Detailed information for compound 332694

Basic information

Technical information
  • TDR Targets ID: 332694
  • Name: ethyl 8-cyclopentyl-7-oxo-2-[(5-piperazin-1-y lpyridin-2-yl)amino]pyrido[2,3-d]pyrimidine-6 -carboxylate
  • MW: 463.532 | Formula: C24H29N7O3
  • H donors: 2 H acceptors: 5 LogP: 2.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cc2cnc(nc2n(c1=O)C1CCCC1)Nc1ccc(cn1)N1CCNCC1
  • InChi: 1S/C24H29N7O3/c1-2-34-23(33)19-13-16-14-27-24(29-21(16)31(22(19)32)17-5-3-4-6-17)28-20-8-7-18(15-26-20)30-11-9-25-10-12-30/h7-8,13-15,17,25H,2-6,9-12H2,1H3,(H,26,27,28,29)
  • InChiKey: RBQSFMVORXJXTL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ethyl 8-cyclopentyl-7-oxo-2-[(5-piperazin-1-yl-2-pyridyl)amino]pyrido[2,3-d]pyrimidine-6-carboxylate
  • 8-cyclopentyl-7-oxo-2-[[5-(1-piperazinyl)-2-pyridyl]amino]-6-pyrido[2,3-d]pyrimidinecarboxylic acid ethyl ester
  • 8-cyclopentyl-7-keto-2-[(5-piperazino-2-pyridyl)amino]pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
  • ethyl 8-cyclopentyl-7-oxo-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[6,5-d]pyrimidine-6-carboxylate
  • ethyl 8-cyclopentyl-7-oxo-2-[(5-piperazin-1-yl-2-pyridyl)amino]pyrido[6,5-d]pyrimidine-6-carboxylate
  • 8-cyclopentyl-7-oxo-2-[[5-(1-piperazinyl)-2-pyridyl]amino]-6-pyrido[6,5-d]pyrimidinecarboxylic acid ethyl ester
  • 8-cyclopentyl-7-keto-2-[(5-piperazin-1-yl-2-pyridyl)amino]pyrido[6,5-d]pyrimidine-6-carboxylic acid ethyl ester
  • Pyrido-[2,3-d]-pyrimidin-7-one 34

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin D2 Starlite/ChEMBL References
Homo sapiens cyclin A1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131242 All targets in OG5_131242
Echinococcus multilocularis G1:S specific cyclin D1 Get druggable targets OG5_131242 All targets in OG5_131242
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131242 All targets in OG5_131242
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G1:S specific cyclin D1 Get druggable targets OG5_131242 All targets in OG5_131242
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_131242 All targets in OG5_131242
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin d Get druggable targets OG5_131242 All targets in OG5_131242
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K10151 cyclin D2, putative Get druggable targets OG5_131242 All targets in OG5_131242
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis cyclin B, putative cyclin D2 289 aa 246 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0118 0.044 0.044
Trichomonas vaginalis cyclins, putative 0.0073 0.0175 0.3973
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Trichomonas vaginalis cyclin B, putative 0.0073 0.0175 0.3973
Echinococcus granulosus xaa Pro dipeptidase 0.0118 0.044 0.044
Echinococcus multilocularis microtubule associated protein 2 0.1756 1 1
Toxoplasma gondii methionine aminopeptidase 0.1478 0.8378 1
Entamoeba histolytica aminopeptidase, putative 0.0118 0.044 1
Leishmania major transcription factor-like protein 0.0118 0.044 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.0541 0.291 0.3334
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0937 0.5217 0.6018
Schistosoma mansoni cyclin B 0.0073 0.0175 0.0175
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0118 0.044 0.044
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0118 0.044 0.0324
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0118 0.044 1
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0118 0.044 1
Toxoplasma gondii hypothetical protein 0.0541 0.291 0.3111
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1478 0.8378 1
Brugia malayi metallopeptidase family M24 containing protein 0.0118 0.044 0.0526
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0937 0.5217 1
Onchocerca volvulus 0.0118 0.044 1
Echinococcus granulosus G1:S specific cyclin D1 0.0193 0.0874 0.0874
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Leishmania major hypothetical protein, conserved 0.0118 0.044 0.0324
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0118 0.044 0.0324
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0118 0.044 0.0526
