TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.441 | Formula: C23H24NO4+
H donors: 0 H acceptors: 0 LogP: 4.83 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCC[n+]1cc2cc(OC)c(cc2c2c1c1cc3OCOc3cc1C2)OC
InChi: 1S/C23H24NO4/c1-4-5-6-24-12-15-9-19(25-2)20(26-3)10-16(15)18-7-14-8-21-22(28-13-27-21)11-17(14)23(18)24/h8-12H,4-7,13H2,1-3H3/q+1
InChiKey: KCEMLTPIXXVOSJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0043	0.0372	1
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0159	0.0372
Brugia malayi	hypothetical protein	0.0021	0.0159	0.3402
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.001	0.0053	0.5
Plasmodium falciparum	ABC transporter B family member 6, putative	0.001	0.0053	0.5
Entamoeba histolytica	ABC transporter, putative	0.0043	0.0372	1
Echinococcus multilocularis	multidrug resistance associated protein 4	0.0033	0.0275	0.0574
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0053	0.2074
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0053	0.005
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0021	0.0159	0.0299
Loa Loa (eye worm)	hypothetical protein	0.001	0.0053	0.0003
Schistosoma mansoni	multidrug resistance protein	0.001	0.0053	0.0124
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0021	0.0159	0.3402
Entamoeba histolytica	hypothetical protein	0.0021	0.0159	0.3392
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.001	0.0053	0.5
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.001	0.0053	0.5
Plasmodium falciparum	multidrug resistance-associated protein 2	0.001	0.0053	0.5
Plasmodium falciparum	ABC transporter B family member 3, putative	0.001	0.0053	0.5
Entamoeba histolytica	hypothetical protein	0.0021	0.0159	0.3392
Loa Loa (eye worm)	ABC transporter	0.001	0.0053	0.0003
Echinococcus multilocularis	regulator of G protein signaling 7	0.0021	0.0159	0.0299
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0053	0.005
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0053	0.005
Brugia malayi	ABC transporter family protein	0.001	0.0053	0.0118
Schistosoma mansoni	multidrug resistance protein	0.001	0.0053	0.0124
Brugia malayi	ABC transporter transmembrane region family protein	0.0043	0.0372	1
Plasmodium vivax	ABC transporter B family member 7, putative	0.001	0.0053	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0053	0.2074
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0159	0.011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0159	0.011
Brugia malayi	hypothetical protein	0.001	0.0053	0.0118
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.001	0.0053	0.5
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.001	0.0053	0.5
Brugia malayi	regulator of G-protein signaling rgs-7	0.0021	0.0159	0.3402
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0372	0.087
Plasmodium falciparum	multidrug resistance-associated protein 1	0.001	0.0053	0.5
Trypanosoma brucei	p-glycoprotein	0.0043	0.0372	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0021	0.0159	0.0372
Schistosoma mansoni	axis inhibition protein axin	0.0021	0.0159	0.0372
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0043	0.0372	1
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0159	0.0372
Plasmodium falciparum	ABC transporter B family member 7, putative	0.001	0.0053	0.5
Brugia malayi	multidrug resistance protein 3	0.001	0.0053	0.0118
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0159	0.0372
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0053	0.005
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0032	0.0074
Brugia malayi	ABC transporter family protein	0.001	0.0053	0.0118
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0531	0.0481
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.001	0.0053	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0053	0.2074
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0053	0.005
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.001	0.0053	0.0118
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.001	0.0053	0.5
Echinococcus multilocularis	cpg binding protein	0.0033	0.0277	0.0578
Brugia malayi	A-kinase anchor protein 10, precursor	0.0021	0.0159	0.3402
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.005	0.0042
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0053	0.0104
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0053	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0369	0.0321
Schistosoma mansoni	cpg binding protein	0.0033	0.0277	0.0648
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0372	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0021	0.0159	0.3402
Giardia lamblia	Multidrug resistance-associated protein 1	0.0043	0.0372	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0372	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0159	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0159	0.011
Brugia malayi	hypothetical protein	0.0021	0.0159	0.3402
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0053	0.005
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0053	0.005
Entamoeba histolytica	P-glycoprotein-2, putative	0.001	0.0053	0.0104
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0021	0.0159	0.3402
Loa Loa (eye worm)	hypothetical protein	0.001	0.0053	0.0003
Echinococcus granulosus	cpg binding protein	0.0033	0.0277	0.0578
Echinococcus multilocularis	regulator of G protein signaling	0.0021	0.0159	0.0299
Echinococcus multilocularis		0.001	0.0053	0.005
Loa Loa (eye worm)	RGS-3 protein	0.0021	0.0159	0.011
Plasmodium vivax	ABC transporter B family member 3, putative	0.001	0.0053	0.5
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0053	0.005
Onchocerca volvulus		0.0031	0.026	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0021	0.0159	0.011
Schistosoma mansoni	smdr2	0.001	0.0053	0.0124
Trichomonas vaginalis	abcb9, putative	0.001	0.0053	0.2074
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.06	0.1403
