Onchocerca volvulus 0.008 0.077 0.3647
Mycobacterium ulcerans beta-lactamase 0.008 0.077 0.1008
Brugia malayi N-terminal motif family protein 0.0203 0.2095 0.8385
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0523 0.2065
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0757 0.3003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0099 0.0089
Loa Loa (eye worm) hypothetical protein 0.008 0.077 0.3058
Mycobacterium leprae Probable lipase LipE 0.008 0.077 0.1008
Schistosoma mansoni regulator of G protein signaling 0.001 0.001 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0636 0.137

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 29.8 uM In vitro inhibitory concentration of the compound against U373MG cell line in MTT assay was determined after 3 days incubation ChEMBL. 15380225
IC50 (functional) = 29.8 uM In vitro inhibitory concentration of the compound against U373MG cell line in MTT assay was determined after 3 days incubation ChEMBL. 15380225
IC50 (functional) = 32.5 uM In vitro inhibitory concentration of the compound against PC-3 cell line in MTT assay was determined after 3 days incubation ChEMBL. 15380225
IC50 (functional) = 32.5 uM In vitro inhibitory concentration of the compound against PC-3 cell line in MTT assay was determined after 3 days incubation ChEMBL. 15380225
IC50 (functional) = 38.2 uM In vitro inhibitory concentration of the compound against SKOV3 cell line in MTT assay was determined after 3 days incubation ChEMBL. 15380225
IC50 (functional) = 38.2 uM In vitro inhibitory concentration of the compound against SKOV3 cell line in MTT assay was determined after 3 days incubation ChEMBL. 15380225

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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