Trypanosoma brucei methionine aminopeptidase, putative 0.1478 0.8378 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0937 0.5217 0.6018
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0937 0.5217 0.5217
Plasmodium vivax methionine aminopeptidase 1b, putative 0.1478 0.8378 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0937 0.5217 1
Echinococcus granulosus methionyl aminopeptidase 2 0.0118 0.044 0.044
Onchocerca volvulus Dipeptidase C homolog 0.0118 0.044 1
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0118 0.044 0.0324
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0118 0.044 0.0526
Loa Loa (eye worm) methionine aminopeptidase type I 0.1478 0.8378 1
Echinococcus multilocularis xaa pro aminopeptidase 0.0118 0.044 0.044
Echinococcus multilocularis FACT complex subunit SPT16 0.0118 0.044 0.044
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.1478 0.8378 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0937 0.5217 0.5217
Brugia malayi metallopeptidase family M24 containing protein 0.0118 0.044 0.0526
Echinococcus granulosus cyclin B 0.0073 0.0175 0.0175
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0118 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0118 0.044 0.0526
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0937 0.5217 1
Leishmania major methionine aminopeptidase 2, putative 0.0118 0.044 0.0324
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0118 0.044 0.0324
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Chlamydia trachomatis methionine aminopeptidase 0.0937 0.5217 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Entamoeba histolytica peptidase, putative 0.0118 0.044 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.1478 0.8378 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0118 0.044 0.0324
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0937 0.5217 1
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0118 0.044 0.044
Giardia lamblia G2/mitotic-specific cyclin B 0.0073 0.0175 0.3973
Loa Loa (eye worm) DNA-binding protein 0.0118 0.044 0.0526
Brugia malayi metallopeptidase family M24 containing protein 0.0118 0.044 0.0526
Echinococcus multilocularis Proliferation associated protein 2G4 0.0118 0.044 0.044
Brugia malayi Cyclin, N-terminal domain containing protein 0.0193 0.0874 0.1043
Giardia lamblia Xaa-Pro dipeptidase 0.0118 0.044 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Echinococcus granulosus xaa pro aminopeptidase 0.0118 0.044 0.044
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Schistosoma mansoni peptidase 0.0118 0.044 0.044
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0175 0.0209
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.0175 0.0209
Brugia malayi Methionine aminopeptidase protein type I 0.1478 0.8378 1
Echinococcus multilocularis methionine aminopeptidase, type I 0.0118 0.044 0.044
Trypanosoma brucei hypothetical protein, conserved 0.0541 0.291 0.3334
Loa Loa (eye worm) hypothetical protein 0.0118 0.044 0.0526
Treponema pallidum methionine aminopeptidase (map) 0.0937 0.5217 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1478 0.8378 0.8378
Plasmodium vivax hypothetical protein, conserved 0.0541 0.291 0.3111
Loa Loa (eye worm) hypothetical protein 0.0182 0.0813 0.0971
Mycobacterium ulcerans methionine aminopeptidase 0.0937 0.5217 1
Entamoeba histolytica hypothetical protein, conserved 0.0118 0.044 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0118 0.044 0.044
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0118 0.044 0.0526
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1478 0.8378 1
Echinococcus multilocularis methionyl aminopeptidase 2 0.0118 0.044 0.044
Trypanosoma brucei Metallopeptidase family M24, putative 0.0118 0.044 0.0324
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0118 0.044 0.0324
Entamoeba histolytica methionine aminopeptidase, putative 0.0118 0.044 1
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0118 0.044 0.0526
Echinococcus granulosus xaa Pro dipeptidase 0.0118 0.044 0.044
Plasmodium falciparum aminopeptidase P 0.0118 0.044 0.0526
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0118 0.044 1