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0053	0.2074
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0372	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0372	1
Brugia malayi	ABC transporter transmembrane region family protein	0.001	0.0053	0.0118
Echinococcus granulosus	multidrug resistance associated protein 7	0.0043	0.0372	0.0801
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0053	0.005
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0053	0.0104
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0053	0.005
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.001	0.0053	0.5
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.001	0.0053	0.5
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.001	0.005	0.0116
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0372	0.087
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.005	0.0044
Giardia lamblia	Multidrug resistance-associated protein 1	0.0043	0.0372	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0159	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0195	0.4531
Echinococcus granulosus	ATP binding cassette sub family B	0.001	0.005	0.0042
Schistosoma mansoni	z-protein (S1r protein)	0.0021	0.0159	0.0372
Loa Loa (eye worm)	hypothetical protein	0.001	0.0053	0.0003
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.001	0.0053	0.0003
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0053	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0053	0.2074
Loa Loa (eye worm)	hypothetical protein	0.1039	1	1
Loa Loa (eye worm)	ABC transporter	0.001	0.0053	0.0003
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0053	0.005
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0372	0.087
Plasmodium vivax	multidrug resistance protein 1, putative	0.001	0.0053	0.5
Giardia lamblia	MRP-like ABC transporter	0.0043	0.0372	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0021	0.0159	0.0299
Echinococcus granulosus	multidrug resistance associated protein 1	0.0043	0.0372	0.0801
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0043	0.0372	1
Schistosoma mansoni	multidrug resistance protein	0.001	0.005	0.0116
Echinococcus granulosus	regulator of G protein signaling 3	0.0021	0.0159	0.0299
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0159	0.0372
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0053	0.2074
Brugia malayi	PXA domain containing protein	0.0021	0.0159	0.3402
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0021	0.0159	0.0299
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0159	0.0372
Plasmodium vivax	ABC transporter B family member 6, putative	0.001	0.0053	0.5
Entamoeba histolytica	hypothetical protein	0.0021	0.0159	0.3392
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Echinococcus granulosus	regulator of G protein signaling 3	0.0021	0.0159	0.0299
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.001	0.0053	0.5
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0021	0.0159	0.0372
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0159	0.0372
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Entamoeba histolytica	P-glycoprotein-1	0.001	0.0053	0.0104
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0043	0.0372	0.0324
Brugia malayi	ABC transporter	0.001	0.0053	0.0118
Echinococcus granulosus	ATP binding cassette sub family B	0.001	0.0053	0.005
Loa Loa (eye worm)	histone methyltransferase	0.001	0.005	0.0001
Echinococcus granulosus	axis inhibition protein axin	0.0021	0.0159	0.0299
Echinococcus granulosus	Regulator of G protein signaling 20	0.0021	0.0159	0.0299
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.005	0.1822
Brugia malayi	P-glycoprotein-like protein	0.001	0.0053	0.0118
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0053	0.005
Loa Loa (eye worm)	PXA domain-containing protein	0.0021	0.0159	0.011
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0043	0.0372	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0021	0.0159	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0159	0.011
Brugia malayi	ABC transporter family protein	0.001	0.0053	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0159	1
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0043	0.0372	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0043	0.0372	0.0801
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0021	0.0159	0.0372
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0053	0.2074
Schistosoma mansoni	cpg binding protein	0.0033	0.0277	0.0648
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0159	1
Plasmodium vivax	multidrug resistance protein 2, putative	0.001	0.0053	0.5
Entamoeba histolytica	P-glyco protein 6, putative	0.001	0.0053	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0372	0.0324
Echinococcus multilocularis	dnaJ subfamily B	0.0447	0.4276	1
Entamoeba histolytica	P-glycoprotein 6, putative	0.001	0.0053	0.0104
Trichomonas vaginalis	abcb9, putative	0.001	0.0053	0.2074
Schistosoma mansoni	smdr1	0.001	0.0053	0.0124
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0043	0.0372	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0053	0.005
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0053	0.2074
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0159	1
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0021	0.0159	0.0299
Brugia malayi	ABC transporter transmembrane region family protein	0.001	0.005	0.0014
Entamoeba histolytica	P-glycoprotein-5	0.001	0.0053	0.0104
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.001	0.005	0.0042
Echinococcus granulosus	multidrug resistance associated protein 4	0.0033	0.0275	0.0574
Echinococcus multilocularis	regulator of G protein signaling 3	0.0021	0.0159	0.0299
Entamoeba histolytica	hypothetical protein	0.0043	0.0372	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0159	0.011
Schistosoma mansoni	multidrug resistance protein	0.001	0.0053	0.0124
