Detailed information for compound 331981

Basic information

Technical information
  • TDR Targets ID: 331981
  • Name: 1,4-bis[(2S)-2-(pyrrolidine-1-carbonyl)pyrrol idin-1-yl]butane-1,4-dione
  • MW: 418.53 | Formula: C22H34N4O4
  • H donors: 0 H acceptors: 4 LogP: 0.17 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC[C@H]1C(=O)N1CCCC1)CCC(=O)N1CCC[C@H]1C(=O)N1CCCC1
  • InChi: 1S/C22H34N4O4/c27-19(25-15-5-7-17(25)21(29)23-11-1-2-12-23)9-10-20(28)26-16-6-8-18(26)22(30)24-13-3-4-14-24/h17-18H,1-16H2/t17-,18-/m0/s1
  • InChiKey: BIPIDUZOUMYISB-ROUUACIJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,4-bis[(2S)-2-[oxo(1-pyrrolidinyl)methyl]-1-pyrrolidinyl]butane-1,4-dione
  • 1,4-bis[(2S)-2-pyrrolidin-1-ylcarbonylpyrrolidin-1-yl]butane-1,4-dione
  • 1,4-bis[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidino]butane-1,4-dione
  • 1,4-bis[(2S)-2-(oxo-1-pyrrolidinylmethyl)-1-pyrrolidinyl]butane-1,4-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Prolyl endopeptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) Get druggable targets OG5_129295 All targets in OG5_129295
Onchocerca volvulus Prolyl endopeptidase homolog Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma congolense prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania mexicana prolyl oligopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum Prolyl endopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Neospora caninum Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related Get druggable targets OG5_129295 All targets in OG5_129295
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus granulosus prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus multilocularis prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Toxoplasma gondii prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania donovani prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania infantum prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei gambiense prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma cruzi prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum oligopeptidase b;with=GeneDB:LmjF09.0770 Prolyl endopeptidase   710 aa 743 aa 24.4 %
Leishmania donovani oligopeptidase b Prolyl endopeptidase   710 aa 743 aa 24.4 %
Trypanosoma brucei gambiense oligopeptidase B, putative Prolyl endopeptidase   710 aa 629 aa 26.4 %
Trypanosoma cruzi oligopeptidase b Prolyl endopeptidase   710 aa 719 aa 25.6 %
Leishmania major oligopeptidase b Prolyl endopeptidase   710 aa 743 aa 24.9 %
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB Prolyl endopeptidase   710 aa 714 aa 26.5 %
Trypanosoma brucei oligopeptidase b Prolyl endopeptidase   710 aa 630 aa 26.3 %
Leishmania braziliensis oligopeptidase b;with=GeneDB:LmjF09.0770 Prolyl endopeptidase   710 aa 608 aa 26.0 %
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) Prolyl endopeptidase   710 aa 741 aa 25.6 %
Dictyostelium discoideum oligopeptidase B Prolyl endopeptidase   710 aa 735 aa 23.7 %
Trypanosoma cruzi oligopeptidase b Prolyl endopeptidase   710 aa 719 aa 25.6 %
Leishmania mexicana oligopeptidase b,serine peptidase, clan SC, family S9A-like protein Prolyl endopeptidase   710 aa 720 aa 24.7 %
Onchocerca volvulus Prolyl endopeptidase   710 aa 722 aa 47.6 %
Trypanosoma congolense oligopeptidase b Prolyl endopeptidase   710 aa 589 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.008 0.0038 1
Plasmodium falciparum serine repeat antigen 2 0.0334 0.1665 0.1659
Toxoplasma gondii cathepsin CPL 0.1635 1 1
Echinococcus granulosus cathepsin b 0.1606 0.9812 0.9812
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0401 0.2097 0.2067
Leishmania major cysteine peptidase A (CPA) 0.1635 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1635 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0334 0.1665 0.1659
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0334 0.1665 0.1659
Giardia lamblia Cathepsin B precursor 0.0727 0.4185 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0401 0.2097 0.2067
Echinococcus granulosus cathepsin l1 0.1108 0.6621 0.6608
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0727 0.4185 0.4163
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0861 0.5044 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.1108 0.6621 0.6621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0861 0.5044 0.5025
Leishmania major cathepsin L-like protease 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0334 0.1665 0.1634
Trypanosoma cruzi cysteine peptidase, putative 0.0528 0.2906 0.2879
