TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 479.39 | Formula: C17H30Cl2N3PRu+++
H donors: 0 H acceptors: 0 LogP: 4.98 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cl[Ru+2](P12CN3CN(C1)C[N+](C2)(C3)C)Cl.Cc1ccc(cc1)C(C)C
InChi: 1S/C10H14.C7H15N3P.2ClH.Ru/c1-8(2)10-6-4-9(3)5-7-10;1-10-3-8-2-9(4-10)6-11(5-8)7-10;;;/h4-8H,1-3H3;2-7H2,1H3;2*1H;/q;+1;;;+3/p-1
InChiKey: IMYJGPXURSQMMA-UHFFFAOYSA-M

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0038	0.0024
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.1472	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0038	0.0104
Brugia malayi	ABC transporter family protein	0.001	0.0038	0.0004
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.0428	0.1403
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0038	0.2067
Loa Loa (eye worm)	multidrug resistance-associated protein	0.0034	0.0199	0.0164
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0379	0.0343
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0043	0.0265	0.0231
Echinococcus multilocularis	cpg binding protein	0.0034	0.0198	0.0279
Plasmodium falciparum	multidrug resistance protein 1	0.001	0.0038	0.5
Brugia malayi	PXA domain containing protein	0.0021	0.0113	0.0125
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0021	0.0113	0.0145
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0035	0.1816
Loa Loa (eye worm)	ABC transporter	0.001	0.0038	0.0002
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0021	0.0113	0.0125
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0025	0.0137	0.0102
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Echinococcus granulosus	cpg binding protein	0.0034	0.0198	0.0279
Echinococcus multilocularis		0.001	0.0038	0.0024
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0021	0.0113	0.0145
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0021	0.0113	0.0145
Schistosoma mansoni	smdr1	0.001	0.0038	0.0124
Plasmodium falciparum	ABC transporter B family member 5, putative	0.001	0.0038	0.5
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0043	0.0265	0.0386
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.001	0.0038	0.5
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0185	0.024
Echinococcus multilocularis	axis inhibition protein axin	0.0021	0.0113	0.0145
Echinococcus granulosus	ATP binding cassette sub family B	0.001	0.0038	0.0024
Echinococcus multilocularis	regulator of G protein signaling 7	0.0021	0.0113	0.0145
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0025	0.0137	0.0162
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0043	0.0265	0.0363
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0139	0.0104
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0113	0.0078
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0038	0.0024
Plasmodium vivax	multidrug resistance protein 1, putative	0.001	0.0038	0.5
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0043	0.0265	0.0363
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0113	1
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0113	0.0372
Brugia malayi	ABC transporter family protein	0.001	0.0038	0.0004
Plasmodium falciparum	multidrug resistance-associated protein 2	0.001	0.0038	0.5
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0036	0.0001
Echinococcus multilocularis	regulator of G protein signaling 3	0.0021	0.0113	0.0145
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0038	0.2067
Plasmodium falciparum	multidrug resistance-associated protein 1	0.001	0.0038	0.5
Schistosoma mansoni	multidrug resistance protein	0.001	0.0038	0.0124
Plasmodium falciparum	ABC transporter B family member 3, putative	0.001	0.0038	0.5
Loa Loa (eye worm)	multidrug resistance protein 3	0.001	0.0038	0.0002
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0038	0.0024
Plasmodium falciparum	ABC transporter B family member 6, putative	0.001	0.0038	0.5
Trypanosoma brucei	p-glycoprotein	0.0043	0.0265	0.0363
Giardia lamblia	MRP-like ABC transporter	0.0043	0.0265	1
Plasmodium vivax	multidrug resistance protein 2, putative	0.001	0.0038	0.5
Echinococcus granulosus	regulator of G protein signaling 3	0.0021	0.0113	0.0145
Schistosoma mansoni	multidrug resistance protein	0.001	0.0035	0.0116
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0021	0.0113	0.0372
Brugia malayi	P38 map kinase family protein 2	0.0929	0.6298	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0038	0.2067
Schistosoma mansoni	hypothetical protein	0.0452	0.3051	1
Echinococcus granulosus	expressed protein	0.0413	0.2782	0.4396
Echinococcus granulosus	ATP binding cassette sub family B	0.001	0.0035	0.002
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0021	0.0113	0.0372
Leishmania major	p-glycoprotein e	0.0043	0.0265	0.0363
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0113	1
Echinococcus granulosus	multidrug resistance associated protein 7	0.0043	0.0265	0.0386
Echinococcus multilocularis	regulator of G protein signaling	0.0021	0.0113	0.0145
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0038	0.0024
Brugia malayi	hypothetical protein	0.0021	0.0113	0.0125
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0038	0.2067
Entamoeba histolytica	P-glycoprotein-2, putative	0.001	0.0038	0.0104
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0113	0.0372
Echinococcus granulosus	mitogen activated protein kinase 14	0.0929	0.6298	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0038	0.2067
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0038	0.2067
Plasmodium vivax	ABC transporter B family member 5, putative	0.001	0.0038	0.5
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0038	0.0024
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0929	0.6298	1
Brugia malayi	hypothetical protein	0.0021	0.0113	0.0125
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0265	0.0231
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0021	0.0113	0.0125
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.001	0.0038	0.5
Loa Loa (eye worm)	ABC transporter	0.001	0.0038	0.0002
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0929	0.6298	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0043	0.0265	0.0363
Echinococcus granulosus	ATP binding cassette sub family B	0.001	0.0038	0.0024
