TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.334 | Formula: C18H17F3N2O3
H donors: 3 H acceptors: 3 LogP: 0.87 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CC(C(=O)O)N)Nc1ccc(c(c1)C)c1ccc(cc1)C(F)(F)F
InChi: 1S/C18H17F3N2O3/c1-10-8-13(23-16(24)9-15(22)17(25)26)6-7-14(10)11-2-4-12(5-3-11)18(19,20)21/h2-8,15H,9,22H2,1H3,(H,23,24)(H,25,26)
InChiKey: JHPMJNZQSSOYSF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0135	0.0296	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0407	0.0407
Chlamydia trachomatis	glutamate symporter	0.0304	0.0962	1
Schistosoma mansoni	coup transcription factor	0.0309	0.098	0.1019
Echinococcus granulosus	FTZ F1 alpha	0.0309	0.098	0.3032
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0146	0.0339	0.1048
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0882	0.3232	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.2605	1	1
Leishmania major	C-8 sterol isomerase-like protein	0.2605	1	1
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0309	0.098	0.098
Schistosoma mansoni	nuclear hormone receptor	0.0146	0.0339	0.0352
Brugia malayi	Inositol-1	0.0073	0.0051	0.0051
Echinococcus granulosus	inositol monophosphatase 1	0.0073	0.0051	0.0159
Loa Loa (eye worm)	nuclear hormone receptor	0.0146	0.0339	0.0339
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0309	0.098	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0304	0.0962	0.2976
Brugia malayi	photoreceptor-specific nuclear receptor	0.0309	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0309	0.098	0.3032
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0146	0.0339	0.0339
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0309	0.098	0.098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0309	0.098	0.098
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0146	0.0339	0.1048
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0309	0.098	0.3032
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0146	0.0339	0.1048
Brugia malayi	conserved hypotetical protein	0.0146	0.0339	0.0339
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.055	0.1926	1
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.0304	0.0962	0.4937
Brugia malayi	steroid hormone receptor	0.0309	0.098	0.098
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0309	0.098	0.3032
Echinococcus granulosus	Excitatory amino acid transporter	0.0304	0.0962	0.2976
Echinococcus multilocularis	neutral amino acid transporter A	0.0304	0.0962	0.2976
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0309	0.098	0.098
Brugia malayi	hypothetical protein	0.0163	0.0407	0.0407
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0063	0.0014	0.0042
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0146	0.0339	0.1048
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0309	0.098	0.3032
Echinococcus multilocularis	lamin b receptor	0.0088	0.0112	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0407	0.0407
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0065	0.0021	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0309	0.098	0.098
Schistosoma mansoni	microtubule-associated protein tau	0.0673	0.2408	0.2505
Brugia malayi	Nuclear hormone receptor E75	0.0146	0.0339	0.0339
Brugia malayi	Nuclear hormone receptor-like 1	0.0163	0.0407	0.0407
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0882	0.3232	0.3232
Brugia malayi	orphan nuclear receptor NR2E1	0.0146	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Onchocerca volvulus	Protein ultraspiracle homolog	0.0309	0.098	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Brugia malayi	nuclear hormone receptor	0.0309	0.098	0.098
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0133	0.0288	0.0238
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0146	0.0339	0.0352
Trypanosoma brucei	C-8 sterol isomerase, putative	0.2605	1	1
Echinococcus multilocularis	neutral amino acid transporter A	0.0304	0.0962	0.2976
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0882	0.3232	0.3232
Brugia malayi	nuclear receptor RXR	0.0146	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0304	0.0962	0.2976
Trichomonas vaginalis	inositol monophosphatase, putative	0.0073	0.0051	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0146	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0407	0.0407
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0309	0.098	0.3032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0309	0.098	0.098
Echinococcus multilocularis	Excitatory amino acid transporter	0.0304	0.0962	0.2976
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Trypanosoma cruzi	Emopamil binding protein, putative	0.0133	0.0288	0.0238
Schistosoma mansoni	inositol monophosphatase	0.0073	0.0051	0.0053
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0146	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0146	0.0339	0.1048
Loa Loa (eye worm)	excitatory amino acid transporter	0.0304	0.0962	0.0962
Onchocerca volvulus		0.0309	0.098	0.3032
