Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0106 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0106 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0106 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.0767 | 1 |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0106 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.0767 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0106 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Mycobacterium ulcerans | lipoprotein LpqF | 0.025 | 0.2515 | 0.3469 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.025 | 0.2515 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0767 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0106 | 0 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0521 | 0.7249 | 1 |
Brugia malayi | beta-lactamase | 0.0106 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0106 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0106 | 0 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.025 | 0.2515 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0106 | 0 | 0.5 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0521 | 0.7249 | 0.7249 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.0767 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0106 | 0 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0106 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0767 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0106 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0106 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.0767 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0106 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.025 | 0.2515 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 0 % | In vitro agonistic binding affinity for human 5-hydroxytryptamine 1A receptor expressed in CHO cells was determined using [35S]-GTP-gammaS, functional assay | ChEMBL. | 15454211 |
Emax (functional) | = 0 % | In vitro agonistic binding affinity for human 5-hydroxytryptamine 1A receptor expressed in CHO cells was determined using [35S]-GTP-gammaS, functional assay | ChEMBL. | 15454211 |
Ki (binding) | = 0.54 nM | In vitro binding affinity for serotonin transporter | ChEMBL. | 15454211 |
Ki (binding) | = 0.54 nM | In vitro binding affinity for serotonin transporter | ChEMBL. | 15454211 |
Ki (binding) | = 173.2 nM | In vitro binding affinity for human 5-hydroxytryptamine 1A receptor expressed in CHO cells was determined using [3H]-8-OH-DPAT radioligand | ChEMBL. | 15454211 |
Ki (binding) | = 173.2 nM | In vitro binding affinity for human 5-hydroxytryptamine 1A receptor expressed in CHO cells was determined using [3H]-8-OH-DPAT radioligand | ChEMBL. | 15454211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.