Brugia malayi	regulator of G-protein signaling egl-10	0.0021	0.0113	0.0125
Brugia malayi	multidrug resistance related protein 1	0.0043	0.0265	0.0367
Giardia lamblia	Multidrug resistance-associated protein 1	0.0043	0.0263	0.9896
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0929	0.6298	0.6285
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0113	1
Entamoeba histolytica	hypothetical protein	0.0021	0.0113	0.3398
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Schistosoma mansoni	multidrug resistance protein	0.001	0.0038	0.0124
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.001	0.0038	0.5
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0038	0.5
Leishmania major	pentamidine resistance protein 1	0.0043	0.0265	0.0363
Echinococcus multilocularis	axis inhibition protein axin	0.0021	0.0113	0.0145
Plasmodium vivax	ABC transporter B family member 6, putative	0.001	0.0038	0.5
Schistosoma mansoni	axis inhibition protein axin	0.0021	0.0113	0.0372
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.001	0.0038	0.5
Entamoeba histolytica	hypothetical protein	0.0021	0.0113	0.3398
Onchocerca volvulus		0.0032	0.0185	1
Trichomonas vaginalis	taga, putative	0.001	0.0038	0.2067
Entamoeba histolytica	P-glycoprotein 6, putative	0.001	0.0038	0.0104
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0002
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0002
Brugia malayi	regulator of G-protein signaling rgs-7	0.0021	0.0113	0.0125
Trypanosoma brucei	multidrug resistance protein E	0.0043	0.0265	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0113	0.0078
Entamoeba histolytica	multidrug resistance protein, putative	0.0043	0.0265	1
Schistosoma mansoni	multidrug resistance protein	0.001	0.0038	0.0124
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0038	0.0024
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0043	0.0265	0.0363
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0035	0.1816
Loa Loa (eye worm)	ABC transporter	0.001	0.0038	0.0002
Trypanosoma cruzi	hypothetical protein	0.0033	0.0196	0.0253
Brugia malayi	ABC transporter transmembrane region family protein	0.001	0.0038	0.0004
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.001	0.0038	0.5
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0025	0.0137	0.0181
Trichomonas vaginalis	abcb9, putative	0.001	0.0038	0.2067
Giardia lamblia	Multidrug resistance-associated protein 1	0.0043	0.0265	1
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.001	0.0035	0.0116
Brugia malayi	hypothetical protein	0.001	0.0038	0.0004
Echinococcus granulosus	regulator of G protein signaling 3	0.0021	0.0113	0.0145
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0038	0.2067
Entamoeba histolytica	P-glycoprotein-5	0.001	0.0038	0.0104
Entamoeba histolytica	hypothetical protein	0.0021	0.0113	0.3398
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0038	0.0024
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0038	0.0024
Plasmodium vivax	ABC transporter B family member 4, putative	0.001	0.0038	0.5
Schistosoma mansoni	cpg binding protein	0.0032	0.0185	0.0608
Schistosoma mansoni	z-protein (S1r protein)	0.0021	0.0113	0.0372
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0043	0.0265	0.0363
Schistosoma mansoni	cpg binding protein	0.0034	0.0198	0.0648
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0265	0.0869
Echinococcus multilocularis	expressed protein	0.0413	0.2782	0.4396
Echinococcus granulosus	Regulator of G protein signaling 20	0.0021	0.0113	0.0145
Plasmodium falciparum	multidrug resistance protein 2	0.001	0.0038	0.5
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0265	1
Schistosoma mansoni	cpg binding protein	0.0034	0.0198	0.0648
Echinococcus multilocularis	dnaJ subfamily B	0.0452	0.3051	0.4826
Brugia malayi	ABC transporter family protein	0.001	0.0038	0.0004
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0038	0.0024
Entamoeba histolytica	P-glycoprotein 5, putative	0.001	0.0038	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0263	0.0228
Echinococcus multilocularis	regulator of G protein signaling 7	0.0021	0.0113	0.0145
Brugia malayi	ABC transporter transmembrane region family protein	0.0043	0.0265	0.0367
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0043	0.0265	0.0363
Leishmania major	ABC-thiol transporter	0.0043	0.0265	0.0363
Echinococcus granulosus	mitogen activated protein kinase 11	0.0929	0.6298	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0038	0.2067
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0038	0.2067
Echinococcus granulosus	axis inhibition protein axin	0.0021	0.0113	0.0145
Echinococcus granulosus	axis inhibition protein axin	0.0021	0.0113	0.0145
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0265	0.0869
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0038	0.0024
Brugia malayi	ABC transporter	0.001	0.0038	0.0004
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0038	0.2067
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0021	0.0113	1
Plasmodium vivax	ABC transporter B family member 3, putative	0.001	0.0038	0.5
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.001	0.0038	0.0004
Giardia lamblia	Multidrug resistance-associated protein 1	0.0043	0.0265	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0036	0.0021
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0265	0.0869
Giardia lamblia	ABC transporter, putative	0.0043	0.0265	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0265	0.0231
Loa Loa (eye worm)	hypothetical protein	0.1472	1	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0265	1
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0929	0.6298	1
Echinococcus granulosus	multidrug resistance associated protein 1	0.0043	0.0265	0.0386
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0265	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0113	0.0078
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0038	0.2067
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0113	0.0372
Echinococcus granulosus	regulator of G protein signaling 7	0.0021	0.0113	0.0145
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0038	0.2067
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0929	0.6298	1
Trichomonas vaginalis	abcb9, putative	0.001	0.0038	0.2067