Echinococcus granulosus cathepsin l1 0.1635 1 1
Echinococcus granulosus cathepsin L 0.0334 0.1665 0.1634
Echinococcus multilocularis sodium channel protein 0.017 0.0617 0.0582
Leishmania major cathepsin L-like protease 0.1635 1 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0334 0.1665 0.1659
Onchocerca volvulus 0.1635 1 1
Onchocerca volvulus Cathepsin F homolog 0.1635 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0334 0.1665 0.1659
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0861 0.5044 0.5025
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Giardia lamblia Cathepsin B precursor 0.0727 0.4185 1
Plasmodium falciparum serine repeat antigen 5 0.0334 0.1665 0.1659
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0334 0.1665 0.1659
Echinococcus multilocularis voltage dependent calcium channel 0.0401 0.2097 0.2067
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.054 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1635 1 1
Onchocerca volvulus Cathepsin L homolog 0.0334 0.1665 0.119
Schistosoma mansoni cathepsin F (C01 family) 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.1108 0.6621 0.6621
Onchocerca volvulus Cathepsin L homolog 0.1635 1 1
Echinococcus multilocularis cathepsin b 0.1606 0.9812 0.9812
Trypanosoma cruzi major cysteine proteinase, putative 0.0334 0.1665 0.1634
Loa Loa (eye worm) hypothetical protein 0.0528 0.2906 0.2906
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0401 0.2097 0.2067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.1635 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0334 0.1665 0.1634
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0334 0.1665 0.1634
Loa Loa (eye worm) hypothetical protein 0.0528 0.2906 0.2906
Trypanosoma cruzi prolyl endopeptidase 0.0158 0.054 0.0504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.017 0.0617 0.0582
Brugia malayi cathepsin L-like precursor 0.1108 0.6621 0.6608
Brugia malayi fibroinase precursor 0.0334 0.1665 0.1634
Echinococcus granulosus prolyl endopeptidase 0.0158 0.054 0.0504
Echinococcus multilocularis voltage dependent calcium channel 0.0401 0.2097 0.2067
Toxoplasma gondii preprocathepsin c precursor, putative 0.0334 0.1665 0.1665
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0401 0.2097 0.2067
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0334 0.1665 0.1665
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1108 0.6621 0.6608
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.1665 0.1634
Echinococcus granulosus cathepsin L 0.0861 0.5044 0.5025
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Plasmodium vivax unspecified product 0.0334 0.1665 0.1659
Leishmania major cathepsin L-like protease 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Loa Loa (eye worm) calcium channel 0.0401 0.2097 0.2097
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.054 0.054
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.008 0.0038 0.5
Echinococcus multilocularis prolyl endopeptidase 0.0158 0.054 0.0504
Brugia malayi Papain family cysteine protease containing protein 0.1635 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.1665 0.1634
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0334 0.1665 0.1634
Brugia malayi cathepsin F-like cysteine proteinase 0.0528 0.2906 0.2879
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0334 0.1665 0.1634
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0334 0.1665 0.1659
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0727 0.4185 0.4163
Brugia malayi Cathepsin L-like precursor 0.1108 0.6621 0.6608
Loa Loa (eye worm) hypothetical protein 0.0084 0.0065 0.0065
Plasmodium vivax serine-repeat antigen (SERA) 0.0334 0.1665 0.1659
Entamoeba histolytica cysteine proteinase 1, putative 0.0861 0.5044 0.4054
Leishmania major cathepsin L-like protease 0.1635 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1635 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1635 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.1635 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1635 1 1
Onchocerca volvulus 0.1635 1 1
Plasmodium vivax unspecified product 0.0528 0.2906 0.2901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0528 0.2906 0.2879
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0334 0.1665 0.1659
Echinococcus granulosus voltage dependent calcium channel 0.0084 0.0065 0.0027
Brugia malayi cathepsin Z-like cysteine proteinase 0.0334 0.1665 0.1634
Plasmodium vivax vivapain-3 0.0861 0.5044 0.5041
Onchocerca volvulus 0.1108 0.6621 0.6428