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0175 0.0209
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0118 0.044 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0541 0.291 0.3334
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0118 0.044 0.044
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0937 0.5217 0.6228
Echinococcus multilocularis xaa Pro dipeptidase 0.0118 0.044 0.044
Plasmodium falciparum methionine aminopeptidase 2 0.0118 0.044 0.0526
Loa Loa (eye worm) hypothetical protein 0.0193 0.0874 0.1043
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.1478 0.8378 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Loa Loa (eye worm) initiation factor 2-associated protein 0.0118 0.044 0.0526
Trichomonas vaginalis cyclin B, putative 0.0073 0.0175 0.3973
Trichomonas vaginalis cyclins, putative 0.0073 0.0175 0.3973
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Echinococcus multilocularis G1:S specific cyclin D1 0.0193 0.0874 0.0874
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0118 0.044 0.0526
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Echinococcus granulosus methionine aminopeptidase type I 0.0118 0.044 0.044
Giardia lamblia Methionine aminopeptidase 0.0118 0.044 1
Trichomonas vaginalis cyclins, putative 0.0073 0.0175 0.3973
Giardia lamblia Xaa-Pro dipeptidase 0.0118 0.044 1
Trypanosoma cruzi aminopeptidase P, putative 0.0118 0.044 0.0324
Trichomonas vaginalis cyclin B, putative 0.0073 0.0175 0.3973
Toxoplasma gondii methionine aminopeptidase 0.0937 0.5217 0.6018
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Trichomonas vaginalis cyclin A, putative 0.0073 0.0175 0.3973
Plasmodium falciparum HP12 protein homolog, putative 0.0541 0.291 0.3474
Echinococcus multilocularis xaa Pro dipeptidase 0.0118 0.044 0.044
Trichomonas vaginalis cyclin B, putative 0.0073 0.0175 0.3973
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0937 0.5217 1
Trichomonas vaginalis cyclins, putative 0.0073 0.0175 0.3973
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0118 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0073 0.0175 0.0209
Loa Loa (eye worm) hypothetical protein 0.0118 0.044 0.0526
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.1478 0.8378 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0937 0.5217 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0118 0.044 0.0324
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Brugia malayi initiation factor 2-associated protein. 0.0118 0.044 0.0526
Entamoeba histolytica cyclin, putative 0.0073 0.0175 0.3973
Echinococcus granulosus FACT complex subunit SPT16 0.0118 0.044 0.044
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0118 0.044 0.0324
Trypanosoma cruzi aminopeptidase P1, putative 0.0118 0.044 0.0324
Echinococcus multilocularis cyclin B 0.0073 0.0175 0.0175
Leishmania major hypothetical protein, conserved 0.0541 0.291 0.3334
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0937 0.5217 0.5217
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.1478 0.8378 0.8378
Schistosoma mansoni microtubule-associated protein tau 0.1756 1 1
Schistosoma mansoni cyclin d 0.0193 0.0874 0.0874
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0118 0.044 0.0324
Echinococcus granulosus Proliferation associated protein 2G4 0.0118 0.044 0.044
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0118 0.044 0.044
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0118 0.044 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 uM Inhibitory concentration was measured by the incorporation of [14C]-thymidine in (human breast carcinoma) MDA-MB-468 cell line (NA=Not Availanle) ChEMBL. 15801831
IC50 (binding) = 0.595 uM Inhibition of Cyclin-dependent kinase 4-cyclinD ChEMBL. 15801831
IC50 (binding) = 0.595 uM Inhibition of Cyclin-dependent kinase 4-cyclinD ChEMBL. 15801831
IC50 (binding) > 5 uM Inhibition of Cyclin dependent kinase 2-cyclin A ChEMBL. 15801831
IC50 (binding) > 5 uM Inhibition of Cyclin dependent kinase 2-cyclin A ChEMBL. 15801831

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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