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0929	0.6298	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0038	0.0024
Loa Loa (eye worm)	hypothetical protein	0.1472	1	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0929	0.6298	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0036	0.0021
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0043	0.0265	0.0386
Toxoplasma gondii	hypothetical protein	0.1472	1	1
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0038	0.0104
Brugia malayi	multidrug resistance protein 3	0.001	0.0038	0.0004
Entamoeba histolytica	P-glycoprotein-1	0.001	0.0038	0.0104
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0023	0.0074
Brugia malayi	A-kinase anchor protein 10, precursor	0.0021	0.0113	0.0125
Schistosoma mansoni	axis inhibition protein axin	0.0021	0.0113	0.0372
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0038	0.0024
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.001	0.0038	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0035	0.1816
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0035	0.1816
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0038	0.0024
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.001	0.0038	0.5
Schistosoma mansoni	multidrug resistance protein	0.001	0.0038	0.0124
Entamoeba histolytica	P-glycoprotein 6, putative	0.001	0.0038	0.0104
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0265	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.001	0.0038	0.5
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0021	0.0113	0.0078
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0038	0.0024
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0038	0.0024
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0025	0.0137	0.0102
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0038	0.2067
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0038	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0137	0.0448
Plasmodium falciparum	ABC transporter B family member 4, putative	0.001	0.0038	0.5
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0043	0.0265	0.0363
Entamoeba histolytica	ABC transporter, putative	0.0043	0.0265	1
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0137	0.0448
Schistosoma mansoni	smdr2	0.001	0.0038	0.0124
Loa Loa (eye worm)	PXA domain-containing protein	0.0021	0.0113	0.0078
Brugia malayi	PXA domain containing protein	0.0021	0.0113	0.0125
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0038	0.2067
Echinococcus granulosus	regulator of G protein signaling 7	0.0021	0.0113	0.0145
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0139	0.0167
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0137	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0113	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0113	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0038	0.2067
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.001	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0113	0.0078
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0185	0.0151
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0038	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0038	0.2067
Brugia malayi	ABC transporter family protein	0.001	0.0038	0.0004
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.001	0.0038	0.0002
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0038	0.0024
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0038	0.2067
Echinococcus granulosus	multidrug resistance associated protein 4	0.0033	0.0196	0.0277
Echinococcus multilocularis	regulator of G protein signaling 3	0.0021	0.0113	0.0145
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0038	0.0024
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0113	0.0372
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.001	0.0035	0.002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0113	0.0078
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0265	0.0869
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0929	0.6298	1
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0113	0.0372
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.001	0.0038	0.5
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0.0038	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0038	0.2067
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0043	0.0265	0.0228
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0113	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0021	0.0113	0.0372
Entamoeba histolytica	P-glyco protein 6, putative	0.001	0.0038	0.0104
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0043	0.0265	0.0363
Echinococcus multilocularis	multidrug resistance associated protein 4	0.0033	0.0196	0.0277
Trichomonas vaginalis	abcb9, putative	0.001	0.0038	0.2067
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.001	0.0038	0.0124
Echinococcus granulosus	dnaJ subfamily B	0.0452	0.3051	0.4826
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0929	0.6298	1
Plasmodium falciparum	ABC transporter B family member 7, putative	0.001	0.0038	0.5
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.001	0.0038	0.5
Brugia malayi	P-glycoprotein-like protein	0.001	0.0038	0.0004
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0043	0.0265	0.0363
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0035	0.002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0113	0.0078
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0025	0.0137	0.0181
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0038	0.2067
Loa Loa (eye worm)	RGS-3 protein	0.0021	0.0113	0.0078
Plasmodium vivax	ABC transporter B family member 7, putative	0.001	0.0038	0.5
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0265	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 246 uM	Inhibitory concentration of the compound against HBL-100 human mammary cell after 72 h of incubation in MTT assay	ChEMBL.	15943488
IC50 (functional)	> 300 uM	Inhibitory concentration of the compound against murine TS/A adenocarcinoma cancer cell line after 72 h of incubation in MTT assay	ChEMBL.	15943488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 423608

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 338527