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1606 0.9812 0.9812
Loa Loa (eye worm) cysteine protease 0.1635 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1635 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.1635 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.1606 0.9812 0.9812
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0401 0.2097 0.2067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1606 0.9812 0.9812
Echinococcus granulosus cathepsin L cysteine protease 0.0861 0.5044 0.5025
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Echinococcus granulosus cathepsin b 0.1606 0.9812 0.9812
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Entamoeba histolytica cysteine proteinase 2 0.0861 0.5044 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0334 0.1665 0.1665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Onchocerca volvulus Cathepsin L homolog 0.1635 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0334 0.1665 0.1634
Echinococcus multilocularis cathepsin L 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1606 0.9812 0.9812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Schistosoma mansoni cathepsin s 0.0528 0.2906 0.2879
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0861 0.5044 0.5025
Leishmania major cathepsin L-like protease 0.1635 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0861 0.5044 0.5025
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0401 0.2097 0.2067
Schistosoma mansoni cathepsin C 0.0334 0.1665 0.1634
Plasmodium vivax vivapain-2 0.1635 1 1
Giardia lamblia Cathepsin B precursor 0.0727 0.4185 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1606 0.9812 0.9812
Brugia malayi Cathepsin L-like precursor 0.1108 0.6621 0.6608
Schistosoma mansoni cathepsin B (C01 family) 0.0334 0.1665 0.1634
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1108 0.6621 0.5946
Echinococcus granulosus voltage dependent calcium channel 0.0401 0.2097 0.2067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Plasmodium falciparum serine repeat antigen 9 0.0334 0.1665 0.1659
Entamoeba histolytica cysteine proteinase, putative 0.1635 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0727 0.4185 0.4163
Trypanosoma cruzi cysteine protease, putative 0.0861 0.5044 0.5025
Loa Loa (eye worm) cathepsin B 0.0727 0.4185 0.4185
Onchocerca volvulus 0.1635 1 1
Trypanosoma brucei prolyl endopeptidase 0.0158 0.054 0.0504
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1635 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0334 0.1665 0.1634
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Trypanosoma brucei cysteine peptidase C (CPC) 0.0727 0.4185 0.4163
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.054 0.0504
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0401 0.2097 0.2067
Toxoplasma gondii transporter, cation channel family protein 0.0084 0.0065 0.0065
Plasmodium falciparum serine repeat antigen 7 0.0334 0.1665 0.1659
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Trypanosoma cruzi cysteine peptidase, putative 0.0861 0.5044 0.5025
Toxoplasma gondii cathepsin CPC2 0.0334 0.1665 0.1665
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0334 0.1665 0.1659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0861 0.5044 0.5025
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0334 0.1665 0.1659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Brugia malayi Cathepsin L-like precursor 0.0528 0.2906 0.2879
Schistosoma mansoni cathepsin F (C01 family) 0.1635 1 1
Leishmania major cathepsin L-like protease 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0334 0.1665 0.1659
Trypanosoma cruzi cruzipain precursor, putative 0.0528 0.2906 0.2879
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0244 0.109 0.1056
Schistosoma mansoni voltage-gated cation channel 0.0401 0.2097 0.2067
Plasmodium vivax vivapain-2 0.1635 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0334 0.1665 0.1665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1108 0.6621 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0861 0.5044 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0334 0.1665 0.1634
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0401 0.2097 0.2067
Loa Loa (eye worm) hypothetical protein 0.1606 0.9812 0.9812
Plasmodium falciparum cysteine proteinase falcipain 1 0.0861 0.5044 0.5041
Plasmodium vivax vivapain-1 0.0861 0.5044 0.5041
Loa Loa (eye worm) hypothetical protein 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Leishmania major cathepsin L-like protease 0.1635 1 1