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Schistosoma mansoni	nuclear receptor	0.0146	0.0339	0.0352
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0309	0.098	0.098
Brugia malayi	Nuclear hormone receptor-like 1	0.0309	0.098	0.098
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0309	0.098	0.1019
Echinococcus multilocularis	excitatory amino acid transporter 3	0.0304	0.0962	0.2976
Onchocerca volvulus		0.0146	0.0339	0.1048
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0309	0.098	0.3032
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0304	0.0962	0.2976
Echinococcus granulosus	excitatory amino acid transporter 2	0.0304	0.0962	0.2976
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Echinococcus granulosus	ecdysone induced protein 78C	0.0309	0.098	0.3032
Echinococcus granulosus	neutral amino acid transporter	0.0304	0.0962	0.2976
Brugia malayi	nuclear hormone receptor family member odr-7	0.0146	0.0339	0.0339
Schistosoma mansoni	inositol monophosphatase	0.0073	0.0051	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0309	0.098	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0309	0.098	0.098
Brugia malayi	Excitatory amino acid transporter	0.0304	0.0962	0.0962
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0135	0.0296	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0554	0.1942	0.6011
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0163	0.0407	0.0424
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0304	0.0962	0.2976
Brugia malayi	nuclear receptor NHR-88	0.0146	0.0339	0.0339
Onchocerca volvulus	Bile acid receptor homolog	0.0309	0.098	0.3032
Brugia malayi	tailless protein	0.0146	0.0339	0.0339
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0163	0.0407	0.126
Echinococcus granulosus	nuclear receptor nhr 48	0.0146	0.0339	0.1048
Brugia malayi	ecdysteroid receptor	0.0309	0.098	0.098
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.0304	0.0962	0.1001
Echinococcus granulosus	neutral amino acid transporter A	0.0304	0.0962	0.2976
Echinococcus granulosus	sodium:dicarboxylate symporter	0.0304	0.0962	0.2976
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0309	0.098	0.098
Onchocerca volvulus		0.0146	0.0339	0.1048
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0309	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0309	0.098	0.1019
Schistosoma mansoni	nuclear receptor nhr-48	0.0146	0.0339	0.0352
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.0304	0.0962	1
Brugia malayi	nuclear receptor RXR	0.0163	0.0407	0.0407
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0146	0.0339	0.1048
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0309	0.098	0.1019
Treponema pallidum	glutamate/aspartate transporter	0.0135	0.0296	1
Echinococcus multilocularis	FTZ F1 alpha	0.0309	0.098	0.3032
Echinococcus granulosus	lamin b receptor	0.0088	0.0112	0.0346
Brugia malayi	ecdysone receptor	0.0146	0.0339	0.0339
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0088	0.0112	0.0061
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0592	0.209	1
Trypanosoma brucei	Emopamil binding protein, putative	0.0133	0.0288	0.0238
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0073	0.0051	0.5
Echinococcus multilocularis	inositol monophosphatase 1	0.0073	0.0051	0.0159
Onchocerca volvulus		0.0133	0.0288	0.0891
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0133	0.0288	0.0238
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0146	0.0339	0.0339
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0309	0.098	0.3032
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0135	0.0296	0.0308
Brugia malayi	hypothetical protein	0.0146	0.0339	0.0339
Schistosoma mansoni	Lamin B receptor (ERG24)	0.0088	0.0112	0.0116
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0309	0.098	0.3032
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0309	0.098	0.098
Leishmania major	hypothetical protein, conserved	0.0133	0.0288	0.0238
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0309	0.098	0.3032
Leishmania major	C-14 sterol reductase, putative	0.0088	0.0112	0.0061
Echinococcus granulosus	excitatory amino acid transporter 3	0.0304	0.0962	0.2976
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Loa Loa (eye worm)	DR-78	0.0146	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0309	0.098	0.098
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0309	0.098	0.3032
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.0304	0.0962	0.2976
Echinococcus granulosus	microtubule associated protein 2	0.0673	0.2408	0.7451
Echinococcus multilocularis	microtubule associated protein 2	0.0673	0.2408	0.7451
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0163	0.0407	0.0407
Echinococcus granulosus	thyroid hormone receptor alpha	0.0146	0.0339	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.2506	0.9611	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0309	0.098	0.098
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.0051	0.5
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.2605	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0309	0.098	0.098