Brugia malayi	PXA domain containing protein	0.0021	0.0159	0.3402
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0021	0.0159	0.3402
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0021	0.0159	0.0299
Loa Loa (eye worm)	multidrug resistance protein 3	0.001	0.0053	0.0003
Loa Loa (eye worm)	ABC transporter	0.001	0.0053	0.0003
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.005	0.1822
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0053	0.005
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0053	0.2074
Echinococcus multilocularis	axis inhibition protein axin	0.0021	0.0159	0.0299
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0159	1
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0021	0.0159	0.0299
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0053	0.2074
Entamoeba histolytica	P-glycoprotein 5, putative	0.001	0.0053	0.0104
Echinococcus granulosus	axis inhibition protein axin	0.0021	0.0159	0.0299
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.001	0.0053	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0159	0.011
Echinococcus multilocularis	expressed protein	0.0408	0.3898	0.911
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0053	0.2074
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0053	0.2074
Plasmodium falciparum	multidrug resistance protein 1	0.001	0.0053	0.5
Brugia malayi	multidrug resistance related protein 1	0.0043	0.0372	1
Loa Loa (eye worm)	hypothetical protein	0.1039	1	1
Echinococcus granulosus	expressed protein	0.0408	0.3898	0.911
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0053	0.2074
Toxoplasma gondii	hypothetical protein	0.1039	1	1
Schistosoma mansoni	cpg binding protein	0.0031	0.026	0.0608
Trichomonas vaginalis	taga, putative	0.001	0.0053	0.2074
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.001	0.0053	0.5
Giardia lamblia	ABC transporter, putative	0.0043	0.0372	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0043	0.0369	0.9896
Leishmania major	p-glycoprotein e	0.0043	0.0372	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.1039	1	1
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0043	0.0372	0.0801
Schistosoma mansoni	hypothetical protein	0.0447	0.4276	1
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0043	0.0372	1
Leishmania major	ABC-thiol transporter	0.0043	0.0372	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0021	0.0159	0.0299
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0053	0.2074
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.005	0.1822
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0043	0.0372	1
Plasmodium vivax	ABC transporter B family member 4, putative	0.001	0.0053	0.5
Plasmodium falciparum	ABC transporter B family member 4, putative	0.001	0.0053	0.5
Brugia malayi	ABC transporter	0.001	0.005	0.0014
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0021	0.0159	0.011
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0053	0.2074
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0021	0.0159	0.011
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0159	0.0372
Schistosoma mansoni	axis inhibition protein axin	0.0021	0.0159	0.0372
Plasmodium falciparum	ABC transporter B family member 5, putative	0.001	0.0053	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0053	0.005
Trichomonas vaginalis	abcb9, putative	0.001	0.0053	0.2074
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0053	0.2074
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.001	0.0053	0.0124
Entamoeba histolytica	P-glycoprotein 6, putative	0.001	0.0053	0.0104
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0159	0.0372
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.026	0.0211
Brugia malayi	CXXC zinc finger family protein	0.0031	0.026	0.6526
Loa Loa (eye worm)	multidrug resistance-associated protein	0.0033	0.0279	0.023
Echinococcus granulosus	dnaJ subfamily B	0.0447	0.4276	1
Plasmodium vivax	ABC transporter B family member 5, putative	0.001	0.0053	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0053	0.2074
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0053	0.2074
Trypanosoma cruzi	hypothetical protein	0.0033	0.0275	0.6976
Echinococcus granulosus	regulator of G protein signaling 7	0.0021	0.0159	0.0299
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0043	0.0372	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0.0053	0.5
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0043	0.0372	1
Trypanosoma brucei	multidrug resistance protein E	0.0043	0.0372	1
Echinococcus granulosus	ATP binding cassette sub family B	0.001	0.0053	0.005
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0195	0.0147
Schistosoma mansoni	multidrug resistance protein	0.001	0.0053	0.0124
Brugia malayi	ABC transporter family protein	0.001	0.0053	0.0118
Entamoeba histolytica	multidrug resistance protein, putative	0.0043	0.0372	1
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0372	0.087
Plasmodium falciparum	multidrug resistance protein 2	0.001	0.0053	0.5
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0021	0.0159	1
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0053	0.005
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0053	0.005
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0053	0.005
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0043	0.0372	0.0321
Echinococcus multilocularis	axis inhibition protein axin	0.0021	0.0159	0.0299
Leishmania major	pentamidine resistance protein 1	0.0043	0.0372	1
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0053	0.2074
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.005	0.0044
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.005	0.1822

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	0	Inhibitory activity against DNA-Topoisomerase I	ChEMBL.	15857129

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10993360

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 338530