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0861 0.5044 0.5025
Loa Loa (eye worm) hypothetical protein 0.1108 0.6621 0.6621
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0334 0.1665 0.1634
Toxoplasma gondii prolyl endopeptidase 0.0158 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Onchocerca volvulus 0.1635 1 1
Onchocerca volvulus 0.0334 0.1665 0.119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1635 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1635 1 1
Plasmodium vivax unspecified product 0.0861 0.5044 0.5041
Schistosoma mansoni cathepsin F (C01 family) 0.1108 0.6621 0.6608
Toxoplasma gondii cathepsin B 0.0727 0.4185 0.4185
Plasmodium falciparum serine repeat antigen 6 0.0334 0.1665 0.1659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Brugia malayi cathepsin L precursor 0.0334 0.1665 0.1634
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0244 0.109 0.1056
Loa Loa (eye worm) hypothetical protein 0.0401 0.2097 0.2097
Plasmodium falciparum serine repeat antigen 8 0.0334 0.1665 0.1659
Echinococcus multilocularis cysteine protease 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1108 0.6621 0.5946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.1665 0.1634
Loa Loa (eye worm) voltage-dependent calcium channel 0.0084 0.0065 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Loa Loa (eye worm) ctsf protein 0.1635 1 1
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Toxoplasma gondii cathepsin CPC1 0.0334 0.1665 0.1665
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0334 0.1665 0.1659
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0334 0.1665 0.1659
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0861 0.5044 0.5025
Loa Loa (eye worm) hypothetical protein 0.0334 0.1665 0.1665
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0142 0.0433 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0401 0.2097 0.2067
Loa Loa (eye worm) IMP dehydrogenase 1 0.008 0.0038 0.0038
Loa Loa (eye worm) fibroinase 0.1635 1 1
Echinococcus multilocularis cysteine protease 0.1635 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0158 0.054 0.0504
Toxoplasma gondii IMP dehydrogenas 0.008 0.0038 0.0038
Echinococcus multilocularis cathepsin b 0.1606 0.9812 0.9812
Plasmodium falciparum serine repeat antigen 3 0.0334 0.1665 0.1659
Leishmania major cathepsin L-like protease 0.1635 1 1
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.008 0.0038 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Brugia malayi Cathepsin L-like precursor 0.1635 1 1
Echinococcus multilocularis cathepsin L 0.0334 0.1665 0.1634
Brugia malayi Cathepsin L-like cysteine proteinase 0.1108 0.6621 0.6608
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.1665 0.1634
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0861 0.5044 0.5025
Plasmodium falciparum serine repeat antigen 4 0.0334 0.1665 0.1659
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Loa Loa (eye worm) hypothetical protein 0.0528 0.2906 0.2906
Onchocerca volvulus 0.1635 1 1
Onchocerca volvulus 0.1635 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0401 0.2097 0.2067
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1635 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0861 0.5044 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1635 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0334 0.1665 0.1634
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0727 0.4185 0.3023
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0158 0.054 0.0504
Echinococcus granulosus cysteine protease 0.0861 0.5044 0.5025
Trypanosoma cruzi cysteine peptidase, putative 0.1635 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1606 0.9812 0.9812
Entamoeba histolytica cysteine protease, putative 0.0861 0.5044 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0861 0.5044 0.5025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Plasmodium falciparum serine repeat antigen 1 0.0334 0.1665 0.1659
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0528 0.2906 0.2906
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1635 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1635 1 1
Onchocerca volvulus 0.1635 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 77 nM In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min ChEMBL. 16033257
IC50 (binding) = 77 nM In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min ChEMBL. 16033257

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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