Brugia malayi	hypothetical protein	0.0163	0.0407	0.0407
Schistosoma mansoni	nuclear receptor	0.0146	0.0339	0.0352
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0135	0.0296	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0407	0.0407
Schistosoma mansoni	zinc finger protein	0.0146	0.0339	0.0352
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0309	0.098	0.1019
Schistosoma mansoni	glutamate receptor NMDA	0.0063	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor-like 1	0.0163	0.0407	0.0407
Brugia malayi	Steroid receptor seven-up type 2	0.0309	0.098	0.098
Echinococcus multilocularis	ecdysone induced protein 78C	0.0309	0.098	0.3032
Loa Loa (eye worm)	steroid hormone receptor	0.0309	0.098	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0309	0.098	0.098
Echinococcus granulosus	neutral amino acid transporter A	0.0304	0.0962	0.2976
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0073	0.0051	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0146	0.0339	0.1048
Brugia malayi	nuclear receptor NHR-67	0.0146	0.0339	0.0339
Brugia malayi	nuclear hormone receptor	0.0146	0.0339	0.0339
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0309	0.098	0.098
Schistosoma mansoni	nuclear hormone receptor	0.0309	0.098	0.1019
Trypanosoma brucei	C-14 sterol reductase, putative	0.0088	0.0112	0.0061
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0882	0.3232	1
Trypanosoma cruzi	Emopamil binding protein, putative	0.0133	0.0288	0.0238
Loa Loa (eye worm)	hypothetical protein	0.1332	0.4997	0.4997
Echinococcus multilocularis	neutral amino acid transporter A	0.0304	0.0962	0.2976
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Loa Loa (eye worm)	inositol-1	0.0073	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0309	0.098	0.098
Schistosoma mansoni	thyroid hormone receptor	0.0309	0.098	0.1019
Schistosoma mansoni	retinoic acid receptor RXR	0.0309	0.098	0.1019
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0088	0.0112	0.0061
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0163	0.0407	0.0424
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0309	0.098	0.098
Echinococcus granulosus	vesicular acetylcholine transporter	0.0882	0.3232	1
Schistosoma mansoni	thyroid hormone receptor	0.0309	0.098	0.1019
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0133	0.0288	0.0238
Brugia malayi	Nuclear hormone receptor E75	0.0146	0.0339	0.0339
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0309	0.098	0.1019
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0146	0.0339	0.1048
Brugia malayi	nuclear receptor NHR-88	0.0309	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Echinococcus multilocularis	nuclear receptor nhr 48	0.0146	0.0339	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0407	0.0407
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0163	0.0407	0.126
Brugia malayi	Serotonin receptor	0.0487	0.1679	0.1679
Echinococcus granulosus	Excitatory amino acid transporter	0.0304	0.0962	0.2976
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0309	0.098	0.098
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0309	0.098	0.3032
Schistosoma mansoni	nuclear hormone receptor	0.0146	0.0339	0.0352
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0309	0.098	0.3032
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0146	0.0339	0.1048
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0309	0.098	0.3032
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0146	0.0339	0.1048
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0309	0.098	0.3032
Echinococcus multilocularis	Excitatory amino acid transporter	0.0304	0.0962	0.2976
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0146	0.0339	0.1048
Schistosoma mansoni	vesicular acetylcholine transporter	0.0882	0.3232	0.3362
Echinococcus granulosus	excitatory amino acid transporter 2	0.0304	0.0962	0.2976
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0309	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Echinococcus granulosus	tm gpcr rhodopsin	0.0554	0.1942	0.6011
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0063	0.0014	0.0042
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0592	0.209	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0309	0.098	0.1019
Brugia malayi	hypothetical protein	0.0146	0.0339	0.0339
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0309	0.098	0.3032
Treponema pallidum	glutamate transporter	0.0135	0.0296	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0339	0.0339
Schistosoma mansoni	RAR-like nuclear receptor	0.0309	0.098	0.1019

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.3 uM	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2	ChEMBL.	16165356
IC50 (binding)	= 3 uM	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3	ChEMBL.	16165356
IC50 (binding)	= 20 uM	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1	ChEMBL.	16165356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 430725

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 345061